662 10 20655 https://www.socictopen.socict.org/files/original/da66fe2549b87f8f29f01869f7a16e9b.pdf fde60e7518db6df93025eccdf4482287 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Process development and scale-up optimization of the SARS-CoV-2 receptor binding domain-based vaccine candidate, RBD219-N1C1. Creator An entity primarily responsible for making the resource Jungsoon Lee, Zhuyun Liu, Wen-Hsiang Chen, Junfei Wei, Rakhi Kundu, Rakesh Adhikari, Joanne Altieri Rivera, Portia M Gillespie, Ulrich Strych, Bin Zhan, Peter J Hotez, Maria Elena Bottazzi Description An account of the resource A SARS-CoV-2 RBD219-N1C1 (RBD219-N1C1) recombinant protein antigen formulated on Alhydrogel® has recently been shown to elicit a robust neutralizing antibody response against SARS-CoV-2 pseudovirus in mice. The antigen has been produced under current good manufacturing practices (cGMPs) and is now in clinical testing. Here, we report on process development and scale-up optimization for upstream fermentation and downstream purification of the antigen. This includes production at the 1-L and 5-L scales in the yeast, Pichia pastoris, and the comparison of three different chromatographic purification methods. This culminated in the selection of a process to produce RBD219-N1C1 with a yield of >400 mg per liter of fermentation with >92% purity and >39% target product recovery after purification. In addition, we show the results from analytical studies, including SEC-HPLC, DLS, and an ACE2 receptor binding assay that were performed to characterize the purified proteins to select the best purification process. Finally, we propose an optimized upstream fermentation and downstream purification process that generates quality RBD219-N1C1 protein antigen and is fully scalable at a low cost. KEY POINTS: • Yeast fermentation conditions for a recombinant COVID-19 vaccine were determined. • Three purification protocols for a COVID-19 vaccine antigen were compared. • Reproducibility of a scalable, low-cost process for a COVID-19 vaccine was shown. Graphical abstract. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource spike protein, covid-19, Fermentation, purification, Pichia pastoris Identifier An unambiguous reference to the resource within a given context 10.1007/s00253-021-11281-3 Source A related resource from which the described resource is derived Applied microbiology and biotechnology https://www.socictopen.socict.org/files/original/78d1ac9daa790d483152a8765a99cdd0.pdf 52d3531c08f791f765a7d569a86333cf Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Abandoned Covid-19 personal protective equipment along the Bushehr shores, the Persian Gulf: An emerging source of secondary microplastics in coastlines. Creator An entity primarily responsible for making the resource Razegheh Akhbarizadeh, Sina Dobaradaran, Iraj Nabipour, Mahbubeh Tangestani, Delaram Abedi, Fatemeh Javanfekr, Faezeh Jeddi, Atefeh Zendehboodi Description An account of the resource During the Covid-19 pandemic, personal protection equipment (PPE) was widely used to control the virus further spared. In this study, the presence of PPE wastes along the coastline of Bushehr port, the Persian Gulf from nine stations was investigated (4 times during 40 days), and their potential for microplastics (MPs) creation was preliminarily assessed. In total, more than 2380 PPE were collected in the study area. No significant differences were found between various beaches regarding their types and common activities. In addition, the estimated disposal rate of PPE per day and year is 350 and 127,750 items, respectively. More than 10% of the collected PPE from Bushehr's coastal areas on each sampling day were damaged. Based on the microscopic analysis, the left surgical masks and torn plastic gloves in the coastal regions are emerging sources of secondary microfibers and MP particles (mostly fragments and films) in the marine environments, respectively. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource coronavirus, face-masks, marine pollution, Micropollutants, Plastic gloves Identifier An unambiguous reference to the resource within a given context 10.1016/j.marpolbul.2021.112386 Source A related resource from which the described resource is derived Marine pollution bulletin https://www.socictopen.socict.org/files/original/18bc0404803daa68e16b79423ad766aa.pdf 6621e1e7e0fbd292b541e71c4f360ce7 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Analysing urban traffic volumes and mapping noise emissions in Rome (Italy) in the context of containment measures for the COVID-19 disease Creator An entity primarily responsible for making the resource Aletta Francesco, Brinchi Stefano, Carrese Stefano, Gemma Andrea, Guattari Claudia, Mannini Livia, Patella Sergio Maria Description An account of the resource This study presents the result of a traffic simulation analysis based on Floating Car Data and a noise emission assessment to show the impact of mobility restriction for COVID-19 containment on urban vehicular traffic and road noise pollution on the road network of Rome, Italy. The adoption of strong and severe measures to contain the spreading of Coronavirus during March-April 2020 generated a significant reduction in private vehicle trips in the city of Rome (-64.6% during the lockdown). Traffic volumes, obtained through a simulation approach, were used as input parameters for a noise emission assessment conducted using the CNOSSOS-EU method, and an overall noise emissions reduction on the entire road network was found, even if its extent varied between road types. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, Containment strategies, noise mapping, traffic simulation, floating car data, italy’s coronavirus epidemic, transport restriction, urban noise pollution Identifier An unambiguous reference to the resource within a given context 10.1515/noise-2020-0010 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Environmental technology. Sanitary engineering https://www.socictopen.socict.org/files/original/7919db8d4a7b8056f9fbbb4f3e551fa9.pdf e3a346daaec7a1deb9ce99289265e0b1 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Decoupling of urban CO₂ and air pollutant emission reductions during the European SARS-CoV-2 lockdown Creator An entity primarily responsible for making the resource C. Lamprecht, M. Graus, M. Striednig, M. Stichaner, T. Karl Description An account of the resource Lockdown and the associated massive reduction in people's mobility imposed by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) mitigation measures across the globe provide a unique sensitivity experiment to investigate impacts on carbon and air pollution emissions. We present an integrated observational analysis based on long-term in situ multispecies eddy flux measurements, allowing for quantifying near-real-time changes of urban surface emissions for key air quality and climate tracers. During the first European SARS-CoV-2 wave we find that the emission reduction of classic air pollutants decoupled from CO2 and was significantly larger. These differences can only be rationalized by the different nature of urban combustion sources and point towards a systematic bias of extrapolated urban NOx emissions in state-of-the-art emission models. The analysis suggests that European policies, shifting residential, public, and commercial energy demand towards cleaner combustion, have helped to improve air quality more than expected and that the urban NOx flux remains to be dominated (e.g., &gt;90 %) by traffic. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Identifier An unambiguous reference to the resource within a given context 10.5194/acp-21-3091-2021 Source A related resource from which the described resource is derived Atmospheric Chemistry and Physics Publisher An entity responsible for making the resource available Copernicus Publications Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Chemistry, Physics https://www.socictopen.socict.org/files/original/1127ad5e5efd78596e2d2712908d753b.pdf 5ef3b46c2d361a7e8d2097c44166f7ae Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Covid-19 in a patient with ANCA-associated systemic vasculitis, receiving anti-B cell therapy (rituximab) Creator An entity primarily responsible for making the resource T. V. Beketova, L. M. Blank, A. M. Lila Description An account of the resource Despite numerous publications on COVID-19, at present, conceptual thinking of the problem is only at a nascence stage. Treatment of patients with ANCA-associated systemic vasculitis (AAV) during the COVID-19 pandemic is one of the relevant issues. Management of COVID-19 in AAV patients undergoing anti-B cell therapy with rituximab (RTM) requires comprehensive reasoning. This paper presents a case report about COVID-19 in a 59-year-old female with AAV in remission, who was previously treated with RTM. COVID-19 was diagnosed one month after the last RTM administration; there were moderate bilateral pneumonia, fever, and extrapulmonary manifestations, including lesions of the gastrointestinal tract and central nervous system. Clinical outcome of COVID-19 was favorable, with no signs of respiratory failure, and CRP values did not exceed 29 mg/l. We discuss published data on RTM use during COVID-19 pandemic and the effects of B cells and their depletion on the course and outcomes of COVID-19. Our case report and available published data do not allow to consider RTM therapy as a factor associated with severe course of COVID-19 and adverse outcome. Further analysis of COVID-19 in patients with AAV and other rheumatic diseases is important. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, rituximab, B cells, vasculitis, ANCA Identifier An unambiguous reference to the resource within a given context 10.47360/1995-4484-2020-456-462 Source A related resource from which the described resource is derived Научно-практическая ревматология Publisher An entity responsible for making the resource available IMA-PRESS LLC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Diseases of the musculoskeletal system https://www.socictopen.socict.org/files/original/25c40d7ab2195b087d67249063a5e01f.pdf e2a3e988d2aaaa63aa9168e2161f9325 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Elderly-onset rheumatoid arthritis: an outlook from a practicing rheumatologist Creator An entity primarily responsible for making the resource Ch. Baimukhamedov Description An account of the resource All current challenges and concerns associated with rheumatoid arthritis (RA) in the elderly are analyzed from the point of view of a practicing rheumatologist, including issues of terminology and diagnostics, the need to develop classification criteria for RA presenting at old age. This paper also discusses RA management in the elderly during the coronavirus disease 2019 (COVID-19) pandemic. A multicenter international study, initiated by the League of Eurasian Rheumatologists, can provide necessary insight to develop unified recommendations for RAP. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, Aged, rheumatoid arthritis Identifier An unambiguous reference to the resource within a given context 10.47360/1995-4484-2020-447-450 Source A related resource from which the described resource is derived Научно-практическая ревматология Publisher An entity responsible for making the resource available IMA-PRESS LLC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Diseases of the musculoskeletal system https://www.socictopen.socict.org/files/original/be8f24a9bafbb6a26d71beca9923a413.pdf 9b74e45fd66da0958c2bc527f2980809 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The Efficacy of Music for Emotional Wellbeing During the COVID-19 Lockdown in Spain: An Analysis of Personal and Context-Related Variables Creator An entity primarily responsible for making the resource Pastora Martínez-Castilla, Isabel M. Gutiérrez-Blasco, Daniel H. Spitz, Roni Granot Description An account of the resource The strict lockdown experienced in Spain during March–June 2020 as a consequence of the COVID-19 crisis has led to strong negative emotions. Music can contribute to enhancing wellbeing, but the extent of this effect may be modulated by both personal and context-related variables. This study aimed to analyze the impact of the two types of variables on the perceived efficacy of musical behaviors to fulfill adults’ emotional wellbeing-related goals during the lockdown established in Spain. Personal variables included age, gender, musical training, personality, resilience, and perception of music’s importance. Contextual variables referred to living in a region with a high COVID-19 impact, perception of belonging to a risk group, being alone, having caring responsibilities during confinement, and amount of time of music listening as compared to prior to the crisis. The study was conducted retrospectively during August–December 2020, when the strict lockdown was over in Spain. An online survey was disseminated among the general population and groups of musicians, and the answers of 507 adults (from 18 years on, 73.9% females, 51.3% musically trained adults) were analyzed. Only personal, but not COVID-19 context-related variables, showed an impact on music’s efficacy. The youngest age group of adults and those with musical training reported the highest efficacy of music for wellbeing enhancement, and music’s importance was found to be the main significant predictor of music’s perceived efficacy. Our findings suggest that the people who have been reported to be emotionally more vulnerable during the lockdown, due to either a strong impact on their daily lives or their lower resilience, perceive a higher benefit from musical behaviors. Being musically trained, even for a small number of years, also leads to a perception of higher efficacy of music for the achievement of emotional wellbeing goals. However, this effect is explained by the musically trained individuals’ higher perception of music’s importance. Although musical behaviors can be generally considered as important for wellbeing enhancement, our study highlights who are the potential individuals who could benefit the most from music-related activities for obtaining better levels of wellbeing, at least within the current context of the COVID-19 crisis. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, Spain, Music, Efficacy, affect regulation, emotional well-being Identifier An unambiguous reference to the resource within a given context 10.3389/fpsyg.2021.647837 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Psychology https://www.socictopen.socict.org/files/original/5a88fc48bbf5053d63e6f734aa8645ce.pdf a1baf071808b9d127bf024525d423116 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The Impact of COVID−19 on Female Sexual Health Creator An entity primarily responsible for making the resource Anna Fuchs, Aleksandra Matonóg, Joanna Pilarska, Paulina Sieradzka, Mateusz Szul, Bartosz Czuba, Agnieszka Drosdzol-Cop Description An account of the resource Introduction: Coronavirus disease (COVID−19), announced as a pandemic by the World Health Organization, recently has dominated people’s lifestyle. The impact of COVID−19 seems to be relevant to the sexual health as well. Methods: This prospective study was conducted on two occasions involving 764 female patients between March and April 2020—before and during the time of social quarantine. The sexual function was assessed using the Polish version of the Female Sexual Function Index (FSFI). Every patient filled out the survey concerning socio-demographic characteristics as well as the influence of SARS-CoV−2 pandemic on their lives. Results: The overall FSFI score before the pandemic was 30.1 ± 4.4 and changed to 25.8 ± 9.7 during it. Scores of every domain: desire, arousal, lubrication, orgasm, satisfaction and pain decreased as well (p < 0.001). There was statistically significant association between the workplace and the change of FSFI scores before and during COVID−19 pandemic (p < 0.01). We noticed the biggest decrease in FSFI score in the group of women who did not work at all (5.2 ± 9.9). Religion had a statistically important impact on level of anxiety (p < 0.01). Conclusion: The main finding of our study was the influence of COVID−19 pandemic on the quality of sexual lifestyle and frequency of intercourse among Polish women. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Sexuality, coronavirus disease 2019 COVID–19, desire, Sexual Dysfunction, COVID−19 virus, SARS-CoV−2 pandemic Identifier An unambiguous reference to the resource within a given context 10.3390/ijerph17197152 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/b4e5d166fdbc9e241db432b3946e747d.pdf 00184b2fc4877330325ee50227900d6a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Beyond the School Walls: Keeping Interactive Learning Environments Alive in Confinement for Students in Special Education Creator An entity primarily responsible for making the resource Sandra Racionero-Plaza, Garazi Álvarez-Guerrero, Ane López de Aguileta, Lirio Gissela Flores-Moncada Description An account of the resource The COVID-19 pandemic and the accompanying safety measures, including confinement, has meant an unprecedented challenge for the world population today. However, it has entailed additional difficulties for specific populations, including children and people with disabilities. Being out of school for months has reduced the learning opportunities for many children, such as those with less academic resources at home or with poorer technological connectivity. For students with disabilities, it has entailed losing the quality of the special attention they often need, in addition to a more limited understanding of the situation. In this context, a case study was conducted in a special education classroom of a secondary education school. This class started implementing Dialogic Literary Gatherings with their special education students before the COVID-19 confinement and continued online during the confinement. Qualitative data was collected after a period of implementation of the gatherings showing positive impacts on the participants. The case study shows that interactive learning environments such as the Dialogic Literary Gatherings can provide quality distance learning for students with disabilities, contributing to overcome some of the barriers that the pandemic context creates for the education of these students. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource distance learning, successful educational actions, interactive learning environments, special education needs, dialogic gatherings Identifier An unambiguous reference to the resource within a given context 10.3389/fpsyg.2021.662646 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Psychology https://www.socictopen.socict.org/files/original/eb056dbe3844c768475bdeb13961081f.pdf be9f4e88decb81a40282f2a0799739d3 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource El riñón en cuidado intensivo durante la pandemia por SARS-COV-2 Creator An entity primarily responsible for making the resource Daniel Ricardo Santiago Ausecha, David Ballesteros, Jorge Armando Pulido Saenz Description An account of the resource Introducción: la emergencia actual por SARS-CoV-2 se ha esparcido rápidamente por todo el mundo, lo cual ha demostrado el potencial epidémico de los coronavirus. La preocupación a nivel mundial se ha centrado en la necesidad de contar con unidades de cuidado intensivo (UCI) y medidas de soporte como la ventilación mecánica. La lesión renal aguda en este contexto es una complicación asociada a una alta morbimortalidad que requiere una atención rápida y oportuna.Objetivo: revisar la literatura sobre el COVID-19 y sus manifestaciones renales en las UCI.Materiales y métodos: se realizó una búsqueda de la literatura en la base de datos de PubMed con las palabras claves “Intensive Care Units “Critial care” “COVID-19” “severe acute respiratory syndrome coronavirus 2” “SARS-CoV-2” “2019 novel coronavirus” “coronavirus disease 2019” “acute kidney injury” y “Nephrologists.Resultados: se encontraron 74 publicaciones, 53 relacionadas directamente con la infección por coronavirus y 21 complementarias en cuanto a lesión renal aguda.Conclusión: el riñón está involucrado en la fisiopatología de la COVID-19 y su disfunción se ha asociado con resultados fatales, por lo que su vigilancia y tratamiento se debe priorizar desde el ingreso del paciente para mejorar su pronóstico Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, SARS-CoV-2, unidad de cuidados intensivos, Lesión renal aguda, terapia de reemplazo renal (decs Identifier An unambiguous reference to the resource within a given context https://doi.org/10.22265/acnef.7.Supl.2.432 Source A related resource from which the described resource is derived Revista Colombiana de Nefrología Publisher An entity responsible for making the resource available Asociación Colombiana de Nefrología e Hipertensión Arterial Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Internal medicine, Diseases of the genitourinary system. Urology