313 10 20655 https://www.socictopen.socict.org/files/original/aece686d762e0f06ec50de1e87104588.pdf 8812e55890769754f25dee360230efb4 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Cardiovascular Impairment in COVID-19: Learning From Current Options for Cardiovascular Anti-Inflammatory Therapy Creator An entity primarily responsible for making the resource Yang Zhang, Shuyang Zhang, Lun Wang Description An account of the resource In December 2019, Coronavirus Disease 2019 (COVID-19) caused by SARS-CoV-2, occurred in China and has currently led to a global pandemic. In addition to respiratory involvement, COVID-19 was also associated with significant multiple organ dysfunction syndrome (MODS). Cardiovascular impairment has been observed and is now drawing growing attention. Cardiovascular protective strategies are urgent and of great significance to the overall prognosis of COVID-19 patients. Direct viral infection, cytokine storm, and aggravation of existing cardiovascular diseases were recognized as possible mechanisms of cardiovascular impairment in COVID-19. Hyperactivated inflammation plays an important role in all three mechanisms and is considered to be fundamental in the development of cardiovascular impairment and MODS in COVID-19. Therefore, in addition to conventional cardiovascular treatment, anti-inflammatory therapy is a reasonable strategy for severe cases to further enhance cardiovascular protection and potentially mitigate MODS. We reviewed the inflammatory features and current promising treatments of COVID-19 as well as cardiovascular anti-inflammatory therapies that have been verified in previous clinical trials with positive outcomes. We believe that targeting the central pathway (IL-1β, TNF-α, IL-6), balancing the Th1 and Th2 response, and administering long-term anti-inflammatory therapy might be promising prospects to reduce cardiovascular impairment and even MODS during the acute and recovery phases of COVID-19. The cardiovascular anti-inflammatory therapies might be of great application value to the management of COVID-19 patients and we further propose an algorithm for the selection of anti-inflammatory therapy for COVID-19 patients with or at high risk of cardiovascular impairment. We recommend to take the experiences in cardiovascular anti-inflammatory therapy as references in the management of COVID-19 and conduct related clinical trials, while the clinical translation of novel treatments from preclinical studies or in vitro drug screening should proceed with caution due to unguaranteed efficacy and safety profiles. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource inflammation, cardiovascular diseases, corona virus disease 2019, cardiovascular impairment, cardiovascular anti-inflammatory therapy Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fcvm.2020.00078 Source A related resource from which the described resource is derived Frontiers in Cardiovascular Medicine Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Diseases of the circulatory (Cardiovascular) system https://www.socictopen.socict.org/files/original/d80bfc84cf520642c9db2505fc6fa25f.pdf ff68ac21a24d9f7566c85615125f3a42 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource COVID-19 and Bangladesh: Challenges and How to Address Them Creator An entity primarily responsible for making the resource Mohammad Jakir Hosen, Saeed Anwar, Mohammad Nasrullah Description An account of the resource As the coronavirus outbreak quickly surges worldwide, many countries are adopting non-therapeutic preventive measures, which include travel bans, remote office activities, country lockdown, and most importantly, social distancing. However, these measures face challenges in Bangladesh, a lower-middle-income economy with one of the world's densest populations. Social distancing is difficult in many areas of the country, and with the minimal resources the country has, it would be extremely challenging to implement the mitigation measures. Mobile sanitization facilities and temporary quarantine sites and healthcare facilities could help mitigate the impact of the pandemic at a local level. A prompt, supportive, and empathic collaboration between the Government, citizens, and health experts, along with international assistance, can enable the country to minimize the impact of the pandemic. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource healthcare, Testing, novel coronavirus, COVID-19, community mitigation, non-therapeutic intervention Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fpubh.2020.00154 Source A related resource from which the described resource is derived Frontiers in Public Health Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Public aspects of medicine https://www.socictopen.socict.org/files/original/ac7cf1da45a74ed6fbaca3bc063a4aed.pdf 2e150a2946284da0c23a669619ca93b3 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Are Children Most of the Submerged Part of SARS-CoV-2 Iceberg? Creator An entity primarily responsible for making the resource Giuseppina Salzano, Stefano Passanisi, Giovanni Battista Pajno, Fortunato Lombardo Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Outbreak, Italy, Children, coronavirus, Pandemic, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fped.2020.00213 Source A related resource from which the described resource is derived Frontiers in Pediatrics Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Pediatrics https://www.socictopen.socict.org/files/original/c786677e28e994ec2158cc8f1e1129f3.pdf cf195d8dee5c12496fd2924863bf71f7 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource COVID-19 and what pediatric rheumatologists should know: a review from a highly affected country Creator An entity primarily responsible for making the resource Francesco Licciardi, Rolando Cimaz, Roberto Caporali, Ennio Giulio Favalli, Teresa Giani, Letizia Baldini Description An account of the resource Abstract On March 11th, 2020 the World Health Organization declared COVID-19 a global pandemic. The infection, transmitted by 2019 novel coronavirus (2019-nCov), was first discovered in December 2019, in Wuhan, Hubei Province, and then rapidly spread worldwide. Italy was early and severely involved, with a critical spread of the infection and a very high number of victims. Person-to-person spread mainly occurs via respiratory droplets and contact. The median incubation period is 5 days. The spectrum of respiratory symptoms may range from mild to severe, strictly depending on the age of the patient and the underlying comorbidities. In children COVID-19 related disease is less frequent and less aggressive. In Italy 1% of positive cases are under 18 years of age, and no deaths have been recorded before 29 years of age. For patients affected by rheumatic disease, despite the concerns related to the imbalance of their immune response and the effect of immunosuppressive treatments, there are still few data to understand the real consequences of this infection. Major scientific societies have issued recommendations to help rheumatologists in caring their patients. Interestingly, some of the drugs mostly used by rheumatologists appear to be promising in critical COVID-19 infected patients, where the hyperinflammation and cytokine storm seem to drive to the multiorgan failure. Pediatric rheumatologists are expected to play a supporting role in this new front of COVID-19 pandemic, both as general pediatricians treating infected children, and as rheumatologists taking care of their rheumatic patients, as well as offering their experience in the possible alternative use of immunomodulatory drugs. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Italy, Children, Respiratory syndrome, 2019ncov, SARS-CoV-2, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s12969-020-00422-z Source A related resource from which the described resource is derived Pediatric Rheumatology Online Journal Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Pediatrics, Diseases of the musculoskeletal system https://www.socictopen.socict.org/files/original/b7351deef5c212106c752f6a3b52b788.pdf 90440d0860f1010587591d005d6b8081 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource COVID-19 Deaths: Are We Sure It Is Pneumonia? Please, Autopsy, Autopsy, Autopsy! Creator An entity primarily responsible for making the resource Cristoforo Pomara, Giovanni Li Volti, Francesco Cappello Description An account of the resource The current outbreak of COVID-19 severe respiratory disease, which started in Wuhan, China, is an ongoing challenge, and a major threat to public health that requires surveillance, prompt diagnosis, and research efforts to understand this emergent pathogen and to develop an effective response. Due to the scientific community’s efforts, there is an increasing body of published studies describing the virus’ biology, its transmission and diagnosis, its clinical features, its radiological findings, and the development of candidate therapeutics and vaccines. Despite the decline in postmortem examination rate, autopsy remains the gold standard to determine why and how death happens. Defining the pathophysiology of death is not only limited to forensic considerations; it may also provide useful clinical and epidemiologic insights. Selective approaches to postmortem diagnosis, such as limited postmortem sampling over full autopsy, can also be useful in the control of disease outbreaks and provide valuable knowledge for managing appropriate control measures. In this scenario, we strongly recommend performing full autopsies on patients who died with suspected or confirmed COVID-19 infection, particularly in the presence of several comorbidities. Only by working with a complete set of histological samples obtained through autopsy can one ascertain the exact cause(s) of death, optimize clinical management, and assist clinicians in pointing out a timely and effective treatment to reduce mortality. Death can teach us not only about the disease, it might also help with its prevention and, above all, treatment. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource diagnosis, Autopsy, infectious diseases, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/jcm9051259 Source A related resource from which the described resource is derived Journal of Clinical Medicine Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/c82c69bac83188b75b0c0c01433f7c02.pdf 24364d6e5b65c7fec8ed6d312fbbd57a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Medical image of the month: viral pnuemonias Creator An entity primarily responsible for making the resource Gotway MB Description An account of the resource No abstract available. Article truncated after 150 words. Numerous viruses, including the corona, influenza and adenoviruses can cause lower respiratory tract infection in adults (1). Viral pneumonia in adults can be classified into two clinical groups: so-called atypical pneumonia in otherwise healthy hosts and viral pneumonia in immunocompromised hosts. Until the COVID-19 pandemic, influenza virus types A and B caused most cases of viral pneumonia in immunocompetentadults. Immunocompromised hosts are susceptible to pneumonias caused by a wide variety of viruses including cytomegalovirus, herpesviruses, measles virus, and adenovirus. The CT imaging findings consist mainly of patchy or diffuse ground-glass opacity, with or without consolidation, and reticular areas of increased opacity, are variable and overlapping. The imaging findings in COVID-19 pneumonia are generally not distinctive compared to other viral pneumonias, including other coronaviruses such as SARS and MERS (2). A recent study systematically reviewed the longitudinal changes of CT findings in COVID-19 pneumonia. The results suggested that the lung … Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource influenza, Pneumonia, coronavirus, CT scan, Ground glass opacity, reticulation, Coronavirus HKU1, multilobar, COVID-19, coronavirus nl62 Identifier An unambiguous reference to the resource within a given context DOI: 10.13175/swjpcc028-20 Source A related resource from which the described resource is derived Southwest Journal of Pulmonary and Critical Care Publisher An entity responsible for making the resource available Arizona Thoracic Society Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medical emergencies. Critical care. Intensive care. First aid, General works https://www.socictopen.socict.org/files/original/1b5b3d424a128d5c6e98ef4d712c608f.pdf 7c494d3bbfff7e6bc8817fb3662f9c5d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Smoking and SARS-CoV-2 Disease (COVID-19): Dangerous Liaisons or Confusing Relationships? Creator An entity primarily responsible for making the resource Giovanni Li Volti, Massimo Caruso, Riccardo Polosa Description An account of the resource We read with great interest the article by Brake SJ and colleagues [...] Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource smoking, Angiotensin converting enzyme-2, SARS-CoV-2, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/jcm9051321 Source A related resource from which the described resource is derived Journal of Clinical Medicine Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/314c8b22323bc01d223c9fb6645ee7cd.pdf beb7066326b33a3a5404c8b0c04765de Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Potential of DNA Intercalating Alkaloids and Other Plant Secondary Metabolites against SARS-CoV-2 Causing COVID-19 Creator An entity primarily responsible for making the resource Michael Wink Description An account of the resource Many plants produce secondary metabolites (PSMs) with antiviral activities. Among the antiviral PSMs, lipophilic terpenoids in essential oils can disturb the lipid envelope of viruses. Phenols and polyphenols (flavonoids, rosmarinic acid and tannins) attack viral proteins present in the viral membrane or inside the virus particle. Both phenolics and essential oils are active against free viral particles but not—or to a lesser degree—after a virus has entered a host cell. Another group of PSMs is directed against DNA or RNA. These are DNA intercalators such as sanguinarine, berberine, emetine and other isoquinoline alkaloids, ß-carboline, and quinoline alkaloids such as quinine, cinchonine, dictamine and skimmianine. The DNA intercalators stabilize double-stranded nucleic acids and inhibit the replication, transcription, and translation of genetic material. These alkaloids can inhibit viral development and viral replication in cells, as shown for SARS-CoV-1 and other viruses. Since chloroquine (which is also a DNA intercalator and a chemical derivative of the alkaloid quinine) is apparently clinically helpful against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, it is assumed that intercalating alkaloids, or the medicinal plants producing them, may be interesting candidates for the development of new antiviral drugs for the treatment of coronavirus disease 2019 (COVID-19). Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Essential oil, polyphenols, plant secondary metabolites, intercalating alkaloids, inhibition of polymerases, inhibition of protein biosynthesis Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/d12050175 Source A related resource from which the described resource is derived Diversity Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General) https://www.socictopen.socict.org/files/original/c005ca3d2cf756839dd1921ca233a2df.pdf 1d819687b6432630e0a4c1a1f16f9c94 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource COVID-19, an Emerging Coronavirus Infection: Current Scenario and Recent Developments - An Overview Creator An entity primarily responsible for making the resource Alfonso J. Rodriguez-Morales, Kuldeep Dhama, Ruchi Tiwari, Ali A. Rabaan, Ranjit Sah, D. Katterine Bonilla-Aldana Description An account of the resource During December 2019, a novel coronavirus virus (2019-nCov) emerged in China, which posed anInternational Public Health Emergency in a couple of weeks, and very recently attained the position ofa very high-risk category by World Health Organization (WHO). This virus was named the Severe AcuteRespiratory Syndrome Coronavirus-2 (SARS-CoV-2) by the International Committee on Taxonomy ofViruses (ICTV), and the disease referred to as Coronavirus Disease-19 (COVID-19). Till March 8, 2020,the virus has claimed the lives of nearly 3,600 humans out a total of approximately 110,000 confirmedcases affected by this infection. The present editorial is a brief overview highlighting the most salientfeatures and facts with regards to COVID-19, an emerging coronavirus infection, its causative virus(SARS-CoV-2), the current worldwide scenario, recent developments and currently ongoing progressesto contain and control this disease which have now spread to more than 100 countries across the globe.Of note, worldwide researchers and various health agencies are all together doing their best to haltthe spread of this virus and avoid any possible pandemic situation to be faced, which otherwise wouldthreaten the lives of millions of human beings. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource prevention, control, current situation, recent developments, SARS-CoV-2, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.22207/JPAM.14.1.02 Source A related resource from which the described resource is derived Journal of Pure and Applied Microbiology Publisher An entity responsible for making the resource available Journal of Pure and Applied Microbiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology https://www.socictopen.socict.org/files/original/42c0835303a1c4245d3a9c23f21aa0b6.pdf 3eee64bdf7ab00993e1f7c9caaea05c3 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Codon Usage and Phenotypic Divergences of SARS-CoV-2 Genes Creator An entity primarily responsible for making the resource Alexandros G Georgakilas, Athanasia Pavlopoulou, Andrea Giansanti, Maddalena Dilucca, Sergio Forcelloni Description An account of the resource Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which first occurred in Wuhan (China) in December of 2019, causes a severe acute respiratory illness with a high mortality rate, and has spread around the world. To gain an understanding of the evolution of the newly emerging SARS-CoV-2, we herein analyzed the codon usage pattern of SARS-CoV-2. For this purpose, we compared the codon usage of SARS-CoV-2 with that of other viruses belonging to the subfamily of Orthocoronavirinae. We found that SARS-CoV-2 has a high AU content that strongly influences its codon usage, which appears to be better adapted to the human host. We also studied the evolutionary pressures that influence the codon usage of five conserved coronavirus genes encoding the viral replicase, spike, envelope, membrane and nucleocapsid proteins. We found different patterns of both mutational bias and natural selection that affect the codon usage of these genes. Moreover, we show here that the two integral membrane proteins (matrix and envelope) tend to evolve slowly by accumulating nucleotide mutations on their corresponding genes. Conversely, genes encoding nucleocapsid (N), viral replicase and spike proteins (S), although they are regarded as are important targets for the development of vaccines and antiviral drugs, tend to evolve faster in comparison to the two genes mentioned above. Overall, our results suggest that the higher divergence observed for the latter three genes could represent a significant barrier in the development of antiviral therapeutics against SARS-CoV-2. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Natural selection, host adaptation, coronaviruses, codon usage bias, mutational bias, SARS-CoV-2 Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/v12050498 Source A related resource from which the described resource is derived Viruses Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology