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                  <text>Dominio científico: Coronavirus</text>
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                <text>Characteristics and Outcomes of Coronavirus Disease Patients under Nonsurge Conditions, Northern California, USA, March–April 2020</text>
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                <text>Jessica Ferguson, Joelle I. Rosser, Orlando Quintero, Jake Scott, Aruna Subramanian, Mohammad Gumma, Angela Rogers, Shanthi Kappagoda</text>
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                <text>Limited data are available on the clinical presentation and outcomes of coronavirus disease (COVID-19) patients in the United States hospitalized under normal-caseload or nonsurge conditions. We retrospectively studied 72 consecutive adult patients hospitalized with COVID-19 in 2 hospitals in the San Francisco Bay area, California, USA, during March 13–April 11, 2020. The death rate for all hospitalized COVID-19 patients was 8.3%, and median length of hospitalization was 7.5 days. Of the 21 (29% of total) intensive care unit patients, 3 (14.3% died); median length of intensive care unit stay was 12 days. Of the 72 patients, 43 (59.7%) had underlying cardiovascular disease and 19 (26.4%) had underlying pulmonary disease. In this study, death rates were lower than those reported from regions of the United States experiencing a high volume of COVID-19 patients.</text>
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                <text>covid-19, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, coronavirus disease, respiratory diseases, Coronavirus diseases</text>
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                <text>10.3201/eid2608.201776</text>
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                <text>Emerging Infectious Diseases</text>
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                <text>Centers for Disease Control and Prevention</text>
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                <text>Medicine, Infectious and parasitic diseases</text>
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                <text>Cervical screening during the COVID-19 pandemic: optimising recovery strategies.</text>
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                <text>Alejandra Castanon, Matejka Rebolj, Emily Annika Burger, Inge M C M de Kok, Megan A Smith, Sharon J B Hanley, Francesca Maria Carozzi, Stuart Peacock, James F O'Mahony</text>
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                <text>Disruptions to cancer screening services have been experienced in most settings as a consequence of the COVID-19 pandemic. Ideally, programmes would resolve backlogs by temporarily expanding capacity; however, in practice, this is often not possible. We aim to inform the deliberations of decision makers in high-income settings regarding their cervical cancer screening policy response. We caution against performance measures that rely solely on restoring testing volumes to pre-pandemic levels because they will be less effective at mitigating excess cancer diagnoses than will targeted measures. These measures might exacerbate pre-existing inequalities in accessing cervical screening by disregarding the risk profile of the individuals attending. Modelling of cervical screening outcomes before and during the pandemic supports risk-based strategies as the most effective way for screening services to recover. The degree to which screening is organised will determine the feasibility of deploying some risk-based strategies, but implementation of age-based risk stratification should be universally feasible.</text>
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                <text>2021</text>
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                <text>10.1016/S2468-2667(21)00078-5</text>
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                <text>The Lancet. Public health</text>
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              <name>Title</name>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Implications in the quantification of SARS-CoV2 copies in concurrent nasopharyngeal swabs, whole mouth fluid and respiratory droplets.</text>
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                <text>Chandra Lavanya, Pasuvaraj Mahanathi, Veeraraghavan Ashwini, Nagalingeswaran Kumarasamy, Gunaseelan Rajan, Kannan Ranganathan, Stephen J Challacombe, Priya Kannian, Bagavad Gita Jayaraman, Swarna Alamelu, Jennifer Webster-Cyriaque, Newell W Johnson</text>
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                <text>Association of SARS-CoV2 burden in the aerodigestive tract with the disease is sparsely understood. We propose to elucidate the implications of SARS-CoV2 copies in concurrent nasopharyngeal swab (NPS), whole mouth fluid (WMF) and respiratory droplet (RD) samples on disease pathogenesis/transmission. SARS-CoV2 copies quantified by RT-PCR in concurrent NPS, WMF and RD samples from 80 suspected COVID-19 patients were analysed with demographics, immune response and disease severity. Among the 55/80 (69%) NPS-positive patients, SARS-CoV2 was detected in 44/55 (80%) WMF (concordance with NPS-84%; p = 0.02) and 17/55(31%) RD samples. SARS-CoV2 copies were similar in NPS (median:8.74 × 10^5) and WMF (median:3.07 × 10^4), but lower in RD (median:3.60 × 10^2). The 25-75% interquartile range of SARS-CoV2 copies in the NPS was significantly higher in patients who shed the virus in WMF (p = 0.0001) and RD (p = 0.01). Multivariate analyses showed that hospitalized patients shed significantly higher virus copies in the WMF (p = 0.01). Hospitalized patients with more severe disease (p = 0.03) and higher IL-6 values (p = 0.001) shed more SARS-CoV2 virus in the RD. WMF may be used reliably as a surrogate for diagnosis. High copy numbers in the NPS probably imply early disease onset, while in the WMF and RD may imply more severe disease and increased inflammation.</text>
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                <text>2021</text>
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                <text>SARS-CoV-2, nasopharyngeal swab, respiratory droplet, whole mouth fluid, quantitation</text>
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                <text>10.1016/j.virusres.2021.198442</text>
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                <text>Virus research</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Universities under Pandemics of Management and COVID</text>
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                <text>Jonas  Dagys</text>
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                <text>The most urgent challenge of this year – the COVID-19 pandemic and measures of response to it – has sharpened and accelerated the process which was initially driven by bureaucratization and formalization: increasing depersonalization of academic life and the erosion of the university as a unique form of coexistence. The Assuming the concept of the university as a value category, this article aims to review and assess the changes in the self-perception of the academic community that have matured and acquired institutional forms in an attempt to adapt to rapidly shifting societal expectations and needs. Modern trends in university development are best expressed in terms such as “bureaucratization”, “formalization”, “depersonalization”, “instrumentalization of knowledge”, and “community fragmentation”. The pandemic of effective management that has affected Western universities and has gradually reached Vilnius University, no less than the pandemic of COVID-19 and administrative response to it, weakens the academic community based on autonomous and collegial decisions, which should be considered among the most important grounds of uniqueness of university as an institution.</text>
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                <text>2020</text>
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                <text>management, Pandemic, ACADEMIC COMMUNITY, european universities, Vilnius University</text>
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                <text>10.15388/Problemos.98.9</text>
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                <text>Problemos</text>
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                <text>Vilnius University Press</text>
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                <text>Philosophy (General)</text>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>A Case of Sars-Cov-2 Infection in an HIV Patient</text>
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                <text>Hüsnü PULLUKÇU, Hüseyin Aytaç ERDEM, Olcay Buse KENANOĞLU, Deniz AKYOL, Rüçhan SERTÖZ, Meltem IŞIKGÖZ TAŞBAKAN</text>
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                <text>Coronavirus disease 2019, which emerged in Wuhan in China in early December 2019, gradually spread across the world and was declared a pandemic by the World Health Organization on March, 12 2020. The disease shows a wide spectrum, ranging from asymptomatic course to severe acute respiratory syndrome. Although data on SARS-CoV-2 infection in HIV-infected cases are still limited, it is thought that the presence of comorbidities is important for mortality and morbidity in infected cases. In this report, it was aimed to evaluate SARS-CoV-2 infection in a patient diagnosed with HIV for six years with negative HIV-1 viral load and a CD4 lymphocyte count of 240 cells/mm3.</text>
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                <text>HIV, Turkey, SARS-CoV-2</text>
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            <description>An unambiguous reference to the resource within a given context</description>
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                <text>10.5578/flora.69897</text>
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                <text>Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Bilimsel Tip Yayinevi</text>
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                <text>Microbiology, Infectious and parasitic diseases</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Quality Standards in  E-learning of Textile printing design VS Traditional learning methods</text>
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                <text>Heba Okasha</text>
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                <text>Research Abstract The Countries all over the world are strongly moving towards replacing traditional learning methods with E-learning. And now it is not a strategic choice as it was in the past. After the pandemic (Covid-19), many countries of the world Suffers and stopped traditional teaching methods that required going to schools and universities and meeting with lecturers and professors face to face to get knowledge and learning. Vigorously, it becomes towards establishing and creating ready-made plans to implementing successful E-learning. To be implemented successfully and efficiently, Now it is not about a plan that was implemented with its advantages and disadvantages when a sudden pandemic occurred in the world, such as the pandemic (Covid 19).From this moment, the foundations (basics) and criteria for formulating the future educational system in general have been changed, and it has become imperative to develop an alternative and rapid plan for replacing traditional methods of teaching and learning curriculum in general and in particular teaching and learning applied arts curriculum. And the question that arises strongly is? how to formulate a future educational system that will achieve the desired goals of the educational process through remote communication (E- learning), not through traditional methods and how will the educational quality standards be achieved in this type of (online learning), although there is no direct physical communication between the teacher and the learner.The (design of textile printing) is one of the most important subjects that a graduate of the textile printing department must be fully aware of all its aspects and topics.</text>
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                <text>2020</text>
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            <name>Subject</name>
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                <text>blended learning; addie model application; interactive learning; textile printing design; instructional design</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>10.21608/mjaf.2020.38394.1796</text>
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            <name>Source</name>
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            <elementTextContainer>
              <elementText elementTextId="64829">
                <text>Journal of Architecture, Art &amp; Humanistic Science</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="64830">
                <text>Arab Association for Islamic Civilization and Art</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="64831">
                <text>Architecture, Fine Arts</text>
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              <name>Title</name>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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            <description>A name given to the resource</description>
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                <text>What do We Learn from Covid?</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Alexander R. Cuthbert</text>
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            <description>An account of the resource</description>
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                <text>-</text>
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            <name>Date</name>
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                <text>2020</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="64836">
                <text>10.24843/JRS.2020.v07.i02.p01</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="64837">
                <text>Ruang-Space: Jurnal Lingkungan Binaan</text>
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            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="64838">
                <text>Universitas Udayana</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="64839">
                <text>Aesthetics of cities. City planning and beautifying</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Telehealth-based eye care during the COVID-19 Pandemic: Utilization, Safety and the Patient Experience.</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="64841">
                <text>Maria A Woodward, Paula Anne Newman-Casey, Lindsey De Lott, Juno Cho, Dena Ballouz, Lyna Azzouz, Sahal Saleh</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="64842">
                <text>To assess the initial utilization, safety, and patient experience with tele-ophthalmology during the COVID-19 pandemic. Cross-sectional study. We conducted a telephone survey and interview of a random sample of patients who received different modalities of care (in-person, telephone, videocall, or visits deferred) during Michigan's shelter-in-place order beginning March 23rd, 2020. The survey assessed patient safety, patient satisfaction with care, perceptions of telehealth-based eye care, and worry about eyesight. Data was analyzed via frequency measures (e.g., means and standard deviations), Chi-square tests, ANOVA, and paired t-tests. Interviews were analyzed using Grounded Theory. 3274 patients were called and 1720 (53%) agreed to participate. In-person participants were significantly older than telephone (p=0.002) and videocall visit (p=0.001) participants. Significantly more white participants had in-person visits than minority participants (p=0.002). In-person visit participants worried about their eyesight more (2.7, SD=1.2) than those who had telephone (2.5, SD 1.3), videocall (2.4, SD=1.1), or deferred visits (2.4, SD=1.2) (p=0.004). Of all telephone or videocall visits, 1.5% (n=26) resulted in an in-person visit within 1 day, 2.9% (n=48) within 2-7 days, and 2.4% (n=40) within 8-14 days after the virtual visit demonstrating appropriate triage to telemedicine-based care. Patients frequently cited a desire for augmenting the telephone or videocall visits with objective test data. When appropriately triaged, tele-ophthalmology appears to be a safe way to reduce the volume of in-person visits to promote social distancing in the clinic. A hybrid model of eye care combining ancillary testing with a video or phone visit represents a promising model of care.</text>
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                <text>2021</text>
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            <name>Subject</name>
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                <text>covid-19, ophthalmology, telemedicine, telehealth, eHealth</text>
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              <elementText elementTextId="64845">
                <text>10.1016/j.ajo.2021.04.014</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="64846">
                <text>American journal of ophthalmology</text>
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              <name>Title</name>
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              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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                <text>Exploring the potential of novel phenolic compounds as potential therapeutic candidates against SARS-CoV-2, using quantum chemistry, molecular docking and dynamic studies.</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="64848">
                <text>Maimoona Zia, Shabbir Muhammad, Shafiq-urRehman, Shamsa Bibi, Sumra Wajid Abbasi, Abdullah G Al-Sehemi, Aijaz Rasool Chaudhary, Fu Quan Bai</text>
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                <text>In the current study, the interaction of SARS-CoV-2 protein (A and B chains of nsp13) with different recently synthesized phenolic compounds (Sreenivasulu et al., Synthetic Communications, 2020, 112-122) has been studied. The interactions have been investigated by using molecular docking, quantum chemical and molecular dynamics simulations methods. The molecular structures of all the ligands are studied quantum chemically in terms of their optimized structures, 3-D orbital distributions, global chemical descriptors, molecular electrostatic potential plots and HOMO-LUMO orbital energies. All the ligands show reasonably good binding affinities with nsp-13 protein. The ligand L2 shows to have better binding affinities to Chain A and Chain B of nsp13 protein, which are -6.7 and -6.4 kcal/mol. The study of intermolecular interactions indicates that L2 shows different hydrophobic and hydrogen bond interactions with both chains. Furthermore, molecular dynamic simulations of the nsp13-L2 complex are obtained over a time scale of 60 ns, which indicates its stability and flexibility behavior as assessed in terms of its RMSD and RMSF graphs. The ADMET analysis also shows no violation of Lipinski rule (RO5) by studied phenolic compounds. We believe that the current findings will be further confirmed by in vitro and in vivo studies of these recent phenolic compounds for their potential as inhibitors for SARS-Co-V-2 virus.</text>
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                <text>2021</text>
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            <name>Subject</name>
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              <elementText elementTextId="64851">
                <text>molecular docking, SARS-CoV-2, ADMET, Phenolic compounds, molecular dynamics</text>
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              <elementText elementTextId="64852">
                <text>10.1016/j.bmcl.2021.128079</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="64853">
                <text>Bioorganic &amp; medicinal chemistry letters</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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                <text>Sensitive Detection of SARS-CoV-2–Specific Antibodies in Dried Blood Spot Samples</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="64855">
                <text>Gabriella L. Morley, Stephen Taylor, Sian Jossi, Marisol Perez-Toledo, Sian E. Faustini, Edith Marcial-Juarez, Adrian M. Shields, Margaret Goodall, Joel D. Allen, Yasunori Watanabe, Maddy L. Newby, Max Crispin, Mark T. Drayson, Adam F. Cunningham, Alex G. Richter, Matthew K. O’Shea</text>
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          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="64856">
                <text>Dried blood spot (DBS) samples can be used for the detection of severe acute respiratory syndrome coronavirus 2 spike antibodies. DBS sampling is comparable to matched serum samples with a relative 98.1% sensitivity and 100% specificity. Thus, DBS sampling offers an alternative for population-wide serologic testing in the coronavirus pandemic.</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="64857">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="64858">
                <text>Viruses, Respiratory Infections, covid-19, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, coronavirus disease</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="64859">
                <text>10.3201/eid2612.203309</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="64860">
                <text>Emerging Infectious Diseases</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="64861">
                <text>Centers for Disease Control and Prevention</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="64862">
                <text>Medicine, Infectious and parasitic diseases</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
</itemContainer>
