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                <text>Dampak Pandemi COVID-19 terhadap Perekonomian Indonesia</text>
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                <text>Iskandar MUDA, Dito Aditia Darma Nasution, Erlina Erlina</text>
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                <text>This study aims to determine the impact of the COVID-19 pandemic on the Indonesian economy. Until this research was written, 93 countries were found infected with COVID-19. The spread of COVID-19 which had spread eventually brought very bad risks to the world economy, including Indonesia, especially in terms of tourism, trade and investment. The method used in this research is descriptive quantitative method that uses an approach called secondary data analysis, which is a research methodology that uses secondary data as the main data source. Based on the results of the study, Indonesia is currently still in a stable economic situation. Strategic steps related to fiscal and monetary are also estimated to still have room to provide economic stimulus if needed. However, as the COVID-19 pandemic case developed, the market did fluctuate more in the negative direction. Not only that, the slow pace of Indonesia's export activities to China will also have a significant impact on the economy in Indonesia.Penelitian ini bertujuan untuk mengetahui dampak pandemi COVID-19 terhadap perekonomian Indonesia. Hingga penelitian ini ditulis ditemukan 93 negara yang telah terjangkit COVID-19. Pandemi COVID-19 yang telah menyebar pada akhirnya membawa risiko yang sangat buruk bagi perekonomian dunia termasuk Indonesia khususnya dari sisi pariwisata, perdagangan serta investasi. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif deskriptif dengan menggunakan pendekatan analisis data sekunder. Berdasarkan hasil penelitian, dampak pandemi COVID-19 menyebabkan rendahnya sentimen investor terhadap pasar yang pada akhirnya membawa pasar ke arah cenderung negatif. Langkah-langkah strategis terkait fiskal dan moneter sangat dibutuhkan untuk memberikan rangsangan ekonomi. Seiring berkembangnya kasus pandemi COVID-19, pasar lebih berfluktuasi ke arah yang negatif. Tidak hanya itu saja, lambatnya ekonomi global khususnya kegiatan ekspor Indonesia ke China juga berdampak signifikan terhadap perekonomian Indonesia. Hal tersebut berdasarkan analisis sensitivitas yang menjelaskan bahwa lambatnya ekonomi global saat ini sangat berdampak terhadap pertumbuhan perekonomian Indonesia.</text>
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                <text>covid-19 pandemic, Tourism, investment, commerce, economy of indonesia</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Finance, Accounting. Bookkeeping</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>D-Dimer, Fibrinogen, and IL-6 in COVID-19 Patients with Suspected Venous Thromboembolism: A Narrative Review</text>
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                <text>Eljilany I, Elzouki AN</text>
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                <text>Islam Eljilany,1 Abdel-Naser Elzouki2,3 1Qatar University, College of Pharmacy, Doha, Qatar; 2Hamad Medical Corporation, Hamad General Hospital, Department of Medicine, Doha, Qatar; 3Department of Medicine, Qatar University, College of Medicine, Doha, QatarCorrespondence: Abdel-Naser ElzoukiDepartment of Medicine, Hamad General Hospital, Hamad Medical Corporation, P.O. Box 3050, Doha, QatarTel +974 66022836Email AElzouki@hamad.qaAbstract: Coronavirus disease 2019 (COVID-19) emerged from the West District of Southern China Seafood Wholesale Market in late December 2019 and has been declared a global pandemic by the World Health Organization (WHO). Infection with severe acute respiratory syndrome coronavirus (SARS-CoV-2) presents with upper respiratory symptoms like cough, fever, and lethargy. At the same time, in later stages, critical COVID-19 patients develop acute respiratory distress syndrome (ARDS), venous thromboembolism (VTE), and multiple organ failure from cytokine storm and coagulation hyperactivity. Primary manifestations of thrombotic events include deep vein thrombosis (DVT), disseminated intravascular coagulation (DIC) and pulmonary embolism (PE). Initial coagulopathy in COVID-19 patients presents with elevated fibrin degradation products, especially D-dimers. In contrast, late presentations show evidence of prolonged prothrombin time (PT) and activated partial thromboplastin (aPTT), increased platelets, and fibrinogen levels. Diagnosis and monitoring of disease progression are done by regular screening of laboratory parameters, including D-dimer and fibrinogen. Management of coagulopathy in COVID-19 patients is like that of critically ill patients, including thromboprophylaxis. Coagulopathy is a poor prognostic factor, and optimum strategies should be developed for early diagnosis, prevention, and prompt treatment of VTE in COVID-19 patients. Thrombosis prophylaxis with low molecular weight heparin (LMWH) has shown beneficial results in preventing coagulopathy a reducing risk of mortality due to thrombotic events. We will discuss VTE in COVID-19 patients highlighting the role of D-dimer, fibrinogen, and interleukin-6 (IL-6).Keywords: COVID-19, SARS-CoV-2, D-dimer, fibrinogen, IL-6, venous thromboembolism</text>
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                <text>covid-19, SARS-CoV-2, D-dimer, venous thromboembolism, IL-6, fibrinogen</text>
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                <text>Biotemas</text>
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                <text>Universidade Federal de Santa Catarina</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Diseases of the circulatory (Cardiovascular) system</text>
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                <text>A Case of Coronavirus Disease 2019 Presenting with Seizures Secondary to Cerebral Venous Sinus Thrombosis</text>
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                <text>Suhail Hussain, Surjith Vattoth, Khawaja Hassan Haroon, Ahmad Muhammad</text>
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                <text>Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2. COVID-19-associated thrombotic events are recognized. A wide variety of neurological presentations have been recently documented. We report the first case of COVID-19 presenting with generalized seizure secondary to cerebral venous sinus thrombosis.</text>
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                <text>Coronavirus disease 2019, seizures, Cerebral venous sinus thrombosis</text>
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                <text>10.1159/000509505</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Neurology. Diseases of the nervous system</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Study the Possibility of Address Complex Models in Linear and Non-Linear Causal Relationships between Oil Price and GDP in KSA: Using the Combination of Toda-Yamamoto, Diks-Panchenko and VAR Approach</text>
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                <text>Hassan Tawakol A. Fadol</text>
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                <text>This paper is about the causal relationship between Oil price, GDP in KSA and to that end, we apply a linear Granger causality test introduced by Toda-Yamamoto 1995 and the nonlinear Granger causality test of Diks-Panchenko 2006. By combining linear causality effects with the nonlinear ones, and VAR approach to possibility of treating complex models in relationships causal. The study applied a bat-tery of unit root tests to ascertain the time series properties of Oil price and GDP in KSA. The results from both the unit root tests indicate that Oil price and GDP are stationary in the 1st difference. The ARDL Bounds-Cointegration test results show that, dynamically, both (Oil price and GDP) are significantly related to each other. The cointegrating equation outcomes demonstrate elasticities whereby both coefficients have positive signs this helps in treating the complexity problem in the models used. The empirical analysis presents three key findings: the linear TY causality analysis supports the neutrality hypothesis, which means that the oil price do cause to GDP in KSA. The nonlinear DP causality test shows that there are nonlinear causal linkages between the oil price and GDP. and finally. The nonlinear causality from the Oil price to GDP seems to be strict and accurate, In all models used TY, DP and VAR approach  We build upon our empirical findings and draw some policy recommendations for Vision 2030 of KSA, As well as the repercussions of the Covid-19 on KSA economy. The study will help and give guiding principle to policymaker make scheme to prop up economic growth in KSA through windows other than oil.Keywords: Linear and Non-Linear Causal, Toda and Yamamoto, Diks-Panchenko, VAR Approach, Oil Price, Gross Domestic ProductJEL Classifications: O1, Q3DOI: https://doi.org/10.32479/ijeep.10130</text>
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                <text>Biotemas</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                <text>Environmental sciences, Energy industries. Energy policy. Fuel trade</text>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Hydroxychloroquine in a G6PD-Deficient Patient with COVID-19 Complicated by Haemolytic Anaemia: Culprit or Innocent Bystander</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Sammy Place, François Mastroianni, Vincent Colombie, Géraldine Claes, Axelle Gilles, Frédéric Vandergheynst</text>
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            <description>An account of the resource</description>
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                <text>Hydroxychloroquine has been used worldwide as a first-line treatment for patients hospitalized with COVID-19. Little is known about COVID-19 and its effects on patients with congenital red blood cell disorders. We report a case of haemolytic anaemia in a 32-year-old patient and a fortuitous highlighting of G6PD deficiency. We reviewed the literature to assess the risk of hydroxychloroquine use in this context.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>covid-19, SARS-CoV-2, G6PD deficiency, haemolytic anaemia</text>
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            </elementTextContainer>
          </element>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="65919">
                <text>10.12890/2020_001875</text>
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            </elementTextContainer>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>Epidemiology and Health</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="65921">
                <text>Korean Society of Epidemiology</text>
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            </elementTextContainer>
          </element>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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              </elementTextContainer>
            </element>
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      </elementSetContainer>
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    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="65923">
                <text>Nursing Surge Capacity Strategies for Management of Critically Ill Adults with COVID-19</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="65924">
                <text>Abbas Al Mutair, Anas Amr, Zainab Ambani, Khulud  Al Salman, Deborah Schwebius</text>
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            </elementTextContainer>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="65925">
                <text>Background: There is a vital need to develop strategies to improve nursing surge capacity for caring of patients with coronavirus (COVID-19) in critical care settings. COVID-19 has spread rapidly, affecting thousands of patients and hundreds of territories. Hospitals, through anticipation and planning, can serve patients and staff by developing strategies to cope with the complications that a surge of COVID-19 places on the provision of adequate intensive care unit (ICU) nursing staff—both in numbers and in training. Aims: The aim is to provide an evidence-based starting point from which to build expanding staffing models dealing with these additional demands. Design/Method: In order to address and develop nursing surge capacity strategies, a five-member expert panel was formed. Multiple questions directed towards nursing surge capacity strategies were posed by the assembled expert panel. Literature review was conducted through accessing various databases including MEDLINE, CINAHL, Cochrane Central, and EMBASE. All studies were appraised by at least two reviewers independently using the Joanna Briggs Institute JBI Critical Appraisal Tools. Results: The expert panel has issued strategies and recommendation statements. These proposals, supported by evidence-based resources in regard to nursing staff augmentation strategies, have had prior success when implemented during the COVID-19 pandemic. Conclusion: The proposed guidelines are intended to provide a basis for the provision of best practice nursing care during times of diminished intensive care unit (ICU) nursing staff capacity and resources due to a surge in critically ill patients. The recommendations and strategies issued are intended to specifically support critical care nurses incorporating COVID-19 patients. As new knowledge evidence becomes available, updates can be issued and strategies, guidelines and/or policies revised. Relevance to Clinical Practice: Through discussion and condensing research, healthcare professionals can create a starting point from which to synergistically develop strategies to combat crises that a pandemic like COVID-19 produces.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="65926">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="65927">
                <text>covid-19, coronavirus 2019, ICU surge capacity, nursing surge capacity and strategies</text>
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            </elementTextContainer>
          </element>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="65928">
                <text>10.3390/nursrep10010004</text>
              </elementText>
            </elementTextContainer>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="65929">
                <text>Nursing Reports</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="65930">
                <text>MDPI AG</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="65931">
                <text>Nursing</text>
              </elementText>
            </elementTextContainer>
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  <item itemId="7516" public="1" featured="0">
    <fileContainer>
      <file fileId="7516">
        <src>https://www.socictopen.socict.org/files/original/1fdbcb4839c9bc166f84faa6086b3239.pdf</src>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
                  <text>Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
          </elementContainer>
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      </elementSetContainer>
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    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="65932">
                <text>Radio Universidad Nacional de La Plata ante la pandemia decidió sostener el servicio y cuidar al personal</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="65933">
                <text>Carlos Milito, Gabriel Morini</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="65934">
                <text>Durante la vigencia del aislamiento social preventivo y obligatorio dispuesto por el Gobierno Nacional Argentino a raíz de la pandemia, aparecieron nuevas modalidades en los consumos   culturales, no obstante, la radio ha sido consecuente con su rol de informar e interpretar lo que sucede en una sociedad, acosada por el COVID-19. En este marco, las radios universitarias argentinas cumplen al informar con responsabilidad e interpretar lo que sucede. Cada una de las radios que integran ARUNA, la Asociación de Radios universitarias argentinas lo hace con su huella institucional y con la responsabilidad de ser un medio de comunicación Público. Gabriel Morini, explicó que se decidió una programación en vivo, remota desde el hogar de los comunicadores y técnicos. Subrayó que informar con responsabilidad, garantizar el derecho a la comunicación y proteger la salud de los trabajadores de la emisora fueron los valores innegociables de la institución.      </text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="65935">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="65936">
                <text>pandemia, Radio, RADIOS UNIVERSITARIAS, rutinas de producción, Programación, contenidos</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="65937">
                <text>10.24215/16696581e375</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="65938">
                <text>Epidemiology and Health</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="65939">
                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="65940">
                <text>Communication. Mass media</text>
              </elementText>
            </elementTextContainer>
          </element>
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  <item itemId="7517" public="1" featured="0">
    <fileContainer>
      <file fileId="7517">
        <src>https://www.socictopen.socict.org/files/original/bbf7404c2f80466066ef7dfe7856f0f4.pdf</src>
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        <elementSet elementSetId="1">
          <name>Dublin Core</name>
          <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
          <elementContainer>
            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
                  <text>Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
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    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="65941">
                <text>Analisis Risiko pada UKM Tahu Takwa Kediri terhadap Dampak Pandemi COVID-19</text>
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            </elementTextContainer>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="65942">
                <text>Imam Safi'i, Silvi Rushanti Widodo, Ria Lestari Pangastuti</text>
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            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="65943">
                <text>The Pandemic of COVID-19 and social restriction policy (PSBB) in Indonesia caused a lot of impacts, one of them is Tofu Takwa SMEs in Kediri. This condition disrupts production activities up to marketing. Then it takes a risk analysis by looking at the main potential risks that arise while pandemic like this and do manage to get a strategy for their business sustainability. This research aims to analyze and manage the main risks that occur in Tofu Takwa SMEs in Kediri. The results showed that there are 3 risks in a high level like decrease of the income, decrease in production amount and increase the price of raw materials and 1 risk in middle level like late in delivery raw material so that it can be done by financial strategy, resize, search for a new market with social media and cooperate with the local government to help the marketing of social service programs.</text>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="65944">
                <text>2020</text>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="65945">
                <text>10.26593/jrsi.v9i2.4003.107-114</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="65946">
                <text>Jurnal Rekayasa Sistem Industri</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="65947">
                <text>LPPM Universitas Katolik Parahyangan</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="65948">
                <text>Industrial engineering. Management engineering</text>
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  <item itemId="7518" public="1" featured="0">
    <fileContainer>
      <file fileId="7518">
        <src>https://www.socictopen.socict.org/files/original/fbc709b0e5a0d31aaf50b8da386cbdcd.pdf</src>
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          <name>Dublin Core</name>
          <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              </elementTextContainer>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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              </elementTextContainer>
            </element>
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      </elementSetContainer>
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    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="65949">
                <text>Javamide-II Inhibits IL-6 without Significant Impact on TNF-alpha and IL-1beta in Macrophage-Like Cells</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="65950">
                <text>Jae B. Park, Renee Peters, Quynhchi Pham, Thomas  T.Y. Wang</text>
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            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="65951">
                <text>The main aim of this study is to find a therapeutic compound to inhibit IL-6, not TNF-alpha and IL-1beta, in macrophage-like cells, because the high-levels of IL-6 production by macrophages are reported to cause unfavorable outcomes under several disease conditions (e.g., autoimmune diseases, and acute viral infections, including COVID-19). In this study, the potential effects of javamide-II on IL-6, IL-1beta and TNF-alpha productions were determined using their ELISA kits in macrophage-like THP-1 cells. Western blots were also performed using the same cells, to determine its effects on signaling pathways (ERK, p38, JNK, c-Fos, ATF-2, c-Jun and NF-κB p65). At concentrations of 0.2–40 µM, javamide-II inhibited IL-6 production significantly in the THP-1 cells (IC50 of 0.8 µM) (P &lt; 0.02). However, javamide-II did not inhibit IL-1beta or TNF-alpha productions much at the same concentrations. In addition, the treatment of javamide-II decreased the phosphorylation of p38 without significant effects on ERK and JNK phosphorylations in the THP-1 cells. Furthermore, the p38 inhibition, followed by the reduction of ATF-2 phosphorylation (not c-Fos, c-Jun or NF-κB p65), led to the suppression of IL-6 mRNA expression in the cells (P &lt; 0.02). The data indicate that javamide-II may be a potent compound to inhibit IL-6 production via suppressing the p38 signal pathway, without significant effects on the productions of TNF-alpha and IL-1beta in macrophage-like THP-1 cells.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="65952">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="65953">
                <text>covid-19, infection, Javamide-II (&lt;i&gt;N&lt;/i&gt;-caffeoyltryptophan), IL-6 inhibition, p38/ATF-2, macrophage-like THP-1 cells</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Identifier</name>
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                <text>Biology (General)</text>
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                <text>تازه های علمی کرونا ویروس ها در سازمان بهداشت جهانی؛ (5) گروه اپیدمیولوژی دانشکده بهداشت و ایمنی دانشگاه علوم پزشکی شهید بهشتی و کرمان</text>
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                <text>محمد آقاعلی, صابر امیرزاده, ندا ایزدی, محمود حاجی پور, سجاد رحیمی, و . . .</text>
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            <description>An account of the resource</description>
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                <text>سخنرانی رئیس سازمان جهانی بهداشت در نشست خبری رسانه ای درباره کورونا ویروس 28 فوریه 2020 در 24 ساعت گذشته، چین 329 مورد را گزارش کرده است، این تعداد کمترین تعداد در یک ماه گذشته است. تا ساعت 6 صبح امروز به وقت ژنو، چین در کل 78959 مورد مبتلا را به WHO گزارش داده است که شامل 2791 مورد مرگ بوده است. در خارج از کشور چین هم اکنون 4351 مورد در 49 کشور و 67 مورد فوت اتفاق افتاده است. از دیروز کشور های دانمارک، استونی، لیتوانی، هلند و نیجریه تولین موارد ابتلا به کوروناویروس را گزارش کرده اند. همه این کشور  ها به طریقی با ایتالیا در ارتباط هستند. از ایتالیا 24 فرد مبتلا به 14 کشور و از ایران 97 مورد به 11 کشور دنیا وارد شده اند. افزایش مداوم تعداد موارد و تعداد کشورهای مبتلا طی چند روز گذشته نگران کننده است. اپیدمیولوژیست های ما به طور مداوم این پیشرفت ها را رصد می کنند و ما اکنون ارزیابی خود را در مورد خطر انتشار و خطر ابتلا به COVID-19 به سطح بسیار بالا در سطح جهانی افزایش داده ایم. آنچه که در حال حاضر می بینیم اپیدمی های مرتبط با هم COVID-19 در چندین کشور است اما اکثر این بیماران همچنان قابل ردیابی به موارد شناخته شده از بیماری یا خوشه هایی از بیماری می باشند. ما شواهدی مبنی بر این که ویروس به صورت آزاد در جوامع در حال چرخش است را نمی بینیم. سناریوهای مختلفی در کشورهای مختلف و حتی سناریوهای مختلف در یک کشور وجود دارد، نکته کلیدی شکستن زنجیره های انتقال این ویروس است. دیروز درخصوص کارهایی که کشورها باید برای آماده سازی بیماران و جلوگیری از انتقال پیشرونده ویروس انجام دهند نیز صحبت کردم. گزارش ماموریت مشترک WHO و چین هم اکنون منتشر شده است که به زبان انگلیسی در وب سایت WHO موجود است و همچنین در وب سایت کمیسیون بهداشت ملی به زبان چینی نیز موجود است.</text>
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            <name>Date</name>
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                <text>2020</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>10.22037/ijem.v6i1.29453</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Medical emergencies. Critical care. Intensive care. First aid</text>
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