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Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence
The symptoms most commonly reported by patients affected by coronavirus disease (COVID-19) include cough, fever, and shortness of breath. However, other major events usually observed in COVID-19 patients (e.g., high blood pressure, arterial and…
Position: 20554 (14 views)
MERS-CoV Spike Protein Vaccine and Inactivated Influenza Vaccine Formulated with Single Strand RNA Adjuvant Induce T-Cell Activation through Intranasal Immunization in Mice
The effectiveness of vaccines is enhanced by adding adjuvants. Furthermore, the selection of an inoculation route depends on the type of adjuvant used and is important for achieving optimum vaccine efficacy. We investigated the immunological…
Position: 13273 (27 views)
Medicine 4.0: New Technologies as Tools for a Society 5.0
Are new technologies in the medicine sector a driver to support the development of a society 5.0? Innovation pushes the artisan to become smart and lean, customer-oriented but within a standardized environment of production, maintaining and ensuring…
Position: 20554 (14 views)
Clinical trials during the COVID-19 pandemic: Challenges of putting scientific and ethical principles into practice
Global pandemic of COVID-19 is a serious unmet medical need requiring clinical research into effective therapies. Clinical trials during pandemics of infections face complex challenges of putting scientific and ethical principles into practice. Some…
Position: 19705 (18 views)
Antiviral Agents: Discovery to Resistance
In the midst of the SARS-CoV-2/Covid-19 outbreak the need for research into, and development of, antiviral agents is brought into sharp focus worldwide for scientists, governments and the public alike [...]
Position: 19280 (19 views)
Early Transmission Dynamics of Novel Coronavirus (COVID-19) in Nigeria
On 31 December 2019, the World Health Organization (WHO) was notified of a novel coronavirus disease in China that was later named COVID-19. On 11 March 2020, the outbreak of COVID-19 was declared a pandemic. The first instance of the virus in…
Position: 20641 (12 views)
Lay perspectives on social distancing and other official recommendations and regulations in the time of COVID-19: a qualitative study of social media posts
Abstract Background COVID-19 caused by a new form of coronavirus (SARS-CoV-2) first appeared in China end of 2019 and quickly spread to all counties of the world. To slow down the spread of the virus and to limit the pressure on the health care…
Position: 20063 (17 views)
Symptomatic Protective Action of Glycyrrhizin (Licorice) in COVID-19 Infection?
The role of the ACE2 enzyme in the COVID-19 infection is 2-fold, with opposing implications for the disease development. 1. The membrane bound angiotensin converting enzyme 2 (ACE2) serves as the entry point of COVID-19 2. Conversely, it supports an…
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Coronavirus Disease (Covid-19): What Are We Learning in a Country With High Mortality Rate?
Position: 13273 (27 views)
Application of a Gray-Based Decision Support Framework for Location Selection of a Temporary Hospital during COVID-19 Pandemic
The hospital location selection problem is one of the most important decisions in the healthcare sector in big cities due to population growth and the possibility of a high number of daily referred patients. A poor location selection process can lead…
Position: 11574 (29 views)