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                  <text>Dominio científico: Coronavirus</text>
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                <text>COVID-19 and renal disease in elderly patients</text>
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                <text>Michele Andreucci, Davide Bolignano, Giuseppe Coppolino, Giovanni Ruotolo, Alberto Castagna, Pierangela Presta, Ramona Nicotera, Giordano Placida, Caterina Vita, Nazzareno Carullo</text>
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                <text>The pandemic blast of COVID-19 uncovered well known weakness of financial chain and put our economic organizations facing off dramatic consequences if new strategies will not be developed to adapt health-care on detailed sub-groups of patients. The exponential number of older and frail subjects aged &gt;65 years represents a challenge for public health. Patients affected by renal disease are an aged population that showed a particular attitude to contract infection and a higher mortality rate respect to general population. In this brief article, we would point out the focus on the management of issues related to renal patients facing off with coronavirus infection, in particular in a geriatric population particularly exposed to contagion like hemodialysis patients and precautions decided to slow the spread of contamination.</text>
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                <text>2020</text>
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                <text>elderly, renal patients, COVID-19</text>
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                <text>DOI: 10.4081/gc.2020.9029</text>
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                <text>Geriatric Care</text>
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                <text>PAGEPress Publications</text>
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                <text>Geriatrics</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>CT Manifestations of Novel Coronavirus Pneumonia: A Case Report</text>
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                <text>Yong Wang, Ping Song, Peng An, Kai Lian</text>
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            <description>An account of the resource</description>
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                <text>Background: Since December 2019, the outbreak of the novel coronavirus has impacted nearly &gt;90,000 people in more than 75 countries. In this case report, we aim to define the chest computed tomography findings of 2019-novel coronavirus associated with pneumonia and its successful resolution after treatment.Case Report: A fifty-year-old female patient, who is a businesswoman, presented with chief complaints of “fever for one week, diarrhea, anorexia, and asthenia.” Initially, she was given Tamiflu. The influenza A virus serology was negative. Three days later, levofloxacin was started because the patient’s symptoms did not improve. The novel coronavirus nucleic acid test was negative. It was noted that before the onset of the disease, the patient went to Wuhan on a business trip. Despite the given treatment, her body temperature rose to 39.2°C and she was referred to our clinic for further evaluation. Then, chest computed tomography was performed and showed bilateral multifocal ground glass opacities with consolidation which suggested viral pneumonia as a differential diagnosis, and the subsequent 2019-novel coronavirus pneumonia nucleic acid test was positive.Conclusion: Chest computed tomography offers fast and convenient evaluation of patients with suspected 2019-novel coronavirus pneumonia.</text>
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                <text>2020</text>
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                <text>influenza, diagnosis, Computed tomography, Pulmonary complications, novel coronavirus pneumonia</text>
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                <text>DOI: 10.4274/balkanmedj.galenos.2020.2020.2.15</text>
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                <text>Balkan Medical Journal</text>
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                <text>Galenos Publishing House</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Headache medication and the COVID-19 pandemic</text>
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                <text>A. H. Jan Danser, Antoinette MaassenVanDenBrink, Tessa de Vries</text>
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                <text>Abstract The world is currently dominated by the Corona Virus Disease 2019 (COVID-19) pandemic. Besides the obvious concerns about limitation of virus spread and providing the best possible care to infected patients, a concomitant concern has now arisen in view of a putative link between the use of certain drugs, such as Renin-Angiotensin System (RAS) inhibitors and ibuprofen, and an increased risk for COVID-19 infection. We here discuss this concern in relation to headache treatment and conclude that, based on current evidence, there is no reason to abandon treatment of headache patients with RAS inhibitors or ibuprofen.</text>
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                <text>2020</text>
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          <element elementId="49">
            <name>Subject</name>
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                <text>headache, migraine, coronavirus, RAS inhibitors, candesartan, COVID-19</text>
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            <name>Identifier</name>
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              <elementText elementTextId="29028">
                <text>DOI: 10.1186/s10194-020-01106-5</text>
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              <elementText elementTextId="29029">
                <text>The Journal of Headache and Pain</text>
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                <text>BMC</text>
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                <text>Medicine</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Pharmacists at the frontline beating the COVID-19 pandemic</text>
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                <text>Zaheer-ud-din Babar, Huma Rasheed, Nadia Bukhari, Bismah Nayyer</text>
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                <text>Abstract As the lockdowns are being observed all over the globe and the national level pharmacy professionals are performing frontline roles, this editorial highlights the role of pharmacists in the COVID − 19 pandemic. Pharmacists globally are providing services amidst pandemic, including TRIAGE services, seeing patients and reducing the patients’ burden on health care facilities such as hospitals and GP practices. Pharmacists are also working to providing home deliveries, as well as dealing with the increasing number of patients coming through to pharmacies with the other ailments. Pharmacy associations have issued their guidelines and in this editorial, several global examples of pharmacists’ role in the COVID 19 are being discussed. Pakistan is used as a country case study in this editorial. The editorial also elaborates how pharmacists in the UK and Pakistan have teamed up together to compile 10-steps protection guidelines for the pharmacy teams in Pakistan in English and Urdu language. This 10-point guidance educates community pharmacies for safety and standard operation as the number of patients in the country continues to rise. These guidelines are endorsed by the government and private bodies. These can be adopted and adapted by any country; keeping in view their laws and regulations.</text>
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                <text>2020</text>
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                <text>DOI: 10.1186/s40545-020-00210-w</text>
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                <text>Journal of Pharmaceutical Policy and Practice</text>
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                <text>BMC</text>
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                <text>Therapeutics. Pharmacology, Pharmacy and materia medica</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Chinese expert consensus on diagnosis and treatment of coagulation dysfunction in COVID-19</text>
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                <text>Yang Zhang, Wei Zhang, Gang Wang, Wei-qin LI, Zhou Zhou, Jing-chun SONG, People’s Liberation Army Professional Committee of Critical Care Medicine, Chinese Society on Thrombosis and Haemostasis</text>
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                <text>Abstract Since December 2019, a novel type of coronavirus disease (COVID-19) in Wuhan led to an outbreak throughout China and the rest of the world. To date, there have been more than 1,260,000 COVID-19 patients, with a mortality rate of approximately 5.44%. Studies have shown that coagulation dysfunction is a major cause of death in patients with severe COVID-19. Therefore, the People’s Liberation Army Professional Committee of Critical Care Medicine and Chinese Society on Thrombosis and Hemostasis grouped experts from the frontline of the Wuhan epidemic to come together and develop an expert consensus on diagnosis and treatment of coagulation dysfunction associated with a severe COVID-19 infection. This consensus includes an overview of COVID-19-related coagulation dysfunction, tests for coagulation, anticoagulation therapy, replacement therapy, supportive therapy and prevention. The consensus produced 18 recommendations which are being used to guide clinical work.</text>
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                <text>2020</text>
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                <text>diagnosis, treatment, Severe, Coagulation dysfunction, COVID-19</text>
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                <text>DOI: 10.1186/s40779-020-00247-7</text>
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                <text>Military Medical Research</text>
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                <text>BMC</text>
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                <text>Medicine (General), Military Science</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Ujjwal Neogi, Anders Sönnerborg, Stefan G. Sarafianos, Siddappa N. Byrareddy, Kamal Singh, Xiao Heng, Thomas P. Quinn, Anoop T. Ambikan, Kyle J. Hill</text>
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                <text>Coronaviruses (CoVs) are positive-stranded RNA viruses that infect humans and animals. Infection by CoVs such as HCoV-229E, -NL63, -OC43 and -HKU1 leads to the common cold, short lasting rhinitis, cough, sore throat and fever. However, CoVs such as Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and the newest SARS-CoV-2 (the causative agent of COVID-19) lead to severe and deadly diseases with mortality rates ranging between ~1 to 35% depending on factors such as age and pre-existing conditions. Despite continuous global health threats to humans, there are no approved vaccines or drugs targeting human CoVs, and the recent outbreak of COVID-19 emphasizes an urgent need for therapeutic interventions. Using computational and bioinformatics tools, here we present the feasibility of reported broad-spectrum RNA polymerase inhibitors as anti- SARS-CoV-2 drugs targeting its main RNA polymerase, suggesting that investigational and approved nucleoside RNA polymerase inhibitors have potential as anti-SARS-CoV-2 drugs. However, we note that it is also possible for SARS-CoV-2 to evolve and acquire drug resistance mutations against these nucleoside inhibitors.</text>
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                <text>coronavirus, RNA polymerase, MERS-CoV, SARS-CoV, SARS-CoV-2, COVID-19</text>
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                <text>DOI: 10.3390/pathogens9050320</text>
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                <text>Pathogens</text>
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                <text>MDPI AG</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Covid-19 and COPD: A Personal Reflection</text>
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                <text>Russell R.</text>
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                <text>Richard Russell Respiratory Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UKCorrespondence: Richard Russell Email richard.russell@ndm.ox.ac.ukAs China seems to be emerging from their COVID epidemic and the rest of the&amp;nbsp;world is plunged headlong into their own perhaps I can be forgiven by the readers&amp;nbsp;of this journal for a moment or two of reflection and even self-indulgence. It is&amp;nbsp;a huge privilege to be the editor of the International Journal of COPD and this&amp;nbsp;enables me to keep abreast of all current COPD research. Loyal readers will know&amp;nbsp;that we accept a catholic spread of research and are very much patient-focused. As&amp;nbsp;editor, I have maintained as a principle that the research we published must be&amp;nbsp;potentially translatable. I am also a committed front-line clinician and clinical&amp;nbsp;researcher. And so, with these three perspectives, I have been able to reflect on&amp;nbsp;the current COVID-19 crisis and what this means to our patients, our colleagues&amp;nbsp;and our families.</text>
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                <text>COVID-19</text>
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              <elementText elementTextId="29063">
                <text>DOI: </text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="29064">
                <text>International Journal of COPD</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="29065">
                <text>Dove Medical Press</text>
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            </elementTextContainer>
          </element>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Diseases of the respiratory system</text>
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            <element elementId="50">
              <name>Title</name>
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                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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          <element elementId="50">
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                <text>Chloroquine and hydroxychloroquine in the context of COVID-19</text>
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              <elementText elementTextId="29068">
                <text>Aparna Wagle Shukla, Hiren J. Mehta, Kartikeya Cherabuddi, Lennox K. Archibald, Ashutosh M Shukla</text>
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                <text>Chloroquine and closely related structural analogs, employed initially for the treatment of malaria, are now gaining worldwide attention due to the rapidly spreading pandemic caused by severe acute respiratory syndrome-coronavirus-2, named coronavirus disease (COVID) of 2019 (COVID-19). Although much of this attention has a mechanistic basis, the hard efficacy data for chloroquine/hydroxychloroquine in the management of the clinical syndrome of COVID-19 have been limited thus far. This review aims to present the available in vitro and clinical data for the role of chloroquine/ hydroxychloroquine in COVID-19 and attempts to put them into perspective, especially in relation to the different risks/benefits particular to each patient who may require treatment.</text>
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                <text>2020</text>
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          <element elementId="49">
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            <description>The topic of the resource</description>
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                <text>anti-inflammatory, antimalarial, chloroquine, antiviral, hydroxychloroquine, Pandemic, Immunomodulatory, SARS-CoV-2, COVID-19</text>
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                <text>DOI: 10.7573/dic.2020-4-5</text>
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          <element elementId="48">
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="29073">
                <text>Drugs in Context</text>
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            </elementTextContainer>
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            <name>Publisher</name>
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              <elementText elementTextId="29074">
                <text>BioExcel Publishing Ltd</text>
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                <text>Therapeutics. Pharmacology</text>
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                <text>Carmelinda Ruggiero, Patrizia Mecocci, Virginia Boccardi</text>
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                <text>The older Italian population is posing a challenge in the number of deaths for coronavirus disease 2019 (COVID-19). According to previous data from China, pre-existing health conditions dramatically increase the risk of dying from COVID-19. The presence of multiple diseases in older patients may be considered as a mark of frailty, which increases the person's vulnerability to stress and impairs the multisystemic compensatory effort to restore homeostasis. The clinical complexity associated with the management of frailty may increase the risk of complications during infection as well as the lack of the early recognition of atypical symptoms. There is an urgent need to share expertise and clinical management skills with geriatricians as well as the need for early diagnosis to start treatment at the earliest convenience in the community, with the aim to avoid the collapse of intensive care units.</text>
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                <text>DOI: 10.3390/geriatrics5020024</text>
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                <text>Geriatrics</text>
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                <text>MDPI AG</text>
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                <text>Geriatrics</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Ageing and COVID-19: What is the Role for Elderly People?</text>
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                <text>Roberto Pili, Donatella Rita Petretto</text>
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            <name>Description</name>
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                <text>Italy is one of the oldest countries in Europe and in the world and now it is also one of the first countries that are fighting against COVID-19. In our country, the increasing life expectancy (80.5 for males and 84.9 for females, with a total life expectancy of 82.9) has led to very positive consequences for health and the well-being of elderly people: a very high number of older adults lives and acts independently in their daily life, even if they have one or more than one chronic disease. In the time of COVID-19′s outbreak in Italy, the focus of the media was on elderly people for two main reasons. First, many older people demonstrated a very high civic sense and they were helping society to fight against the pandemic. Second, also in Italy, like in China, the older adults are at higher risk in being infected with COVID-19 and if they get ill, they have a higher risk of death. The balance previously achieved between age-related disorders and a good quality of life and good health is now under high pressure. It is very important to protect elderly people from infection, but also it is important to respect them and to support them in this complex situation. There is a great risk of “ageism”. In agreement with Lloyd-Sherlock and colleagues (2020), in this editorial we propose some hints of analysis, starting from the ongoing experience in Italy.</text>
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                <text>2020</text>
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                <text>Outbreak, ageing, people with disability, ageism, active ageing, COVID-19</text>
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                <text>DOI: 10.3390/geriatrics5020025</text>
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                <text>Geriatrics</text>
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                <text>MDPI AG</text>
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                <text>Geriatrics</text>
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