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                <text>A Review on SARS-CoV-2 Virology, Pathophysiology, Animal Models, and Anti-Viral Interventions</text>
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                <text>Sabari  Nath Neerukonda, Upendra Katneni</text>
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                <text>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of CoV disease 2019 (COVID-19) is a highly pathogenic and transmissible CoV that is presently plaguing the global human population and economy. No proven effective antiviral therapy or vaccine currently exists, and supportive care remains to be the cornerstone treatment. Through previous lessons learned from SARS-CoV-1 and MERS-CoV studies, scientific groups worldwide have rapidly expanded the knowledge pertaining to SARS-CoV-2 virology that includes in vitro and in vivo models for testing of antiviral therapies and randomized clinical trials. In the present narrative, we review SARS-CoV-2 virology, clinical features, pathophysiology, and animal models with a specific focus on the antiviral and adjunctive therapies currently being tested or that require testing in animal models and randomized clinical trials.</text>
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                <text>10.3390/pathogens9060426</text>
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                <text>Biotemas</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                <text>Does Two-Class Training Extract Real Features? A COVID-19 Case Study</text>
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                <text>Luis Muñoz-Saavedra, Javier Civit-Masot, Francisco Luna-Perejón, Manuel Domínguez-Morales, Antón Civit</text>
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                <text>Diagnosis aid systems that use image analysis are currently very useful due to the large workload of health professionals involved in making diagnoses. In recent years, Convolutional Neural Networks (CNNs) have been used to help in these tasks. For this reason, multiple studies that analyze the detection precision for several diseases have been developed. However, many of these works distinguish between only two classes: healthy and with a specific disease. Based on this premise, in this work, we try to answer the questions: When training an image classification system with only two classes (healthy and sick), does this system extract the specific features of this disease, or does it only obtain the features that differentiate it from a healthy patient? Trying to answer these questions, we analyze the particular case of COVID-19 detection. Many works that classify this disease using X-ray images have been published; some of them use two classes (with and without COVID-19), while others include more classes (pneumonia, SARS, influenza, etc.). In this work, we carry out several classification studies with two classes, using test images that do not belong to those classes, in order to try to answer the previous questions. The first studies indicate problems in these two-class systems when using a third class as a test, being classified inconsistently. Deeper studies show that deep learning systems trained with two classes do not correctly extract the characteristics of pathologies, but rather differentiate the classes based on the physical characteristics of the images. After the discussion, we conclude that these two-class trained deep learning systems are not valid if there are other diseases that cause similar symptoms.</text>
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                <text>10.3390/app11041424</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>BCG Vaccination and Mortality of COVID-19 across 173 Countries: An Ecological Study</text>
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                <text>Mitsuyoshi Urashima, Katharina Otani, Yasutaka Hasegawa, Taisuke Akutsu</text>
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                <text>Ecological studies have suggested fewer COVID-19 morbidities and mortalities in Bacillus Calmette–Guérin (BCG)-vaccinated countries than BCG-non-vaccinated countries. However, these studies obtained data during the early phase of the pandemic and did not adjust for potential confounders, including PCR-test numbers per population (PCR-tests). Currently—more than four months after declaration of the pandemic—the BCG-hypothesis needs reexamining. An ecological study was conducted by obtaining data of 61 factors in 173 countries, including BCG vaccine coverage (%), using morbidity and mortality as outcomes, obtained from open resources. ‘Urban population (%)’ and ‘insufficient physical activity (%)’ in each country was positively associated with morbidity, but not mortality, after adjustment for PCR-tests. On the other hand, recent BCG vaccine coverage (%) was negatively associated with mortality, but not morbidity, even with adjustment for percentage of the population ≥ 60 years of age, morbidity, PCR-tests and other factors. The results of this study generated a hypothesis that a national BCG vaccination program seems to be associated with reduced mortality of COVID-19, although this needs to be further examined and proved by randomized clinical trials.</text>
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                <text>Urbanization, covid-19, Coronavirus disease 2019, Vaccination, BCG, bacillus Calmette–Guérin</text>
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                <text>10.3390/ijerph17155589</text>
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                <text>Korean Society of Epidemiology</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>High-Efficiency Simulation Framework to Analyze the Impact of Exhaust Air from COVID-19 Temporary Hospitals and its Typical Applications</text>
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                <text>Xinzheng Lu, Zhe Zheng, Donglian Gu, Pengju Zhao, Linlin Xie, Zhen Xu</text>
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                <text>The outbreak of COVID-19 resulted in severe pressure on the existing medical infrastructure in China. Several Chinese cities began to construct temporary hospitals for the centralized treatment of COVID-19 patients. The harmful exhaust air from the outlets of these hospitals may have a significant adverse impact on the fresh-air intakes and surrounding environment. Owing to the need to rapidly construct these hospitals within 6–10 days, just a few hours are allowed for the analysis of the impact of this exhaust air on the environment. To overcome this difficulty, a high-efficiency simulation framework is proposed in this study. Based on the open-source computational fluid dynamics software, FDS, the proposed framework is adaptive and incorporates building information with different levels of detail during various design phases of the hospital, and has been applied in the design of the Wuhan Huoshenshan Hospital, the first typical COVID-19 temporary hospital in China. According to the simulation results, neither the fresh-air intakes nor the surrounding buildings would be polluted by the harmful air discharged from the air outlets of the Huoshenshan hospital. The proposed simulation framework can provide a reference for the design and overall planning of similar hospitals in China and other affected countries.</text>
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                <text>covid-19, SARS-CoV-2, FDS, Pollutant dispersion, LOD</text>
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                <text>10.3390/app10113949</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Biology (General), Chemistry, Engineering (General). Civil engineering (General), Technology, Physics</text>
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          <element elementId="39">
            <name>Creator</name>
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            <elementTextContainer>
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                <text>Nikolovski Srđan, Knežević Snežana, Marković Ivan, Milojević Stefan, Živković Dragan, Mitrović Aleksandra, Fišer Zlatko, Đurđević Dragan</text>
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            <description>An account of the resource</description>
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                <text>Background/Aim. Along with the great impact of 2019 coronavirus disease (COVID-19) on physical health, social functioning, and economy, this public health emergency has significant impact on mental health of people as well. The aim of this study was to assess the impact of outbreak-related information and public trust in the health system and preventive measures during the COVID-19 outbreak in Serbia in 2020 on levels of anxiety and depression in education, army and healthcare professionals. Methods. An anonymous questionnaire was disseminated to skilled professionals working in fields of education, army, and healthcare. The questionnaire included the Beck Anxiety Inventory, Zung Self-Rating Depression Scale, as well as the section assessing the perceived disturbance by the outbreak-related information and the trust of participants in healthcare system and preventive measures proposed by the crisis team. Results. Out of 110 subjects enrolled in this study (mean age 35.25 ± 9.23 years), 59.1% were women. Among healthcare workers, the frequency of perceiving outbreak-related information available in public media as disturbing, as well as the average level of anxiety, were higher compared to the group of army professionals (p &lt; 0.05). Women also perceived outbreak-related information available in public media as disturbing in a higher percentage compared to men (p &lt; 0.01), and had higher levels of anxiety (p = 0.01) and depression (p &lt; 0.05). The lack of public trust was associated with higher levels of depression, and the perception of outbreak-related information as disturbing with higher levels of both anxiety and depression. Conclusion. Significant perception of outbreak-related information as disturbing among healthcare workers, as well as the lack of trust in healthcare system and preventive measures proposed by the crisis team are important factors influencing the mental state. This finding has the guiding purpose for competent institutions to make efforts to increase public trust, as one of the important preventive measures, in order to preserve and improve the mental well-being of the population in outbreak conditions.</text>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>Anxiety, mental health, covid-19, Depression, Medicine, preventive, Surveys and questionnaires, Communications media</text>
              </elementText>
            </elementTextContainer>
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            <name>Identifier</name>
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                <text>10.2298/VSP200713108M</text>
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          </element>
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              <elementText elementTextId="47883">
                <text>Biotemas</text>
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            </elementTextContainer>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Universidade Federal de Santa Catarina</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="47885">
                <text>Medicine (General)</text>
              </elementText>
            </elementTextContainer>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Impact of COVID-19 on Performance Evaluation Large Market Capitalization Stocks and Open Innovation</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="47887">
                <text>Immas Nurhayati, Endri Endri, Renea  Shinta Aminda, Leny Muniroh</text>
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            <description>An account of the resource</description>
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                <text>This research is an event study that evaluates the performance of large market capitalization shares using a performance model that is adjusted to risks due to the COVID-19 outbreak. The study measured the performance of large market capitalization stocks which represented each tick size on the Indonesian Stock Exchange during the COVID-19 pandemic using the Sharpe Index, the Treynor Ratio, and Jensen’s Alpha. The sample selection used a purposive sampling technique and 24 stocks were selected as samples in the study. We used the daily closing price of stocks, the Indonesia composite index, and average risk-free rate return (BI rate). By using Jensen’s Alpha, this study found that FREN was the highest beta with a value of 1.8189, indicating that the index was an effective and well-diversified stock. FREN is low priced and the highest market capitalization stock in its tick size (third tier stocks). Jensen’s Alpha is good for measuring the performance of large capitalization and low-priced stocks. There are eight stocks that always have negative values in each method of measuring stock performance, which indicates that these stocks underperformed during COVID-19.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2021</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="47890">
                <text>Covid-19 outbreak, event study, Risk-adjusted Performance, large market capitalization, underperformed</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="47891">
                <text>10.3390/joitmc7010056</text>
              </elementText>
            </elementTextContainer>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="47892">
                <text>Epidemiology and Health</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="47893">
                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="47894">
                <text>Business, Management. Industrial management</text>
              </elementText>
            </elementTextContainer>
          </element>
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          <elementContainer>
            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
                  <text>Coronavirus</text>
                </elementText>
              </elementTextContainer>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="47895">
                <text>The relationship among performance risk, safety risk, social risk, psychological risk, satisfaction and intentions to use grab service in Vietnam amid Covid-19 crisis</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="47896">
                <text>Van Dat Tran</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="47897">
                <text>This study aims to investigate the relationship among performance risk, safety risk, social risk, psychological risk, satisfaction, and intention to use Grab in Vietnam. Validated measurements were identified from a literature review. A convenience sample of 276 respondents was collected through online and offline survey. It was then analyzed by using SPSS and AMOS software. A reliability test, EFA, CFA and SEM were implemented. The results of this study indicate a negative relationship between safety risk and satisfaction and intention to use Grab cars. In addition, passengers’ satisfaction influenced intentions to use Grab cars. However, performance risk and social risk show no effect on satisfaction and intentions to use Grab service. The main contribution of this study is to create a framework of the effect of perceived risk types on intention to use Grab cars. The users care about their own safety and information security. In addition, the issue of said psychological risk is important because consumers are concerned about health and infectious diseases.</text>
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            </elementTextContainer>
          </element>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="47898">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
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            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="47899">
                <text>intentions to use, social risk, safety risk, psychological risk, Performance risk</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="47900">
                <text>10.5267/j.jpm.2020.8.003</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="47901">
                <text>Journal of Project Management</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="47902">
                <text>Growing Science</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="47903">
                <text>Business, Management. Industrial management</text>
              </elementText>
            </elementTextContainer>
          </element>
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  <item itemId="5347" public="1" featured="0">
    <fileContainer>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
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      </elementSetContainer>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Erratum to: Joint Guidance from the Society of Gastrointestinal Endoscopy of India (SGEI), Indian Society of Gastroenterology (ISG), and Indian National Association for Study of the Liver (INASL) for Gastroenterologists and Gastrointestinal Endoscopists on the Prevention, Care, and Management of Patients with COVID-19</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Mathew Philip, Sundeep Lakhtakia, Rakesh Aggarwal, Kaushal Madan, Vivek Saraswat, Govind Makharia</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2019</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>10.1055/s-0040-1710776</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="47908">
                <text>Journal of Digestive Endoscopy</text>
              </elementText>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="47909">
                <text>Thieme Medical and Scientific Publishers Pvt. Ltd.</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="47910">
                <text>Diseases of the digestive system. Gastroenterology</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Potential COVID-19 Outbreak in Fire Camp: Modeling Scenarios and Interventions</text>
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            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="47912">
                <text>Matthew P. Thompson, Jude Bayham, Erin Belval</text>
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            <description>An account of the resource</description>
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                <text>The global COVID-19 pandemic will pose unique challenges to the management of wildland fire in 2020. Fire camps may provide an ideal setting for the transmission of SARS-CoV-2, the virus that causes COVID-19. However, intervention strategies can help minimize disease spread and reduce the risk to the firefighting community. We developed a COVID-19 epidemic model to highlight the risks posed by the disease during wildland fire incidents. Our model accounts for the transient nature of the population on a wildland fire incident, which poses unique risks to the management of communicable diseases in fire camps. We used the model to assess the impact of two types of interventions: the screening of a firefighter arriving on an incident, and social distancing measures. Our results suggest that both interventions are important to mitigate the risks posed by the SARS-CoV-2 virus. However, screening is relatively more effective on short incidents, whereas social distancing is relatively more effective during extended campaigns. We conclude with a discussion of model limitations and potential extensions to the model.</text>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>risk, SARS-CoV-2, suppression, Wildland Fire, workforce capacity</text>
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            <name>Identifier</name>
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                <text>10.3390/fire3030038</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Physics</text>
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          <name>Dublin Core</name>
          <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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          </elementContainer>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="47920">
                <text>Reliable energy and responsive built environment: the missing links in COVID-19 response in resource-limited settings</text>
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            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="47921">
                <text>Arvind Vashishta Rinkoo, Dinesh Songara, Arnika Sharma, Biswa Ranjan Patnaik, Rajesh Ranjan Singh, Rakesh Kumar Srivastava</text>
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            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="47922">
                <text>Abstract Irrespective of how the COVID-19 pandemic evolves over time across the globe, our past experiences with comparable zoonotic diseases demonstrate the significance of having resilient primary healthcare systems to successfully respond to public health emergencies. However, literature corroborates that in low- and middle-income countries, the primary healthcare systems are plagued with significant energy insecurity and inadequate built environment. These gaps in reliable energy and responsive built environment in primary healthcare systems are exacerbated during disruptive public health emergencies such as COVID-19. In this letter, we discuss the way forward to address these gaps and the policy and practical implications thereof.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="47923">
                <text>2020</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="47924">
                <text>Low- and middle-income countries, covid-19, PRIMARY HEALTH CARE, Built environment, energy insecurity</text>
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            </elementTextContainer>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="47925">
                <text>10.1186/s41182-020-00255-2</text>
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            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="47926">
                <text>Epidemiology and Health</text>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="47927">
                <text>Korean Society of Epidemiology</text>
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            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="47928">
                <text>Arctic medicine. Tropical medicine</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
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    </elementSetContainer>
  </item>
</itemContainer>
