47 10 20655 https://www.socictopen.socict.org/files/original/ca8bcfc7504141ecacfc878060da5420.pdf f40e4248fde3bbb805ede78ec447ddfb Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Epidemiology of severe acute respiratory syndrome Hospital Santa Cruz / RS - Brazil Creator An entity primarily responsible for making the resource Marcelo Carneiro Description An account of the resource . Date A point or period of time associated with an event in the lifecycle of the resource 2013 Identifier An unambiguous reference to the resource within a given context DOI: 10.17058/reci.v3i2.3999 Source A related resource from which the described resource is derived Revista de Epidemiologia e Controle de Infecção Publisher An entity responsible for making the resource available Universidade de Santa Cruz do Sul Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Internal medicine, Infectious and parasitic diseases, Medicine Language A language of the resource PT https://www.socictopen.socict.org/files/original/57ace060f82e1b9e03e0ad8c7df3a0a8.pdf e1bf34331f7ccbe7d818c29011db5e07 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource How conserved are the conserved 16S-rRNA regions? Creator An entity primarily responsible for making the resource Marcel Martinez-Porchas, Enrique Villalpando-Canchola, Luis Enrique Ortiz Suarez, Francisco Vargas-Albores Description An account of the resource The 16S rRNA gene has been used as master key for studying prokaryotic diversity in almost every environment. Despite the claim of several researchers to have the best universal primers, the reality is that no primer has been demonstrated to be truly universal. This suggests that conserved regions of the gene may not be as conserved as expected. The aim of this study was to evaluate the conservation degree of the so-called conserved regions flanking the hypervariable regions of the 16S rRNA gene. Data contained in SILVA database (release 123) were used for the study. Primers reported as matches of each conserved region were assembled to form contigs; sequences sizing 12 nucleotides (12-mers) were extracted from these contigs and searched into the entire set of SILVA sequences. Frequency analysis shown that extreme regions, 1 and 10, registered the lowest frequencies. 12-mer frequencies revealed segments of contigs that were not as conserved as expected (≤90%). Fragments corresponding to the primer contigs 3, 4, 5b and 6a were recovered from all sequences in SILVA database. Nucleotide frequency analysis in each consensus demonstrated that only a small fraction of these so-called conserved regions is truly conserved in non-redundant sequences. It could be concluded that conserved regions of the 16S rRNA gene exhibit considerable variation that has to be considered when using this gene as biomarker. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Subject The topic of the resource Kmers, Biodiversity, Conserved regions 16S, Primer design Identifier An unambiguous reference to the resource within a given context DOI: 10.7717/peerj.3036 Source A related resource from which the described resource is derived PeerJ Publisher An entity responsible for making the resource available PeerJ Inc. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/c0ad058a834580db450e411b24112ca5.pdf c2c39a52393532804d861dcd252d4b9e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A Review of Novel Coronavirus, cause of Middle East Respiratory Syndrome Creator An entity primarily responsible for making the resource Katayoun Vahdat, Azam Amini, Akram Najafi, Mohammad Javad Haeri‌nejad Description An account of the resource Abstract Background: Isolation of a novel virus belonging to coronavirdae family in September 2012, from patients in Middle East who had died of an acute respiratory illness & renal failure lead to researches on this new virus. Here, a brief review to summarize the events of scientific findings of this new emerging virus. Material and Methods: This review is based on a comprehensive search of three databases (Pubmed, Embase and Cochrane) and WHO reports. The searched keywords were new coronavirus, Middle East, acute respieratory distress syndrom & Saudi Arabia. Results: Due to novelty of virus only limited papers exist on searched databases, so only 50 papers were identified which after omitting repeated case reports, papers related to SARS and updated WHO reports, 30 papers were finally reviewed. Conclusion: WHO recommendation is evaluation of all patients with acute respiratory illness and history of travel to Saudi Arabia or other countries where this novel virus is epidemic. Date A point or period of time associated with an event in the lifecycle of the resource 2014 Subject The topic of the resource Acute Respirototy Distress Syndrom - Middle East - New coronavirus- Saudi Arabia Identifier An unambiguous reference to the resource within a given context DOI: Source A related resource from which the described resource is derived Iranian South Medical Journal Publisher An entity responsible for making the resource available Bushehr University of Medical Sciences Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General) Language A language of the resource EN, FA https://www.socictopen.socict.org/files/original/6b1dd833f5bccb548363b0a381d0b788.pdf 499bae6009fe77f316a4fc0df1f65ebc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Canine Enteric Coronaviruses: Emerging Viral Pathogens with Distinct Recombinant Spike Proteins Creator An entity primarily responsible for making the resource Beth N. Licitra, Gerald E. Duhamel, Gary R. Whittaker Description An account of the resource Canine enteric coronavirus (CCoV) is an alphacoronavirus infecting dogs that is closely related to enteric coronaviruses of cats and pigs. While CCoV has traditionally caused mild gastro-intestinal clinical signs, there are increasing reports of lethal CCoV infections in dogs, with evidence of both gastrointestinal and systemic viral dissemination. Consequently, CCoV is now considered to be an emerging infectious disease of dogs. In addition to the two known serotypes of CCoV, novel recombinant variants of CCoV have been found containing spike protein N-terminal domains (NTDs) that are closely related to those of feline and porcine strains. The increase in disease severity in dogs and the emergence of novel CCoVs can be attributed to the high level of recombination within the spike gene that can occur during infection by more than one CCoV type in the same host. Date A point or period of time associated with an event in the lifecycle of the resource 2014 Subject The topic of the resource canine coronavirus, viral pathogenesis, spike protein, recombination Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/v6083363 Source A related resource from which the described resource is derived Viruses Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/91c5c3d9740021ff6739637061cdb05a.pdf af6b204a10f42d5e039b0643fc6c31bc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Epigenetic Landscape during Coronavirus Infection Creator An entity primarily responsible for making the resource Alexandra Schäfer, Ralph S. Baric Description An account of the resource Coronaviruses (CoV) comprise a large group of emerging human and animal pathogens, including the highly pathogenic severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) strains. The molecular mechanisms regulating emerging coronavirus pathogenesis are complex and include virus–host interactions associated with entry, replication, egress and innate immune control. Epigenetics research investigates the genetic and non-genetic factors that regulate phenotypic variation, usually caused by external and environmental factors that alter host expression patterns and performance without any change in the underlying genotype. Epigenetic modifications, such as histone modifications, DNA methylation, chromatin remodeling, and non-coding RNAs, function as important regulators that remodel host chromatin, altering host expression patterns and networks in a highly flexible manner. For most of the past two and a half decades, research has focused on the molecular mechanisms by which RNA viruses antagonize the signaling and sensing components that regulate induction of the host innate immune and antiviral defense programs upon infection. More recently, a growing body of evidence supports the hypothesis that viruses, even lytic RNA viruses that replicate in the cytoplasm, have developed intricate, highly evolved, and well-coordinated processes that are designed to regulate the host epigenome, and control host innate immune antiviral defense processes, thereby promoting robust virus replication and pathogenesis. In this article, we discuss the strategies that are used to evaluate the mechanisms by which viruses regulate the host epigenome, especially focusing on highly pathogenic respiratory RNA virus infections as a model. By combining measures of epigenome reorganization with RNA and proteomic datasets, we articulate a spatial-temporal data integration approach to identify regulatory genomic clusters and regions that play a crucial role in the host’s innate immune response, thereby defining a new viral antagonism mechanism following emerging coronavirus infection. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Subject The topic of the resource coronaviruses, epigenetics, Systems Biology Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/pathogens6010008 Source A related resource from which the described resource is derived Pathogens Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/e30c6d3d9ce6b41b2e79821552f152f1.pdf ca664c1b63072cc7f3c28980257c57fb Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Adenovirus infection in adults: reactive response of polymorphonuclear neutrophilic leukocytes study Creator An entity primarily responsible for making the resource V. D. Moskaliuk, I. V. Balaniuk, A. S. Sydorchuk, Kh. I. Vozna, M. O. Andruschak, I. V. Rudan Description An account of the resource The role of adenovirus infection in the SARS is significant but every year this group of infections makes up to 30 % of general infectious morbidity. Nowadays features of nonspecific immune defence in patients with adenovirus infection are insufficiently studied. Particularly acute AVI problem appears to clinicians and scientists as a contagious disease, which is rapidly spreading in organized collectives, among military personnel, students.Purpose. To study the reactive response of polymorphonuclear granulocytes in the peripheral blood of adult patients with adenovirus infection.Materials and methods. 37 volunteers with SARS signs (Unified Protocol Criteria) were involved in this “case – control” type study. Absolute and relative quantities of the main immune cells populations in the peripheral blood were analyzed. Immunohematological indicators which characterize reactive response of the main non-specific immune cells were calculated. Clinical diagnosis was confirmed by the serological method of complement fixation test in paired sera and using adenoviruses common soluble complement-fixing antigen.Results. Neutrophil granulocytes reactivity increased by 83.92 % indicating these cells activation by cytokine system. The inflammatory process is accompanied by an increase in leukocytes absolute count – 19.76 %, band neutrophil leukocytes - in 2.18 times; lymphocytes – 30.30 % and monocytes – 48.15 %.Conclusions. Aforementioned means that there are different types of immune response to adenovirus infection antigens. Patients immune reactivity decreasing by 14.86 % means that specific immune response is formed later. Method of neutrophils reactive response evaluation can be used by practicing doctors for the early prediction of possible anti-infectious protection system alteration. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource adenovirus infections, cellular reactivity, Neutrophils, active immune response Identifier An unambiguous reference to the resource within a given context DOI: 10.14739/2310-1210.2018.3.132123 Source A related resource from which the described resource is derived Zaporožskij Medicinskij Žurnal Publisher An entity responsible for making the resource available Zaporozhye State Medical University Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine Language A language of the resource EN, RU, UK https://www.socictopen.socict.org/files/original/8f40d94c24057135e0f89477a8962fe1.pdf 642582be898b1c7cbf09aeae48ccae5c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Use of Aptamers as Diagnostics Tools and Antiviral Agents for Human Viruses Creator An entity primarily responsible for making the resource Víctor M González, M Elena Martín, Gerónimo Fernández, Ana García-Sacristán Description An account of the resource Appropriate diagnosis is the key factor for treatment of viral diseases. Time is the most important factor in rapidly developing and epidemiologically dangerous diseases, such as influenza, Ebola and SARS. Chronic viral diseases such as HIV-1 or HCV are asymptomatic or oligosymptomatic and the therapeutic success mainly depends on early detection of the infective agent. Over the last years, aptamer technology has been used in a wide range of diagnostic and therapeutic applications and, concretely, several strategies are currently being explored using aptamers against virus proteins. From a diagnostics point of view, aptamers are being designed as a bio-recognition element in diagnostic systems to detect viral proteins either in the blood (serum or plasma) or into infected cells. Another potential use of aptamers is for therapeutics of viral infections, interfering in the interaction between the virus and the host using aptamers targeting host-cell matrix receptors, or attacking the virus intracellularly, targeting proteins implicated in the viral replication cycle. In this paper, we review how aptamers working against viral proteins are discovered, with a focus on recent advances that improve the aptamers’ properties as a real tool for viral infection detection and treatment. Date A point or period of time associated with an event in the lifecycle of the resource 2016 Subject The topic of the resource aptamer, diagnosis, Ebola, HBV, HCV, HIV, influenza, SELEX, therapeutic, virus Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/ph9040078 Source A related resource from which the described resource is derived Pharmaceuticals Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Pharmacy and materia medica Language A language of the resource EN https://www.socictopen.socict.org/files/original/f51ecde7a1e35173bf055de8903daf9f.pdf 5f724352cdb0f8a99fb41ce546bbe85f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Determinación de anticuerpos contra patógenos virales y bacterianos seleccionados en la población de cerdos silvestres (Sus scrofa) de la Reserva Natural Bahía Samborombón, Argentina Creator An entity primarily responsible for making the resource B. Carpinetti, G. Castresana, P. Rojas, J. Grant, A. Marcos, M. Monterubbianesi, H. R. Sanguinetti, M. S. Serena, M.G. Echeverría, M. Garciarena, A. Aleksa Description An account of the resource Los cerdos silvestres (Sus scrofa) descienden de cruzamientos entre cerdos domésticos liberados durante la colonización con jabalíes salvajes euroasiáticos, liberados con propósitos cinegéticos. Son invasivos y su coexistencia con especies domésticas implica riesgos sanitarios. Argentina es considerada libre de fiebre aftosa (FA), peste porcina clásica (PPC) y africana (PPA) y síndrome reproductivo y respiratorio porcino (PRRS). La enfermedad de Aujeszky (EA) y la leptospirosis son endémicas en ciertas áreas del país. El objetivo fue evaluar la presencia de ciertas enfermedades zoonóticas y/o de importancia para la producción animal y la conservación de la biodiversidad en cerdos silvestres de la Bahía de Samborombón. Se capturaron 118 animales. Se tomaron muestras de suero, tonsilas, músculo, intestino delgado, linfonódulos, entre otras. Se estudió la presencia de anticuerpos contra Brucella spp., coronavirus respiratorio porcino, virus de la estomatitis vesicular, de la FA, de la gastroenteritis transmisible porcina (TGEV), de la PPC, PPA, EA, PRRS y Leptospira spp. Se realizaron análisis bacteriológicos para Mycobacterium spp. Los resultados ratificaron la ausencia de las enfermedades exóticas e indicaron que 36 % de los animales presentó anticuerpos contra Leptospira interrogans serovar pomona y 62,5 % contra el virus de la EA. Estos resultados remarcan la importancia del monitoreo de la interfase productiva/silvestre en función de la salud pública, producción animal y conservación de la biodiversidad. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Subject The topic of the resource cerdos silvestres, Sus scrofa, Bahía Samborombón, zoonosis Identifier An unambiguous reference to the resource within a given context DOI: 10.24215/15142590e004 Source A related resource from which the described resource is derived Analecta Veterinaria Publisher An entity responsible for making the resource available Universidad Nacional de La Plata Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Veterinary medicine, Animal culture Language A language of the resource EN, ES https://www.socictopen.socict.org/files/original/539377e70989443fd364316eb4650e8f.pdf 5aab465167636d91faf08451e9e9a4d6 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Multi-omic network signatures of disease Creator An entity primarily responsible for making the resource David L Gibbs, Lisa E Gralinski, Ralph S. Baric, Shannon K McWeeney Description An account of the resource To better understand dynamic disease processes, integrated multi-omic methods are needed, yet comparing different types of omic data remains difficult. Integrative solutions benefit experimenters by eliminating potential biases that come with single omic analysis.We have developed the methods needed to explore whether a relationship exists between co-expression network models built from transcriptomic and proteomic data types, and whether this relationship can be used to improve the disease signature discovery process. A naïve, correlation based method is utilized for comparison. Using publicly available infectious disease time series data, we analyzed the related co-expression structure of the transcriptome and proteome in response to SARS-CoV infection in mice. Transcript and peptide expression data was filtered using quality scores and subset by taking the intersection on mapped Entrez IDs. Using this data set, independent co-expression networks were built. The networks were integrated by constructing a bipartite module graph based on module member overlap, module summary correlation, and correlation to phenotypes of interest. Compared to the module level results, the naïve approach is hindered by a lack of correlation across data types, less significant enrichment results, and little functional overlap across data types. Our module graph approach avoids these problems, resulting in an integrated omic signature of disease progression, which allows prioritization across data types for down-stream experiment planning. Integrated modules exhibited related functional enrichments and could suggest novel interactions in response to infection. These disease and platform-independent methods can be used to realize the full potential of multi-omic network signatures. Date A point or period of time associated with an event in the lifecycle of the resource 2014 Subject The topic of the resource proteomics, Transcription, Genetic, transfection, Virology, omics, biomarkers Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fgene.2013.00309 Source A related resource from which the described resource is derived Frontiers in Genetics Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Genetics Language A language of the resource EN https://www.socictopen.socict.org/files/original/b71d5629741e10f99206bcd0dde4eabe.pdf c28e09afad9b09e3de37f7da0b5d02a5 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource N-Pyrrylarylsulfones with High Therapeutic Potential Creator An entity primarily responsible for making the resource Valeria Famiglini, Sabrina Castellano, Romano Silvestri Description An account of the resource This review illustrates the various studies made to investigate the activity of N-pyrrylarylsulfone containing compounds as potential antiviral, anticancer and SNC drugs. A number of synthetic approaches to obtain tetracyclic, tricyclic and non-cyclic compounds, and their biological activity with regard to structure–activity relationships (SARs) have been reviewed. The literature reviewed here may provide useful information on the potential of N-pyrrylarylsulfone pharmacophore as well as suggest concepts for the design and synthesis of new N-pyrrylarylsulfone based agents. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Subject The topic of the resource sulfonamide, heterocycle, polycyclic compound, therapeutic agent Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/molecules22030434 Source A related resource from which the described resource is derived Molecules Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Organic chemistry Language A language of the resource EN