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IL-12 RB1 genetic variants contribute to human susceptibility to severe acute respiratory syndrome infection among Chinese.
BACKGROUND: Cytokines play important roles in antiviral action. We examined whether polymorphisms of interleukin (IL)-12 receptor B1 (IL-12RB1) affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). METHODS: A…
Position: 4029 (38 views)
A k-mer-based method for the identification of phenotype-associated genomic biomarkers and predicting phenotypes of sequenced bacteria.
We have developed an easy-to-use and memory-efficient method called PhenotypeSeeker that (a) identifies phenotype-specific k-mers, (b) generates a k-mer-based statistical model for predicting a given phenotype and (c) predicts the phenotype from the…
Position: 4029 (38 views)
Feature selection methods for identifying genetic determinants of host species in RNA viruses.
Despite environmental, social and ecological dependencies, emergence of zoonotic viruses in human populations is clearly also affected by genetic factors which determine cross-species transmission potential. RNA viruses pose an interesting case study…
Position: 2574 (46 views)
Using routine surveillance data to estimate the epidemic potential of emerging zoonoses: application to the emergence of US swine origin influenza A H3N2v virus.
BACKGROUND:Prior to emergence in human populations, zoonoses such as SARS cause occasional infections in human populations exposed to reservoir species. The risk of widespread epidemics in humans can be assessed by monitoring the reproduction number…
Position: 3409 (41 views)
Predicting peptide structures in native proteins from physical simulations of fragments.
It has long been proposed that much of the information encoding how a protein folds is contained locally in the peptide chain. Here we present a large-scale simulation study designed to examine the extent to which conformations of peptide fragments…
Position: 1565 (54 views)
Differential sensitivity of bat cells to infection by enveloped RNA viruses: coronaviruses, paramyxoviruses, filoviruses, and influenza viruses.
Bats (Chiroptera) host major human pathogenic viruses including corona-, paramyxo, rhabdo- and filoviruses. We analyzed six different cell lines from either Yinpterochiroptera (including African flying foxes and a rhinolophid bat) or Yangochiroptera…
Position: 4273 (37 views)
Evaluation of phage display discovered peptides as ligands for prostate-specific membrane antigen (PSMA).
The aim of this study was to identify potential ligands of PSMA suitable for further development as novel PSMA-targeted peptides using phage display technology. The human PSMA protein was immobilized as a target followed by incubation with a 15-mer…
Position: 1063 (60 views)
Genetic characterization of the hemagglutinin genes of wild-type measles virus circulating in china, 1993-2009.
BACKGROUND: China experienced several large measles outbreaks in the past two decades, and a series of enhanced control measures were implemented to achieve the goal of measles elimination. Molecular epidemiologic surveillance of wild-type measles…
Position: 1001 (61 views)
Cyclomorphosis in Daphnia lumholtzi Sars (Crustacea: Cladocera) -An Intermittent Species from a Subtropical Water body
Cyclomorphosis in Daphnia lumholtzi Sars (Crustacea: Cladocera) -An Intermittent Species from a Subtropical Water body
Position: 5866 (32 views)
Thermocyclops oblongatus (Sars) (Crustacea: Copepoda): A New Cyclopid for the Fauna of India, and Zoogeography of the Species
Thermocyclops oblongatus (Sars) (Crustacea: Copepoda): A New Cyclopid for the Fauna of India, and Zoogeography of the Species
Position: 4029 (38 views)