230 10 20655 https://www.socictopen.socict.org/files/original/1d89418cb92cc744ee4c075833553020.pdf 8375431d8e93947fc230f95156ff571d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bakımevinde Ölüm ile Sonuçlanan Engelli Çocuğa Yönelik Fiziksel İstismar Olgusu Creator An entity primarily responsible for making the resource Ali Metin, Nursel Gamsız Bilgin, Veli Yıldırım Description An account of the resource Engelliler toplumumuzun yaklaşık %12.3 gibi büyük bir bölümünü oluşturmaktadır. Engelli bireyler, şiddet açısından risk grubunda bulunmaktadır. Engelliler çocuklar, kadınlar, yaşlılar gibi fiziksel, cinsel, ekonomik, duygusal şiddettin hedefi olmaktadır. Yaşanan şiddetin sonucunda fiziksel ve ruhsal sorunlar yaşamakta, engel durumları artmakta veya yaşamlarını yitirebilmektedirler. Yapılan ulusal ve uluslararası birçok çalışmada engellilerin fiziksel ve cinsel başta olmak üzere birçok şiddet türüne maruz kaldıkları vurgulanmaktadır 9 yaşında bakımevinde kalan olgumuzda bakımından sorumlu kişi tarafından şiddetin en ağır sonucuna maruz kalmıştır. Şiddetin boyutu ve etkilerinin ortaya konulması şiddetin kaynağının yok edilmesine katkı sağlayacaktır.   Anahtar Kelimeler: engelli çocuk; fiziksel istismar; ölüm Date A point or period of time associated with an event in the lifecycle of the resource 2014 Subject The topic of the resource engelli çocuk, fiziksel istismar, Ölüm Identifier An unambiguous reference to the resource within a given context DOI: 10.17986/blm.2014193258 Source A related resource from which the described resource is derived Adli Tıp Bülteni Publisher An entity responsible for making the resource available Adli Tıp Uzmanları Derneği Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General) Language A language of the resource EN, TR https://www.socictopen.socict.org/files/original/55e16c48dbd8fea18500566acf6b9836.pdf 2ac9e7e18b54cdd977712d90f2e5b945 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Prevalence and phylogenetic analysis of porcine diarrhea associated viruses in southern China from 2012 to 2018 Creator An entity primarily responsible for making the resource Fanfan Zhang, Suxian Luo, Jun Gu, Zhi-Quan Li, Kai Li, Wei-feng YUAN, Yu Ye, Hao Li, Zhen Ding, Deping Song, Yu-Xin Tang Description An account of the resource Abstract Background In China, large-scale outbreaks of severe diarrhea caused by viruses have occurred in pigs since late 2010. To investigate the prevalence and genetic evolution of diarrhea-associated viruses responsible for the outbreaks, a total of 2987 field diarrheal samples collected from 168 pig farms in five provinces in Southern China during 2012–2018 were tested. Results Porcine epidemic diarrhea virus (PEDV) was most frequently detected virus with prevalence rates between 50.21 and 62.10% in samples, and 96.43% (162/168) in premises, respectively. Porcine deltacoronavirus (PDCoV) was the second prevalent virus with prevalence rates ranging from 19.62 to 29.19% in samples, and 70.24% (118/168) in premises, respectively. Both transmissible gastroenteritis virus (TGEV) and porcine rotavirus (PoRV) were detected at low prevalence rates of Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource Porcine diarrhea, Prevalence, porcine epidemic diarrhea virus, porcine deltacoronavirus, Swine acute diarrhea syndrome coronavirus Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s12917-019-2212-2 Source A related resource from which the described resource is derived BMC Veterinary Research Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Veterinary medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/501c36e7ea5bef9a8b8a86ac50c85854.pdf 9df65b38f4d55b5747c6668dffb11901 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Could human coronavirus OC43 have co-evolved with early humans? Creator An entity primarily responsible for making the resource Paulo Eduardo Brandão Description An account of the resource Abstract This paper reports on an investigation of the role of codon usage evolution on the suggested bovine-to-human spillover of Bovine coronavirus (BCoV), an enteric/respiratory virus of cattle, resulting in the emergence of the exclusively respiratory Human coronavirus OC43 (HCoV-OC43). Analyses based on full genomes of BCoV and HCoV-OC43 and on both human and bovine mRNAs sequences of cholecystokinin (CCK) and surfactant protein 1 A (SFTP1-A), representing the enteric and respiratory tract codon usage, respectively, have shown natural selection leading to optimization or deoptimization of viral codon usage to the human enteric and respiratory tracts depending on the virus genes under consideration. A higher correlation was found for the nucleotide distance at the 3rd nucleotide position of codons and codon usage optimization to the human respiratory tract when BCoV and HCoV-OC43 were compared. An MCC tree based on relative synonymous codon usage (RSCU) data integrating data from both viruses and hosts into a same analysis indicated three putative host/virus contact dates ranging from 1.54E8 to 2.44E5 years ago, suggesting that an ancestor coronavirus might have followed human evolution. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource codon usage, coronavirus, spillover, coevolution Identifier An unambiguous reference to the resource within a given context DOI: 10.1590/1678-4685-gmb-2017-0192 Source A related resource from which the described resource is derived Genetics and Molecular Biology Publisher An entity responsible for making the resource available Sociedade Brasileira de Genética Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Genetics Language A language of the resource EN https://www.socictopen.socict.org/files/original/c6b5ff43d15e0b17d1a2df28915a5b6b.pdf 9222e03eff4cac4b54c956784470789e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Human Coronavirus Infections in Israel: Epidemiology, Clinical Symptoms and Summer Seasonality of HCoV-HKU1 Creator An entity primarily responsible for making the resource Nehemya Friedman, Hadar Alter, Musa Hindiyeh, Ella Mendelson, Yonat Shemer-Avni, Michal Mandelboim Description An account of the resource Human coronaviruses (HCoVs) cause mild to severe respiratory diseases. Six types of HCoVs have been discovered, the most recent one termed the Middle East respiratory syndrome coronavirus (MERS-CoV). The aim of this study is to monitor the circulation of HCoV types in the population during 2015–2016 in Israel. HCoVs were detected by real-time PCR analysis in 1910 respiratory samples, collected from influenza-like illness (ILI) patients during the winter sentinel influenza survey across Israel. Moreover, 195 HCoV-positive samples from hospitalized patients were detected during one year at Soroka University Medical Center. While no MERS-CoV infections were detected, 10.36% of patients in the survey were infected with HCoV-OC43 (43.43%), HCoV-NL63 (44.95%), and HCoV-229E (11.62%) viruses. The HCoVs were shown to co-circulate with respiratory syncytial virus (RSV) and to appear prior to influenza virus infections. HCoV clinical symptoms were more severe than those of RSV infections but milder than influenza symptoms. Hospitalized patients had similar HCoV types percentages. However, while it was absent from the public winter survey, 22.6% of the patients were HCoV-HKU1 positives, mainly during the spring-summer period. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource human coronavirus, HCoV-OC43, HCoV-NL63, HCoV-229E, HCoV-HKU1, Israel Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/v10100515 Source A related resource from which the described resource is derived Viruses Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/80ca46adc7d9947ba56bc6fbf643cca2.pdf cfca34b2d88b5bf16f67b80869adf783 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Synthesis, Antifungal Activities and Molecular Docking Studies of Benzoxazole and Benzothiazole Derivatives Creator An entity primarily responsible for making the resource Bo Luo, Ding Li, Anling Zhang, Jin-Ming Gao Description An account of the resource Based on benzoxazole and benzothiazole scaffold as an important pharmacophore, two series of 2-(aryloxymethyl) benzoxazole and benzothiazole derivatives were synthesized and their antifungal effects against eight phytopathogenic fungi were evaluated. Compounds 5a, 5b, 5h, and 5i exhibited significant antifungal activities against most of the pathogens tested. Especially 5a, 5b, 5h, 5i, 5j, and 6h inhibited the growth of F. solani with IC50 of 4.34–17.61 μg/mL, which were stronger than that of the positive control, hymexazol (IC50 of 38.92 μg/mL). 5h was the most potent inhibitor (IC50 of 4.34 μg/mL) against F. Solani, which was about nine times more potent than hymexazol. Most of the test compounds displayed significant antifungal effects against B. cinerea (IC50 of 19.92–77.41 μg/mL), among them, 5a was the best one (IC50 of 19.92 μg/mL). The structure-activity relationships (SARs) were compared and analyzed. The result indicates that the electron-drawing ability and position of the substituents have a significant impact on biological activities. Furthermore, docking studies were carried out on the lipid transfer protein sec14p from S. cerevisiae, and preliminarily verified the antifungal activities. Taken together, these results provide 2-(phenoxymethyl)benzo[d]oxazole as an encouraging framework that could lead to the development of potent novel antifungal agents. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource benzoxazole derivatives, benzothiazole derivatives, fungicidal activity, plant pathogens, structure-activity relationships, molecular docking Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/molecules23102457 Source A related resource from which the described resource is derived Molecules Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Organic chemistry Language A language of the resource EN https://www.socictopen.socict.org/files/original/0c262301c43e59995c80686f6700985c.pdf ae88ee07bb56f3f6b4df988810b6dc7a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Molecular analysis of the bovine coronavirus S1 gene by direct sequencing of diarrheic fecal specimens Creator An entity primarily responsible for making the resource E. Takiuchi, A.F. Alfieri, A.A. Alfieri Description An account of the resource Bovine coronavirus (BCoV) causes severe diarrhea in newborn calves, is associated with winter dysentery in adult cattle and respiratory infections in calves and feedlot cattle. The BCoV S protein plays a fundamental role in viral attachment and entry into the host cell, and is cleaved into two subunits termed S1 (amino terminal) and S2 (carboxy terminal). The present study describes a strategy for the sequencing of the BCoV S1 gene directly from fecal diarrheic specimens that were previously identified as BCoV positive by RT-PCR assay for N gene detection. A consensus sequence of 2681 nucleotides was obtained through direct sequencing of seven overlapping PCR fragments of the S gene. The samples did not undergo cell culture passage prior to PCR amplification and sequencing. The structural analysis was based on the genomic differences between Brazilian strains and other known BCoV from different geographical regions. The phylogenetic analysis of the entire S1 gene showed that the BCoV Brazilian strains were more distant from the Mebus strain (97.8% identity for nucleotides and 96.8% identity for amino acids) and more similar to the BCoV-ENT strain (98.7% for nucleotides and 98.7% for amino acids). Based on the phylogenetic analysis of the hypervariable region of the S1 subunit, these strains clustered with the American (BCoV-ENT, 182NS) and Canadian (BCQ20, BCQ2070, BCQ9, BCQ571, BCQ1523) calf diarrhea and the Canadian winter dysentery (BCQ7373, BCQ2590) strains, but clustered on a separate branch of the Korean and respiratory BCoV strains. The BCoV strains of the present study were not clustered in the same branch of previously published Brazilian strains (AY606193, AY606194). These data agree with the genealogical construction and suggest that at least two different BCoV strains are circulating in Brazil. Date A point or period of time associated with an event in the lifecycle of the resource 2008 Subject The topic of the resource Bovine coronavirus, S1 gene, Sequencing, Genetic polymorphism Identifier An unambiguous reference to the resource within a given context DOI: Source A related resource from which the described resource is derived Brazilian Journal of Medical and Biological Research Publisher An entity responsible for making the resource available Associação Brasileira de Divulgação Científica Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Medicine (General) Language A language of the resource EN https://www.socictopen.socict.org/files/original/176ae8174ddad5b9fb7d90f971f80517.pdf 6c60be40853df06e5f8dda3868a4abc8 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource HostPhinder: A Phage Host Prediction Tool Creator An entity primarily responsible for making the resource Julia Villarroel, Kortine Annina Kleinheinz, Vanessa Isabell Jurtz, Henrike Zschach, Ole Lund, Morten Nielsen, Mette Voldby Larsen Description An account of the resource The current dramatic increase of antibiotic resistant bacteria has revitalised the interest in bacteriophages as alternative antibacterial treatment. Meanwhile, the development of bioinformatics methods for analysing genomic data places high-throughput approaches for phage characterization within reach. Here, we present HostPhinder, a tool aimed at predicting the bacterial host of phages by examining the phage genome sequence. Using a reference database of 2196 phages with known hosts, HostPhinder predicts the host species of a query phage as the host of the most genomically similar reference phages. As a measure of genomic similarity the number of co-occurring k-mers (DNA sequences of length k) is used. Using an independent evaluation set, HostPhinder was able to correctly predict host genus and species for 81% and 74% of the phages respectively, giving predictions for more phages than BLAST and significantly outperforming BLAST on phages for which both had predictions. HostPhinder predictions on phage draft genomes from the INTESTI phage cocktail corresponded well with the advertised targets of the cocktail. Our study indicates that for most phages genomic similarity correlates well with related bacterial hosts. HostPhinder is available as an interactive web service [1] and as a stand alone download from the Docker registry [2]. Date A point or period of time associated with an event in the lifecycle of the resource 2016 Subject The topic of the resource “host specificity”, Prediction, genome, Kmers Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/v8050116 Source A related resource from which the described resource is derived Viruses Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/4fd0a24c7d1c2b81697c3323caa29c04.pdf 46305ebff642e22593a530d48b523d94 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Interacting Temperature, Nutrients and Zooplankton Grazing Control Phytoplankton Size-Abundance Relationships in Eight Swiss Lakes Creator An entity primarily responsible for making the resource Francesco Pomati, Jonathan B Shurin, Ken H. Andersen, Christoph Tellenbach, Andrew D. Barton Description An account of the resource Biomass distribution among size classes follows a power law where the Log-abundance of taxa scales to Log-size with a slope that responds to environmental abiotic and biotic conditions. The interactions between ecological mechanisms controlling the slope of locally realized size-abundance relationships (SAR) are however not well understood. Here we tested how warming, nutrient levels, and grazing affect the slope of phytoplankton community SARs in decadal time-series from eight Swiss lakes of the peri-alpine region, which underwent environmental forcing due to climate change and oligotrophication. We expected rising temperature to have a negative effect on slope (favoring small phytoplankton), and increasing nutrient levels and grazing pressure to have a positive effect (benefiting large phytoplankton). Using a random forest approach to extract robust patterns from the noisy data, we found that the effects of temperature (direct and indirect through water column stability), nutrient availability (phosphorus and total biomass), and large herbivore (copepods and daphnids) grazing and selectivity on slope were non-linear and interactive. Increasing water temperature or total grazing pressure, and decreasing phosphorus levels, had a positive effect on slope (favoring large phytoplankton, which are predominantly mixotrophic in the lake dataset). Our results therefore showed patterns that were opposite to the expected long-term effects of temperature and nutrient levels, and support a paradigm in which (i) small phototrophic phytoplankton appear to be favored under high nutrients levels, low temperature and low grazing, and (ii) large mixotrophic algae are favored under oligotrophic conditions when temperature and grazing pressure are high. The effects of temperature were stronger under nutrient limitation, and the effects of nutrients and grazing were stronger at high temperature. Our study shows that the phytoplankton local SARs in lakes respond to both the independent and the interactive effects of resources, grazing and water temperature in a complex, unexpected way, and observations from long-term studies can deviate significantly from general theoretical expectations. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource size spectra, bottom–up and top–down controls, main effects and interactions, nonlinear effects, Random Forests, Eutrophication Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fmicb.2019.03155 Source A related resource from which the described resource is derived Frontiers in Microbiology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/9da18251984a93f597e07a6d674cb864.pdf 8a4c5343f730f44ce11de71ec5336515 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The behavioral impacts of SARS and its implication for societal preparedness for other emerging infections Creator An entity primarily responsible for making the resource Kathleen Pik-san Kwok, Corina Shuk-ching Fung, Shui Shan Lee, Sing Lee Description An account of the resource Introduction: This study examined public attitudes toward Severe Acute Respiratory Syndrome (SARS) in Hong Kong three months after the peak of the 2003 outbreak in order to shed light on SARS-related complaints received by the Equal Opportunities Commission of Hong Kong. Methods: A cross-sectional telephone survey was conducted three months after the SARS outbreak of 1,023 randomly selected Chinese-speaking residents in Hong Kong. Results: Most of the respondents (72.2%) reported worry about contracting SARS. They attributed their anxiety to the perceived danger of the disease, the government’s unsatisfactory style of crisis management, and inconsistent health information dissemination. The majority of respondents endorsed up to 3 avoidant (67.8%) and 3 imposing (72.7%) attitudes toward individuals and/or situations considered to be at risk of spreading SARS. Logistic Regression analyses indicated that the odds for avoidant and imposing attitudes increased significantly for those who were middle aged (35-54), employed full-time or part-time, and worried over contracting SARS. Conclusions: Public attitudes that endorsed avoidant and imposing behaviors were common during the outbreak of SARS. While essential for preventive health practices, they might bring about workplace conflicts, stigma, and other negative interpersonal experiences. These problems may complicate public health efforts to control the epidemic. They may also suggest ways in which societal preparedness for future emerging infections can be improved. Date A point or period of time associated with an event in the lifecycle of the resource 2008 Subject The topic of the resource severe acute respiratory syndrome (SARS), Anxiety, stigma, Hong Kong, discrimination Identifier An unambiguous reference to the resource within a given context DOI: Source A related resource from which the described resource is derived Social Medicine Publisher An entity responsible for making the resource available Social Medicine Publication Group Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Public aspects of medicine, Sociology (General) Language A language of the resource EN, ES, PT https://www.socictopen.socict.org/files/original/41eae7593e65c386a14f3da41552dff5.pdf 0c85c12bb97a010e2766d050e1ac57d4 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Light whole genome sequence for SNP discovery across domestic cat breeds Creator An entity primarily responsible for making the resource Driscoll Carlos, Cruz Pedro, Young Alice C, Rubenfield Marc J, Brand Adrianne, Saranga David J, Tao Wei, Donahue William F, Ebling Heather, Shen Lei, Hansen Nancy F, Mullikin James C, David Victor, Al-Murrani Samer WK, Locniskar Mary F, Abrahamsen Mitchell S, O'Brien Stephen J, Smith Douglas R, Brockman Jeffrey A Description An account of the resource Abstract Background The domestic cat has offered enormous genomic potential in the veterinary description of over 250 hereditary disease models as well as the occurrence of several deadly feline viruses (feline leukemia virus -- FeLV, feline coronavirus -- FECV, feline immunodeficiency virus - FIV) that are homologues to human scourges (cancer, SARS, and AIDS respectively). However, to realize this bio-medical potential, a high density single nucleotide polymorphism (SNP) map is required in order to accomplish disease and phenotype association discovery. Description To remedy this, we generated 3,178,297 paired fosmid-end Sanger sequence reads from seven cats, and combined these data with the publicly available 2X cat whole genome sequence. All sequence reads were assembled together to form a 3X whole genome assembly allowing the discovery of over three million SNPs. To reduce potential false positive SNPs due to the low coverage assembly, a low upper-limit was placed on sequence coverage and a high lower-limit on the quality of the discrepant bases at a potential variant site. In all domestic cats of different breeds: female Abyssinian, female American shorthair, male Cornish Rex, female European Burmese, female Persian, female Siamese, a male Ragdoll and a female African wildcat were sequenced lightly. We report a total of 964 k common SNPs suitable for a domestic cat SNP genotyping array and an additional 900 k SNPs detected between African wildcat and domestic cats breeds. An empirical sampling of 94 discovered SNPs were tested in the sequenced cats resulting in a SNP validation rate of 99%. Conclusions These data provide a large collection of mapped feline SNPs across the cat genome that will allow for the development of SNP genotyping platforms for mapping feline diseases. Date A point or period of time associated with an event in the lifecycle of the resource 2010 Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/1471-2164-11-406 Source A related resource from which the described resource is derived BMC Genomics Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Genetics, Biotechnology Language A language of the resource EN