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Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells.
The acid sphingomyelinase/ceramide system has been shown to be important for cellular infection with at least some viruses, for instance rhinovirus or SARS-CoV-2. Functional inhibition of the acid sphingomyelinase using tricyclic antidepressants…
Position: 6235 (40 views)
Chicha-Coronavirus: 1-0. On trust, natural disasters, and pandemics in the Ecuadorian Amazon
Sarayaku is an Amazonian Kichwa community on the shores of Río Bobonaza, Ecuador. There is no road connecting it to the rest of the country no electricity and no telephone network. I happened to be there on fieldwork during the times of a double…
Position: 9323 (34 views)
Analisis Beban Kerja Mental Mahasiswa saat Perkuliahan Online Synchronous dan Asynchronous Menggunakan Metode Rating Scale Mental Effort
In 2020, Indonesia experienced a pandemic known as the Corona Virus or Covid-19. The government-imposed social distancing rules affect Indonesian society for teaching and learning activities at the university. Governments impose rules on online…
Position: 12295 (30 views)
Synthesis and physicochemical studies of a series of mixed-ligand transition metal complexes and their molecular docking investigations against Coronavirus main protease
Position: 16519 (25 views)
Dynamical model for social distancing in the U.S. during the COVID-19 epidemic
Background Social distancing has led to a “flattening of the curve” in many states across the U.S. This is part of a novel, massive, global social experiment which has served to mitigate the COVID-19 pandemic in the absence of a vaccine or effective…
Position: 12295 (30 views)
COVID-19 and Hematopoietic Cell Transplantation Center-Specific Survival Analysis: Can We Adjust for the Impact of the Pandemic? Recommendations of the COVID-19 Task Force of the 2020 Center for International Blood and Marrow Transplantation Research Center Outcomes Forum.
COVID-19 has significantly impacted the practice of hematopoietic cell transplantation (HCT) and likely affected outcomes of HCT recipients. Early reports document substantially higher case fatality rates for HCT recipients than seen in faced by the…
Position: 12295 (30 views)
Implications of Oxidative Stress and Potential Role of Mitochondrial Dysfunction in COVID-19: Therapeutic Effects of Vitamin D
Due to its high degree of contagiousness and like almost no other virus, SARS-CoV-2 has put the health of the world population on alert. COVID-19 can provoke an acute inflammatory process and uncontrolled oxidative stress, which predisposes one to…
Position: 16519 (25 views)
Spatial variation of dissolved organic nitrogen in Wuhan surface waters: Correlation with the occurrence of disinfection byproducts during the COVID-19 pandemic.
Intensified sanitization practices during the recent coronavirus disease-2019 (COVID-19) led to the release of chlorine-based disinfectants in surface water, potentially triggering the formation of disinfection byproducts (DBPs) in the presence of…
Position: 11500 (31 views)
Deaths associated with newly launched SARS-CoV-2 vaccination (Comirnaty®).
Since 27th December 2020, a mRNA vaccine from BioNTech / Pfizer (Comirnaty®) has been used across Germany. As of 12th March 2021, 286 fatalities of vaccinated German individuals were registered at the Paul-Ehrlich-Institute with time intervals after…
Position: 13106 (29 views)
Nationwide seroprevalence of antibodies to SARS-CoV-2 in asymptomatic population in South Korea: a cross-sectional study
Objective Asymptomatic active infection might be an important contributor to the COVID-19 outbreak. Serological tests can assess the extent of exposure and herd immunity to COVID-19 in general populations. This study aimed to estimate the nationwide…
Position: 13106 (29 views)