COVID-19: Changing Trends and Its Impact on Future of Dentistry
The outbreak of coronavirus disease 2019 (COVID-19) rapidly escalated into a worldwide pandemic, creating a global health and economic crisis. It is a novel virus which is distinct from SARS-CoV and MERS-CoV, with Chinese horseshoe bats being the most probable origin. Transmission occurs primarily through droplet spread or contact routes. Due to the characteristics of dental settings, the risk of cross infection between dental health care personnel (DHCP) and patients can be very high. This article provides a brief overview of the structure of the virus, modes of transmission, and clinical features of COVID-19 disease. The aim of this article is to recommend infection control strategies and patient management protocols to provide optimum dental care and simultaneously prevent nosocomial infection in dental settings.
Farhin Katge, Shilpa Shetty, Shantanu Deshpande, Parin Bhanushali, Vamsi Krishna Chimata, Debapriya Pradhan
Early Detection and Assessment of Covid-19
leukopenia, incubation, lymphopenia, SARS-CoV-2, Hashmi-Asif Covid-19 Chart, thrombopenia
Background: Since the Covid-19 global pandemic emerged, developing countries have been facing multiple challenges over its diagnosis. We aimed to establish a relationship between the signs and symptoms of COVID-19 for early detection and assessment to reduce the transmission rate of SARS-Cov-2.Methods: We collected published data on the clinical features of Covid-19 retrospectively and categorized them into physical and blood biomarkers. Common features were assigned scores by the Borg scoring method with slight modifications and were incorporated into a newly-developed Hashmi-Asif Covid-19 assessment Chart. Correlations between signs and symptoms with the development of Covid-19 was assessed by Pearson correlation and Spearman Correlation coefficient (rho). Linear regression analysis was employed to assess the highest correlating features. The frequency of signs and symptoms in developing Covid-19 was assessed through Chi-square test two tailed with Cramer's V strength. Changes in signs and symptoms were incorporated into a chart that consisted of four tiers representing disease stages.Results: Data from 10,172 Covid-19 laboratory confirmed cases showed a correlation with Fever in 43.9% (P = 0.000) cases, cough 54.08% and dry mucus 25.68% equally significant (P = 0.000), Hyperemic pharyngeal mucus membrane 17.92% (P = 0.005), leukopenia 28.11% (P = 0.000), lymphopenia 64.35% (P = 0.000), thrombopenia 35.49% (P = 0.000), elevated Alanine aminotransferase 50.02% (P = 0.000), and Aspartate aminotransferase 34.49% (P = 0.000). The chart exhibited a maximum scoring of 39. Normal tier scoring was ≤ 12/39, mild state scoring was 13–22/39, and star values scoring was ≥7/15; this latter category on the chart means Covid-19 is progressing and quarantine should be adopted. Moderate stage scored 23–33 and severe scored 34–39 in the chart.Conclusion: The Hashmi-Asif Covid-19 Chart is significant in assessing subclinical and clinical stages of Covid-19 to reduce the transmission rate.
Hafiz Muhammad Asif, Hafiz Abdul Sattar Hashmi
Proposal of Research Model for the Detection of COVID-19 among Asymptomatic Carriers
Saliva, Epidemiology, diagnosis, PCR, Asymptomatic, COVID-19
Coronavirus disease 2019 (COVID-19) is a pandemic and rapidly progressing infectious disease that represents a global health care emergency due to severe acute respiratory syndrome. Rapid tests detect antigen or antibody presence, which is useful for patient care and for assisting in disease surveillance and epidemiological research. The complicating aspect of the COVID-19 spread may be due to asymptomatic individuals. Unfortunately, asymptomatic individuals are not detected in the early stages of infection, which could help to prevent community spread. The present paper shares an opinion through the proposal of a research model for detecting COVID-19 among asymptomatic carriers.
Arvind Babu Rajendra Santosh, Kandamaran Krishnamurthy, Venkat Ramana Reddy Baddam
International Archives of Otorhinolaryngology
The Psychological Impacts of a COVID-19 Outbreak on College Students in China: A Longitudinal Study
Anxiety, college students, depression, longitudinal study, mood, COVID-19
An outbreak in Wuhan, China in late 2019 of a highly infectious new coronary pneumonia (COVID-19) led to the imposition of countrywide confinement measures from January to March 2020. This is a longitudinal study on changes in the mental health status of a college population before and after their COVID-19 confinement for the first two weeks, focusing on states of psychological distress, depression, anxiety and affectivity. The influence of possible stressors on their mental health were investigated, including inadequate supplies and fears of infection. Five hundred and fifty-five undergraduate students were recruited from Hebei Agricultural University in Baoding, China. The participants completed two online surveys—on anxiety and depression, and on positive and negative affect. One survey was conducted before the confinement and the other was conducted 15–17 days after the start of the confinement. Increases in negative affect and symptoms of anxiety and depression (p-values < 0.001) were observed after 2 weeks of confinement. Inadequate supplies of hand sanitizers, a higher year of study, and higher scores on anxiety and depression were common predictors of increased negative affect, anxiety, and depression across the confinement period. The results suggest that healthcare policymakers should carefully consider the appropriate confinement duration, and ensure adequate supplies of basic infection-control materials.
Hongyan Li, Hui Cao, Doris Y. P. Leung, Yim Wah Mak
International Journal of Environmental Research and Public Health
COVID-19: Taiwan’s epidemiological characteristics and public and hospital responses
mask, quarantine, Public Response, novel coronavirus, SARS-CoV-2, COVID-19
Background Coronavirus disease 19 (COVID-19) is a global health threat with significant medical, economic, social and political implications. The optimal strategies for combating COVID-19 have not been fully determined and vary across countries. Methods By the end of February 2020 in Taiwan, 2,150 patients received diagnostic COVID-19 testing and 39 confirmed cases were detected. This is a relatively lower rate of infection compared to other Asian countries. In this article, we summarize the epidemiological characteristics of the 39 infected patients as well as public and hospital responses to COVID-19. Results Thirty-nine COVID-19 cases and one death have been confirmed in Taiwan. Seventeen of these patients were infected by family members or in hospital wards, emphasizing how COVID-19 is mostly spread by close contact. We examined how hospital have responded to COVID-19, including their implementation of patient route control, outdoor clinics, hospital visit restrictions and ward and staff modifications. We also studied the public’s use of face masks in response to COVID-19. These strategies may reduce the spread of COVID-19 in other countries. Conclusion The emergence and spread of COVID-19 is a threat to health worldwide. Taiwan has reported lower infected cases and its strategies may contribute to further disease prevention and control.
Tsung-Hsien Su, Chien-Yu Lin, Chung-Chu Chen, Chih-Ming Chang, Ting-Wan Tan, Tai-Cheng Ho
Current Status of Computed Tomography in Novel Coronavirus Disease 2019 Pneumonia
Computed tomography, consolidation, severe acute respiratory syndrome, Ground glass opacity, COVID-19, Coronavirus disease
The novel coronavirus disease, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), has developed into a pandemic affecting more than three million people worldwide. It predominantly affects the respiratory system and patients present with fever, dry cough, dyspnea, and myalgia. The confirmatory diagnostic test is real-time reverse transcriptase polymerase chain reaction on blood or respiratory samples. Imaging with computed tomography, although not routinely recommended, may not only assist in making a diagnosis but also in assessing disease progression, assessing complications, and in prognostication. This review describes the objectives, techniques, imaging features, and reporting of computed tomography findings of SARS-CoV2 pneumonia.
Kumble Seetharama Madhusudhan, Deep Narayan Srivastava
Annals of the National Academy of Medical Sciences (India)
SARS-CoV-2 Risk Management in Clinical Psychiatry: A Few Considerations on How to Deal With an Unrivaled Threat
coronavirus, hospital management, Pandemic, pandemia, clinical psychiatry, SARS-CoV-2
The pandemic spread of the corona virus SARS-CoV-2 has even-handedly shattered national and international health systems and economies almost in an instant. As numbers of infections and COVID-19–related deaths rise from day to day, fears and uncertainties on how to deal with this unknown threat are extremely present both for individuals and societies as a whole. In this manuscript, we aim to exemplarily describe the bullet points concerning (a) the internal risk management, (b) the organizational and structural changes, and (c) the communicational strategies applied in a Psychiatric University Hospital in the Southern part of Germany. The authors are well aware about the fact that almost none of these considerations may be considered as evidence-based at the moment. However, the authors trust that these reflections and experiences may be useful as an orientation for similar risk constellations in other afflicted countries due to the temporal delay of the pandemic course.
Berthold Langguth, Peter M. Kreuzer, Dagmar Steffling, Rainer Rupprecht, Thomas C. Baghai, Markus Wittmann, Michael Ziereis, Marc Zowe, Helmut Hausner
Activation of TRL-7 and Innate Immunity as an Efficient Method Against COVID-19 Pandemic: Imiquimod as a Potential Therapy
Innate Immunity, immune activation, SARS-CoV-2, COVID-19, Imiquimod (IMQ)
Konstantinos Farsalinos, Konstantinos Poulas, Charilaos Zanidis
COVID-19 Infection Diagnosis: Potential Impact of Isothermal Amplification Technology to Reduce Community Transmission of SARS-CoV-2
LAMP, Point-of care testing, RPA, Rapid testing, novel coronavirus, COVID-19, near
The current coronavirus disease 2019 (COVID-19) pandemic is largely driven by community transmission, after 2019 novel Coronavirus (2019-nCoV or SARS-CoV-2) crosses the borders. To stop the spread, rapid testing is required at community clinics and hospitals. These rapid tests should be comparable with the standard PCR technology. Isothermal amplification technology provides an excellent alternative that is highly amenable to resource limited settings, where expertise and infrastructure to support PCR are not available. In this review, we provide a brief description of isothermal amplification technology, its potential and the gaps that need to be considered for SARS-CoV-2 detection. Among this emerging technology, loop-mediated amplification (LAMP), recombinase polymerase amplification (RPA) and Nicking enzyme-assisted reaction (NEAR) technologies have been identified as potential platforms that could be implemented at community level, without samples referral to a centralized laboratory and prolonged turnaround time associated with the standard COVID-19 RT-PCR test. LAMP, for example, has recently been shown to be comparable with PCR and could be performed in less than 30 min by non-laboratory staff, without RNA extractions commonly associated with PCR. Interestingly, NEAR (ID NOW™ COVID-19 (Abbott, IL, USA) was able to detect the virus in 5 min. More so, isothermal platforms are cost effective and could easily be scaled up to resource limited settings. Diagnostics developers, scientific community and commercial companies could consider this alternative method to help stop the spread of COVID-19.
Statistical evaluation of selected air quality parameters influenced by COVID-19 lockdown
Bangladesh, air pollution, air quality index (AQI), coronavirus disease (covid-19), lockdown
Air pollution has become a serious concern for its potential health hazard, however, often got less attention in developing countries, like Bangladesh. It is expected that worldwide lockdown due to COVID-19 widespread cause reduction in environmental pollution in particularly the air pollution: however, such changes have been different in different places. In Chittagong, a city scale lockdown came in force on 26 March 2020, a week after when first three cases of COVID-19 have been reported in Bangladesh. This study aims to statistically evaluate the effects of COVID-19 lockdown (26 March to 26 April 2020) on selected air quality pollutants and air quality index s. The daily average concentrations of air pollutants PM10, PM2.5, NO2, SO2 and CO of Chittagong city during COVID-19 lockdown were statistically evaluated and were compared with dry season data averaging over previous 8 years (2012 to 2019). During lockdown, except NO2, all other pollutants studied showed statistically significant decreasing trend. During the COVID-19 shutdown notable reduction of 40%, 32% and 13% compared to the daily mean concentrations of these previous dry season were seen for PM2.5, PM10 and NO2, respectively. The improvement in air quality index value was found as 26% in comparison to the previous dry season due to less human activities in COVID-19 shutdown. The factor analysis showed that AQI in Chittagong city is largely influenced by PM10 and PM2.5 during COVID-19 shutdown. The lesson learnt in this forced measure of lockdown is not surprising and unexpected. It is rather thought provoking for the decision makers to tradeoff the tangible air quality benefits with ongoing development strategies’ that was often overlooked directly or indirectly.
Global Journal of Environmental Science and Management