Genetic lesions within the 3a gene of SARS-CoV
Abstract A series of frameshift mutations within the 3a gene has been observed in culture-derived severe acute respiratory syndrome coronavirus (SARS-CoV). We report here that viral RNA from clinical samples obtained from SARS-CoV infected patients also contains a heterogeneous population of wild-type and mutant 3a transcripts.
Lim Seng, Shen Shuo, Chou Chih-Fong, Fielding Burtram C, Barkham Timothy, Tan Timothy HP, Hong Wanjin, Tan Yee-Joo