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                  <text>Dominio científico: Coronavirus</text>
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                <text>The SARS-CoV-2 Exerts a Distinctive Strategy for Interacting with the ACE2 Human Receptor</text>
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                <text>Michal Linial, Dina Schneidman-Duhovny, Esther  S. Brielle</text>
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                <text>The COVID-19 disease has plagued over 200 countries with over three million cases and has resulted in over 200,000 deaths within 3 months. To gain insight into the high infection rate of the SARS-CoV-2 virus, we compare the interaction between the human ACE2 receptor and the SARS-CoV-2 spike protein with that of other pathogenic coronaviruses using molecular dynamics simulations. SARS-CoV, SARS-CoV-2, and HCoV-NL63 recognize ACE2 as the natural receptor but present a distinct binding interface to ACE2 and a different network of residue–residue contacts. SARS-CoV and SARS-CoV-2 have comparable binding affinities achieved by balancing energetics and dynamics. The SARS-CoV-2–ACE2 complex contains a higher number of contacts, a larger interface area, and decreased interface residue fluctuations relative to the SARS-CoV–ACE2 complex. These findings expose an exceptional evolutionary exploration exerted by coronaviruses toward host recognition. We postulate that the versatility of cell receptor binding strategies has immediate implications for therapeutic strategies.</text>
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                <text>2020</text>
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                <text>Molecular dynamics, ACE2, virus–host interactions, SARS-CoV-2, protein–protein complex, coronavirus evolution</text>
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                <text>DOI: 10.3390/v12050497</text>
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                <text>Viruses</text>
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                <text>MDPI AG</text>
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                <text>Microbiology</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Epidemiologic and Clinical Characteristics of 26 Cases of COVID-19 Arising from Patient-to-Patient Transmission in Liaocheng, China [Corrigendum]</text>
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                <text>Li H, Xu J, Zhang W, Zhang Y, Wang L, Xu Y, Liang J, Wu C, Duan Y</text>
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                <text>Wang L, Duan Y, Zhang W, et al. Clin Epidemiol.&amp;nbsp;2020;12:387&amp;ndash;391. Page 388, left column, last sentence of the first paragraph,&amp;nbsp;the text &amp;ldquo;Here we report early clinical features of 25&amp;nbsp;patients with confirmed COVID-19 who were admitted&amp;nbsp;to Liaocheng Infectious Disease Hospital in Shandong&amp;nbsp;Province&amp;rdquo; should read &amp;ldquo;Here we report early clinical features&amp;nbsp;of 26 patients with confirmed COVID-19 who were&amp;nbsp;admitted to Liaocheng Infectious Disease Hospital inShandong Province&amp;rdquo;. Page 389, Discussion section, first sentence, the text &amp;ldquo;We&amp;nbsp;report here a cohort of 25 cases of laboratory-confirmed&amp;nbsp;COVID-19 at our hospital caused by patient-to-patient&amp;nbsp;transmission of 2019-nCoV&amp;rdquo; should read &amp;ldquo;We report here&amp;nbsp;a cohort of 26 cases of laboratory-confirmed COVID-19 at&amp;nbsp;our hospital caused by patient-to-patient transmission of&amp;nbsp;2019-nCoV&amp;rdquo;. The authors apologize for these errors. Read the original article</text>
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                <text>DOI: </text>
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                <text>Clinical Epidemiology</text>
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                <text>Dove Medical Press</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="29463">
                <text>Infectious and parasitic diseases</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>On Facing the SARS-CoV-2 (COVID-19) with Combination of Nanomaterials and Medicine: Possible Strategies and First Challenges</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="29465">
                <text>George Z. Kyzas, Sabyasachi  Das, Abbas Rahdar, Athanasios  C. Mitropoulos, Vishnu Sankar Sivasankarapillai, Akhilash M. Pillai, Anumol P. Sobha, Mahboobeh Heidari Mokarrar</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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                <text>Global health is facing the most dangerous situation regarding the novel severe acute respiratory syndrome called coronavirus 2 (SARS-CoV-2), which is widely known as the abbreviated COVID-19 pandemic. This is due to the highly infectious nature of the disease and its possibility to cause pneumonia induced death in approximately 6.89% of infected individuals (data until 27 April 2020). The pathogen causing COVID-19 is called severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which is believed to be originated from the Wuhan Province in China. Unfortunately, an effective and approved vaccine for SARS-CoV-2 virus is still not available, making the situation more dangerous and currently available medical care futile. This unmet medical need thus requires significant and very urgent research attention to develop an effective vaccine to address the SARS-CoV-2 virus. In this review, the state-of-the-art drug design strategies against the virus are critically summarized including exploitations of novel drugs and potentials of repurposed drugs. The applications of nanochemistry and general nanotechnology was also discussed to give the status of nanodiagnostic systems for COVID-19.</text>
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                <text>2020</text>
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            <description>The topic of the resource</description>
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              <elementText elementTextId="29468">
                <text>Public Health, Medicinal chemistry, coronavirus, SARS-CoV-2, COVID-19, theranostic strategies</text>
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              <elementText elementTextId="29469">
                <text>DOI: 10.3390/nano10050852</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="29470">
                <text>Nanomaterials</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="29471">
                <text>MDPI AG</text>
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            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Chemistry</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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                <text>Prevalence and Influencing Factors of Anxiety and Depression Symptoms in the First-Line Medical Staff Fighting Against COVID-19 in Gansu</text>
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              <elementText elementTextId="29474">
                <text>Wei Li, Lin Sun, Lan Zhang, Huan Wang, Shifu Xiao, Bin Yang, Juhong Zhu, Ajiao Fan</text>
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                <text>BackgroundThe outbreak of novel coronavirus pneumonia (COVID-19) has brought enormous physical and psychological pressure on Chinese medical staff. It is extremely important to understand the prevalence and influencing factors of anxiety and depression symptoms in first-line anti-epidemic medical staff and their coping styles for these negative emotions.MethodsA cross-sectional survey was conducted in Gansu (China), with a questionnaire packet which consisted of the self-rating anxiety scale (SAS), self-rating depression scale (SDS), and the simplified coping style questionnaire (SCSQ). A total of 79 doctors and 86 nurses participated in the survey. Correlation analysis was performed to explore the relationship between SAS, SDS, and SCSQ score. A linear regression model was used to determine the influencing factors for anxiety or depression symptoms.ResultsThe prevalence rates of anxiety and depression symptoms among doctors was 11.4% and 45.6%, respectively. History of depression or anxiety (T=-2.644, p= 0.010, 95%CI: -10.514~-1.481) was shown to be a risk factor for anxiety symptoms in doctors, while being male (T=2.970, p=0.004, 95%CI: 2.667~13.521) was a protective factor for depression. The prevalence rate of anxiety and depression symptoms among nurses was 27.9% and 43.0%, respectively. History of depression or anxiety was a common risk factor for anxiety symptoms (T=-3.635, p=0.000, 95%CI: -16.360~-4.789) and depression symptoms (T=-2.835, p=0.005, 95%CI:-18.238~-3.254) in nurses. The results of partial correlation analysis (controlled for gender and history of depression or anxiety) indicated that the total score of positive coping was negatively correlated with the total score of anxiety (r=-0.182, p=0.002) and depression (r=-0.253, p=0.001).ConclusionsThe first-line anti-epidemic medical staff have high anxiety and depression symptoms and adopting positive coping styles will help to improve their negative emotions.</text>
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                <text>2020</text>
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                <text>Anxiety, depression, Chinese, medical staff, COVID-19</text>
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            <name>Identifier</name>
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              <elementText elementTextId="29478">
                <text>DOI: 10.3389/fpsyt.2020.00386</text>
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                <text>Frontiers in Psychiatry</text>
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              <elementText elementTextId="29480">
                <text>Frontiers Media S.A.</text>
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                <text>Psychiatry</text>
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                <text>Chang-Jun Lan, Qin YANG, Xuan LIAO</text>
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                <text>Since the outbreak of severe acute respiratory syndrome coronavirus(SARS-CoV)and Middle East respiratory syndrome coronavirus(MERS-CoV), the study of coronavirus pathogens and the identification of host organisms has been an important task in the medical domain. New coronavirus SARS-CoV-2 appeared in 2019 was more contagious and pathogenic, which quickly attracted a global attention. So far, there have been clinical reports that patients with coronavirus infection can develop ocular symptoms mainly conjunctivitis, and ocular nucleic acid detection has been proposed as an assistant method for early coronavirus identification. This paper reviewed the ocular manifestations and detection of coronavirus to provide references for further research.</text>
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                <text>DOI: 10.3980/j.issn.1672-5123.2020.5.41</text>
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                <text>Guoji Yanke Zazhi</text>
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                <text>Press of International Journal of Ophthalmology (IJO PRESS)</text>
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                <text>SARS-CoV-2 in the ocular surface of COVID-19 patients</text>
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                <text>Lin Wang, Xin Liu, Bing Xu, Kangkang Xu, Hua-Tao Xie, Ming-Chang Zhang, Shi-Yun Jiang</text>
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                <text>Abstract The 2019 novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally, while the routes of transmission of this virus are still controversial. We enrolled 33 patients, without any ocular manifestation, with their ocular surface swabs collected for virus detection. RNA was detected strong positive in samples of both eyes from two patients. Therefore, SARS-CoV-2 may exist in the normal ocular surface of COVID-19 patients, suggesting that this virus might be spread through conjunctival contact.</text>
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                <text>ocular surface, SARS-CoV-2, COVID-19</text>
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                <text>DOI: 10.1186/s40662-020-00189-0</text>
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                <text>Eye and Vision</text>
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                <text>BMC</text>
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                <text>Ophthalmology</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Emergence of Drift Variants That May Affect COVID-19 Vaccine Development and Antibody Treatment</text>
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                <text>Laxmi Parida, Takahiko Koyama, Jane L. Snowdon, Dilhan Weeraratne</text>
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                <text>New coronavirus (SARS-CoV-2) treatments and vaccines are under development to combat COVID-19. Several approaches are being used by scientists for investigation, including (1) various small molecule approaches targeting RNA polymerase, 3C-like protease, and RNA endonuclease; and (2) exploration of antibodies obtained from convalescent plasma from patients who have recovered from COVID-19. The coronavirus genome is highly prone to mutations that lead to genetic drift and escape from immune recognition; thus, it is imperative that sub-strains with different mutations are also accounted for during vaccine development. As the disease has grown to become a pandemic, B-cell and T-cell epitopes predicted from SARS coronavirus have been reported. Using the epitope information along with variants of the virus, we have found several variants which might cause drifts. Among such variants, 23403A&gt;G variant (p.D614G) in spike protein B-cell epitope is observed frequently in European countries, such as the Netherlands, Switzerland, and France, but seldom observed in China.</text>
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                <text>2020</text>
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                <text>vaccine, Variant, immune escape, SARS-CoV-2, COVID-19, genomic drift</text>
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                <text>DOI: 10.3390/pathogens9050324</text>
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                <text>Pathogens</text>
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                <text>MDPI AG</text>
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                <text>Medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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                <text>Twenty-Year Span of Global Coronavirus Research Trends: A Bibliometric Analysis</text>
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                <text>Yi Zhou, Liyu Chen</text>
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                <text>The coronavirus disease 2019 (COVID-19) pandemic aroused global public concern and became a major medical issue. This study aims to investigate the global research routine and trends of coronavirus over the last twenty years based on the production, hotspots, and frontiers of published articles as well as to provide the global health system with a bibliometric reference. The Web of Science core collection database was retrieved for coronavirus articles published from 1 January 2000 to 17 March 2020. Duplicates and discrete papers were excluded. Analysis parameters including time, regions, impact factors, and citation times were processed through professional software. A total of 9043 coronavirus articles originated from 123 countries and were published in 1202 journals. The USA contributed most articles (3101) followed by China (2230). The research was published in specialized journals including the Journal of Virology. Universities were the main institutions of science progress. High-impact articles covered fields of basic science and clinical medicine. There were two sharp increases in research yields after the severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS) outbreaks. International collaborations promoted study progress, and universities and academies act as the main force in coronavirus research. More research on prevention and treatment is needed according to an analysis of term density.</text>
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                <text>2020</text>
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                <text>Bibliometrics, coronavirus, SARS, MERS, SARS-CoV-2, COVID-19</text>
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                <text>DOI: 10.3390/ijerph17093082</text>
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                <text>International Journal of Environmental Research and Public Health</text>
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                <text>MDPI AG</text>
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                <text>Medicine</text>
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                <text>Our sustainable coronavirus future</text>
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                <text>Bondarenko Olga, Danylchuk Hanna, Semerikov Serhiy, Chukharev Serhii, Osadchyi Viacheslav, Vakaliuk Tetiana, Striuk Andrii, Sakhno Serhiy, Solovieva Victoria, Nechypurenko Pavlo</text>
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                <text>This is an introductory text to a collection of papers from the ICSF 2020: The International Conference on Sustainable Futures: Environmental, Technological, Social, and Economic Matters, which held at Kryvyi Rih National University, Kryvyi Rih, Ukraine, on May 20-22, 2020. It consists of an introduction, conference topics review, and some observations about the event and its future.</text>
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                <text>DOI: 10.1051/e3sconf/202016600001</text>
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                <text>E3S Web of Conferences</text>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="29526">
                <text>COVID-19 Epidemic and Public Health Measures in China</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="29527">
                <text>Ting-Ting Xu, Ruoyu Yang</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="29528">
                <text>Objectives: The study aims to analyze the status quo of public health emergency measures taken in China in dealing with the spread of new coronavirus pneumonia (COVID-19), and to put forward policy suggestions for system construction and improvement.Methods: According to the official data released by the National Health Commission, the epidemic data of infected people from 0:00 on January 24, 2020 to 24:00 on February 23, 2020 were quantitatively analyzed through statistical analysis. We used EXCEL software to draw the overall epidemic trend chart and SPSS to carry out descriptive statistical analysis of mortality and cure rate. We made qualitative analysis on the emergency measures implemented by national administrative departments and provincial governments to work on controlling and monitoring COVID-19 nationwide spread.Results: The number of patients diagnosed showed a linear increasing trend, with the slope increasing first and decreasing later. Suspected and new cases showed an inverted V pattern, with the peak occurring on February 8 and 12, respectively. There was a linear increase in the number of deaths and an exponential increase in the number of cures. Over the 31-day study period, the mortality rate fluctuated between 2.0% and 3.4%. The mean cure rate was 10.03%, the minimum value was 1.33%, and the maximum value was 32.05%. The quantitative and qualitative analysis shows that the public health emergency response system constructed in China plays a significant role in controlling the epidemic in a certain period of time.Discussion: The four-tier emergency management system and the joint prevention mechanism established in China have provided various resources to control the epidemic, but there are still many problems in dealing with the spread of COVID-19. It is suggested to improve and strengthen the emergency management system, public health service system, health legal system, citizen health education, and international exchange and cooperation.</text>
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            <name>Date</name>
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              <elementText elementTextId="29529">
                <text>2020</text>
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          <element elementId="49">
            <name>Subject</name>
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              <elementText elementTextId="29530">
                <text>China, epidemic, COVID-19, public health measure</text>
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            <name>Identifier</name>
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              <elementText elementTextId="29531">
                <text>DOI: 10.2991/jegh.k.200421.001</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="29532">
                <text>Journal of Epidemiology and Global Health</text>
              </elementText>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="29533">
                <text>Atlantis Press</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="29534">
                <text>Public aspects of medicine</text>
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