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                <text>Available Evidence and Ongoing Clinical Trials of Remdesivir: Could It Be a Promising Therapeutic Option for COVID-19?</text>
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                <text>Mekonnen Sisay</text>
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                <text>The novel coronavirus strain, severe acute respiratory syndrome coronavirus-2, the causative agent of COVID-19 emerged in Wuhan, China, in December 2019 and is skyrocketing throughout the globe and become a global public health emergency. Despite promising preventive measures being taken, there is no vaccine or drug therapy officially approved to prevent or treat the infection. Everybody is waiting the findings of ongoing clinical trials in various chemical and biological products. This review is specifically aimed to summarize the available evidence and ongoing clinical trials of remdesivir as a potential therapeutic option for COVID-19. Remdesivir is an investigational drug having broad spectrum antiviral activity with its target RNA dependent RNA polymerase. It has not yet been officially approved for Ebola and Coronaviruses. Several studies showed that remdesivir had promising in vitro and in vivo antiviral activities against SARS-CoV-1 and MERS-CoV strains. On the top of this, it exhibited a promising in vitro activity against SARS-CoV-2 strains though there are no published studies that substantiate its activity in vivo until the time of this review. There are few phase 3 randomized double-blind placebo controlled trials on the way to investigate the safety and efficacy of remdesivir. Of which, one completed double blind, placebo controlled trial showed that remdesivir showed faster time to clinical improvement in severe COVID-19 patients compared to placebo though not found statistically significant. In addition, two phase 3 randomized open label clinical trials coordinated by Gilead Sciences are being conducted. In addition, WHO Solidarity trial and INSERM DisCoVeRy trials (randomized open labels) were launched recently.</text>
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                <text>covid-19, SARS-CoV-2, Remdesivir, RdRp, GS-5734</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Therapeutics. Pharmacology</text>
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                <text>The Emerging Adults Gambling Survey: study protocol [version 1; peer review: 2 approved]</text>
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                <text>Heather Wardle</text>
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                <text>The Emerging Adults Gambling Survey is a longitudinal survey of young adults aged 16-24 living in Great Britain. It aims to explore a range of gambling behaviours and harms among young adults and examine how this changes over time. It is part of a broader project funded by Wellcome into the gambling behaviours of young people and its relationship with technological change. Funding is currently available for two waves of data collection: the first collected in June/August 2019 (n=3549) and the second to be collected in June/August 2020. The second wave of data collection will also obtain information about the immediate impact of coronavirus on gambling behaviours. With a sample size of 3549 for Wave 1, this is one of the largest study of gambling behaviours among young adults to be conducted in Great Britain and is a resource for other researchers to draw on. Data will be deposited in the UK Data Archive upon completion of Wave 2 data collection and analysis.  This protocol is intended to support other researchers to use this resource by setting out the study design and methods.</text>
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                <text>10.12688/wellcomeopenres.15969.1</text>
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                <text>Biotemas</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Das Strafrecht in der Krise</text>
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                <text>Gian Ege, David Eschle</text>
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                <text>Der Bundesrat hat im Rahmen der Massnahmen zur Bekämpfung des Coronavirus (Covid-19) Strafvorschriften auf Verordnungsebene erlassen und diese als Reaktion auf die sich rasch ändernden Umstände häufig angepasst. Das wirft die Fragen auf, ob der Bundesrat überhaupt Strafvorschriften erlassen darf und welchen Anforderungen diese genügen müssen. Eine Analyse der Strafbestimmungen in der COVID-19-Verordnung 2 zeigt, dass sich diese auf eine – wenn auch diskussionswürdige – Grundlage stützen können. Die konkrete Ausgestaltung verletzt allerdings teilweise das Verhältnismässigkeitsprinzip und das strafrechtliche Bestimmtheitsgebot. Ausserdem vermag die Notverordnungskompetenz des Bundesrates die Anwendung des Ordnungsbussenverfahrens auf gewisse Übertretungen nicht zu decken. Insgesamt ist es angezeigt, dass der bundesrätliche Umgang mit den Strafvorschriften überdacht wird, um für zukünftige Krisensituationen die richtigen Schlüsse zu ziehen.</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Law</text>
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                <text>Aggressive course of pemphigus vulgaris following COVID-19 infection.</text>
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                <text>Mohammad Reza Pourani, Fariba Ghalamkarpour</text>
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                <text>10.1111/dth.14398</text>
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                <text>Dermatologic therapy</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Study to Explore Psychological Aspects of COVID-19 Among Patients in Pakistan</text>
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                <text>Ali Farhan Farhan, Laraib Imran, Ali Hassan, Anum Munir, Afaque Ahmed, Sania Khurshid</text>
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                <text>COVID-19 outbreak is affecting the world population and has emerged as a global pandemic, started from the city Wuhan, China in December 2019. The physical and mental health that is being affected due to the trauma and suffering from COVID-19 leads to additional associated factors. It has been pointed by the physicians that mental health implications of COVID-19 are still unknown. In this study we analyzed the extent of response under the ambit of anxiety, depression and physical well-being of persons who have recovered from the novel COVID-19 in Pakistan. The rapid spread of COVID-19 has lead to health emergencies in mental health institutes implemented by the Governments of different countries. Considering the social impact, the outbreak leaves large and growing financial loses as business and trade industries are severely affected due to lockdown. Such situations are likely to increase the stress among the population and patients.  Patients with co-morbids, and old age were mostly affected.  Individuals from different districts of Pakistan were included in this study and total 104 designed questionnaires were distributed to the affected persons who have recovered from COVID-19.</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Social sciences (General)</text>
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                <text>Mauricio González Arias</text>
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                <text>The clinical case of a 38-year-old female patient, seen in an emergency room in a New York hospital, who consults for abdominal pain, fever and fatigue is presented. Complementary studies show lymphopenia and slight alteration of transaminases. Abdominopelvic CT scan visualizes images in the lung bases, reticulonodular type. A sample was taken for COVID-19. She was managed in emergencies with parenteral hydration, antipyretics, oral antibiotics are indicated and social isolation measures are instructed. Two days later, it cost again, confirming positive COVID-19. It is followed on an outpatient basis, one week later with good clinical evolution. Additionally, a clinical review and pathophysiological explanation of the involvement of the digestive tract by the virus and the atypical form of presentation with abdominal pain are shown.</text>
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                <text>2020</text>
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                <text>covid-19, Pandemic, Coronavirus infection, abdominal pain, glycoprotein  from  the  coronavirus  spike;</text>
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                <text>10.25176/RFMH.v20i2.2934</text>
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                <text>Revista de la Facultad de Medicina Humana</text>
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                <text>Universidad Ricardo Palma</text>
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                <text>Medicine, Medicine (General)</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>The Rationale for Potential Pharmacotherapy of COVID-19</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Eman Abu-Gharbieh, Mohamed  A. Saleh, Maha Saber-Ayad</text>
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                <text>On 11 March 2020, the coronavirus disease (COVID-19) was defined by the World Health Organization as a pandemic. Severe acute respiratory syndrome-2 (SARS-CoV-2) is the newly evolving human coronavirus infection that causes COVID-19, and it first appeared in Wuhan, China in December 2019 and spread rapidly all over the world. COVID-19 is being increasingly investigated through virology, epidemiology, and clinical management strategies. There is currently no established consensus on the standard of care in the pharmacological treatment of COVID-19 patients. However, certain medications suggested for other diseases have been shown to be potentially effective for treating this infection, though there has yet to be clear evidence. Therapies include new agents that are currently tested in several clinical trials, in addition to other medications that have been repurposed as antiviral and immune-modulating therapies. Previous high-morbidity human coronavirus epidemics such as the 2003 SARS-CoV and the 2012 Middle East respiratory syndrome coronavirus (MERS-CoV) prompted the identification of compounds that could theoretically be active against the emerging coronavirus SARS-CoV-2. Moreover, advances in molecular biology techniques and computational analysis have allowed for the better recognition of the virus structure and the quicker screening of chemical libraries to suggest potential therapies. This review aims to summarize rationalized pharmacotherapy considerations in COVID-19 patients in order to serve as a tool for health care professionals at the forefront of clinical care during this pandemic. All the reviewed therapies require either additional drug development or randomized large-scale clinical trials to be justified for clinical use.</text>
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                <text>2020</text>
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                <text>covid-19, SARS-CoV-2, chloroquine, favipiravir, Remdesivir, lopinavir</text>
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            <name>Identifier</name>
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                <text>10.3390/ph13050096</text>
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                <text>Epidemiology and Health</text>
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              <elementText elementTextId="44840">
                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="44841">
                <text>Medicine, Pharmacy and materia medica</text>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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                <text>From Preaching Faith to Spreading the Virus: A Study of The Tablighi Jama’at in Pakistan</text>
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                <text>Kausar Ali, Huang Minxing</text>
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                <text>With the emergence of coronavirus disease or coronavirus pandemic, now popularly known as COVID-19, a new world-wide discussion started that religion and religious gatherings playing an active role in accelerating the spread of coronavirus in the world. If, on the one hand, religious gatherings were banned or at least limited in some Muslim countries while on the other hand, such faith-based gatherings have proven to be the hotbeds for outbreaks. The purpose of this study is to investigate the connection between the Tablighi Jama’at (TJ) and the coronavirus in Pakistan. It is believed that the participants carried the virus into different parts of Pakistan. This study finds that Tablighi Jamaat’s factor in the spread of coronavirus in Pakistan cannot be ignored. Shia pilgrims from Iran also brought the virus from Iran into Pakistan. The paper finds that this pandemic may once again raise the issue of sectarianism in the county. The present research finds that Islamists have always been supported by the state. Now it has become very difficult for state policy-makers to resist them in the present fight against the coronavirus.</text>
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              <elementText elementTextId="44845">
                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>coronavirus, Pakistan, political Islam, Tablīghī Jamaʻāt, shia pilgrims, annual ijtima</text>
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              <elementText elementTextId="44847">
                <text>Epidemiology and Health</text>
              </elementText>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="44848">
                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="44849">
                <text>Social sciences (General)</text>
              </elementText>
            </elementTextContainer>
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              <name>Title</name>
              <description>A name given to the resource</description>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>International Evidence of COVID-19 and Stock Market Returns: An Event Study Analysis</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Ahmad Bash</text>
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            <description>An account of the resource</description>
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                <text>We study the effect of the first registered case of COVID-19 on stock market returns using event study analysis. Mean-adjusted returns and market model methods are used to estimate cumulative abnormal returns for 30 countries. The results show that stock market returns experience a downwards trend as well as significant negative returns following the COVID-19 outbreak.Keywords: COVID-19, event study, index returns; pandemicsJEL Classification: G14DOI: https://doi.org/10.32479/ijefi.9941</text>
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            <name>Date</name>
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              <elementText elementTextId="44853">
                <text>2020</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="44854">
                <text>Biotemas</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="44855">
                <text>Universidade Federal de Santa Catarina</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Business, Economics as a science</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              </elementTextContainer>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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              </elementTextContainer>
            </element>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
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                <text>COVID-19 and lessons from multi-hazard early warning systems</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="44858">
                <text>D. P. Rogers, L. Anderson-Berry, A.-M. Bogdanova, G. Fleming, H. Gitay, S. Kahandawa, H. Kootval, M. Staudinger, M. Suwa, V. Tsirkunov, W. Wang</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>Having a common framework for early action to cope with complex disasters can make it easier for authorities and other stakeholders, including populations at risk, to understand the full spectrum of secondary and tertiary effects and thus where to focus preparedness efforts, and how best to provide more targeted warnings and response services. Meteorological and hydrological services world-wide have developed and implemented Multi-Hazard Early Warning Systems (MHEWS) for weather and climate related hazards that are now being expanded and transitioned towards Multi-Hazard Impact-based Early Warning Systems (MHIEWS). While it is still early days it is becoming clear that there are useful lessons from this approach in the COVID-19 global pandemic, and some valuable insight to be gained in risk communication, risk analysis and monitoring methodologies and approaches. The ability to understand and respond effectively to warnings through appropriate behaviours and actions is central to resilient societies and communities. By avoiding physical, societal and economic harm to the greatest extent possible, recovery from a hazard is likely to be faster, less costly and more complete.     MHIEWS can be a common approach for all hazards and therefore more likely to become a trusted tool that everyone can understand and use as a basic element of their national disaster risk management system. The interconnectedness of hazards and their impacts is a strong motivator for a common approach. One of the lessons from the COVID-19 pandemic and extreme weather events is the need to understand the vulnerability of individuals, communities and societies so as to provide reliable, targeted guidance and warnings and the willingness and capacity to prepare for a reasonable worst-case scenario based on informed long-term planning. Meteorology and hydrology are making good progress in this direction and the process can be readily applied to health and other sectors.</text>
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                <text>2020</text>
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