395 10 20655 https://www.socictopen.socict.org/files/original/d4b9be4ad28ea479df91b9e130122837.pdf 6dabeebf662d661d8f49cc864648f4d6 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2): An Emerging Zoonotic Respiratory Pathogen in Humans Creator An entity primarily responsible for making the resource Balamurugan Shanmugaraj, Ashwini Malla, Sathishkumar Ramalingam Description An account of the resource Two highly human pathogenic coronaviruses outbreak in the beginning of 21st century i.e. Severe AcuteRespiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus(MERS-CoV) in 2002 and 2012 respectively caused high pathogenicity and fatality rates in humanpopulations. Recently, a new coronavirus named as SARS-CoV-2 or nCoV-2019 was first reportedin Wuhan, China in December 2019 which is responsible for an acute human respiratory illnessreferred as Coronavirus Disease (COVID-19), an ongoing pandemic. SARS-CoV-2 is the third knownhighly pathogenic virus affecting human population. This virus spread globally within few weeks offirst identification and nearly 5.52 million confirmed cases with more than 3,47,000 deaths reportedas of May 25, 2020. Till date, there are no specific anti-viral drugs, therapies or vaccines to containand prevent this infectious pathogen outbreak. The global spread of this virus to over 210 countriesresulted in both human and economic losses, highlighting the need for an immediate imperativeresearch exploration on prophylactic and therapeutic measures. Current knowledge and understandingof the pathogenesis of similar coronavirus SARS-CoV and MERS-CoV might be helpful for the rapiddevelopment of treatment strategies to prevent the further spread of this virus. In this review, werecapitulate the topical understanding on the structure, pathogenesis and epidemiology of SARS-CoV-2that has emerged as a major health concern worldwide. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Epidemiology, coronavirus, MERS-CoV, SARS-CoV, SARS-CoV-2, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.22207/JPAM.14.SPL1.30 Source A related resource from which the described resource is derived Journal of Pure and Applied Microbiology Publisher An entity responsible for making the resource available Journal of Pure and Applied Microbiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology https://www.socictopen.socict.org/files/original/2fb76fc2cc74dfe47718bb0c93f6911c.pdf 94fbbdcd599f05d582db2e483e38d40e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Different Cases of SARS-CoV-2 Infection and Its Impact on Health and Economy with Special Emphasis on Antiviral Drug Targets Creator An entity primarily responsible for making the resource Debdulal Banerjee, Hiran Kanti Santra Description An account of the resource COVID-19 caused by SARS-CoV-2 has not only issued a pandemic situation but also lead to economicdisaster and unprecedented health emergency. Being a close relative of Bat corona-virus, SARS andMERS it’s structural and sequence similarity has abled scientists for repurposing of popular drugs likehydroxychloroquine, cloroquine and also scavenging for lead molecules by in-silico and in-vivo or in-vitroapproach. The potent drug targets are ACE2; spike protein binding receptor to host cell surface, Mpro;proteo-lytic polyprotein processing enzymes needed for virion maturation and RdRp; RNA dependentRNA polymerase needed for RNA replication. The recent trend focuses on the fact that cocktail of anticorona virus treatment will be available soon by broad spectrum antiviral compounds. It takes timeto develop such drug targets till then social distancing and following of hygiene are the only way tothrive well. This article incorporates the present World scenario related to COVID infection, focuseson its origin and also future possibilities for a COVID free future. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource in vitro, in vivo, ACE2, in silico, Broad-spectrum, RdRp, COVID-19, MPro Identifier An unambiguous reference to the resource within a given context DOI: 10.22207/JPAM.14.SPL1.17 Source A related resource from which the described resource is derived Journal of Pure and Applied Microbiology Publisher An entity responsible for making the resource available Journal of Pure and Applied Microbiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology https://www.socictopen.socict.org/files/original/27d794d13b878dd2f7b5237e24dadefb.pdf b8a126d29f55ef664dac2bc3f67b2024 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Impact of COVID-19 on gastrointestinal endoscopy practice in India: a cross-sectional study Creator An entity primarily responsible for making the resource Uday C Ghoshal, Nalini Guda, Mahesh K. Goenka, Nageshwar Reddy, Shivaraj Afzalpurkar Description An account of the resource Background and study aims Gastrointestinal endoscopy, being an aerosol-generating procedure, has the potential to transmit Severe Acute Respiratory Distress Syndrome Corona Virus-2 (SARS-CoV-2) during the current pandemic. Adequate knowledge is the key to prevention. A survey, perhaps the first, was conducted among Indian endoscopists to assess the impact of Coronavirus Disease (COVID)-19 on gastroinestinal endoscopy practice in the country. Methods From April 24 to 28, 2020, an electronic survey (using Google Form) was conducted with 23 questions (single or multiple answers) on: (1) endoscopy practice before the pandemic; (2) knowledge about COVID-19; and (3) its impact on endoscopy practice. Results Responses were received from 375 of 1205 (31.1 %) endoscopists. Most (35.7 %) were young (31–40 years), practicing in corporate multi-speciality hospitals (44.6 %) or independent practice set-up (17.7 %) in metropolitan cities (55.6 %) and urban areas (42.3 %). In most units (75.4 %), fewer than 10 % of procedures performed are endoscopies, as compared to before the pandemic. A reduction in volume of endoscopy related to restriction of the routine procedures by the latest guideline was reported by 86.9 % of respondents. Most are using N95 masks (74.7 %) and/or complete personal protective equipment (PPE, 49.2 %) during endoscopic procedures. Only 18.3 % of respondents had access to negative pressure rooms either within (5.4 %) or outside (12.9 %) the usual endoscopy suite. Conclusion Endoscopy units in India are performing fewer than 10 % of their usual volumes due to current restrictions. Resources to follow current international guidelines, including use of negative pressure rooms and PPE, are limited. Alternate measures are needed to keep up the services. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context DOI: 10.1055/a-1181-8391 Source A related resource from which the described resource is derived Endoscopy International Open Publisher An entity responsible for making the resource available Georg Thieme Verlag Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Diseases of the digestive system. Gastroenterology https://www.socictopen.socict.org/files/original/bfb11a72d5a56e858cbc31a3f24bdd53.pdf c42b9e7fb77100afeaee9f1490f285af Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A Snapshot of the Global Race for Vaccines Targeting SARS-CoV-2 and the COVID-19 Pandemic Creator An entity primarily responsible for making the resource Colin D. Funk, Craig Laferriere, Ali Ardakani Description An account of the resource A novel coronavirus SARS-CoV-2 causing Coronavirus disease 2019 (COVID-19) has entered the human population and has spread rapidly around the world in the first half of 2020 causing a global pandemic. The virus uses its spike glycoprotein receptor-binding domain to interact with host cell angiotensin-converting enzyme 2 (ACE2) sites to initiate a cascade of events that culminate in severe acute respiratory syndrome in some individuals. In efforts to curtail viral spread, authorities initiated far-reaching lockdowns that have disrupted global economies. The scientific and medical communities are mounting serious efforts to limit this pandemic and subsequent waves of viral spread by developing preventative vaccines and repurposing existing drugs as potential therapies. In this review, we focus on the latest developments in COVID-19 vaccine development, including results of the first Phase I clinical trials and describe a number of the early candidates that are emerging in the field. We seek to provide a balanced coverage of the seven main platforms used in vaccine development that will lead to a desired target product profile for the “ideal” vaccine. Using tales of past vaccine discovery efforts that have taken many years or that have failed, we temper over exuberant enthusiasm with cautious optimism that the global medical community will reach the elusive target to treat COVID-19 and end the pandemic. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource vaccine, immune response, coronavirus, clinical trial, SARS-CoV-2, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fphar.2020.00937 Source A related resource from which the described resource is derived Frontiers in Pharmacology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Therapeutics. Pharmacology https://www.socictopen.socict.org/files/original/aff66077182bbb3b4540390725fdb8fb.pdf 5391bba3a8c9a07e0625e59b2928d30f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Leucocyte Subsets Effectively Predict the Clinical Outcome of Patients With COVID-19 Pneumonia: A Retrospective Case-Control Study Creator An entity primarily responsible for making the resource Jingjing Li, Shu-Sheng Li, Jiahua Gan, Chunguang Yang Description An account of the resource Background: The clinical characteristics of coronavirus disease 2019 (COVID-19) have been well-studied, while effective predictors for clinical outcome and research on underlying mechanisms are scarce.Methods: Hospitalized COVID-19 pneumonia patients with definitive clinical outcome (cured or died) were retrospectively studied. The diagnostic performance of the leucocyte subsets and other parameters were compared using the area under the receiver operating characteristic curve (AUC). Further, the correlations between leucocyte subsets and inflammation-related factors associated with clinical outcome were subsequently investigated.Results: Among 95 subjects included, 56 patients were cured, and 39 died. Older age, elevated aspartate aminotransferase, total bilirubin, serum lactate dehydrogenase, blood urea nitrogen, prothrombin time, D-dimer, Procalcitonin, and C-reactive protein levels, decreased albumin, elevated serum cytokines (IL2R, IL6, IL8, IL10, and TNF-α) levels, and a decreased lymphocyte count indicated poor outcome in patients with COVID-19 pneumonia. Lymphocyte subset (lymphocytes, T cells, helper T cells, suppressor T cells, natural killer cells, T cells+B cells+NK cells) counts were positively associated with clinical outcome (AUC: 0.777; AUC: 0.925; AUC: 0.900; AUC: 0.902; AUC: 0.877; AUC: 0.918, resp.). The neutrophil-to-lymphocyte ratio (NLR), neutrophil to T lymphocyte count ratio (NTR), neutrophil percentage to T lymphocyte ratio (NpTR) effectively predicted mortality (AUC: 0.900; AUC: 0.905; AUC: 0.932, resp.). Binary logistic regression showed that NpTR was an independent prognostic factor for mortality. Serum IL6 levels were positively correlated with leucocyte count, neutrophil count, and eosinophil count and negatively correlated with lymphocyte count.Conclusion: These results indicate that leucocyte subsets predict the clinical outcome of patients with COVID-19 pneumonia with high efficiency. Non-self-limiting inflammatory response is involved in the development of fatal pneumonia. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Prognosis, cytokine, Lymphocyte, Leucocyte, SARS-CoV-2, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fpubh.2020.00299 Source A related resource from which the described resource is derived Frontiers in Public Health Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Public aspects of medicine https://www.socictopen.socict.org/files/original/02cd98d3ed23e0ad7c2032c61c5afd88.pdf 7c24ff20d81c8cc1e17f72a0ed606642 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Psychological Symptoms During the Two Stages of Lockdown in Response to the COVID-19 Outbreak: An Investigation in a Sample of Citizens in Northern Spain Creator An entity primarily responsible for making the resource Nahia Idoiaga Mondragon, Naiara Ozamiz-Etxebarria, Maitane Picaza Gorrotxategi, Maria Dosil-Santamaria Description An account of the resource Spain has been in a state of emergency since 14th March due to the COVID-19 crisis. This state of emergency means that the population must comply with strict rules such as lockdown (confinement to their homes except for essential trips) and social distancing. The aim of this study was to examine the psychological state of the general population in a sample recruited in Northern Spain. Sociodemographic and psychological data were gathered, assessing variables such as stress, anxiety, and depression. A questionnaire was administered at the beginning of the lockdown and three weeks later. The sample was recruited using an online questionnaire by means of a non-probabilistic snowball sampling methodology. A total of 1,933 people participated in this study. The results reveal that more than a quarter of the participants have reported symptoms of depression (27.5%), anxiety (26.9%) and stress (26.5%) and as the time spent in lockdown has progressed, psychological symptoms have risen. In relation to gender, data indicate that men have higher levels of depression than women, and similar levels of anxiety and stress. Greater symptomatology has also been found among the younger population and in people with chronic diseases. We discuss the need to continue carrying out these types of studies to prevent and treat psychological problems that could emerge amidst this pandemic. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Anxiety, stress, depression, COVID-19, lockdown Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fpsyg.2020.01491 Source A related resource from which the described resource is derived Frontiers in Psychology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Psychology https://www.socictopen.socict.org/files/original/547242a808dddb5000ee29573d9565df.pdf 726543b20db19640372f9b804eca09b4 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource COVID-19: Persistence, Precautions, Diagnosis and Challenges Creator An entity primarily responsible for making the resource Bhushan P. Bhusare, Vasudeo P. Zambare, Archana A. Naik Description An account of the resource After a century, the whole world fighting against the pandemic viral infection: a novel coronavirus,COVID-19. Currently, more than 210 countries are suffering from COVID-19 with the number of affectedcountries and patients are exponentially increasing day by day. It became a global health issue wheremore than 2.7 million cases were reported with a death ratio of approximate 7% globally by WorldHealth Organization (WHO) (as of 24 April 2020) which is a 22 times higher numbers in 1.5 month andthis figure increasing day by day at an alarming rate. The maximum infected cases reported from themost developed country and the world leader America however, the maximum death cases are fromthe world’s second health service provider country Italy. China, the origin country of COVID-19, hastaken serious actions in terms of prevention, control against the spreading of this coronavirus throughlockdown, sanitation, medication, and social distancing. The risk of transmissions of coronavirusfrom humans to humans is more and thus a social distancing is the best way for its persistence andprecautions. Thus, the COVID-19 outbreak continues must explore and evolve, certain strict andmandatory precautions to stop this dangerous devil virus. Also, it is a major challenge for all globalscientists to find out an effective remedial drug to control this deadly coronavirus before uncontrolledconditions. Thus, considering the depth of the spreading of coronavirus and its impact on global health,it is necessitating to know the dos and don’ts for persistence, precautions, and diagnostic strategiesagainst the challenging COVID-19. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Challenges, diagnosis, coronavirus, persistence, precautions, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.22207/JPAM.14.SPL1.19 Source A related resource from which the described resource is derived Journal of Pure and Applied Microbiology Publisher An entity responsible for making the resource available Journal of Pure and Applied Microbiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology https://www.socictopen.socict.org/files/original/8fb325262e15d523d4a10a2f62138f39.pdf 9dd35898da3af351e34429e72ce477c0 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Genetic Variant Severe Acute Respiratory Syndrome Coronavirus 2 Isolates in Thailand Creator An entity primarily responsible for making the resource Viroj Wiwanitkit, Beuy Joob Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource - Identifier An unambiguous reference to the resource within a given context DOI: 10.22207/JPAM.14.SPL1.01 Source A related resource from which the described resource is derived Journal of Pure and Applied Microbiology Publisher An entity responsible for making the resource available Journal of Pure and Applied Microbiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology https://www.socictopen.socict.org/files/original/0ebfdc2b025c9c061aab2e4eb44a924c.pdf beeed70e6c7c30b4b75bd42070cedce2 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19) Creator An entity primarily responsible for making the resource Paul E Marik, Ruben Manuel Luciano Colunga Biancatelli, John D Catravas, Max Berrill Description An account of the resource Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) represents an emergent global threat which is straining worldwide healthcare capacity. As of May 27th, the disease caused by SARS-CoV-2 (COVID-19) has resulted in more than 340,000 deaths worldwide, with 100,000 deaths in the US alone. It is imperative to study and develop pharmacological treatments suitable for the prevention and treatment of COVID-19. Ascorbic acid is a crucial vitamin necessary for the correct functioning of the immune system. It plays a role in stress response and has shown promising results when administered to the critically ill. Quercetin is a well-known flavonoid whose antiviral properties have been investigated in numerous studies. There is evidence that vitamin C and quercetin co-administration exerts a synergistic antiviral action due to overlapping antiviral and immunomodulatory properties and the capacity of ascorbate to recycle quercetin, increasing its efficacy. Safe, cheap interventions which have a sound biological rationale should be prioritized for experimental use in the current context of a global health pandemic. We present the current evidence for the use of vitamin C and quercetin both for prophylaxis in high-risk populations and for the treatment of COVID-19 patients as an adjunct to promising pharmacological agents such as Remdesivir or convalescent plasma. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Flavonoids, vitamin C, quercetin, antiviral, SARS-CoV-2, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fimmu.2020.01451 Source A related resource from which the described resource is derived Frontiers in Immunology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Immunologic diseases. Allergy https://www.socictopen.socict.org/files/original/c447756ab6fa6eeb827c750725e4e865.pdf 4bd122267004db24b6b33fb61ec5d1a1 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource When COVID-19 affects muscle: effects of quarantine in older adults Creator An entity primarily responsible for making the resource Antonio Paoli, Tatiana Moro Description An account of the resource At the beginning of 2020 a respiratory diseased named COVID-19 rapidly spread worldwide. Due to the presence of comorbidities and a greater susceptibility to infections, older adults are the population most affected by this pandemic. An efficient pharmacological treatment for COVID-19 is not ready yet; in the meanwhile, a general quarantine has been initiated as a preventive action against the spread of the disease.  If on one side this countermeasure is slowing the spread of the virus, on the other side is also reducing the amount of physical activity. Sedentariness is associated with numerous negative health outcomes and increase risk of fall, fractures and disabilities in older adults. Models of physical inactivity have been widely studied in the past decades, and most studies agreed that is necessary to implement physical exercise (such as walking, low load resistance or in bed exercise) during periods of disuse to protect muscle mass and function from catabolic crisis. Moreover, older adults have a blunted response to physical rehabilitation, and a combination of intense resistance training and nutrition are necessary to overcome the loss of in skeletal muscle due to disuse. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Aging, exercise, COVID-19, step reduction Identifier An unambiguous reference to the resource within a given context DOI: 10.4081/ejtm.0.9069 Source A related resource from which the described resource is derived European Journal of Translational Myology Publisher An entity responsible for making the resource available PAGEPress Publications Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine, Human anatomy