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                <text>Vitamin D Deficiency and Air Pollution Exacerbate COVID-19 Through Suppression of Antiviral Peptide LL37</text>
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                <text>Vitamin D deficiency and insufficiency (VDD) are widely recognized as risk factors for respiratory tract infections. Vitamin D influences expression of many genes with well-established relevance to airway infections and relevant to immune system function. Recently, VDD has been shown to be a risk factor for acquisition and severity of COVID-19. Thus, treating VDD presents a safe and inexpensive opportunity for modulating the severity of the disease. VDD is common in those over 60 years of age, many with co-morbid conditions and in people with skin pigmentation sufficient to reduce synthesis of vitamin D. Exposure to fine particulate air pollution is also associated with worse outcomes from COVID19. Vitamin D stimulates transcription of cathelicidin which is cleaved to generate LL37. LL37 is an innate antimicrobial with demonstrated activity against a wide range of microbes including envelope viruses. LL37 also modulates cytokine signaling at the site of infections. Fine particles in air pollution can interfere with LL37 destruction of viruses and may reduce effective immune signaling modulation by LL37. While vitamin D influences transcription of many immune related genes, the weakened antimicrobial response of those with VDD against SARS-CoV-2 may be in part due to reduced LL37.Conclusion: Vitamin D plays an important role reducing the impact of viral lung disease processes. VDD is an acknowledged public health threat that warrants population-wide action to reduce COVID-19 morbidity and mortality. While vitamin D influences transcription of many immune related genes, the weakened antimicrobial response of those with VDD against SARS-CoV-2 may be in part due to reduced LL37. Action is needed to address COVID-19 associated risks of air pollution from industry, transportation, domestic sources and from primary and second hand tobacco smoke.</text>
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                <text>DOI: 10.3389/fpubh.2020.00232</text>
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                <text>University, Spain, barcelona, SARS-CoV-2, COVID-19, lockdown</text>
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                <text>DOI: 10.5195/ijms.2020.504</text>
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                <text>Chen Y, Liu P, Song Y, Tang X, Fan H</text>
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                <text>Hongyang Fan,1,2,* Xiaojia Tang,2,3,* Yuxia Song,2,3,* Peipei Liu,1,2 Yingzhu Chen1,2 1Clinical Medical College, Yangzhou University, Yangzhou City, Jiangsu Province, People&amp;rsquo;s Republic of China; 2Department of Neurology, Northern Jiangsu Province Hospital, Yangzhou City, Jiangsu Province, People&amp;rsquo;s Republic of China; 3Department of Neurology, Clinical Medical College of Yangzhou, Dalian Medical University, Yangzhou City, Jiangsu Province, People&amp;rsquo;s Republic of China*These authors contributed equally to this workCorrespondence: Yingzhu Chen; Peipei Liu Email yzchendr@163.com; doclpp87@163.comAbstract: The global spread of COVID-19 has caused a substantial societal burden and become a major global public health issue. The COVID-19 elderly population with hypertension, diabetes, cardiovascular, and cerebrovascular diseases are at risk. Mortality rates are highest in these individuals if infected with COVID-19. Although the lungs are the main organs involved in acute respiratory distress syndrome caused by COVID-19 infection, COVID-19 triggers inflammatory and immune mechanisms, inducing a &amp;ldquo;cytokine storm&amp;rdquo; that aggravates disease progression and may lead to death. Presently, effective drugs are lacking, although current studies have confirmed that drugs with therapeutic potential include redaciclovir, lopinavir/ritonavir combined with interferon-&amp;beta;, convalescent plasma, and monoclonal antibodies. Currently, the most reasonable and effective way to prevent COVID-19 is to control the source of infection, terminate routes of transmission, and protect susceptible populations. With the rise of COVID-19 in China and worldwide, further prevention, diagnosis, and treatment measures are a critical unmet need. Cerebrovascular disease has high incidence, disability rate, and fatality rate. COVID-19 patient outcomes may also be complicated with acute stroke. This paper summarizes the influence of COVID-19 on cerebrovascular disease and discusses possible pathophysiological mechanisms to provide new angles for the prevention and diagnosis of this disease.Keywords: novel coronavirus pneumonia, 2019-nCoV, SARS-CoV-2, cerebral vascular disease</text>
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                <text>Cerebral Vascular disease, 2019ncov, SARS-CoV-2, novel coronavirus pneumonia</text>
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                <text>DOI: </text>
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                <text>Neuropsychiatric Disease and Treatment</text>
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                <text>Dove Medical Press</text>
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                <text>Neurosciences. Biological psychiatry. Neuropsychiatry, Neurology. Diseases of the nervous system</text>
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                <text>antibody protection for Covid-19, SARS-CoV-2 immunity, gamma globulin for Covid-19 protection, antibody therapy for Covid-19, convalescent plasma for Covid-19 therapy, vaccine and therapeutics testing for Covid-19</text>
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                <text>DOI: 10.3389/fimmu.2020.01196</text>
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                <text>Frontiers in Immunology</text>
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                <text>COVID19, the pandemic which may exemplify a need for harm-reduction approaches to eating disorders: a reflection from a person living with an eating disorder</text>
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                <text>Margaret Janse van Rensburg</text>
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                <text>Abstract This reflective piece, written by a woman with an eating disorder aims to identify the impact of COVID-19 on persons living with eating disorders and provide a social justice approach as a resolution. The author identifies that eating disorder behaviors may be the only coping tool available for many persons with eating disorders during this time of uncertainty. While she acknowledges the risks associated with eating disorder behaviors, she identifies that this time of uncertainty may be a time to embrace harm-reduction in approaching the health and wellness of persons with eating disorders.</text>
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            <description>The topic of the resource</description>
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                <text>Reflection, Harm Reduction, Strengths-based approach</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>DOI: 10.1186/s40337-020-00306-3</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="32411">
                <text>Journal of Eating Disorders</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>BMC</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="32413">
                <text>Psychiatry</text>
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              <name>Title</name>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>“The ancient and the new”: is there an interaction between cytomegalovirus and SARS-CoV-2 infection?</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Paul Moss</text>
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            <description>An account of the resource</description>
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                <text>Summary The SARS-CoV-2 pandemic represents one of the greatest infectious challenges to humanity in recent history. One of the striking features of infection is the heterogeneous clinical response with worse outcomes observed in older patients and those with underlying health conditions. To date the potential impact of previous infection history has been poorly investigated as a potential determinant of risk. Cytomegalovirus (CMV), a persistent herpesvirus infection whose prevalence increases with age, is a major modulator of immune function and several observations suggest that infection might act to influence clinical outcome following SARS-CoV-2 infection. In particular, CMV is associated with the acceleration of immune senescence and has been linked to a range of cardiovascular and metabolic disorders. This review addresses mechanisms by which cytomegalovirus infection may act to worsen the clinical outcome of SARS-CoV-2 infection, discusses how these potential links could be investigated, and assesses the potential significance of any findings that emerge.</text>
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                <text>2020</text>
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                <text>DOI: 10.1186/s12979-020-00185-x</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="32419">
                <text>Immunity &amp; Ageing</text>
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            </elementTextContainer>
          </element>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>BMC</text>
              </elementText>
            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="32421">
                <text>Immunologic diseases. Allergy, Geriatrics</text>
              </elementText>
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          <name>Dublin Core</name>
          <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
          <elementContainer>
            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32422">
                <text>Control Algorithms for UAVs: A Comprehensive Survey</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="32423">
                <text>Minh Nguyen, Hoa Nguyen, Cuong Nguyen, Anh Le, Hoa Tran, Toan Quyen</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="32424">
                <text>The development of unmanned aerial vehicles (UAVs) has become a revolution in the ﬁelds of data collection, surveying, monitoring, and tracking objects in the ﬁeld. Many control and navigation algorithms are experimented and deployed for UAVs, especially quadrotors. Recent numerous approaches are geared towards reducing the inﬂuence of external disturbances to enhance the performance of UAVs. Nevertheless, designing cutting-edge controllers following the requirements of the applications is still a huge challenge. Based on the operating characteristics and movement principle of a quadrotor, this work reviews potential control algorithms of the current researches in the ﬁeld of the quadrotor ﬂight controller. Besides, a comparison has been made to provide an overview of the advantages and disadvantages of the mentioned methods. At last, the challenges and future directions of the quadrotor ﬂight controller are suggested.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="32425">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>Quadcopter, control algorithms, quadrotor, control algorithm, linear controller, Nonlinear controller, Fixed-wing, COVID-19, unmanned aerial vehicles (uavs) - drones, ﬁxedwing hybrid vtol</text>
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            </elementTextContainer>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="32427">
                <text>DOI: 10.4108/eai.18-5-2020.164586</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="32428">
                <text>EAI Endorsed Transactions on Industrial Networks and Intelligent Systems</text>
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            </elementTextContainer>
          </element>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="32429">
                <text>European Alliance for Innovation (EAI)</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="32430">
                <text>Computer engineering. Computer hardware, Systems engineering</text>
              </elementText>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              </elementTextContainer>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32431">
                <text>Can Human Transmit COVID-19 to Animal?</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32432">
                <text>Boujamaa Imziln, Soraia El Baz</text>
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          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="32433">
                <text>Coronavirus (COVID-19) has infected more than three million people worldwide and it’s widely believed to have originated in horseshoe bats and passed to humans through other species on sale in a wildlife market in Wuhan. First human transmission to dogs has been detected in Hong Kong; which they have caught the novel coronavirus from owners. Other reported cases of cats in Belgium tested positive with COVID-19. Researchers reveal that cats are not only susceptible to contracting coronavirus but can transmit it on other cats as well. Also, a tiger tested positive for COVID-19 after coming into contact with an asymptomatic caretaker. In this report, we provide all cases registered over the world prompting to take a closer look at the human to pet transmission of the virus and to keep measures to prevent exposure. Also, increased transmission of COVID-19 from human to animal can affect the global health security owing to its ability to rapidly spread due to movement of animals. So, we should reevaluate the probability that this outbreak might also be caused by infected pets’ hosts. Particular attention must be also paid to the distribution and the evolution of the virus in animals to control the COVID-19 pandemic.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32434">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32435">
                <text>pets, cat, Dog, coronavirus, COVID-19, human-animal transmission</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="32436">
                <text>DOI: 10.5799/jcei/8262</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="32437">
                <text>Journal of Clinical and Experimental Investigations</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="32438">
                <text>Association of Health Investigations</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="32439">
                <text>Medicine</text>
              </elementText>
            </elementTextContainer>
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    <fileContainer>
      <file fileId="3507">
        <src>https://www.socictopen.socict.org/files/original/1ebde3b944ea7d787df09f2010810c00.pdf</src>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>The Effect of Climate and the Equator on the Total Coronavirus Cases of the Nine Countries from Africa</text>
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              <elementText elementTextId="32441">
                <text>Said Benramache, Hanane Bougherara</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>On the 01 March, 2020, an outbreak of coronavirus disease 2019 (COVID-19) has resulted in 88 585 confirmed cases. African countries move from COVID-19 readiness to respond as many confirmed cases. The equator differs from the rest of the world in its climate and environment. In this work we conducted a comparative study of cases of coronavirus infection and the number of deaths, this study was investigated in nine countries from Africa with the same climate and which belong to the equator, where the results were compared with the relation to the general population and total area. From the studied results, we found a zero % of the Deaths for Rwanda, Equatorial Guinea and Uganda. The equator countries of Africa have not been affected much by this virus, Climate found in the equator countries helped these countries to obtain a small number of injuries, Air and temperature affected the number of deaths, and the equator countries authorize its climate to help them acquire special immunity.</text>
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                <text>2020</text>
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            <name>Subject</name>
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                <text>climate, Africa, equator, COVID-19</text>
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            <description>An unambiguous reference to the resource within a given context</description>
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                <text>DOI: 10.5799/jcei/8263</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="32446">
                <text>Journal of Clinical and Experimental Investigations</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="32447">
                <text>Association of Health Investigations</text>
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            </elementTextContainer>
          </element>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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                <text>Transmission of SARS-CoV-2 and Other Infections at Large Sports Gatherings: A Surprising Gap in Our Knowledge</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32450">
                <text>Walter Ricciardi, Stefania Boccia, Martin McKee, Michele Sassano</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32451">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32452">
                <text>Outbreaks, Sports, sporting events, gatherings, SARS-CoV-2, COVID-19</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="32453">
                <text>DOI: 10.3389/fmed.2020.00277</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="32454">
                <text>Frontiers in Medicine</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="32455">
                <text>Frontiers Media S.A.</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="32456">
                <text>Medicine (General)</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
</itemContainer>
