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                  <text>Dominio científico: Coronavirus</text>
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                <text>Blockchain-Based Healthcare Workflow for Tele-Medical Laboratory in Federated Hospital IoT Clouds</text>
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                <text>Antonio Celesti, Maria Fazio, Massimo Villari, Armando Ruggeri, Antonino Galletta, Agata Romano</text>
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                <text>In a pandemic situation such as that we are living at the time of writing of this paper due to the Covid-19 virus, the need of tele-healthcare service becomes dramatically fundamental to reduce the movement of patients, thence reducing the risk of infection. Leveraging the recent Cloud computing and Internet of Things (IoT) technologies, this paper aims at proposing a tele-medical laboratory service where clinical exams are performed on patients directly in a hospital by technicians through IoT medical devices and results are automatically sent via the hospital Cloud to doctors of federated hospitals for validation and/or consultation. In particular, we discuss a distributed scenario where nurses, technicians and medical doctors belonging to different hospitals cooperate through their federated hospital Clouds to form a virtual health team able to carry out a healthcare workflow in secure fashion leveraging the intrinsic security features of the Blockchain technology. In particular, both public and hybrid Blockchain scenarios are discussed and assessed using the Ethereum platform.</text>
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                <text>healthcare, hospital, cloud, workflow, Blockchain, Smart contract</text>
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                <text>DOI: 10.3390/s20092590</text>
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                <text>Sensors</text>
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                <text>MDPI AG</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Chemical technology</text>
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                <text>Too much but less effective: Managing the cognitive load while designing the distanced learning instructional formats</text>
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                <text>SSSN Rajasekhar, DINESH KUMAR V</text>
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                <text>In the light of educational disruptions due to COVID-19 outbreak, most, if not all institutions have adopted distanced online based learning methodologies. But, most educators seem to unaware regarding the cognitive load associated while designing such instructional formats. Through this letter, we intend to convey our practical experiences while shifting to such formats and wish to discuss the basics of educational psychology related to cognitive load. Since it is a pandemic problem, we feel that educators across world might read this letter with great interest.</text>
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                <text>2020</text>
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                <text>learning process, instructional design, Cognitive Load, distanced learning</text>
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                <text>DOI: 10.30476/jamp.2020.85990.1208</text>
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              <elementText elementTextId="29725">
                <text>Journal of Advances in Medical Education and Professionalism</text>
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            <description>An entity responsible for making the resource available</description>
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                <text>Shiraz University of Medical Sciences</text>
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                <text>Education (General), Medicine (General)</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>COVID-19 Surface Persistence: A Recent Data Summary and Its Importance for Medical and Dental Settings</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Marco Cicciù, Maria Teresa Fiorillo, Gabriele Cervino, Luca Fiorillo, Sergio Baldari, Cesare D’Amico, Marco Matarese, Riccardo Laudicella, Giovanni Luca Romano, Giovanni Surace, Valeria Paduano, Antonio Moschella, Alessia  La Bruna</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>Recently, due to the coronavirus pandemic, many guidelines and anti-contagion strategies continue to report unclear information about the persistence of coronavirus disease 2019 (COVID-19) in the environment. This certainly generates insecurity and fear in people, with an important psychological component that is not to be underestimated at this stage of the pandemic. The purpose of this article is to highlight all the sources currently present in the literature concerning the persistence of the different coronaviruses in the environment as well as in medical and dental settings. As this was a current study, there are still not many sources in the literature, and scientific strategies are moving towards therapy and diagnosis, rather than knowing the characteristics of the virus. Such an article could be an aid to summarize virus features and formulate new guidelines and anti-spread strategies.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="29731">
                <text>2020</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="29732">
                <text>Epidemiology, virus, surfaces, infection risk, COVID-19</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="29733">
                <text>DOI: 10.3390/ijerph17093132</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="29734">
                <text>International Journal of Environmental Research and Public Health</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>MDPI AG</text>
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            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="29736">
                <text>Medicine</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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            <name>Title</name>
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                <text>Gender Differences in Patients With COVID-19: Focus on Severity and Mortality</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Shi Liu, Wei He, Fei Wu, Xiao-Fang Liu, Demin Han, Jin-Kui Yang, Peng Bai, Jian-Min Jin</text>
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                <text>Objective: The recent outbreak of Novel Coronavirus Disease (COVID-19) is reminiscent of the SARS outbreak in 2003. We aim to compare the severity and mortality between male and female patients with COVID-19 or SARS.Study Design and Setting: We extracted the data from: (1) a case series of 43 hospitalized patients we treated, (2) a public data set of the first 37 cases of patients who died of COVID-19 and 1,019 patients who survived in China, and (3) data of 524 patients with SARS, including 139 deaths, from Beijing in early 2003.Results: Older age and a high number of comorbidities were associated with higher severity and mortality in patients with both COVID-19 and SARS. Age was comparable between men and women in all data sets. In the case series, however, men's cases tended to be more serious than women's (P = 0.035). In the public data set, the number of men who died from COVID-19 is 2.4 times that of women (70.3 vs. 29.7%, P = 0.016). In SARS patients, the gender role in mortality was also observed. The percentage of males were higher in the deceased group than in the survived group (P = 0.015).Conclusion: While men and women have the same prevalence, men with COVID-19 are more at risk for worse outcomes and death, independent of age.</text>
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                <text>2020</text>
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                <text>gender, Mortality, Morbidity, SARS, SARS-CoV-2, COVID-19</text>
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                <text>DOI: 10.3389/fpubh.2020.00152</text>
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              <elementText elementTextId="29743">
                <text>Frontiers in Public Health</text>
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              <elementText elementTextId="29744">
                <text>Frontiers Media S.A.</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Public aspects of medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Risk Perception and COVID-19</text>
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                <text>Fabrizio Bianchi, Liliana Cori, Carmen Anthonj, Ennio Cadum</text>
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                <text>The call for articles for the International Journal of Environmental Research and Public Health Special Issue “Research about risk perception in the Environmental Health domain” was proposed at the beginning of 2020 as part of multidisciplinary efforts to understand the complex interactions between people and the environment [...]</text>
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                <text>DOI: 10.3390/ijerph17093114</text>
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                <text>International Journal of Environmental Research and Public Health</text>
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                <text>KAIMRC’S Second Therapeutics Discovery Conference</text>
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                <text>Theam Soon Lim, Majid Alfadhel, Ahmed Alaskar, Mo Li, Sheraz Gul, Ahmed Bakillah, Bader Aldebasi, Salam Massadeh, Adel Nefzi, Mohamed Boudjelal, Tlili Barhoumi, Bandar Alghanem, Bahauddeen M Alrfaei, Atef Nehdi, Manal Alaamery, Zeyad Alehaideb, Jahad Alghamdi, Mohammed Al-Assiri, Nimer Mehyar, Mai Al Ajaji, Barrak Al Somaie, Yosra Boudjelal, Ibrahim Bushnak, Imadul Islam, Lamis Mouyes, Wyatt Yue</text>
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                <text>Following the success of our first therapeutic discovery conference in 2017 and the selection of King Abdullah International Medical Research Centre (KAIMRC) as the first Phase 1 clinical site in the Kingdom of Saudi Arabia, we organized our second conference in partnership with leading institutions in academic drug discovery, which included the Structural Genomic Constorium (Oxford, UK), Fraunhofer (Germany) and Institute Material Medica (China); the participation of members of the American Drug Discovery Consterium; European Biotech companies; and local pharma companies, SIPMACO and SudairPharma. In addition, we had European and Northern American venture capital experts attending and presenting at the conference. The purpose of the conference was to bridge the gap between biotech, pharma and academia regarding drug discovery and development. Its aim primarily was to: (a) bring together world experts on academic drug discovery to discuss and propose new approaches to discover and develop new therapies; (b) establish a permanent platform for scientific exchange between academia and the biotech and pharmaceutical industries; (c) entice national and international investors to consider funding drugs discovered in academia; (d) educate the population about the causes of diseases, approaches to prevent them from happening and their cure; (e) attract talent to consider the drug discovery track for their studies and career. During the conference, we discussed the unique academic drug discovery disrupting business models, which can make their discoveries easily accessible in an open source mode. This unique model accelerates the dissemination of knowledge to all world scientists to guide them in their research. This model is aimed at bringing effective and affordable medicine to all mankind in a very short time. Moreover, the program discussed rare disease targets, orphan drug discovery, immunotherapy discovery and process, the role of bioinformatics in drug discovery, anti-infective drug discovery in the era of bad bugs, natural products as a source of novel drugs and innovative drug formulation and delivery. Additionally, as the conference was organized during the surge of the epidemic, we dedicated the first day (25 February) to coronavirus science, detection and therapy. The day was co-organized with the King Saud bin Abdulaziz University for Health Sciences, Kingdom of Saudi Arabia(KSA) Ministry of Education to announce the grant winner for infectious diseases. Simultaneously, intensive courses were delivered to junior scientists on the principle of drug discovery, immunology and clinical trials, as well as rare diseases. The second therapeutics discovery forum provided a platform for interactive knowledge sharing and the convergence of researchers, governments, pharmaceuticals, biopharmaceuticals, hospitals and non-profit organizations on the topic of academic drug discovery. The event presented showcases on global drug discovery initiatives and demonstrated how collaborations are leading to successful new therapies. In line with the KSA 2030 vision on becoming world leaders with an innovative economy and healthy population, therapeutic discovery is becoming an area of interest to science leaders in the kingdom, and our conference gave us the opportunity to identity key areas of interest as well as potential future collaborations.</text>
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                <text>2020</text>
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                <text>rare diseases, coronavirus, infectious diseases, drug discovery and development, academic drug discovery, KAIMRC</text>
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                <text>DOI: 10.3390/proceedings2020043006</text>
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                <text>Proceedings</text>
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                <text>MDPI AG</text>
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            </elementTextContainer>
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                <text>General Works</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>ACE2: The key Molecule for Understanding the Pathophysiology of Severe and Critical Conditions of COVID-19: Demon or Angel?</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="29765">
                <text>Li Xiao, Hiroshi Sakagami, Nobuhiko Miwa</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="29766">
                <text>Recently, the SARS-CoV-2 induced disease COVID-19 has spread all over the world. Nearly 20% of the patients have severe or critical conditions. SARS-CoV-2 exploits ACE2 for host cell entry. ACE2 plays an essential role in the renin–angiotensin–aldosterone system (RAAS), which regulates blood pressure and fluid balance. ACE2 also protects organs from inflammatory injuries and regulates intestinal functions. ACE2 can be shed by two proteases, ADAM17 and TMPRSS2. TMPRSS2-cleaved ACE2 allows SARS-CoV-2 cell entry, whereas ADAM17-cleaved ACE2 offers protection to organs. SARS-CoV-2 infection-caused ACE2 dysfunction worsens COVID-19 and could initiate multi-organ failure. Here, we will explain the role of ACE2 in the pathogenesis of severe and critical conditions of COVID-19 and discuss auspicious strategies for controlling the disease.</text>
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            <name>Date</name>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="29768">
                <text>ACE2, ADAM17, Ang-(1-7), RAAS, SARS-CoV-2, COVID-19</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="29769">
                <text>DOI: 10.3390/v12050491</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="29770">
                <text>Viruses</text>
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            </elementTextContainer>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="29771">
                <text>MDPI AG</text>
              </elementText>
            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="29772">
                <text>Microbiology</text>
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  <item itemId="3196" public="1" featured="0">
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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              </elementTextContainer>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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          <element elementId="50">
            <name>Title</name>
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              <elementText elementTextId="29773">
                <text>Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)</text>
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              <elementText elementTextId="29774">
                <text>Min Li, Ying Liu, Yi Zhang, Li Chen, Gang Wang, Bo Diao, Yuzhang Wu, Ze-Qing Feng, Chenhui Wang, Yongwen Chen, Yueping Liu, Xie-wan Chen, Yingjun Tan, Lifen Ning, Zilin Yuan</text>
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            <description>An account of the resource</description>
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                <text>Background: The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed great threat to human health. T cells play a critical role in antiviral immunity but their numbers and functional state in COVID-19 patients remain largely unclear.Methods: We retrospectively reviewed the counts of T cells and serum cytokine concentration from data of 522 patients with laboratory-confirmed COVID-19 and 40 healthy controls. In addition, the expression of T cell exhaustion markers were measured in 14 COVID-19 cases.Results: The number of total T cells, CD4+ and CD8+ T cells were dramatically reduced in COVID-19 patients, especially in patients requiring Intensive Care Unit (ICU) care. Counts of total T cells, CD8+ T cells or CD4+ T cells lower than 800, 300, or 400/μL, respectively, were negatively correlated with patient survival. T cell numbers were negatively correlated to serum IL-6, IL-10, and TNF-α concentration, with patients in the disease resolution period showing reduced IL-6, IL-10, and TNF-α concentrations and restored T cell counts. T cells from COVID-19 patients had significantly higher levels of the exhausted marker PD-1. Increasing PD-1 and Tim-3 expression on T cells was seen as patients progressed from prodromal to overtly symptomatic stages.Conclusions: T cell counts are reduced significantly in COVID-19 patients, and the surviving T cells appear functionally exhausted. Non-ICU patients with total T cells counts lower than 800/μL may still require urgent intervention, even in the immediate absence of more severe symptoms due to a high risk for further deterioration in condition.</text>
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                <text>2020</text>
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                <text>T-cell exhaustion, SARS-CoV-2, COVID-19, T cell reduction, cytokine strom</text>
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                <text>DOI: 10.3389/fimmu.2020.00827</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="29779">
                <text>Frontiers in Immunology</text>
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            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="29780">
                <text>Frontiers Media S.A.</text>
              </elementText>
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                <text>Immunologic diseases. Allergy</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>The Zebrafish Disease and Drug Screening Model: A Strong Ally Against Covid-19</text>
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              <elementText elementTextId="29783">
                <text>Jorge Galindo-Villegas</text>
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                <text>2020</text>
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            <name>Subject</name>
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                <text>Zebrafish, animal models, Pandemic, drug screening, COVID-19, SASRS-CoV-2</text>
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              <elementText elementTextId="29786">
                <text>DOI: 10.3389/fphar.2020.00680</text>
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          <element elementId="48">
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="29787">
                <text>Frontiers in Pharmacology</text>
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              <elementText elementTextId="29788">
                <text>Frontiers Media S.A.</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Therapeutics. Pharmacology</text>
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                <text>Dengue, culture, Religion, gender, Transmission, COVID-19</text>
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                <text>Frontiers in Public Health</text>
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