Nucleocapsid Protein as Early Diagnostic Marker for SARS
SARS-CoV, Nucleocapsid protein, Monoclonal antibody, Enzyme-Linked Immunosorbent Assay, Early diagnosis, severe acute respiratory syndrome, dispatch, China
Serum samples from 317 patients with patients with severe acute respiratory syndrome (SARS) were tested for the nucleocapsid (N) protein of SARS-associated coronavirus, with sensitivities of 94% and 78% for the first 5 days and 6–10 days after onset, respectively. The specificity was 99.9%. N protein can be used as an early diagnostic maker for SARS.
Xiao-Yan Che, Wei Hao, Yadi Wang, Biao Di, Kai Yin, Yin-Chao Xu, Changsen Feng, Zhuo-Yue Wan, Vincent C.C. Cheng, Patrick C. Y. Woo
Centers for Disease Control and Prevention
Infectious and parasitic diseases, Medicine