Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children
subject: Children, Shock, Acute myocarditis, SARS-CoV-2, Multisystem inflammatory syndrome
description: Abstract Background A recent increase in children admitted with hypotensive shock and fever in the context of the COVID-19 outbreak requires an urgent characterization and assessment of the involvement of SARS-CoV-2 infection. This is a case series performed at 4 academic tertiary care centers in Paris of all the children admitted to the pediatric intensive care unit (PICU) with shock, fever and suspected SARS-CoV-2 infection between April 15th and April 27th, 2020. Results 20 critically ill children admitted for shock had an acute myocarditis (left ventricular ejection fraction, 35% (25–55); troponin, 269 ng/mL (31–4607)), and arterial hypotension with mainly vasoplegic clinical presentation. The first symptoms before PICU admission were intense abdominal pain and fever for 6 days (1–10). All children had highly elevated C-reactive protein (> 94 mg/L) and procalcitonin (> 1.6 ng/mL) without microbial cause. At least one feature of Kawasaki disease was found in all children (fever, n = 20, skin rash, n = 10; conjunctivitis, n = 6; cheilitis, n = 5; adenitis, n = 2), but none had the typical form. SARS-CoV-2 PCR and serology were positive for 10 and 15 children, respectively. One child had both negative SARS-CoV-2 PCR and serology, but had a typical SARS-CoV-2 chest tomography scan. All children but one needed an inotropic/vasoactive drug support (epinephrine, n = 12; milrinone, n = 10; dobutamine, n = 6, norepinephrine, n = 4) and 8 were intubated. All children received intravenous immunoglobulin (2 g per kilogram) with adjuvant corticosteroids (n = 2), IL 1 receptor antagonist (n = 1) or a monoclonal antibody against IL-6 receptor (n = 1). All children survived and were afebrile with a full left ventricular function recovery at PICU discharge. Conclusions Acute myocarditis with intense systemic inflammation and atypical Kawasaki disease is an emerging severe pediatric disease following SARS-CoV-2 infection. Early recognition of this disease is needed and referral t…
creator: Michael Levy, Marianne Leruez-Ville, Florence Moulin, Sylvain Renolleau, Pierre Quartier, Pierre-Louis Léger, Sandrine Jean, Matthieu Bendavid, Mehdi Oualha, Diala Khraiche, Guillaume Geslain, Marion Grimaud, Julie Starck, Clémence Marais, Judith Chareyre, Nada Semaan, Géraldine Poncelet
source: Annals of Intensive Care
publisher: SpringerOpen
date: 2020
identifier: DOI: 10.1186/s13613-020-00690-8
coverage: Medical emergencies. Critical care. Intensive care. First aid