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                  <text>Dominio científico: Coronavirus</text>
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                <text>Neuro-ophthalmologic complications of coronavirus disease 2019 (COVID-19).</text>
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                <text>Doria M Gold, Steven L Galetta</text>
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                <text>Multiple neuro-ophthalmological manifestations have been described in association with COVID-19. These symptoms and signs may be the result of a range of pathophysiological mechanisms throughout the course from acute illness to recovery phase. Optic nerve dysfunction, eye movement abnormalities and visual field defects have been described.</text>
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                <text>2021</text>
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                <text>Stroke, covid-19 infection, myasthenia gravis, neuro-ophthalmology, Optic neuritis, Diplopia, cranial nerve palsy, Venous sinus thrombosis, Miller-Fisher variant Guillain Barre syndrome, Opsoclonus, Oscillopsia, Visual field defect</text>
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                <text>10.1016/j.neulet.2020.135531</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Neuroscience letters</text>
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              <name>Title</name>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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            <description>A name given to the resource</description>
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                <text>SEDAR-SEMICYUC consensus on the management of haemostasis disorders in severe COVID-19 patients.</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>J V Llau, R Ferrandis, P Sierra, F Hidalgo, C Cassinello, A Gómez-Luque, M Quintana, R Amezaga, M Geroi, A Serrano, P Marcos</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2020</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>10.1016/j.medin.2020.08.007</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Medicina intensiva</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>New Ways to Manage Pandemics: Using Technologies in the Era of COVID-19, a Narrative Review</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="39730">
                <text>Mohammad Reza Mohammadi, Ali Khaleghi, Hadi Zarafshan, Gila Pirzad Jahromi</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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                <text>Objective: Health care systems and professionals worldwide are relying on technology as an essential partner to manage the COVID-19 epidemic. This paper explains how digital technologies can benefit the public, medical workers, and health care systems.  Method: This nonsystematic literature review was conducted on different technologies and their impact and applications in the COVID-19 epidemic using proper search keywords on the PubMed, Google Scholar, and Science Direct databases.  Results: We found various helpful technologies, which can help us to appropriately contain and manage the COVID-19 pandemic through broad areas of clinical care, logistics, maintenance of socioeconomic activities, and inspection. However, main challenges still need to be addressed for obtaining the full capacities of the technologies to support health care systems.  Conclusion: Technologies can offer many innovative ideas and solutions against global and local emergencies. In this time of great vagueness and danger, we require all the resources we can collect to rescue ourselves and our patients. Barriers and challenges, such as lack of technology proficiency, confidentiality requirements, and reimbursement matters, need to be recognized and resolved rapidly, accurately, and compassionately.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="39732">
                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="39733">
                <text>covid-19, health care, telehealth, Robotics, Technology, informatics</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="39734">
                <text>Iranian Journal of Psychiatry</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="39735">
                <text>Tehran University of Medical Sciences</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Psychiatry</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Intranasal immunization with plasmid DNA encoding spike protein of SARS-coronavirus/polyethylenimine nanoparticles elicits antigen-specific humoral and cellular immune responses</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Yang Moon-Sik, Jang Yong-Suk, Kim Dong, Song Man, Chu Hyuk, Jere Dhananjay, Quan Ji-Shan, Park Sung-Moo, Shim Byoung-Shik, Han Seung, Park Yong-Ho, Cho Chong-Su, Yun Cheol-Heui</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>Abstract Background Immunization with the spike protein (S) of severe acute respiratory syndrome (SARS)-coronavirus (CoV) in mice is known to produce neutralizing antibodies and to prevent the infection caused by SARS-CoV. Polyethylenimine 25K (PEI) is a cationic polymer which effectively delivers the plasmid DNA. Results In the present study, the immune responses of BALB/c mice immunized via intranasal (i.n.) route with SARS DNA vaccine (pci-S) in a PEI/pci-S complex form have been examined. The size of the PEI/pci-S nanoparticles appeared to be around 194.7 ± 99.3 nm, and the expression of the S mRNA and protein was confirmed in vitro. The mice immunized with i.n. PEI/pci-S nanoparticles produced significantly (P &lt; 0.05) higher S-specific IgG1 in the sera and mucosal secretory IgA in the lung wash than those in mice treated with pci-S alone. Compared to those in mice challenged with pci-S alone, the number of B220+ cells found in PEI/pci-S vaccinated mice was elevated. Co-stimulatory molecules (CD80 and CD86) and class II major histocompatibility complex molecules (I-Ad) were increased on CD11c+ dendritic cells in cervical lymph node from the mice after PEI/pci-S vaccination. The percentage of IFN-γ-, TNF-α- and IL-2-producing cells were higher in PEI/pci-S vaccinated mice than in control mice. Conclusion These results showed that intranasal immunization with PEI/pci-S nanoparticles induce antigen specific humoral and cellular immune responses.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="39724">
                <text>2010</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="39725">
                <text>10.1186/1471-2172-11-65</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="39726">
                <text>Biotemas</text>
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            </elementTextContainer>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="39727">
                <text>Universidade Federal de Santa Catarina</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="39728">
                <text>Immunologic diseases. Allergy</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
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    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="39712">
                <text>A Parallelized Database Damage Assessment Approach after Cyberattack for Healthcare Systems</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="39713">
                <text>Karam Al Kontar, Sanaa Kaddoura, Ramzi  A. Haraty, Omar Alfandi</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>In the current Internet of things era, all companies shifted from paper-based data to the electronic format. Although this shift increased the efficiency of data processing, it has security drawbacks. Healthcare databases are a precious target for attackers because they facilitate identity theft and cybercrime. This paper presents an approach for database damage assessment for healthcare systems. Inspired by the current behavior of COVID-19 infections, our approach views the damage assessment problem the same way. The malicious transactions will be viewed as if they are COVID-19 viruses, taken from infection onward. The challenge of this research is to discover the infected transactions in a minimal time. The proposed parallel algorithm is based on the transaction dependency paradigm, with a time complexity O((M+NQ+N^3)/L) (M = total number of transactions under scrutiny, N = number of malicious and affected transactions in the testing list, Q = time for dependency check, and L = number of threads used). The memory complexity of the algorithm is O(N+KL) (N = number of malicious and affected transactions, K = number of transactions in one area handled by one thread, and L = number of threads). Since the damage assessment time is directly proportional to the denial-of-service time, the proposed algorithm provides a minimized execution time. Our algorithm is a novel approach that outperforms other existing algorithms in this domain in terms of both time and memory, working up to four times faster in terms of time and with 120,000 fewer bytes in terms of memory.</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="39715">
                <text>2021</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="39716">
                <text>damage assessment, information warfare, malicious transactions, transactions dependency</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="39717">
                <text>10.3390/fi13040090</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="39718">
                <text>Epidemiology and Health</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="39719">
                <text>Korean Society of Epidemiology</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Information technology</text>
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                <text>Giuliano Rizzardini, Antonella Foschi, Alessandro Mancon, Stefania Merli, Federica Staurenghi, Laura Pezzati, Alberto Rizzo, Federico Conti, Francesca Romeri, Dario Bernacchia, Rachele Meroni, Maria Rita Gismondo, Valeria Micheli, Davide Mileto</text>
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                <text>This study addressed the case of a patient with prolonged COVID-19 viral shedding, reported by Real-Time PCR, until 71 days from symptom onset. However, viral culture received negative results after 30 days from symptom onset. Therefore, viral culture may be a worthwhile test for patients requiring discharge, in particular for those presenting prolonged viral shedding.</text>
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                <text>International Journal of Infectious Diseases</text>
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                <text>Raphaëlle Binois, Mathilda Colin, Vincent Rzepecki, Thierry Prazuck, Eric Esteve, Laurent Hocqueloux</text>
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                <text>10.1111/ijd.15158</text>
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                <text>International journal of dermatology</text>
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                <text>Assessing severe acute respiratory coronavirus virus 2 (SARS-CoV-2) preparedness in US community hospitals: A forgotten entity.</text>
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                <text>Sonali D Advani, Esther Baker, Andrea Cromer, Brittain Wood, Kathryn L Crawford, Linda Crane, Linda Adcock, Linda Roach, Polly Padgette, Deverick J Anderson, Daniel J Sexton</text>
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                <text>We performed a cross-sectional survey of infection preventionists in 60 US community hospitals between April 22 and May 8, 2020. Several differences in hospital preparedness for SARS-CoV-2 emerged with respect to personal protective equipment conservation strategies, protocols related to testing, universal masking, and restarting elective procedures.</text>
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                <text>Infection control and hospital epidemiology</text>
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                <text>Repurposing Antiviral Protease Inhibitors Using Extracellular Vesicles for Potential Therapy of COVID-19</text>
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                <text>Kelli Gerth, Santosh Kumar, Kaining Zhi, Ahona Mukherji</text>
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                <text>In January 2020, Chinese health agencies reported an outbreak of a novel coronavirus-2 (CoV-2) which can lead to severe acute respiratory syndrome (SARS). The virus, which belongs to the coronavirus family (SARS-CoV-2), was named coronavirus disease 2019 (COVID-19) and declared a pandemic by the World Health Organization (WHO). Full-length genome sequences of SARS-CoV-2 showed 79.6% sequence identity to SARS-CoV, with 96% identity to a bat coronavirus at the whole-genome level. COVID-19 has caused over 133,000 deaths and there are over 2 million total confirmed cases as of April 15th, 2020. Current treatment plans are still under investigation due to a lack of understanding of COVID-19. One potential mechanism to slow disease progression is the use of antiviral drugs to either block the entry of the virus or interfere with viral replication and maturation. Currently, antiviral drugs, including chloroquine/hydroxychloroquine, remdesivir, and lopinavir/ritonavir, have shown effective inhibition of SARS-CoV-2 in vitro. Due to the high dose needed and narrow therapeutic window, many patients are experiencing severe side effects with the above drugs. Hence, repurposing these drugs with a proper formulation is needed to improve the safety and efficacy for COVID-19 treatment. Extracellular vesicles (EVs) are a family of natural carriers in the human body. They play a critical role in cell-to-cell communications. EVs can be used as unique drug carriers to deliver protease inhibitors to treat COVID-19. EVs may provide targeted delivery of protease inhibitors, with fewer systemic side effects. More importantly, EVs are eligible for major aseptic processing and can be upscaled for mass production. Currently, the FDA is facilitating applications to treat COVID-19, which provides a very good chance to use EVs to contribute in this combat.</text>
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                <text>2020</text>
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                <text>Coronaviruses, HIV, covid-19, Extracellular vesicles, antiviral drugs, Protease Inhibitors</text>
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                <text>10.3390/v12050486</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Microbiology</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Evaluation of Mental Health Factors among People with Systemic Lupus Erythematosus during the SARS-CoV-2 Pandemic</text>
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                <text>Iwona Rotter, Aleksandra Szylińska, Paweł Wańkowicz</text>
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                <text>There are considerable psychological and psychiatric consequences of the pandemic. Researchers have started to take into account the real or perceived sense of social threats that may be expressed, such as anxiety, depression, and sleep disorders. However, analyses on pandemic-related anxiety, depression, and sleep disorders mostly rarely addresses the situation of people with autoimmune diseases. Therefore, the aim of this study was to assess the mental health factors among people with systemic lupus erythematosus by quantifying the severity of anxiety, depression, and sleep disorders during the SARS-CoV-2 pandemic. In total, 723 people took part in the study. The study group consisted of 134 individuals with a systemic lupus erythematosus. The control group consisted of 589 people without systemic lupus erythematosus. The regression adjusted by age, gender, and diagnosis of other chronic diseases showed individuals with systemic lupus erythematosus were at a much higher risk of elevated symptoms of anxiety on the GAD-7 scale (OR = 3.683; p &lt; 0.001), depression on the PHQ-9 scale (OR = 4.183; p &lt; 0.001), and sleep disorders on the Insomnia Severity Index (ISI) scale (OR = 6.781; p &lt; 0.001). Therefore, the mental health of patients with systemic lupus erythematosus in the times of the SARS-CoV-2 pandemic is not only an extremely important medical problem but also a social one and must require special attention.</text>
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                <text>2020</text>
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                <text>covid-19, SARS-CoV-2, PHQ-9, gad-7, ISI, SLE</text>
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                <text>10.3390/jcm9092872</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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