195 10 20655 https://www.socictopen.socict.org/files/original/d2ddece9f558c66c61f41da441a6b438.pdf e93330dcd162c37387b855bb9f462aaf Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Relationship of SARS-CoV to other pathogenic RNA viruses explored by tetranucleotide usage profiling Creator An entity primarily responsible for making the resource Danchin Antoine, ZHANG Xue, Yap Yee Description An account of the resource Abstract Background The exact origin of the cause of the Severe Acute Respiratory Syndrome (SARS) is still an open question. The genomic sequence relationship of SARS-CoV with 30 different single-stranded RNA (ssRNA) viruses of various families was studied using two non-standard approaches. Both approaches began with the vectorial profiling of the tetra-nucleotide usage pattern V for each virus. In approach one, a distance measure of a vector V, based on correlation coefficient was devised to construct a relationship tree by the neighbor-joining algorithm. In approach two, a multivariate factor analysis was performed to derive the embedded tetra-nucleotide usage patterns. These patterns were subsequently used to classify the selected viruses. Results Both approaches yielded relationship outcomes that are consistent with the known virus classification. They also indicated that the genome of RNA viruses from the same family conform to a specific pattern of word usage. Based on the correlation of the overall tetra-nucleotide usage patterns, the Transmissible Gastroenteritis Virus (TGV) and the Feline CoronaVirus (FCoV) are closest to SARS-CoV. Surprisingly also, the RNA viruses that do not go through a DNA stage displayed a remarkable discrimination against the CpG and UpA di-nucleotide (z = -77.31, -52.48 respectively) and selection for UpG and CpA (z = 65.79,49.99 respectively). Potential factors influencing these biases are discussed. Conclusion The study of genomic word usage is a powerful method to classify RNA viruses. The congruence of the relationship outcomes with the known classification indicates that there exist phylogenetic signals in the tetra-nucleotide usage patterns, that is most prominent in the replicase open reading frames. Date A point or period of time associated with an event in the lifecycle of the resource 2003 Subject The topic of the resource RNA virus, convergent evolution, horizontal gene transfer, Factor analysis, SARS Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/1471-2105-4-43 Source A related resource from which the described resource is derived BMC Bioinformatics Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Computer applications to medicine. Medical informatics Language A language of the resource EN https://www.socictopen.socict.org/files/original/3b29a933f0c36ce81a6bc74bcb19f1e4.pdf d696ee4047aea713428a29c56f111d47 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Experimental Study on Bluff-Body Stabilized Premixed Flame with a Central Air/Fuel Jet Creator An entity primarily responsible for making the resource Yiheng Tong, Shuang Chen, Mao Li, Zhongshan Li, Jens Klingmann Description An account of the resource Bluff-body flame holders are commonly employed in many industrial applications. A bluff-body is usually adopted to enhance the downstream mixing of the combustion products and the fresh fuel-air mixtures, thus to improve the flame stability and to control the combustion process. In the present paper, flames stabilized by a conical-shape bluff-body flame holder with a central air/fuel jet were studied. Effects of both a central air jet and a central fuel jet on the structures and lean blowout limits of the premixed annular flames, and on the temperature on the upper surface of the bluff-body were investigated and presented. It was revealed that a central jet led to a considerable reduction of the temperature on the upper surface of the bluff-body. It was proposed to be caused by the alternation of flow structures (in the case with a central air jet) altogether with the flame lifting from the burner (in the case with a central fuel jet). Thus, it might be used to solve the problem of the bluff-body with high heat loads in practical applications. The flame stability characteristics, for example the unstable flame dynamics and the lean blowout limits, varied with the injection of an air or fuel jet through the central pipe. Different blowout behaviors, being with or without the occurrence of flame split and flashing, caused by a central air jet were presented in the paper. In addition, when a small amount of central fuel jet (i.e., Uf/Ua = 0.045) was injected into the flow fields, an unsteady circular motion of the flame tip along the outer edge of the bluff-body was observed as well. Whereas, with an increase in the amount of the central fuel jet, the flame detached from the outer edge of the bluff-body and then became much more unstable. With a central air or fuel jet injecting into the flow field, premixed flames stabilized by the bluff-body became more unstable and easier to blowout. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Subject The topic of the resource Bluff body, premixed flame, flame structures, flame instabilities, lean blowout Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/en10122011 Source A related resource from which the described resource is derived Energies Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Technology Language A language of the resource EN https://www.socictopen.socict.org/files/original/84a44c01ff17cb67b535e09065083f4f.pdf 6bc25c62f55f89ee7ced273c1a8f34f1 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Clinical and virological factors associated with gastrointestinal symptoms in patients with acute respiratory infection: a two-year prospective study in general practice medicine Creator An entity primarily responsible for making the resource Laetitia Minodier, Shirley Masse, Lisandru Capai, Thierry Blanchon, Pierre-Emmanuel Ceccaldi, Sylvie van der Werf, Thomas Hanslik, Rémi Charrel, Alessandra Falchi Description An account of the resource Abstract Background Gastrointestinal (GI) symptoms, such as diarrhea, vomiting, abdominal pain and nausea are not an uncommon manifestation of an acute respiratory infection (ARI). We therefore evaluated clinical and microbiological factors associated with the presence of GI symptoms in patients consulting a general practitioner (GP) for ARI. Methods Nasopharyngeal swabs, stool specimens and clinical data from patients presenting to GPs with an ARI were prospectively collected during two winter seasons (2014-2016). Samples were tested by quantitative real-time PCR for 12 respiratory pathogen groups and for 12 enteric pathogens. Results Two hundred and four of 331 included patients (61.6%) were positive for at least one respiratory pathogen. Sixty-nine stools (20.8%) were positive for at least one pathogen (respiratory and/or enteric). GI symptoms were more likely declared in case of laboratory confirmed-enteric infection (adjusted odds ratio (aOR) = 3.2; 95% confidence interval [CI] [1.2–9.9]; p = 0.02) or human coronavirus (HCoV) infection (aOR = 2.7; [1.2–6.8]; p = 0.02). Consumption of antipyretic medication before the consultation seemed to reduce the risk of developing GI symptoms for patients with laboratory-confirmed influenza (aOR = 0.3; [0.1–0.6]; p = 0.002). Conclusions The presence of GI symptoms in ARI patients could not be explained by the detection of respiratory pathogens in stools. However, the detection of enteric pathogens in stool samples could explained by the presence of GI symptoms in some of ARI cases. The biological mechanisms explaining the association between the presence of HCoVs in nasopharynx and GI symptoms need to be explored. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Subject The topic of the resource Acute respiratory infection, Gastrointestinal symptoms, enteric pathogens, Influenza virus, general practitioner Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s12879-017-2823-9 Source A related resource from which the described resource is derived BMC Infectious Diseases Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases Language A language of the resource EN https://www.socictopen.socict.org/files/original/258c2c2ae7861e3fe0561275fd743c79.pdf d9d9d1b4fcd8b43549c766058aa8847b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Checklist with first records for the Echinoderms of northern Tunisia (central Mediterranean Sea) Creator An entity primarily responsible for making the resource Hayfa Chammem, Jamila Ben Souissi, Angel Pérez-Ruzafa Description An account of the resource Tunisia occupies a strategic biogeographic position in the Mediterranean Sea and the Strait of Sicily is considered a biogeographical boundary that separates the eastern and western basins. Despite the importance of marine biodiversity in Tunisia, the few studies of Echinodermata fauna in this region data from long ago. In order to update and produce a validated checklist of the echinoderms that occur in northern Tunisia, a study of this phylum was carried out between 2012 and 2016. Forty-five species were inventoried and distributed into the five living Echinodermata classes (Crinoidea, Asteroidea, Ophiuroidea, Echinoidea and Holothuroidea). New occurrences of four species from Tunisian marine waters [Asterina pancerii (Gasco, 1876), Luidia atlantidea (Madsen, 1950), Ophiactis virens (Sars, 1859) and Leptopentacta tergestina (Sars, 1857)], are cited and discussed here for the first time. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource Echinoderms, new occurrences, Biodiversity, Tunisia, Mediterranean Sea Identifier An unambiguous reference to the resource within a given context DOI: 10.3989/scimar.04899.19A Source A related resource from which the described resource is derived Scientia Marina Publisher An entity responsible for making the resource available Consejo Superior de Investigaciones Científicas Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Aquaculture. Fisheries. Angling Language A language of the resource EN https://www.socictopen.socict.org/files/original/9bfab1f772d47486fb13e09b401cead4.pdf e4081ebd50beaf20ba48817222e58cd4 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource ACTION RESEARCH METHODOLOGY: POSSIBILITIES OF APPLICATION IN ANIMAL HEALTH AND VETERINARY PUBLIC HEALTH Creator An entity primarily responsible for making the resource Arnaldo Rocha, Julia Rosas Hochheim, Osleny Viaro, Fabio Gregori Description An account of the resource Action research is a methodology that has been little used within Veterinary Medicine.  It emerged in the second half of the 20th century and it values the researchers’ approximation, participation and immersion in the fieldwork, aiming at reality transformations and, at the same time, a greater social impact of the research on the community. It begins with recognizing the problems and demands, followed by the construction of collective solutions, mediated by the researcher, in the environment of occurrence of the investigated subject, proposing measures adaptable to local conditions, seeking transformations and construction of meanings. It is composed of cycles of planning, actions, reflections and resignifications that repeat until the end of works. The data are obtained and analyzed within a qualitative approach, although it may be also combined with a quantitative one. It has proved to be an option for interactive, socially critical, strategic, technical, practical and collaborative initiatives in one health. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource abordagens participativas, epidemiologia participativa, Pesquisa Participante Identifier An unambiguous reference to the resource within a given context DOI: Source A related resource from which the described resource is derived Atas de Saúde Ambiental Publisher An entity responsible for making the resource available Faculdades Metropolitanas Unidas Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Environmental sciences Language A language of the resource PT https://www.socictopen.socict.org/files/original/7e30731c21d13149ce0d8ed18f446731.pdf 28cc945f3989e025dc59bb2ee2c63cc2 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Potent MERS-CoV Fusion Inhibitory Peptides Identified from HR2 Domain in Spike Protein of Bat Coronavirus HKU4 Creator An entity primarily responsible for making the resource Shuai Xia, Qiaoshuai Lan, Jing Pu, Cong Wang, Zezhong Liu, Wei Xu, Qian Wang, Huan Liu, Shibo Jiang, Lu Lu Description An account of the resource The Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 and caused continual outbreaks worldwide with high mortality. However, no effective anti-MERS-CoV drug is currently available. Recently, numerous evolutionary studies have suggested that MERS-CoV originated from bat coronavirus (BatCoV). We herein reported that three peptides derived from the HR2 region in spike protein of BatCoV HKU4, including HKU4-HR2P1, HKU4-HR2P2 and HKU4-HR2P3, could bind the MERS-CoV HR1-derived peptide to form a six-helix bundle (6-HB) with high stability. Moreover, these peptides, particularly HKU4-HR2P2 and HKU4-HR2P3, exhibited potent inhibitory activity against MERS-CoV S-mediated cell–cell fusion and viral infection, suggesting that these HKU4 HR2-derived peptides could be candidates for futher development as antiviral agents against MERS-CoV infection. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource MERS-CoV, fusion inhibitor, peptide, cell–cell fusion, HKU4 Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/v11010056 Source A related resource from which the described resource is derived Viruses Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/9b2b8025ab1e0841adfe5c18be61c272.pdf c6f550de9bba12a7e2dfe9dbf0318a27 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Activation of Membrane Estrogen Receptors Attenuates NOP-Mediated Tactile Antihypersensitivity in a Rodent Model of Neuropathic Pain Creator An entity primarily responsible for making the resource Danyeal M. Wright, Keri M. Small, Subodh Nag, Sukhbir S. Mokha Description An account of the resource Women manifest a higher prevalence of several chronic pain disorders compared to men. We demonstrated earlier that estrogen rapidly attenuates nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP)-mediated thermal antinociception through the activation of membrane estrogen receptors (mERs). However, the effect of mER activation on NOP-mediated attenuation of tactile hypersensitivity in a neuropathic model of pain and the underlying mechanisms remain unknown. Following spared nerve injury (SNI), male and ovariectomized (OVX) female rats were intrathecally (i.t.) injected with a selective mER agonist and nociceptin/orphanin FQ (N/OFQ), the endogenous ligand for NOP, and their effects on paw withdrawal thresholds (PWTs) were tested. In addition, spinal cord tissue was used to measure changes in phosphorylated extracellular signal regulated kinase (ERK), protein kinase A (PKA), protein kinase C (PKC), and protein kinase B (Akt) levels. SNI significantly reduced PWTs in males and OVX females, indicating tactile hypersensitivity. N/OFQ restored PWTs, indicating an antihypersensitive effect. Selective mER activation attenuated the effect of N/OFQ in an antagonist-reversible manner. SNI led to a robust increase in the phosphorylation of ERK, PKA, PKC, and Akt. However, mER activation did not further affect it. Thus, we conclude that activation of mERs rapidly abolishes NOP-mediated tactile antihypersensitivity following SNI via an ERK-, PKA-, PKC-, and Akt-independent mechanism. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource nociceptin/orphanin FQ receptor, neuropathic pain, spinal cord, spared nerve injury, Analgesia Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/brainsci9060147 Source A related resource from which the described resource is derived Brain Sciences Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Neurosciences. Biological psychiatry. Neuropsychiatry Language A language of the resource EN https://www.socictopen.socict.org/files/original/9bf8948a12f5909ed2f21b4d0dce7efb.pdf 310fda41b279fa4b846e8e600ea57ca3 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Long-term adaptation of Daphnia to toxic environment in Lake Orta: the effects of short-term exposure to copper and acidification Creator An entity primarily responsible for making the resource Marina Manca, Roberta Bettinetti, Roberta Piscia, Benedetta PONTI Description An account of the resource Because of its 80-year history of heavy pollution and re-colonization, Lake Orta provides a good opportunity for investigating the response of zooplankton organisms to heavy metals and acidification as well as the mechanisms involved. After the recent establishment of Daphnia galeata Sars, and the detection of an extremely low clonal diversity of Lake Orta population, we carried out a study to investigate the lethal tolerance to ionic copper, as well as to acidity, and the impact of newborn Daphnia exposure to sublethal concentrations of copper for their later development and reproduction. We conducted acute toxicity tests to estimate the EC50 for ionic copper and tolerance to low pH, as well as life table experiments. Tolerance to ionic copper was high, three times that reported in literature. An increased mortality soon after exposure to low pH confirmed a high sensitivity to acidity and explained the success of the species in Lake Orta only after pH recovery. An analysis of reproductive and demographic parameters revealed that D. galeata Sars was stressed at concentrations of ionic copper only twice higher than those presently recorded in the lake (i.e., ca 3 μg L-1). An increased cumulative number of eggs produced by each female were in fact counterbalanced by an increasing abortion rate, which resulted in an unaltered or lower intrinsic rate of population increase. Our results are likely due to the strong selective pressure, more than physiological processes (acclimation), in a polluted area in which only specific adapted clones are able to grow, confirming the results previously obtained on Lake Orta's D. obtusa Kurz population. The reproductive response and the relatively low within treatment variability suggest that clone specificity, rather than physiological acclimation, was the driving force. The low variability confirmed results previously obtained from life tables experiments on Lake Orta's D. obtusa clone. Overall, our results suggest that, despite the chemical recovery, Lake Orta may be regarded as highly vulnerable to biodiversity loss. Date A point or period of time associated with an event in the lifecycle of the resource 2010 Subject The topic of the resource Ecotoxicology, reproduction, growth, fertility, Cladocerans Identifier An unambiguous reference to the resource within a given context DOI: 10.4081/jlimnol.2010.217 Source A related resource from which the described resource is derived Journal of Limnology Publisher An entity responsible for making the resource available PAGEPress Publications Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Environmental sciences, Geography. Anthropology. Recreation, Physical geography Language A language of the resource EN https://www.socictopen.socict.org/files/original/b9e8c50dbb72c8517d201b5027fdea29.pdf 1a5ee7495b0684f515f9fd1a73dcafce Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Nucleocapsid protein-dependent assembly of the RNA packaging signal of Middle East respiratory syndrome coronavirus Creator An entity primarily responsible for making the resource Wei-Chen Hsin, Chan-Hua Chang, Chi-You Chang, Wei-Hao Peng, Chung-Liang Chien, Ming-Fu Chang, Shin C. Chang Description An account of the resource Abstract Background Middle East respiratory syndrome coronavirus (MERS-CoV) consists of a positive-sense, single-stranded RNA genome and four structural proteins: the spike, envelope, membrane, and nucleocapsid protein. The assembly of the viral genome into virus particles involves viral structural proteins and is believed to be mediated through recognition of specific sequences and RNA structures of the viral genome. Methods and Results A culture system for the production of MERS coronavirus-like particles (MERS VLPs) was determined and established by electron microscopy and the detection of coexpressed viral structural proteins. Using the VLP system, a 258-nucleotide RNA fragment, which spans nucleotides 19,712 to 19,969 of the MERS-CoV genome (designated PS258(19712–19969)ME), was identified to function as a packaging signal. Assembly of the RNA packaging signal into MERS VLPs is dependent on the viral nucleocapsid protein. In addition, a 45-nucleotide stable stem-loop substructure of the PS258(19712–19969)ME interacted with both the N-terminal domain and the C-terminal domain of the viral nucleocapsid protein. Furthermore, a functional SARS-CoV RNA packaging signal failed to assemble into the MERS VLPs, which indicated virus-specific assembly of the RNA genome. Conclusions A MERS-oV RNA packaging signal was identified by the detection of GFP expression following an incubation of MERS VLPs carrying the heterologous mRNA GFP-PS258(19712–19969)ME with virus permissive Huh7 cells. The MERS VLP system could help us in understanding virus infection and morphogenesis. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource MERS-CoV, RNA packaging signal, Nucleocapsid protein Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s12929-018-0449-x Source A related resource from which the described resource is derived Journal of Biomedical Science Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/4afb9660761cf5f73e13ef1130dc2aac.pdf c26387a146040660ffa7de351943136c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The development and reform of public health in China from 1949 to 2019 Creator An entity primarily responsible for making the resource Li Wang, Zhihao Wang, Qinglian Ma, Guixia Fang, Jinxia YANG Description An account of the resource Abstract Background Public health system plays a vital role in the development of health sector in China and protects the health of Chinese people. However, there are few comprehensive reviews and studies focusing on its evolution and reform. It is worthwhile to pay attention to the public health development in China, given that the history and structure of public health system have their own characteristics in China. Methods The study is a retrospective review of the development public health over seven decades in China. It presents the findings from some national or provincial survey data, interviews with key informants, reviews of relevant published papers and policy contents. Results This study identified four key stages that public health experienced in China: the initial stage centering on prevention, the stage of deviation with more attention to treatment but little to prevention, the recovery stage after SARS(Severe Acute Respiratory Syndromes) Crisis, and the new stage to an equitable and people-centered system. In the latest stage, the National Basic Public Health Service Program (NBPHSP) is implemented to respond the threat of noncommunicable diseases (NCDs) and has achieved some initial results, while there are still many challenges including service quality, poor integration among service items and IT system, lack of quality professionals and insufficient intersectoral endeavor. Discussion There are unique Chinese wisdom and remarkable achievements as well as twists and turns on the development of China’s public health. Prevention-first, flexible structure of the system, multi-agency collaboration and mass mobilization and society participation are the main experience of public health in early stage. Despite twists and turns since 1980s, public health system in China shows substantial resilience which may be from the government’s continuous commitment to social development and people’s livelihoods and its flexible governance. In 2010s, in order to achieve the well-off society, Chinese government pays unprecedented attention to health sector, which bring a new wave of opportunities to public health such as remaining the NBPHSP for priority. The evolution and reform of China’s public health is based on its national condition, accumulates rich experience but also faces many common worldwide challenges. Getting this development and reform right is important to China’s social and economic development in future, and China’s experience in public health may provide many lessons for other countries. Conclusion Public health in China needs to focus on prevention, strengthen multi-agency coordination mechanism, improve the quality of public health services in the future. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource Public Health, development, reform, National Basic Public Health Service Program Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s12992-019-0486-6 Source A related resource from which the described resource is derived Globalization and Health Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Public aspects of medicine Language A language of the resource EN