Adli Otopsilerde Resusitasyon Artefaktları
adli otopsi, kardiyopulmoner resusitasyon, artefakt lezyonlar, tıbbi uygulama hatası, sarsılmış bebek sendromu
Acil tıbbi müdahale uygulanmış otopsi olgularında, travma bulgularını yorumlamak güçleşmekte, ortaya çıkan artefakt lezyonların ölüme katkısının olup olmadığı tartışma konusu olabilmektedir. Bu çalışmada, İstanbul’da Ocak 1998-Ocak 2002 tarihleri arasında otopsisi yapılmış olgulara ait otopsi raporları, ayırım yapılmadan tek tek incelenmiş, resusitasyon sonucu meydana geldiğine karar verilen lezyonların yeri ve niteliği ile ortaya çıkan sorunlar, ilgili literatür bilgileri ışığında irdelenmiştir. Olguların 51’inde (%11.7) defibrilasyona bağlı ekimozlu veya ekimozsuz kırıklar, 19’unda (%4.2) yalnızca ekimoz saptanmıştır. Kırıkların en sık sol 3-4-5. kotlarda ve midklaviküler hatta oluştuğu, sternumda kırık görülme oranmm %33.33 olduğu saptanmıştır. Birçok olguda pnömotoraks testi yapılmamış olduğu için pnömotoraks oluşma sıklığı kontrol edilememiştir. Anahtar kelimeler: Adli otopsi, kardiyopulmoner resusitasyon, artefakt lezyonlar, tıbbi uygulama hatası, sarsılmış bebek sendromu.
Microevolution of Outbreak-Associated Middle East Respiratory Syndrome Coronavirus, South Korea, 2015
Middle East respiratory syndrome, MERS-CoV, coronavirus, Phylogenetic analysis, genome sequencing, Viruses
During the 2015 Middle East respiratory syndrome coronavirus outbreak in South Korea, we sequenced full viral genomes of strains isolated from 4 patients early and late during infection. Patients represented at least 4 generations of transmission. We found no evidence of changes in the evolutionary rate and no reason to suspect adaptive changes in viral proteins.
Moon-Woo Seong, So-Yeon Kim, Victor Max Corman, Taek Soo Kim, Sung Im Cho, Man Jin Kim, Seung-Jun Lee, Jeesoo Lee, Soo Hyun Seo, Ji Soo Ahn, Byeong Su Yu, Nare Park, Myoung-don Oh, Wan Beom Park, Ji Yeon Lee, Ga-Yeon Kim, Joon Sung Joh, Ina Jeong, Eui Chong Kim, Christian Drosten, Sung Sup Park
Centers for Disease Control and Prevention
Infectious and parasitic diseases, Medicine
Porcine Epidemic Diarrhea Virus and Discovery of a Recombinant Swine Enteric Coronavirus, Italy
porcine epidemic diarrhea virus, coronavirus, Viruses, Transmissible gastroenteritis virus, porcine respiratory coronavirus, recombinant coronavirus
Porcine epidemic diarrhea virus (PEDV) has been detected sporadically in Italy since the 1990s. We report the phylogenetic relationship of swine enteric coronaviruses collected in Italy during 2007–2014 and identify a drastic shift in PEDV strain variability and a new swine enteric coronavirus generated by recombination of transmissible gastroenteritis virus and PEDV.
M. Beatrice Boniotti, Alice Papetti, Antonio Lavazza, Giovanni Alborali, Enrica Sozzi, Chiara Chiapponi, Silvia Faccini, Paolo Bonilauri, Paolo Cordioli, Douglas Marthaler
Variations in Spike Glycoprotein Gene of MERS-CoV, South Korea, 2015
Middle East respiratory syndrome coronavirus, MERS-CoV, Viruses, Middle East respiratory syndrome, spike glycoprotein gene, genetic evolution
An outbreak of nosocomial infections with Middle East respiratory syndrome coronavirus occurred in South Korea in May 2015. Spike glycoprotein genes of virus strains from South Korea were closely related to those of strains from Riyadh, Saudi Arabia. However, virus strains from South Korea showed strain-specific variations.
Daewon Kim, You-Jin Kim, Sung-Han Park, Mi-Ran Yun, Jeong-Sun Yang, Hae Ji Kang, Young Woo Han, Han Saem Lee, Heui Man Kim, Hak Kim, A Reum Kim, Deok Rim Heo, Su Jin Kim, Jun-Ho JEON, Deokbum Park, Joo Ae Kim, Hyang-Min Cheong, Jeong-Gu Nam, Kisoon Kim, Sung Soon Kim
Des Isles d’Auvergne aux Outremers, parcours utopiques
Repenser l’île comme une espérance d’archipel a été la voie d’Homère puis des écrivains caribéens. Désormais l’expérience des origines montagnardes de l’île définit l’écriture comme une éruption volcanique. Ces images charriées au-delà des mers supposent une nostalgie de l’état sauvage dont la montagne, les côtes rocheuses et la forêt font écrin à des populations mystérieuses, espèces animales et végétales mêlées, dont les voyageurs n’ont pas fini de tisser leurs rêves. Mais la tapisserie séculaire ne se défait plus comme celle de Pénélope, car les îles s’entraident grâce aux archipels et le font savoir aux continents.
RAD tag sequencing as a source of SNP markers in Cynara cardunculus L
Abstract Background The globe artichoke (Cynara cardunculus L. var. scolymus) genome is relatively poorly explored, especially compared to those of the other major Asteraceae crops sunflower and lettuce. No SNP markers are in the public domain. We have combined the recently developed restriction-site associated DNA (RAD) approach with the Illumina DNA sequencing platform to effect the rapid and mass discovery of SNP markers for C. cardunculus. Results RAD tags were sequenced from the genomic DNA of three C. cardunculus mapping population parents, generating 9.7 million reads, corresponding to ~1 Gbp of sequence. An assembly based on paired ends produced ~6.0 Mbp of genomic sequence, separated into ~19,000 contigs (mean length 312 bp), of which ~21% were fragments of putative coding sequence. The shared sequences allowed for the discovery of ~34,000 SNPs and nearly 800 indels, equivalent to a SNP frequency of 5.6 per 1,000 nt, and an indel frequency of 0.2 per 1,000 nt. A sample of heterozygous SNP loci was mapped by CAPS assays and this exercise provided validation of our mining criteria. The repetitive fraction of the genome had a high representation of retrotransposon sequence, followed by simple repeats, AT-low complexity regions and mobile DNA elements. The genomic k-mers distribution and CpG rate of C. cardunculus, compared with data derived from three whole genome-sequenced dicots species, provided a further evidence of the random representation of the C. cardunculus genome generated by RAD sampling. Conclusion The RAD tag sequencing approach is a cost-effective and rapid method to develop SNP markers in a highly heterozygous species. Our approach permitted to generate a large and robust SNP datasets by the adoption of optimized filtering criteria.
Scaglione Davide, Acquadro Alberto, Portis Ezio, Tirone Matteo, Knapp Steven J, Lanteri Sergio
TEKSTİL VE/VEYA KONFEKSİYON SEKTÖRLERİNDE FAALİYET GÖSTEREN KÜÇÜK VE ORTA BÜYÜKLÜKTEKİ İŞLETMELERİN PAZARLAMA SORUNLARI VE ELEKTRONİK TİCARETTEN BEKLENTİLERİ -MERSİN ÖLÇEKLİ BİR UYGULAMA-
In this article, the marketing problems of 44 SMEs’ which function in textile and garment sectors in Mersin region, were questioned and analyzed. Thus, the opinions of these SMEs’ managers’ about electronic commerce are investigated. By this way, we tried to conduct new perspectives to these businesses about the solution of marketing problems, electronic commerce and electronic marketing.
Dokuz Eylül Üniversitesi İktisadi ve İdari Bilimler Fakültesi Dergisi
Economics as a science, Political science, Political science (General)
Population dynamics of Moina minuta Hansen (1899), Ceriodaphnia cornuta Sars (1886), and Diaphanosoma spinulosum Herbst (1967) (Crustacea: Branchiopoda) in different nutrients (N and P) concentration ranges Dinâmica populacional de Moina minuta Hansen (1899), Ceriodaphnia cornuta Sars (1886) e Diaphanosoma spinulosum Herbst (1967) (Crustacea: Branchiopoda) em diferentes faixas de concentração de nutrientes (N e P)
cladóceros, Semiárido, nutrientes, estado trófico, Cladocera, semi-arid, nutrient, trophic state
AIM: Aquatic environments of semi-arid regions are subject to changes in water quality and volume due to short and irregular rain seasons. Consequently, zooplankton composition changes in association to fluctuations in the trophic degree. To comprehend these processes, this study analyzed the influence of nutrient concentrations (N and P) on the population dynamics of three species of Cladocera - Moina minuta, Ceriodaphnia cornuta, and Diapahnosoma spinulosum - from the Taperoá II Dam, Paraíba, Brazil; METHODS: Animals were experimentally submitted to different nutrient concentrations as a means to reproduce specific trophic conditions from natural environments. Zooplankton densities were evaluated once every three days, with food (i.e. algal cultures) being supplied in alternate days. To compare population growth, an ANOVA was performed, followed by Tukey's HSD post-hoc test; RESULTS: The population growth of the three species differed significantly both among species and among treatments. Moina minuta populations showed higher growth rates under higher nutrient concentrations, whereas Ceriodaphnia cornuta growed more efficiently in intermediate concentrations, and Diaphanosoma spinulosum showed a better development in low nutrient concentrations; CONCLUSIONS: The results from the experimental approach, presented here, are similar to what is observed in the field, based on previous studies carried out in the Taperoá II Dam. Therefore, these results suggest that the hydrological cycle seems to be the major determinant of zooplankton population dynamics in aquatic semi-arid environmentsOBJETIVO: Os ambientes aquáticos de regiões semi-áridas sofrem alterações na qualidade da água e no seu volume devido à irregularidade do período chuvoso. Consequentemente, o zooplâncton sofre alterações em sua composição com a evolução do estado trófico. Para a compreensão desse processo, este trabalho analisou experimentalmente a influência da concentração de nutrientes (N e P) sobre a dinâmica populacional de três espécies de cladóceros: Moina minuta, Ceriodaphnia cornuta e Diaphanosoma spinulosum; MÉTODOS: Os animais foram submetidos a diferentes concentrações de nutrientes (N e P), de modo a representar diferentes níveis tróficos. As suas densidades foram medidas a cada três dias, e alimentação feita com uma cultura plurialgal em dias alternados. Para a comparação do desenvolvimento das populações, foi feito o teste ANOVA, seguido do teste de Tukey; RESULTADOS: O crescimento populacional das três espécies diferiu significativamente tanto entre as espécies quanto entre os tratamentos. As populações de Moina minuta obtiveram maior crescimento nas concentrações mais elevadas de nutrientes e Ceriodaphnia cornuta em concentrações intermediárias, enquanto Diaphanosoma spinulosum se desenvolveu melhor no tratamento com baixa concentração de nutrientes; CONCLUSÕES: Observa-se que, para as três espécies, o resultado obtido em laboratório é similar ao observado em campo, obtidos em estudos realizados anteriormente no local, e que o ciclo hidrológico parece ser o principal regulador da dinâmica desses organismos em ambientes aquáticos do semi-árido.
Ana Carolina Brito Vieira, Ana Maria Alves Medeiros, Leonardo Leôncio Ribeiro, Maria Cristina Crispim
Biopolymers as materials for developing products in pharmaceutical applications and biomedical uses
Biopolymer, Modified release, therapeutic system, biomedical device
Biopolymers have been widely studied for use in pharmaceutical applications. They have been used for modifying drug release, orientating a drug towards its therapeutic target, penetrating physiological barriers (tissues and cells) and protecting unstable therapeutic agents against physiological conditions which are present in a less invasive administration routes. The importance of biopolymers in designing new biomedical devices must thus be stressed, es-pecially when a pharmaceutical substance must be incorporated into a polymer matrix. A new generation of alterna-tives for human health has thus been generated by designing pharmaceutical therapeutic systems in line with the concept of “integrated custom-made product design”. This document reviews the trends concerning using biopoly-mers for designing products having pharmaceutical and biomedical applications. The paper also introduces the elements which should be mastered by engineers for obtaining material which can be used in the health field and tries to provide a reference point regarding the state of the art in this specific field of knowledge.
Manuel Guillermo Rojas Cortés, Bibiana Margarita Vallejo Díaz, JAIRO ERNESTO PERILLA PERILLA
Engineering (General). Civil engineering (General)
Seroprevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) in public health workers responding to a MERS outbreak in Seoul, Republic of Korea, in 2015
MERS-CoV, seroprevalence study, Republic of Korea, MERS outbreak, public health responders
Boyeong Ryu, Sung-il Cho, Myoung-don Oh, Jong-Koo Lee, Jaein Lee, Youngok Hwang, Jeong-Sun Yang, Sung Soon Kim, Ji-Hwan Bang
Western Pacific Surveillance and Response