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                <text>Samad N, Sodunke TE, Banna HA, Sapkota A, Fatema AN, Iskandar K, Jahan D, Hardcastle TC, Nusrat T, Chowdhury TS, Haque M</text>
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                <text>Nandeeta Samad,1 Temitayo Eniola Sodunke,2 Hasan Al Banna,3 Ashmita Sapkota,4 Aneeka Nawar Fatema,5 Katia Iskandar,6 Dilshad Jahan,7 Timothy Craig Hardcastle,8 Tanzina Nusrat,9 Tajkera Sultana Chowdhury,10 Mainul Haque11 1Department of Public Health, North South University, Dhaka 1229, Bangladesh; 2University of Ilorin, Ilorin, Kwara State, Nigeria; 3Institute of Social Welfare and Research, University of Dhaka, Dhaka 1000, Bangladesh; 4Department of Microbiology, Mahidol University, Ratchathewi, Bangkok 10400, Thailand; 5Department of Microbiology, Prima Asia University, Dhaka 1213, Bangladesh; 6School of Pharmacy, Lebanese University, Beirut, Lebanon; 7Department of Hematology, Asgar Ali Hospital, Dhaka 1204, Bangladesh; 8Department of Surgery, Nelson R Mandela School of Clinical Medicine, University of KwaZulu-Natal, Umbilo, Berea 4001, South Africa; 9Department of Microbiology, Chittagong Medical College, Chattogram 4203, Bangladesh; 10Department of Urology, Shaheed Suhrawardy Medical College Hospital, Dhaka 1207, Bangladesh; 11Unit of Pharmacology, Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia (National Defence University of Malaysia), Kuala Lumpur 57000, MalaysiaCorrespondence: Mainul HaqueUnit of Pharmacology, Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia (National Defence University of Malaysia), Kem Perdana Sungai Besi, Kuala Lumpur 57000, MalaysiaTel +60 109265543Email runurono@gmail.comAbstract: The world is striving against the severe crisis of the COVID-19 pandemic. Healthcare professionals are struggling to treat their patients based on nonspecific therapies. Amidst this uncertainty, convalescent plasma therapy (CPT) has appeared to be an interim adjuvant therapy for severely ill patients of COVID-19 until long-term clinical trial treatment options are available. Considering the transfusion-related hazards, especially lung injuries and microbial transmission, where sensitivity is not ensured, rigorous trials should be conducted to determine this therapy&amp;rsquo;s efficacy. Moreover, the ratio of recovered cases to plasma donors is not satisfying, which questioning this therapy&amp;rsquo;s availability and accessibility. Although some countries are making the treatment free, the attributable cost mandates a justification for its suitability and sustainability. Our article aimed to review the published facts and findings of CPT&amp;rsquo;s effectiveness in lowering the mortality rate of COVID-19. This pandemic showed that healthcare systems worldwide need core reform. A unified global collaboration must align and coordinate to face the current pandemic and enhance world readiness for future outbreaks based on health equity and equality.Keywords: convalescent plasma therapy, safety, risk, availability, accessibility, COVID-19, global pandemic</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                <text>La mayoría de nosotros, probablemente podamos en un período más o menos corto y vacuna mediante, inmunizarnos frente al COVID-19 y regresar a las aulas, pero salir de la virtualización de las relaciones nos llevará mucho más tiempo, si es que acaso lo logremos. En este trabajo, reflexionamos y relatamos la experiencia llevada adelante para favorecer la socialidad entre estudiantes, y entre estes y les docentes, mediante la creación de espacios lúdicos incluidos en las aulas virtuales de asignaturas de distinto nivel.</text>
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                <text>Evidence has emerged that SARS-CoV-2, the coronavirus that causes COVID-19, can be transmitted airborne in aerosol particles as well as in larger droplets or by surface deposits. This minireview outlines the underlying aerosol science, making links to aerosol research in other disciplines. SARS-CoV-2 is emitted in aerosol form during normal breathing by both asymptomatic and symptomatic people, remaining viable with a half-life of up to about an hour during which air movement can carry it considerable distances, although it simultaneously disperses. The proportion of the droplet size distribution within the aerosol range depends on the sites of origin within the respiratory tract and on whether the distribution is presented on a number or volume basis. Evaporation and fragmentation reduce the size of the droplets, whereas coalescence increases the mean droplet size. Aerosol particles containing SARS-CoV-2 can also coalesce with pollution particulates, and infection rates correlate with pollution. The operation of ventilation systems in public buildings and transportation can create infection hazards via aerosols, but provides opportunities for reducing the risk of transmission in ways as simple as switching from recirculated to outside air. There are also opportunities to inactivate SARS-CoV-2 in aerosol form with sunlight or UV lamps. The efficiency of masks for blocking aerosol transmission depends strongly on how well they fit. Research areas that urgently need further experimentation include the basis for variation in droplet size distribution and viral load, including droplets emitted by “superspreader” individuals; the evolution of droplet sizes after emission, their interaction with pollutant aerosols and their dispersal by turbulence, which gives a different basis for social distancing.</text>
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            <name>Subject</name>
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                <text>mask, Ventilation, evaporation, wind, ultraviolet, turbulence</text>
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                <text>10.3389/fpubh.2020.590041</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Public aspects of medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Novel Immunological Aspects of Sirolimus as a New Targeted Therapy for COVID-19</text>
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                <text>Mahshid Naserifar, Hesamoddin Hosseinjani</text>
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                <text>Journal of Pharmaceutical Care</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Research Center for Rational Use of Drugs (RCRUD)</text>
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                <text>Therapeutics. Pharmacology, Pharmacy and materia medica</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>On Reduced Consumption of Fossil Fuels in 2020 and Its Consequences in the Global Environment and Exergy Demand</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="65846">
                <text>A. Rashedi, Taslima Khanam, Mirjam Jonkman</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>: As the world grapples with the COVID-19 pandemic, there has been a sudden and abrupt change in global energy landscape. Traditional fossil fuels that serve as the linchpin of modern civilization have found their consumption has rapidly fallen across most categories due to strict lockdown and stringent measures that have been adopted to suppress the disease. These changes consequently steered various environmental benefits across the world in recent time. The present article is an attempt to investigate these environmental benefits and reversals that have been materialized in this unfolding situation due to reduced consumption of fossil fuels. The life cycle assessment tool was used hereby to evaluate nine environmental impacts and one energy based impact. These impacts include ozone formation (terrestrial ecosystems), terrestrial acidification, freshwater eutrophication, marine eutrophication, terrestrial ecotoxicity, freshwater ecotoxicity, marine ecotoxicity, land use, mineral resources scarcity, and cumulative exergy demand. Outcomes from the study demonstrate that COVID-19 has delivered impressive changes in global environment and life cycle exergy demand, with about 11–25% curtailment in all the above-mentioned impacts in 2020 in comparison to their corresponding readings in 2019.</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>covid-19, resources, environment, Fossil Fuels, exergy, life cycle assessment (LCA)</text>
              </elementText>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="65850">
                <text>10.3390/en13226048</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Epidemiology and Health</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="65852">
                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Technology</text>
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        <src>https://www.socictopen.socict.org/files/original/4b7a037027fa125dc8b07eb8b3b35a97.pdf</src>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="65854">
                <text>Globalization and Regionalization: Empirical Evidence from Itinerary Structure and Port Organization of World Cruise of Cunard</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="65855">
                <text>Xumao Li, Chengjin Wang, César Ducruet</text>
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            <description>An account of the resource</description>
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                <text>Cruise tourism is an obviously global industry in different dimensions. From a geographical perspective, cruise ships are mobile and capable of being repositioned at a company’s notice, which forms the inherent basis for its global spatial layout. As a branch of the cruise industry, the world cruise is clearly globalizing in geographical space by offering long itinerary, even round-the-world trips, for everyone. Using the schedule data from 2018 to 2019, this paper analyzes the spatial characteristics of the itinerary and port organization of Cunard, a world cruise company. We find that the itinerary distribution and port organization of Cunard are both globalization and regionalization, and the latter is the core and main component of the former. Under the influence of the COVID-19 epidemic, the global mobility of cruises has ground to a halt, while local mobility offers the possibility of its resumption as soon as possible. Turning to the regional voyage with the shorter and simple itinerary is feasible for Cunard and other world cruises, which is conducive to the realization of the resuming voyage as soon as possible. Moreover, strict boarding and safety onboard are essential.</text>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>itinerary, spatial system, cunard, Cruise port, organizing ability</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="65859">
                <text>10.3390/su12197893</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>Biotemas</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="65861">
                <text>Universidade Federal de Santa Catarina</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="65862">
                <text>Environmental effects of industries and plants, Renewable energy sources, Environmental sciences</text>
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        <src>https://www.socictopen.socict.org/files/original/7e2fa8afc05f6b99ef1bc1628c1c78cf.pdf</src>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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            <name>Title</name>
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                <text>Identification of Novel Hypothalamic MicroRNAs as Promising Therapeutics for SARS-CoV-2 by Regulating ACE2 and TMPRSS2 Expression: An In Silico Analysis</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Debasmita Mukhopadhyay, Bashair  M. Mussa</text>
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            <description>An account of the resource</description>
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                <text>Background: Neuroinvasion of severe acute respiratory syndrome coronavirus (SARS-CoV) is well documented and, given the similarities between this virus and SARS-CoV-2, it seems that the neurological impairment that is associated with coronavirus disease 2019 (COVID-19) is due to SARS-CoV-2 neuroinvasion. Hypothalamic circuits are exposed to the entry of the virus via the olfactory bulb and interact centrally with crucial respiratory nuclei. Hypothalamic microRNAs are considered as potential biomarkers and modulators for various diseases and future therapeutic targets. The present study aims to investigate the microRNAs that regulate the expression of hypothalamic angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2), essential elements for SARS-CoV-2 cell entry. Methods: To determine potential hypothalamic miRNAs that can directly bind to ACE2 and TMPRSS2, multiple target bioinformatics prediction algorithms were used, including miRBase, Target scan, and miRWalk2.029. Results: Our in silico analysis has revealed that, although there are over 5000 hypothalamic miRNAs, around 31 miRNAs and 29 miRNAs have shown binding sites and strong binding capacity against ACE2 and TMPRSS2, respectively. Conclusion: These novel potential hypothalamic miRNAs can be used to identify new therapeutic targets to treat neurological symptoms in COVID-19 patients via regulation of ACE2 and TMPRSS2 expression.</text>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>TMPRSS2, covid-19, SARS-CoV-2, ACE2, miRNA, hypothalamic circuits</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="65868">
                <text>10.3390/brainsci10100666</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="65869">
                <text>Epidemiology and Health</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="65870">
                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="65871">
                <text>Neurosciences. Biological psychiatry. Neuropsychiatry</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Apitherapy for Age-Related Skeletal Muscle Dysfunction (Sarcopenia): A Review on the Effects of Royal Jelly, Propolis, and Bee Pollen</text>
              </elementText>
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          <element elementId="39">
            <name>Creator</name>
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              <elementText elementTextId="65873">
                <text>Amira Mohammed Ali, Hiroshi Kunugi</text>
              </elementText>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>The global pandemic of sarcopenia, skeletal muscle loss and weakness, which prevails in up to 50% of older adults is increasing worldwide due to the expansion of aging populations. It is now striking young and midlife adults as well because of sedentary lifestyle and increased intake of unhealthy food (e.g., western diet). The lockdown measures and economic turndown associated with the current outbreak of Coronavirus Disease 2019 (COVID-19) are likely to increase the prevalence of sarcopenia by promoting sedentarism and unhealthy patterns of eating. Sarcopenia has multiple detrimental effects including falls, hospitalization, disability, and institutionalization. Although a few pharmacological agents (e.g., bimagrumab, sarconeos, and exercise mimetics) are being explored in different stages of trials, not a single drug has been approved for sarcopenia treatment. Hence, research has focused on testing the effect of nutraceuticals, such as bee products, as safe treatments to prevent and/or treat sarcopenia. Royal jelly, propolis, and bee pollen are common bee products that are rich in highly potent antioxidants such as flavonoids, phenols, and amino acids. These products, in order, stimulate larval development into queen bees, promote defenses of the bee hive against microbial and environmental threats, and increase royal jelly production by nurse bees. Thanks to their versatile pharmacological activities (e.g., anti-aging, anti-inflammatory, anticarcinogenic, antimicrobial, etc.), these products have been used to treat multiple chronic conditions that predispose to muscle wasting such as hypertension, diabetes mellitus, cardiovascular disorder, and cancer, to name a few. They were also used in some evolving studies to treat sarcopenia in laboratory animals and, to a limited degree, in humans. However, a collective understanding of the effect and mechanism of action of these products in skeletal muscle is not well-developed. Therefore, this review examines the literature for possible effects of royal jelly, bee pollen, and propolis on skeletal muscle in aged experimental models, muscle cell cultures, and humans. Collectively, data from reviewed studies denote varying levels of positive effects of bee products on muscle mass, strength, and function. The likely underlying mechanisms include amelioration of inflammation and oxidative damages, promotion of metabolic regulation, enhancement of satellite stem cell responsiveness, improvement of muscular blood supply, inhibition of catabolic genes, and promotion of peripheral neuronal regeneration. This review offers suggestions for other mechanisms to be explored and provides guidance for future trials investigating the effects of bee products among people with sarcopenia.</text>
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            <name>Date</name>
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              <elementText elementTextId="65875">
                <text>2020</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="65876">
                <text>sarcopenia, propolis, royal jelly, apitherapy, dietary interventions, bee pollen</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="65877">
                <text>10.3390/foods9101362</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="65878">
                <text>Epidemiology and Health</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="65879">
                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="65880">
                <text>Chemical technology</text>
              </elementText>
            </elementTextContainer>
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