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                  <text>Dominio científico: Coronavirus</text>
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                <text>A Nanoscaffolded Spike-RBD Vaccine Provides Protection against SARS-CoV-2 with Minimal Anti-Scaffold Response</text>
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                <text>Žiga Strmšek, Duško Lainšček, Tina Fink, Vida Forstnerič, Iva Hafner-Bratkovič, Sara Orehek, Mateja Manček-Keber, Peter Pečan, Hana Esih, Špela Malenšek, Jana Aupič, Petra Dekleva, Tjaša Plaper, Sara Vidmar, Lucija Kadunc, Mojca Benčina, Neža Omersa, Gregor Anderluh, Florence Pojer, Kelvin Lau, David Hacker, Bruno  E. Correia, David Peterhoff, Ralf Wagner, Valter Bergant, Alexander Herrmann, Andreas Pichlmair, Roman Jerala</text>
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                <text>The response of the adaptive immune system is augmented by multimeric presentation of a specific antigen, resembling viral particles. Several vaccines have been designed based on natural or designed protein scaffolds, which exhibited a potent adaptive immune response to antigens; however, antibodies are also generated against the scaffold, which may impair subsequent vaccination. In order to compare polypeptide scaffolds of different size and oligomerization state with respect to their efficiency, including anti-scaffold immunity, we compared several strategies of presentation of the RBD domain of the SARS-CoV-2 spike protein, an antigen aiming to generate neutralizing antibodies. A comparison of several genetic fusions of RBD to different nanoscaffolding domains (foldon, ferritin, lumazine synthase, and β-annulus peptide) delivered as DNA plasmids demonstrated a strongly augmented immune response, with high titers of neutralizing antibodies and a robust T-cell response in mice. Antibody titers and virus neutralization were most potently enhanced by fusion to the small β-annulus peptide scaffold, which itself triggered a minimal response in contrast to larger scaffolds. The β-annulus fused RBD protein increased residence in lymph nodes and triggered the most potent viral neutralization in immunization by a recombinant protein. Results of the study support the use of a nanoscaffolding platform using the β-annulus peptide for vaccine design.</text>
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                <text>2021</text>
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                <text>vaccine, SARS-CoV-2, T cell response, RBD-bann, nano-scaffolding domains</text>
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                <text>10.3390/vaccines9050431</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Between flowers and fears: the new coronavirus pandemic (COVID-19) and the flower retail trade</text>
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                <text>Adilson Anacleto, Anna Paula de Araújo Bornancin, Silas Hallel Camilo Mendes, Luciane Scheuer</text>
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                <text>In order to support a better understanding of the current scenario of the crisis installed by the New Coronavirus (SARS-CoV-2: COVID-19) in the flower retail trade, it is presented a descriptive exploratory research carried out between April and May 2020 with 30 flower shop managers located in the Southern region of Brazil. The results showed that the most significant impacts were the drop in the number of customers, which reduced the company’s income when compared to the values sold before the pandemic, and that the pandemic scenario generated a 45.3% reduction in financial transactions on average. Among the flower shops in this survey, 70% of flower shops were closed for an average of 21.4 days, when they were reopened with restrictions on attendance related to hours or the number of people inside the stores. The e-commerce and social media were the main tools to confront this situation, and the most used Apps were WhatsApp and Instagram. But other actions such as discounting on purchases by quantity, free delivery and marketing in the surrounding were also registered. Among the possible complementary actions in order to face this crisis and which can have positive effects, it is highlighted the online courses directed to the trade of gardening kits, the adoption of the Just In Time (JIT) methodology that can result in partnerships with local producers in order to reduce inventory costs and purchase prices, and the organization of collective purchasing groups to bargain prices with wholesalers, as well as the reduction of transportation and operational costs at Veiling in Holambra.</text>
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                <text>2020</text>
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                <text>Social isolation, economy, ornamental plants, flower shops, ornamental horticulture</text>
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                <text>10.1590/2447-536X.v27i1.2232</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Plant culture</text>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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            <description>A name given to the resource</description>
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                <text>User-Engagement Score and SLIs/SLOs/SLAs Measurements Correlation of E-Business Projects Through Big Data Analysis</text>
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              <elementText elementTextId="62373">
                <text>Solomiia Fedushko, Yuriy Syerov, Tomas Peracek, Taras Ustyianovych</text>
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            <description>An account of the resource</description>
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                <text>The Covid-19 crisis lockdown caused rapid transformation to remote working/learning modes and the need for e-commerce-, web-education-related projects development, and maintenance. However, an increase in internet traffic has a direct impact on infrastructure and software performance. We study the problem of accurate and quick web-project infrastructure issues/bottleneck/overload identification. The research aims to achieve and ensure the reliability and availability of a commerce/educational web project by providing system observability and Site Reliability Engineering (SRE) methods. In this research, we propose methods for technical condition assessment by applying the correlation of user-engagement score and Service Level Indicators (SLIs)/Service Level Objectives (SLOs)/Service Level Agreements (SLAs) measurements to identify user satisfaction types along with the infrastructure state. Our solution helps to improve content quality and, mainly, detect abnormal system behavior and poor infrastructure conditions. A straightforward interpretation of potential performance bottlenecks and vulnerabilities is achieved with the developed contingency table and correlation matrix for that purpose. We identify big data and system logs and metrics as the central sources that have performance issues during web-project usage. Throughout the analysis of an educational platform dataset, we found the main features of web-project content that have high user-engagement and provide value to services’ customers. According to our study, the usage and correlation of SLOs/SLAs with other critical metrics, such as user satisfaction or engagement improves early indication of potential system issues and avoids having users face them. These findings correspond to the concepts of SRE that focus on maintaining high service availability.</text>
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                <text>2020</text>
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                <text>Big Data, business plan, System Performance, real-time data analysis, educational web-projects, Application Performance Monitoring (APM)</text>
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            <name>Identifier</name>
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                <text>10.3390/app10249112</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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            <name>Coverage</name>
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                <text>Biology (General), Chemistry, Engineering (General). Civil engineering (General), Technology, Physics</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Drivers of employee sustainable motivation on private enterprises on Saudi Arabia during the crisis of COVID-19</text>
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                <text>Abdullah Abdulmohsen Alfalih</text>
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            <name>Identifier</name>
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                <text>10.5267/j.msl.2020.8.018</text>
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                <text>Management Science Letters</text>
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                <text>Growing Science</text>
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                <text>Business records management</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Fernando Jesus da Rocha, Caroline Patatt</text>
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            <description>An account of the resource</description>
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                <text>Neste artigo avançamos de uma pesquisa inicial sobre o fact-checking nos dois portais de notícias mais acessados de Brasil e Portugal, que dispõem de páginas específicas para verificação de conteúdo, nominadas, respectivamente, Fato ou Fake e Polígrafo. O estudo compreende os primeiros noventa dias após a Organização Mundial de Saúde (OMS) declarar estado de pandemia de coronavírus. Através da Análise de Conteúdo de modo quali-quantitativo foi possível perceber as particularidades no trabalho realizado por veículos semelhantes, situados em dois países de língua portuguesa, mas com situações distintas quanto ao enfrentamento da COVID-19 – especialmente quanto à influência político-ideológica.</text>
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                <text>2020</text>
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                <text>coronavirus, Internet, fake news, jornalismo, Análise de conteúdo</text>
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                <text>Korean Society of Epidemiology</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Visual arts</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Advanced Passenger Movement Model Depending On the Aircraft Cabin Geometry</text>
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                <text>Marc Engelmann, Tim Kleinheinz, Mirko Hornung</text>
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                <text>The aircraft cabin and boarding procedures are steadily increasing focus points for both aircraft manufacturers and airlines, as they play a key part in the customer experience. In the German research project AVACON (AdVAnced Aircraft CONcepts), the boarding procedure is assessed using the PAXelerate boarding simulation. As the project demands an increased level of detail concerning the passenger movement model, this publication introduces an improved methodology. Additions to the model include the development of a method capable of describing the passenger walking speed in dependence of the surrounding objects, their proximity as well as the location of other passengers within the cabin. The validation of the model is performed using the AVACON research baseline and an Airbus A320. The model is then applied to an altered version of the Airbus A320 with an extended aisle and to a COVID-19 safe distance scenario. Regarding the results, an extended aisle width delivers boarding times reduced by up to 3%, whereas the COVID-19 assessment delivers a 67% increase in boarding times. Concluding, the integration of the newly developed model empowers PAXelerate to simulate a more detailed boarding process and enables a better understanding of the influence of cabin layout changes to an aircraft’s boarding performance.</text>
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                <text>10.3390/aerospace7120182</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Motor vehicles. Aeronautics. Astronautics</text>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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            <description>A name given to the resource</description>
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                <text>PIMS-TS, the New Paediatric Systemic Inflammatory Disease Related to Previous Exposure to SARS-CoV-2 Infection—“Rheumatic Fever” of the 21st Century?</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Violetta Opoka-Winiarska, Ewelina Grywalska, Jacek Roliński</text>
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            <description>An account of the resource</description>
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                <text>Paediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PIMS-TS) is a new systemic inflammatory disease that mainly affects children. Its course in many features resembles that of acute rheumatic fever (ARF). Therefore, it is interesting that the experiences with ARF can be used in the management of patients with PIMS-TS. The aim of the article is to analyse the current data on PIMS-TS in relation to ARF. PIMS-TS and ARF are associated with an abnormal immune response to specific pathogens (SARS-CoV-2 and group A streptococcus, respectively). The main symptoms of both diseases are fever and cardiac involvement. Current therapy for PIMS-TS is based on anti-inflammatory treatment: intravenous immunoglobulin (first-line), intravenous glucocorticoids (second-line), or biological therapy (third-line; including interleukin [IL]-1 antagonists, IL-6 receptor blockers, and anti-tumour necrosis factor agents). Vaccination might be good prophylaxis, but the efficacy and safety of the vaccines against SARS-CoV-2 have not yet been established in children. Interesting insights may be gained by considering PIMS-TS in light of what is known of ARF due to their similar courses, but there are still many unanswered questions surrounding this disease and its pathogenesis.</text>
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                <text>2021</text>
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                <text>covid-19, Rheumatic fever, paediatric inflammatory multisystemic syndrome (PIMS)</text>
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                <text>10.3390/ijms22094488</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="62411">
                <text>Epidemiology and Health</text>
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          </element>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="62412">
                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Biology (General), Chemistry</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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            <description>A name given to the resource</description>
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                <text>Mutation Signatures and In Silico Docking of Novel SARS-CoV-2 Variants of Concern</text>
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                <text>Gary  P. Kobinger, Nariman Shahhosseini, Gary Wong, George  (Giorgi) Babuadze</text>
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                <text>One year since the first severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported in China, several variants of concern (VOC) have appeared around the world, with some variants seeming to pose a greater thread to public health due to enhanced transmissibility or infectivity. This study provides a framework for molecular characterization of novel VOC and investigates the effect of mutations on the binding affinity of the receptor-binding domain (RBD) to human angiotensin-converting enzyme 2 (hACE2) using in silico approach. Notable nonsynonymous mutations in RBD of VOC include the E484K and K417N/T that can be seen in South African and Brazilian variants, and N501Y and D614G that can be seen in all VOC. Phylogenetic analyses demonstrated that although the UK-VOC and the BR-VOC fell in the clade GR, they have different mutation signatures, implying an independent evolutionary pathway. The same is true about SA-VOC and COH-VOC felling in clade GH, but different mutation signatures. Combining molecular interaction modeling and the free energy of binding (FEB) calculations for VOC, it can be assumed that the mutation N501Y has the highest binding affinity in RBD for all VOC, followed by E484K (only for BR-VOC), which favors the formation of a stable complex. However, mutations at the residue K417N/T are shown to reduce the binding affinity. Once vaccination has started, there will be selective pressure that would be in favor of emergence of novel variants capable of escaping the immune system. Therefore, genomic surveillance should be enhanced to find and monitor new emerging SARS-CoV-2 variants before they become a public health concern.</text>
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                <text>2021</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="62418">
                <text>SARS-CoV-2, Mutation, binding free energy, variants of concern, Molecular interaction</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="62419">
                <text>10.3390/microorganisms9050926</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="62420">
                <text>Epidemiology and Health</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="62421">
                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Biology (General)</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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          <element elementId="50">
            <name>Title</name>
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                <text>PREFACE: THE 2020 EDITION OF THE XXIVTH ISPRS CONGRESS</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>C. Mallet, F. Lafarge, M. Poreba, E. Rupnik, G. Bahl, N. Girard, A. Garioud, I. Dowman, N. Paparoditis</text>
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            <description>An account of the resource</description>
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                <text>We report key elements and figures related to the proceedings of the 2020 edition of the XXIVth ISPRS Congress. The COVID-19 pandemic causes global travel challenges and restrictions for the full year 2020. Consequently, the Congress planned in June 2020 in Nice (France) was postponed to July 2021. Papers were already submitted and the review process was almost complete. Thus, it has been decided to achieve the publication of the proceedings of these papers under the label ”2020 Edition”. The authors of published papers have the opportunity to present their work during a Virtual Event (31 August – 2 September 2020), while the papers of the 2021 edition will be presented during the (physical) Congress in July 2021.</text>
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                <text>2020</text>
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                <text>10.5194/isprs-archives-XLIII-B2-2020-1-2020</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="62428">
                <text>The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences</text>
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              <elementText elementTextId="62429">
                <text>Copernicus Publications</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Engineering (General). Civil engineering (General), Technology, Applied optics. Photonics</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Dysregulation of the Renin-Angiotensin-Aldosterone System (RAA) in Patients Infected with SARS-CoV-2-Possible Clinical Consequences</text>
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            <name>Creator</name>
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                <text>Agnieszka Dettlaff-Pokora, Julian Swierczynski</text>
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                <text>SARS-CoV-2 impairs the renin-angiotensin-aledosterone system via binding ACE2 enzyme. ACE2 plays a key role in the biosynthesis of angiotensin (1-7), catalyzing the conversion of angiotensin 2 into angiotensin (1-7) and the reaction of angiotensin synthesis (1-9), from which angiotensin is (1-7) produced under the influence of ACE (Angiotensin-Converting Enzyme). Angiotensin 2 is a potent vasoconstrictor and atherogenic molecule converted by ACE2 to reducing inflammation and vasodilating in action angiotensin (1-7). Angiotensin (1-9), that is a product of angiotensin 1 metabolism and precursor of angiotensin (1-7), also exerts cell protective properties. Balance between angiotensin 2 and angiotensin (1-7) regulates blood pressure and ACE2 plays a critical role in this balance. ACE2, unlike ACE, is not inhibited by ACE inhibitors at the doses used in humans during the treatment of arterial hypertension. Membrane ACE2 is one of the receptors that allows SARS-CoV-2 to enter the host cells. ACE2 after SARS-CoV-2 binding is internalized and degraded. Hence ACE2 activity on the cell surface is reduced leading to increase the concentration of angiotensin 2 and decrease the concentration of angiotensin (1-7). Disturbed angiotensins metabolism, changes in ratio between angiotensins with distinct biological activities leading to domination of atherogenic angiotensin 2 can increase the damage to the lungs.</text>
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            <name>Date</name>
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                <text>2021</text>
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            <name>Subject</name>
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                <text>SARS-CoV-2, angiotensin, renin-angiotensin-aldosterone system, angiotensin converting enzyme</text>
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            <name>Identifier</name>
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                <text>10.3390/ijms22094503</text>
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            <name>Source</name>
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              <elementText elementTextId="62437">
                <text>Epidemiology and Health</text>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="62438">
                <text>Korean Society of Epidemiology</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Biology (General), Chemistry</text>
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