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Cynomolgus macaque as an animal model for severe acute respiratory syndrome.
The emergence of severe acute respiratory syndrome (SARS) in 2002 and 2003 affected global health and caused major economic disruption. Adequate animal models are required to study the underlying pathogenesis of SARS-associated coronavirus (SARS-CoV)…
Position: 1497 (30 views)
Conformational reorganization of the SARS coronavirus spike following receptor binding: implications for membrane fusion.
The SARS coronavirus (SARS-CoV) spike is the largest known viral spike molecule, and shares a similar function with all class 1 viral fusion proteins. Previous structural studies of membrane fusion proteins have largely used crystallography of static…
Position: 4484 (22 views)
A phenomenological model for predicting melting temperatures of DNA sequences.
We report here a novel method for predicting melting temperatures of DNA sequences based on a molecular-level hypothesis on the phenomena underlying the thermal denaturation of DNA. The model presented here attempts to quantify the energetic…
Position: 731 (38 views)
Isolation and characterization of avian coronavirus from healthy Eclectus parrots (Eclectus roratus) from Indonesia
Background and Aim: Avian coronavirus has a wide range of hosts, from chickens and turkeys to wild birds. This virus causes an economically and, possibly, environmentally, important loss in the poultry industry. Therefore, research into the avian…
Position: 5279 (21 views)
A three-stemmed mRNA pseudoknot in the SARS coronavirus frameshift signal.
A wide range of RNA viruses use programmed -1 ribosomal frameshifting for the production of viral fusion proteins. Inspection of the overlap regions between ORF1a and ORF1b of the SARS-CoV genome revealed that, similar to all coronaviruses, a…
Position: 7305 (19 views)
Self-interest versus group-interest in antiviral control.
Antiviral agents have been hailed to hold considerable promise for the treatment and prevention of emerging viral diseases like H5N1 avian influenza and SARS. However, antiviral drugs are not completely harmless, and the conditions under which…
Position: 11472 (16 views)
Asap: a framework for over-representation statistics for transcription factor binding sites.
BACKGROUND: In studies of gene regulation the efficient computational detection of over-represented transcription factor binding sites is an increasingly important aspect. Several published methods can be used for testing whether a set of…
Position: 10018 (17 views)
Identifying SARS-CoV membrane protein amino acid residues linked to virus-like particle assembly.
Severe acute respiratory syndrome coronavirus (SARS-CoV) membrane (M) proteins are capable of self-assembly and release in the form of membrane-enveloped vesicles, and of forming virus-like particles (VLPs) when coexpressed with SARS-CoV nucleocapsid…
Position: 7305 (19 views)
Identification of upper respiratory tract pathogens using electrochemical detection on an oligonucleotide microarray.
Bacterial and viral upper respiratory infections (URI) produce highly variable clinical symptoms that cannot be used to identify the etiologic agent. Proper treatment, however, depends on correct identification of the pathogen involved as antibiotics…
Position: 8592 (18 views)
Avian viral surveillance in Victoria, Australia, and detection of two novel avian herpesviruses.
Viruses in avian hosts can pose threats to avian health and some have zoonotic potential. Hospitals that provide veterinary care for avian patients may serve as a site of exposure of other birds and human staff in the facility to these viruses. They…
Position: 8592 (18 views)