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                  <text>Dominio científico: Coronavirus</text>
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                <text>Potential SARS-CoV-2 Preimmune IgM Epitopes</text>
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                <text>Peter K. Petrov, Velizar Shivarov, Anastas D Pashov</text>
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                <text>While studying the human public IgM igome as represented by a library of 224,087 linear mimotopes, three exact matches to peptides in the proteins of SARS-CoV-2 were found: two in the open reading frame 1ab and one in the spike protein. Joining the efforts to fast track SARS-CoV-2 vaccine development, here we describe briefly these potential epitopes in comparison to mimotopes representing peptides of SARS-CoV, HCoV 229E and OC43.</text>
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                <text>2020</text>
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                <text>DOI: 10.3389/fimmu.2020.00932</text>
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                <text>Frontiers in Immunology</text>
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                <text>Frontiers Media S.A.</text>
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                <text>Immunologic diseases. Allergy</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>2019-nCoV/COVID-19 - Approaches to Viral Vaccine Development and Preventive Measures</text>
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                <text>Muhammad Bilal, Roberto Parra-Saldívar, Hafiz  M. N. Iqbal, Muhammad  Shahzad Nazir</text>
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                <text>The severity assessment of COVID-19 and transmissibility of newly emerged novel-Coronavirus(2019-nCoV) can effectively help and support to quantify the ongoing pandemic risks. Among severalepidemiological measures against COVID-19 severity, the case fatality risk (CFR) assessment is animportant measure to track record the overall proportion/ratio of the cumulative number of infectedpatients with the known outcome (confirmed, recovered, or deceased). Considering the ongoing fatalityrate, several case-based preventive measures, Coronavirus protein visualization, and approaches to viralvaccine development are discussed herein. The prompt identification of high-risk entities to confront theuncertainty in the risk of death using the approaches highlighted, herein, is of utmost requirement totackle the current COVID-19 severity. Moreover, the protein visualization available at the viral surface/body can give further insight into the appropriate vaccine development.</text>
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                <text>Surface proteins, Respiratory disease, safety measures, viral vaccine, 2019ncov, COVID-19, control precautions</text>
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                <text>DOI: 10.22207/JPAM.14.1.05</text>
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                <text>Journal of Pure and Applied Microbiology</text>
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                <text>Journal of Pure and Applied Microbiology</text>
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                <text>Microbiology</text>
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                <text>Facial Pressure Ulcers in a COVID-19 50-year-old Female Intubated Patient</text>
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                <text>Marianna Pesce, Renzo Panizza, Marco Ghiglione, Silvia Scarrone, Enrico M. Zingarelli, Ileana Orejuela</text>
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                <text>In case of severe acute respiratory distress syndrome (ARDS), as in coronavirus disease 2019 (COVID-19) affected patients, the invasive ventilation in prone position can improve the prognosis, albeit with an increased risk of facial pressure ulcers. In this report, we will relate a case of facial pressure ulcers in a SARS-CoV-2 positive 50 year-old woman with the aim to describe the high-complexity management of COVID 19 in which healthcare professionals across the world are still involved.</text>
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                <text>SARS-CoV-2, COVID-19, facial pressure ulcers</text>
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                <text>DOI: 10.1055/s-0040-1710403</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Indian Journal of Plastic Surgery</text>
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                <text>Thieme Publishers</text>
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                <text>Surgery</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Adapted Physical Activity through COVID-19</text>
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                <text>Kwok Ng</text>
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            <description>An account of the resource</description>
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                <text>Editorial for Volume 13, Issue 1, 2020Staying physically activeStaying physically educatedStaying connected with research and practice</text>
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                <text>sars-cov-2; social distancing; isolation; disabilities</text>
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                <text>European Journal of Adapted Physical Activity</text>
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                <text>Palacký University Olomouc</text>
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                <text>Sports</text>
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                <text>COVID-19: ICU delirium management during SARS-CoV-2 pandemic</text>
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                <text>E. Wesley Ely, Wojciech Dąbrowski, Katarzyna Kotfis, Shawniqua Williams Roberson, Jo Ellen Wilson, Brenda T. Pun</text>
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                <text>Abstract The novel coronavirus, SARS-CoV-2-causing Coronavirus Disease 19 (COVID-19), emerged as a public health threat in December 2019 and was declared a pandemic by the World Health Organization in March 2020. Delirium, a dangerous untoward prognostic development, serves as a barometer of systemic injury in critical illness. The early reports of 25% encephalopathy from China are likely a gross underestimation, which we know occurs whenever delirium is not monitored with a valid tool. Indeed, patients with COVID-19 are at accelerated risk for delirium due to at least seven factors including (1) direct central nervous system (CNS) invasion, (2) induction of CNS inflammatory mediators, (3) secondary effect of other organ system failure, (4) effect of sedative strategies, (5) prolonged mechanical ventilation time, (6) immobilization, and (7) other needed but unfortunate environmental factors including social isolation and quarantine without family. Given early insights into the pathobiology of the virus, as well as the emerging interventions utilized to treat the critically ill patients, delirium prevention and management will prove exceedingly challenging, especially in the intensive care unit (ICU). The main focus during the COVID-19 pandemic lies within organizational issues, i.e., lack of ventilators, shortage of personal protection equipment, resource allocation, prioritization of limited mechanical ventilation options, and end-of-life care. However, the standard of care for ICU patients, including delirium management, must remain the highest quality possible with an eye towards long-term survival and minimization of issues related to post-intensive care syndrome (PICS). This article discusses how ICU professionals (e.g., physicians, nurses, physiotherapists, pharmacologists) can use our knowledge and resources to limit the burden of delirium on patients by reducing modifiable risk factors despite the imposed heavy workload and difficult clinical challenges posed by the pandemic.</text>
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                <text>Subha V Raman, Yuchi Han, James Carr, Matthias G. Friedrich, Tiffany Chen, Victor A. Ferrari, Andrew J. Powell, Warren J. Manning, Jennifer Bryant, Chris Lawton, Chiara Bucciarelli-Ducci, Sven Plein, Karen Ordovas, Christopher Dyke, Michael D. Elliott</text>
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                <text>Abstract The aim of this document is to provide general guidance and specific recommendations on the practice of cardiovascular magnetic resonance (CMR) in the era of the COVID-19 pandemic. There are two major considerations. First, continued urgent and semi-urgent care for the patients who have no known active COVID-19 should be provided in a safe manner for both patients and staff. Second, when necessary, CMR on patients with confirmed or suspected active COVID-19 should focus on the specific clinical question with an emphasis on myocardial function and tissue characterization while optimizing patient and staff safety.</text>
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                <text>DOI: 10.1186/s12968-020-00628-w</text>
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                <text>Venerando Rapisarda, Fulvio Plescia, Emanuele Cannizzaro, Caterina Ledda, Luigi Cirrincione, Daniela Martorana, Raluca  Emilia Moldovan, Kelly Theodoridou</text>
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                <text>Introduction: SARS-CoV-2, identified in Wuhan, China, for the first time in December 2019, is a new viral strain, which has not been previously identified in humans; it can be transmitted both by air and via direct and indirect contact; however, the most frequent way it spreads is via droplets. Like the other viruses belonging to the same family of coronaviruses, it can cause from mild flu-like symptoms, such as cold, sore throat, cough and fever, to more severe ones such as pneumonia and breathing difficulties, and it can even lead to death. Since no effective specific drug therapy has been found yet, nor any vaccine capable of limiting the spread of this pathogen, it is important for ways of preventing the spread of this infection to be established. Methods: the purpose of our research was to provide a protocol to prevent the spread of SARS-CoV-2 infection in light of the limited information related to this coronavirus. In detail, we analysed and searched targeted evidence-based guidelines issued in the various countries affected by this epidemic up till now. In addition, we analyzed the recommendations for the prevention and control of other epidemics caused by other pathogens belonging to the same family of coronaviruses or others that present the same mechanisms of transmission. Discussion: general organizational measures regarding the containment and management of the epidemiological emergency of COVID-19 have been imposed by the competent authorities for an adequate and proportionate management of the evolution of the epidemiological situation. The prevention and protection organizational measures therefore aim to minimize the probability of being exposed to SARS-CoV-2. For this purpose, measures must also be taken at work to avoid new infections or even the spread of the virus where it has already been present. Furthermore, environmental measures are aimed at reducing the risk of transmission of SARS-CoV-2 to individuals through contact with infected subjects, objects, equipment, or contaminated environmental surfaces. Conclusion: protective devices must be used whenever there is potentially close contact with a suspect case, especially when the potentially infected person does not wear a surgical mask that could reduce the spread of viruses in the environment. By adopting this specific prevention and protection measures recommended in the workplace, it will be possible to help overcome this COVID-19 pandemic.</text>
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                <text>DOI: 10.3390/su12093603</text>
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                <text>MDPI AG</text>
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                <text>Environmental sciences, Renewable energy sources, Environmental effects of industries and plants</text>
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                <text>The COVID-19 pandemic is spreading fast globally. Vietnam’s strict containment measures have significantly reduced the spread of the epidemic in the country. This was achieved through the use of emergency control measures in the epidemic areas and integration of resources from multiple sectors including health, mass media, transportation, education, public affairs, and defense. This paper reviews and shares specific measures for successful prevention and control of COVID-19 in Vietnam, which could provide useful learning for other countries.</text>
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                <text>2020</text>
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                <text>DOI: 10.3390/ijerph17093125</text>
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                <text>International Journal of Environmental Research and Public Health</text>
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                <text>Medicine</text>
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                <text>Hsin-Hou Chang, Su-Hua Huang, Cheng-Wen Lin, Jyh-Cherng Ju, Bo-Han Ko, Young-Sheng Chang</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="29440">
                <text>Severe acute respiratory syndrome–associated coronavirus (SARS-CoV) initiates the cytokine/chemokine storm-mediated lung injury. The SARS-CoV unique domain (SUD) with three macrodomains (N, M, and C), showing the G-quadruplex binding activity, was examined the possible role in SARS pathogenesis in this study. The chemokine profile analysis indicated that SARS-CoV SUD significantly up-regulated the expression of CXCL10, CCL5 and interleukin (IL)-1β in human lung epithelial cells and in the lung tissues of the mice intratracheally instilled with the recombinant plasmids. Among the SUD subdomains, SUD-MC substantially activated AP-1-mediated CXCL10 expression in vitro. In the wild type mice, SARS-CoV SUD-MC triggered the pulmonary infiltration of macrophages and monocytes, inducing CXCL10-mediated inflammatory responses and severe diffuse alveolar damage symptoms. Moreover, SUD-MC actuated NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome-dependent pulmonary inflammation, as confirmed by the NLRP3 inflammasome inhibitor and the NLRP3−/− mouse model. This study demonstrated that SARS-CoV SUD modulated NLRP3 inflammasome-dependent CXCL10-mediated pulmonary inflammation, providing the potential therapeutic targets for developing the antiviral agents.</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="29441">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="29442">
                <text>NLRP3 inflammasome, pulmonary inflammation, CXCL10, SARS-coronavirus, SARS-CoV unique domain (SUD)</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="29443">
                <text>DOI: 10.3390/ijms21093179</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="29444">
                <text>International Journal of Molecular Sciences</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="29445">
                <text>MDPI AG</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="29446">
                <text>Biology (General), Chemistry</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
</itemContainer>
