Acute Kidney Injury Can Predict In-Hospital Mortality in Elderly Patients with COVID-19 in the ICU: A Single-Center Study
subject: Diagnosis, acute kidney injury, Coronavirus disease 2019, nomogram, in-hospital mortality
description: Qinglin Li, 1,* Tianyi Zhang, 2,* Fei Li, 3, 4,* Zhi Mao, 1 Hongjun Kang, 1 Ling Tao, 3,* Feihu Zhou, 1, 3,* Yue Cai 1, 3, 4,* 1Department of Critical Care Medicine, The First Medical Centre, Chinese PLA General Hospital, Beijing 100853, People’s Republic of China; 2Institution of Hospital Management, Medical Innovation Research Division of Chinese PLA General Hospital, Beijing 100853, People’s Republic of China; 3Department of Cardiology, Xijing Hospital, Xi’an 710032, People’s Republic of China; 4Department of Infectious Diseases, Huo Shen Shan Hospital, Wuhan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Feihu Zhou Tel +86 10 6693 8148Email feihuzhou301@126.comYue Cai Tel + 86 159 0238 8078Email caiyueclear1981@163.comObjective: Severe or critical patients with coronavirus disease 2019 (COVID-19) are at increased risk for developing acute kidney injury (AKI). However, the rate of AKI in patients of different severities and independent predictive factors associated with AKI are not well understood.Patients and Methods: We enrolled 107 severely or critically ill elderly patients with COVID-19 who were admitted to the intensive care unit (ICU) in Wuhan, China. AKI was defined according to the 2012 KDIGO criteria. We explored the association between AKI and in-hospital mortality using logistic regression. A predictive nomogram was formulated to predict the AKI development of patients with COVID-19 based on multivariate logistic regression.Results: A total of 107 elderly patients were enrolled during the study period. The mean age was 70 (64– 78) years, and 69 (64.5%) were men. For the 107 patients, the degree of severity of COVID-19 was categorized as 37 patients with the severe type (34.6%) and 70 patients with the critical type (65.4%). Overall, 48 of the 107 patients (44.9%) developed AKI during their hospitalization, while AKI occurred in 7 (18.9%) out of the 37 severe patients and 41 (44.9%) out of the 70 critical pati…
creator: Li Q, Zhang T, Li F, Mao Z, Kang H, Tao L, Zhou F, Cai Y
source: Biotemas
publisher: Universidade Federal de Santa Catarina
date: 2020
coverage: Geriatrics