A Cohort of Patients with COVID-19 in a Major Teaching Hospital in Europe
Background: Since the confirmation of the first patient infected with SARS-CoV-2 in Spain in January 2020, the epidemic has grown rapidly, with the greatest impact on the region of Madrid. This article describes the first 2226 adult patients with COVID-19, consecutively admitted to La Paz University Hospital in Madrid. Methods: Our cohort included all patients consecutively hospitalized who had a final outcome (death or discharge) in a 1286-bed hospital of Madrid (Spain) from 25 February (first case admitted) to 19 April 2020. The data were manually entered into an electronic case report form, which was monitored prior to the analysis. Results: We consecutively included 2226 adult patients admitted to the hospital who either died (460) or were discharged (1766). The patients’ median age was 61 years, and 51.8% were women. The most common comorbidity was arterial hypertension (41.3%), and the most common symptom on admission was fever (71.2%). The median time from disease onset to hospital admission was 6 days. The overall mortality was 20.7% and was higher in men (26.6% vs. 15.1%). Seventy-five patients with a final outcome were transferred to the intensive care unit (ICU) (3.4%). Most patients admitted to the ICU were men, and the median age was 64 years. Baseline laboratory values on admission were consistent with an impaired immune-inflammatory profile. Conclusions: We provide a description of the first large cohort of hospitalized patients with COVID-19 in Europe. Advanced age, male sex, the presence of comorbidities and abnormal laboratory values were more common among the patients with fatal outcomes.
Jesús Mingorance, Juan J. Rios, Miguel A. Hernán, Elena Ramírez, Concepción Prados Sánchez, Alberto M. Borobia, Manuel Quintana, Rodolfo Álvarez-Sala, Alejandro Martín-Quirós, Francisco Arnalich, Gonzalo Martínez-Alés, Antonio J Carcas, Juan Carlos Figueira, Antonio Buño, José R Arribas, Jesús Frías, Francisco Moreno-Ramos, Julio García-Rodríguez, Francisco Reinoso-Barbero, Jaime Monserrat Villatoro, Rosario M. Torres Santos-Olmo, Alberto Martín-Vega, Nicolás García-Arenzana, M. Concepción Núñez, Milagros Martí-de-Gracia, Angélica Rivera Núñez, Carlos J. Carpio Segura, Daniel Prieto Arribas, Esther Rey Cuevas, on behalf of the COVID@HULP Working Group