Introduction, Transmission Dynamics, and Fate of Early SARS-CoV-2 Lineages in Santa Clara County, California.
epidemiology, Public Health Surveillance, covid-19, SARS-CoV-2, viral evolution, viral whole-genome sequencing, D614 lineage
We combined viral genome sequencing with contact tracing to investigate introduction and evolution of SARS-CoV-2 lineages in Santa Clara County, California from January 27 to March 21, 2020. Of 558 persons with COVID-19, 101 genomes from 143 available clinical samples comprised 17 different lineages including SCC1 (n=41), WA1 (n=9, including the first 2 reported deaths in the United States, diagnosed post-mortem), D614G (n=4), ancestral Wuhan Hu-1 (n=21), and 13 others (n=26). Public health intervention may have curtailed the persistence of lineages that appeared transiently during February-March. By August, only D614G lineages introduced after March 21 were circulating in SCC.
Suxiang Tong, Elsa Villarino, Xianding Deng, Carol A Kemper, Michelle A Jorden, Brandon Bonin, Sarah L Rudman, George S Han, Guixia Yu, Candace Wang, Scot Federman, Brian Bushnell, Debra A Wadford, Wen Lin, Ying Tao, Clinton R Paden, Julu Bhatnagar, Tara MacCannell, Joshua Batson, Charles Y Chiu