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                <text>Oil Flow Analysis in the Maritime Silk Road Region Using AIS Data</text>
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                <text>Yijia Xiao, Yanming Chen, Xiaoqiang Liu, Zhao Jinyan, Liang Cheng, Manchun Li</text>
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                <text>Monitoring maritime oil flow is important for the security and stability of energy transportation, especially since the “21st Century Maritime Silk Road” (MSR) concept was proposed. The U.S. Energy Information Administration (EIA) provides public annual oil flow data of maritime oil chokepoints, which do not reflect subtle changes. Therefore, we used the automatic identification system (AIS) data from 2014 to 2016 and applied the proposed technical framework to four chokepoints (the straits of Malacca, Hormuz, Bab el-Mandeb, and the Cape of Good Hope) within the MSR region. The deviations and the statistical values of the annual oil flow from the results estimated by the AIS data and the EIA data, as well as the general direction of the oil flow, demonstrate the reliability of the proposed framework. Further, the monthly and seasonal cycles of the oil flows through the four chokepoints differ significantly in terms of the value and trend but generally show an upward trend. Besides, the first trough of the oil flow through the straits of Hormuz and Malacca corresponds with the military activities of the U.S. in 2014, while the second is owing to the outbreak of the Middle East Respiratory Syndrome in 2015.</text>
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                <text>DOI: 10.3390/ijgi9040265</text>
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                <text>ISPRS International Journal of Geo-Information</text>
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                <text>Pathogenesis of COVID-19</text>
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                <text>A.E. Abaturov, E.A. Agafonova, E.L. Krivusha, A.A. Nikulina</text>
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                <text>Based on the literature, the article presents modern data on the main pathogenetic features of coronavirus infection associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused a pandemic, according to the World Health Organization definition, in 2019. The literature review details the processes of SARS-CoV-2 binding to a human cell receptor that express angiotensin-converting enzyme 2 (ACE2), as well as the internalization, replication of the virus, and the release of new virions from an infected cell, which affect target organs (lungs, digestive tract, heart, central nervous system and kidneys) and induce the development of local and systemic inflammatory respon­ses. Existing methods of drug exposure that prevent human infection with SARS-CoV-2 are described. The main epidemiological moments of infection with SARS-CoV-2 were identified, indica­ting a predominant damage in the elderly and more often males due to the higher level of expression of angiotensin-converting enzyme 2, mostly in alveolocytes, than in females. The mechanisms of the development of the response of the innate and adaptive immune systems of a macroorganism to infection with SARS-CoV-2 are demonstrated. Therapeutic strategies are presented that are related to the effect of SARS-CoV-2 on various stages of vital activity: internalization — the use of soluble S-protein domains, antibodies against S-protein, single-chain variable fragment of antibodies to ACE2 or inhibition of glycosylation of cell receptors, blocking the interaction of SARS-CoV-2 S-protein with ACE2 protein and suppression of internalization of the virus by administration of chloroquine and hydroxychloroquine; replication — inhibition of a viral RNA-dependent RNA polymerase and the use of favipiravir, a non-nucleoside antiviral drug triazavirin, antiretroviral drugs (lopinavir in combination with ritonavir), nelfinavir, ribavirin, halidesivir, umifenovir, inhibitors of chymotrypsin-like protease (cinancerin, flavonoids) and papain-like protease. The above therapeutic me­thods in the near future will be aimed at preventing the development and treatment of both acute respiratory distress syndrome and conditions caused by damage to other targeted organs with COVID-19.</text>
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                <text>Coronavirus infection, acute respiratory distress syndrome, pathogenesis, immune response, Angiotensin converting enzyme-2</text>
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                <text>DOI: 10.22141/2224-0551.15.2.2020.200598</text>
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                <text>Zdorovʹe Rebenka</text>
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                <text>Publishing House Zaslavsky</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Pediatrics</text>
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            <description>A language of the resource</description>
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                <text>EN, RU, UK</text>
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                <text>The Use of Digital Health in the Detection and Management of COVID-19</text>
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            <elementTextContainer>
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                <text>Meshari  F. Alwashmi</text>
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                <text>Digital health is uniquely positioned to enhance the way we detect and manage infectious diseases. This commentary explores the potential of implementing digital technologies that can be used at different stages of the COVID-19 outbreak, including data-driven disease surveillance, screening, triage, diagnosis, and monitoring. Methods that could potentially reduce the exposure of healthcare providers to the virus are also discussed.</text>
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                <text>digital health, mhealth, infectious disease, COVID-19</text>
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                <text>DOI: 10.3390/ijerph17082906</text>
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                <text>International Journal of Environmental Research and Public Health</text>
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                <text>Medicine</text>
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                <text>Discrimination and Social Exclusion in the Outbreak of COVID-19</text>
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                <text>Jun He, Leshui He, Wen Zhou, Xuanhua Nie, Ming He</text>
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                <text>This paper is aimed to document the observed social exclusion and discrimination in the outbreak of COVID-19 across the world and inside of China. Discrimination and social exclusion has occurred in various forms, while 25.11% of respondents overseas experienced discrimination in the breakout of COVID-19, and 90% of respondents inside of China exhibited discriminatory attitudes. The discrimination and social exclusion also lead to a range of damaging social outcomes. Thus, this is an urgent call for the inclusiveness in policy and media in the face of this public health emergency.</text>
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                <text>discrimination, Social exclusion, coronavirus</text>
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                <text>DOI: 10.3390/ijerph17082933</text>
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                <text>International Journal of Environmental Research and Public Health</text>
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                <text>The ongoing episode of coronavirus disease 19 (COVID-19) has imposed a serious threat to global health and the world economy. The disease has rapidly acquired a pandemic status affecting almost all populated areas of the planet. The causative agent of COVID-19 is a novel coronavirus known as SARS-CoV-2. The virus has an approximate 30 kb single-stranded positive-sense RNA genome, which is 74.5% to 99% identical to that of SARS-CoV, CoV-pangolin, and the coronavirus the from horseshoe bat. According to available information, SARS-CoV-2 is inferred to be a recombinant virus that originated from bats and was transmitted to humans, possibly using the pangolin as the intermediate host. The interaction of the SARS-CoV-2 spike protein with the human ACE2 (angiotensin-converting enzyme 2) receptor, and its subsequent cleavage by serine protease and fusion, are the main events in the pathophysiology. The serine protease inhibitors, spike protein-based vaccines, or ACE2 blockers may have therapeutic potential in the near future. At present, no vaccine is available against COVID-19. The disease is being treated with antiviral, antimalarial, anti-inflammatory, herbal medicines, and active plasma antibodies. In this context, the present review article provides a cumulative account of the recent information regarding the viral characteristics, potential therapeutic targets, treatment options, and prospective research questions.</text>
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                <text>Xuyu Chen, LI Ran, Qing Liu, Qikai Hu, Xueying Du, Xiaodong Tan</text>
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                <text>Although the emphasis on behaviors of hand-washing and mask-wearing was repeated during the pandemic of Coronavirus Disease 2019 (COVID-19), not everyone paid enough attention to this. A descriptive statistic was used to make sense of the status of hand hygiene and mask-wearing among primary school students in Wuhan, China. A binary logistic regression analysis was conducted to identify the risk factors affecting the behaviors of hand-washing and mask-wearing. p &lt; 0.05 (two-sides) was considered as significant at statistics. 42.05% of the primary school students showed a good behavior of hand-washing, while 51.60% had a good behavior of mask-wearing. Gender, grade, out-going history, father’s occupation, mother’s educational background, and the time filling out the survey were significantly associated with hand hygiene, whereas grade, mother’s educational background, and residence were associated with mask-wearing. The behaviors of hand-washing and mask-wearing among primary school students were influenced by gender, grade, shady is back tell a friendand other factors, therefore, parents should make efforts of behavior guidance whereas governments should enlarge medium publicity.</text>
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                <text>International Journal of Environmental Research and Public Health</text>
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                <text>Medicine</text>
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