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                  <text>Dominio científico: Coronavirus</text>
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                <text>La enseñanza de ELE en línea ante emergencia de salud pública. Estudio de caso: China</text>
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                <text>Liu Liu</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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                <text>Hoy día no se puede tratar la enseñanza de una lengua extranjera al margen de Internet y las nuevas tecnologías, puesto que las nuevas modalidades basadas en ellas están teniendo y van a tener un papel preponderante. La repentina emergencia de salud pública causada por la COVID-19 obliga a las instituciones educativas a suspender las actividades académicas y convierte las clases presenciales en la enseñanza-aprendizaje en línea, lo cual cambia la forma en que se imparte la educación y al mismo tiempo posibilita investigaciones sobre la plena implementación de esta modalidad y discusión sobre su factibilidad. El presente estudio tiene la finalidad de manifestar la situación actual de China, encontrar problemas y proponer soluciones a los mismos, de manera que tiene carácter descriptivo.</text>
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                <text>2020</text>
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            <name>Subject</name>
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                <text>Simulación virtual, On-line education, MOOC, ELE, virtual simulation, Educación en línea, Spanish teaching, COVID-19</text>
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            <name>Identifier</name>
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                <text>DOI: </text>
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            <name>Source</name>
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                <text>marcoELE. Revista de Didáctica Español Lengua Extranjera</text>
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            <name>Publisher</name>
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                <text>MarcoELE</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Language and Literature</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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            <name>Title</name>
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                <text>Clinical Characteristics of Covid-19 among Old Adult Patients with Chronic Diseases: A Systematic Review Study</text>
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                <text>Abdolrahim Asadollahi, Ogholgol Ghajari, Farzaneh Kasraie</text>
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                <text>Background: COVID-19[1] is a new infectious disease that has been declared by WHO[2]  as a public health emergency worldwide due to its rapid spread to China and then to other parts of the world. The present study was designed to evaluate the clinical manifestations of this disease in the elderly. Methods: We performed a systematic review on the database of the World Health Organization, CDC[3], PubMed, Google Scholar, Scopus, and lancet. All of the articles published until March 15, 2020, have been extracted from the above articles in English on coronavirus infection, disease, virology, epidemiology, clinical features, treatment, and prevention of the disease. Of the 1376 articles, 5 were selected out of recently published articles focusing on the epidemiological information of the virus, pneumonia caused by new corona virus, and the effects of the disease on different age groups, especially the elderly, and the rest were excluded from the review. The mean age of the patients, the mean age of mortality and the  underlying diseases were chosen as the criteria of data extraction. Findings:  Based on the researchers' perceptions of the text of the articles, 342 cases were included in these 5 studies. The mean age of the patients was 58.4 and that of the diceased patients was 66.5. More than 50% of the total cases had one or more underlying diseases.  Conclusion: Despite the involvement of various age groups in this infection, the virus is most likely to cause severe complications and fatalities in older people with underlying diseases.</text>
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                <text>2020</text>
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            <name>Subject</name>
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                <text>vulnerability, older adults, COVID-19, New coronavirus, global pandemic</text>
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            <name>Identifier</name>
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                <text>DOI: 10.30476/jhsss.2020.85959.1080</text>
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                <text>Journal of Health Sciences and Surveillance System</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Shiraz University of Medical Sciences</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Public aspects of medicine</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Etheresia Pretorius, Douglas B. Kell, Eugene L. Heyden</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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                <text>Lactoferrin is a nutrient classically found in mammalian milk. It binds iron and is transferred via a variety of receptors into and between cells, serum, bile, and cerebrospinal fluid. It has important immunological properties, and is both antibacterial and antiviral. In particular, there is evidence that it can bind to at least some of the receptors used by coronaviruses and thereby block their entry. Of importance are Heparan Sulfate Proteoglycans (HSPGs) and the host receptor angiotensin-converting enzyme 2 (ACE2), as based on other activities lactoferrin might prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from attaching to the host cells. Lactoferrin (and more specifically enteric-coated LF because of increased bioavailability) may consequently be of preventive and therapeutic value during the present COVID-19 pandemic.</text>
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              <elementText elementTextId="32653">
                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="32654">
                <text>Iron, coronaviruses, Lactoferrin, membrane receptors, HSPGs</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>DOI: 10.3389/fimmu.2020.01221</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="32656">
                <text>Frontiers in Immunology</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="32657">
                <text>Frontiers Media S.A.</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Immunologic diseases. Allergy</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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            <description>A name given to the resource</description>
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                <text>Medical and Paramedical Care of Patients With Cerebellar Ataxia During the COVID-19 Outbreak: Seven Practical Recommendations of the COVID 19 Cerebellum Task Force</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Aasef G. Shaikh, Elan D Louis, Michael Strupp, Hiroshi Mitoma, Mario Manto, Frank Van Overwalle, Bing-Wen Soong, Jeremy D. Schmahmann, Marios Hadjivassiliou, Nicolas Dupré, Marco Molinari</text>
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            <description>An account of the resource</description>
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                <text>The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), the cause of the current pandemic coronavirus disease 2019 (COVID-19), primarily targets the respiratory system. Some patients also experience neurological signs and symptoms ranging from anosmia, ageusia, headache, nausea, and vomiting to confusion, encephalitis, and stroke. Approximately 36% of those with severe COVID-19 experience neurological complications. The virus may enter the central nervous system through the olfactory nerve in the nasal cavity and damage neurons in the brainstem nuclei involved in the regulation of respiration. Patients with cerebellar ataxia (CA) are particularly vulnerable to severe outcome if they contract COVID-19 because of the complexity of their disease, the presence of comorbidities, and their use of immunosuppressive therapies. Most CA patients burdened by progressive neurologic deficits have substantially impaired mobility and other essential functions, for which they rely heavily on ambulatory services, including rehabilitation and psychosocial care. Cessation of these interventions because of isolation restrictions places the CA patient population at risk of further deterioration. This international panel of ataxia experts provides recommendations for neurologists caring for patients with CA, emphasizing a pro-active approach designed to maintain their autonomy and well-being: continue long-term medications, promote rehabilitation efforts, utilize the technology of virtual visits for regular contact with healthcare providers, and pay attention to emotional and psychosocial health. Neurologists should play an active role in decision-making in those CA cases requiring escalation to intensive care and resuscitation. Multi-disciplinary collaboration between care teams is always important, and never more so than in the context of the current pandemic.</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2020</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>ataxia, Cerebellum, Therapies, SARS-CoV-2, COVID-19</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="32664">
                <text>DOI: 10.3389/fneur.2020.00516</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="32665">
                <text>Frontiers in Neurology</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="32666">
                <text>Frontiers Media S.A.</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Neurology. Diseases of the nervous system</text>
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                <text>COVID-19 UK Lockdown Forecasts and R0</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Greg Dropkin</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="32670">
                <text>Introduction: The first reported UK case of COVID-19 occurred on 30 January 2020. A lockdown from 24 March was partially relaxed on 10 May. One model to forecast disease spread depends on clinical parameters and transmission rates. Output includes the basic reproduction number R0 and the log growth rate r in the exponential phase.Methods: Office for National Statistics data on deaths in England and Wales is used to estimate r. A likelihood for the transmission parameters is defined from a gaussian density for r using the mean and standard error of the estimate. Parameter samples from the Metropolis-Hastings algorithm lead to an estimate and credible interval for R0 and forecasts for cases and deaths.Results: The UK initial log growth rate is r = 0.254 with s.e. 0.004. R0 = 6.94 with 95% CI (6.52, 7.39). In a 12 week lockdown from 24 March with transmission parameters reduced throughout to 5% of their previous values, peaks of around 90,000 severely and 25,000 critically ill patients, and 44,000 cumulative deaths are expected by 16 June. With transmission rising from 5% in mid-April to reach 30%, 50,000 deaths and 475,000 active cases are expected in mid-June. Had such a lockdown begun on 17 March, around 30,000 (28,000, 32,000) fewer cumulative deaths would be expected by 9 June.Discussion: The R0 estimate is compatible with some international estimates but over twice the value quoted by the UK government. An earlier lockdown could have saved many thousands of lives.</text>
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                <text>2020</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>Modelling, Bayesian, forecast, UK, NHS, COVID-19</text>
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            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="32673">
                <text>DOI: 10.3389/fpubh.2020.00256</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="32674">
                <text>Frontiers in Public Health</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="32675">
                <text>Frontiers Media S.A.</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
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                <text>Public aspects of medicine</text>
              </elementText>
            </elementTextContainer>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>COVID-19 Outbreak Perception in Italian Dentists</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32678">
                <text>Giovanni Bruno, Sabrina Mutinelli, Antonio Gracco, Alberto De Stefani</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="32679">
                <text>The aim of this study is an evaluation of the Italian dentists’ knowledge regarding COVID-19 and their perception of the risks associated with COVID-19, their attitude in resuming their activities, and how they judge the institutional intervention on a health and economic basis. Methods: This research evaluated Italian dentists from 11 to 18 April 2020, using a questionnaire submitted via Google Forms (Alphabet, Mountain View, CA, USA). It consisted of different investigations about sociodemographic aspects, profession-related characteristics, knowledge about COVID-19 infection transmission modalities, symptoms, and attitude in treating potentially infected patients. Statistical analysis was performed using the Pearson chi2 test and Student t-test. The α-level was fixed at p = 0.05. All data were analyzed with STATA 16 (StataCorp LP, College Station, TX, USA). Results: 1500 dentists (664 men and 836 women) completed the questionnaire. The majority of respondents declared having been trained in infection prevention procedures (64.3%) but not specifically to prevent the spread of COVID-19 (48.7%). A total of 57.2% declared that they were not trained sufficiently to restart working after lockdown, with a significantly higher prevalence (Pearson chi2 test, p &lt; 0.001) among women (62.3%) than men (50.9%). Conclusion: Italian dentists were informed correctly on the mode of transmission but partially missed COVID-19 symptoms. Dentists considered the virus infection highly dangerous, and they were not confident in being able to work safely. The lack of precise operating guidelines creates uncertainties on infection control measures and appropriate personal protective equipment (PPE) use. The participants revealed apprehension for their health and the current and future economic situation of their practices.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32680">
                <text>2020</text>
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            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32681">
                <text>infection control, Questionnaire, dentistry, SARS-CoV-2, COVID-19</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="32682">
                <text>DOI: 10.3390/ijerph17113867</text>
              </elementText>
            </elementTextContainer>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="32683">
                <text>International Journal of Environmental Research and Public Health</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="32684">
                <text>MDPI AG</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="32685">
                <text>Medicine</text>
              </elementText>
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          <elementContainer>
            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
                  <text>Coronavirus</text>
                </elementText>
              </elementTextContainer>
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              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32686">
                <text>Application of a Gray-Based Decision Support Framework for Location Selection of a Temporary Hospital during COVID-19 Pandemic</text>
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            </elementTextContainer>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="32687">
                <text>Sarfaraz Hashemkhani Zolfani, Morteza Yazdani, Ali Ebadi Torkayesh, Arman Derakhti</text>
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            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32688">
                <text>The hospital location selection problem is one of the most important decisions in the healthcare sector in big cities due to population growth and the possibility of a high number of daily referred patients. A poor location selection process can lead to many issues for the health workforce and patients, and it can result in many unnecessary costs for the healthcare systems. The COVID-19 outbreak had a noticeable effect on people’s lives and the service quality of hospitals during recent months. The hospital location selection problem for infected patients with COVID-19 turned out to be one of the most significant and complicated decisions with many uncertain involved parameters for healthcare sectors in countries with high cases. In this study, a gray-based decision support framework using criteria importance through inter-criteria correlation (CRITIC) and combined compromise solution (CoCoSo) methods is proposed for location selection of a temporary hospital for COVID-19 patients. A case study is performed for Istanbul using the proposed decision-making framework.</text>
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          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32689">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32690">
                <text>Location selection, COVID-19, criteria importance through inter-criteria correlation (CRITIC), combined compromise solution (CoCoSo), gray values, temporary hospital</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="32691">
                <text>DOI: 10.3390/sym12060886</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="32692">
                <text>Symmetry</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="32693">
                <text>MDPI AG</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="32694">
                <text>Mathematics</text>
              </elementText>
            </elementTextContainer>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              </elementTextContainer>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
          </elementContainer>
        </elementSet>
      </elementSetContainer>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32695">
                <text>Correction to: Nationwide system to centralize decisions around ECMO use for severe COVID-19 pneumonia in Japan (Special Correspondence)</text>
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            </elementTextContainer>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32696">
                <text>Japan ECMOnet for COVID-19</text>
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            </elementTextContainer>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="32697">
                <text>An amendment to this paper has been published and can be accessed via the original article.</text>
              </elementText>
            </elementTextContainer>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32698">
                <text>2020</text>
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            </elementTextContainer>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="32699">
                <text>DOI: 10.1186/s40560-020-00454-3</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="32700">
                <text>Journal of Intensive Care</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="32701">
                <text>BMC</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="32702">
                <text>Medical emergencies. Critical care. Intensive care. First aid</text>
              </elementText>
            </elementTextContainer>
          </element>
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          <elementContainer>
            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
                  <text>Coronavirus</text>
                </elementText>
              </elementTextContainer>
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              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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              </elementTextContainer>
            </element>
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      </elementSetContainer>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Protecting children in low-income and middle-income countries from COVID-19</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="32704">
                <text>William Checkley, Mike English, Stephen R. C. Howie, Claudio F. Lanata, Salahuddin Ahmed, Mohammod Jobayer Chisti, Madhu Gupta, Charl Verwey, Carina King, Harry Campbell, Anneke C. Hesseling, James A. Seddon, Tisungane Mvalo, Osawaru Oviawe, Naor Bar-Zeev, Heather J. Zar, Tim Colbourn, Shubhada Hooli, Norman Lufesi, Eric D McCollum, Kevin Baker, Harish Nair, Hamish R. Graham, Adegoke G. Falade, Trevor Duke, John P. McCracken, Mathuram Santosham, Samuel Akech, Ambrose Agweyu, Steve Cunningham, Lay Myint Yoshida, Brian Wahl, Grant A. Mackenzie, William S. Pomat, Miles A. Kirby, Marieke van der Zalm, Diane M. Gray, Peter P Moschovis, Nicholas SS Fancourt, Amy S Ginsburg, Laura Hammitt, Abdul-Wahab BR Johnson, Lineo Keneuoe Thahane</text>
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                <text>2020</text>
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            <name>Identifier</name>
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                <text>DOI: 10.1136/bmjgh-2020-002844</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="32707">
                <text>BMJ global health</text>
              </elementText>
            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine (General), Infectious and parasitic diseases</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
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    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32709">
                <text>Javamide-II Inhibits IL-6 without Significant Impact on TNF-alpha and IL-1beta in Macrophage-Like Cells</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32710">
                <text>Thomas Ty Wang, Jae B. Park, Quynhchi Pham, Renee Peters</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32711">
                <text>The main aim of this study is to find a therapeutic compound to inhibit IL-6, not TNF-alpha and IL-1beta, in macrophage-like cells, because the high-levels of IL-6 production by macrophages are reported to cause unfavorable outcomes under several disease conditions (e.g., autoimmune diseases, and acute viral infections, including COVID-19). In this study, the potential effects of javamide-II on IL-6, IL-1beta and TNF-alpha productions were determined using their ELISA kits in macrophage-like THP-1 cells. Western blots were also performed using the same cells, to determine its effects on signaling pathways (ERK, p38, JNK, c-Fos, ATF-2, c-Jun and NF-κB p65). At concentrations of 0.2–40 µM, javamide-II inhibited IL-6 production significantly in the THP-1 cells (IC50 of 0.8 µM) (P &lt; 0.02). However, javamide-II did not inhibit IL-1beta or TNF-alpha productions much at the same concentrations. In addition, the treatment of javamide-II decreased the phosphorylation of p38 without significant effects on ERK and JNK phosphorylations in the THP-1 cells. Furthermore, the p38 inhibition, followed by the reduction of ATF-2 phosphorylation (not c-Fos, c-Jun or NF-κB p65), led to the suppression of IL-6 mRNA expression in the cells (P &lt; 0.02). The data indicate that javamide-II may be a potent compound to inhibit IL-6 production via suppressing the p38 signal pathway, without significant effects on the productions of TNF-alpha and IL-1beta in macrophage-like THP-1 cells.</text>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="32712">
                <text>2020</text>
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            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="32713">
                <text>infection, COVID-19, Javamide-II (&lt;i&gt;N&lt;/i&gt;-caffeoyltryptophan), IL-6 inhibition, p38/ATF-2, macrophage-like THP-1 cells</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="32714">
                <text>DOI: 10.3390/biomedicines8060138</text>
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          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="32715">
                <text>Biomedicines</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="32716">
                <text>MDPI AG</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="32717">
                <text>Biology (General)</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
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    </elementSetContainer>
  </item>
</itemContainer>
