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                <text>La toma de decisiones de gobiernos y sectores de la sociedad, intuiciones y datos en tiempos de pandemia SARS-COVID-19</text>
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                <text>Uno de los cuestionamientos más recurrentes durante la pandemia ha girado alrededor de la toma de decisiones y el tipo de evidencia que las respalda. Comparada con otras crisis como la económica del 2008, que principalmente afectó al sector financiero; o el escenario de malas decisiones durante la epidemia de la gripe aviar en la década de los setenta (1), la pandemia por COVID-19 ha afectado todo el sistema socioeconómico y generando incertidumbre ha aumentado la percepción de riesgo. Esto ha hecho que se requieran tiempos de respuesta más cortos, así como una reflexión del sistema de valores de las sociedades en el proceso de toma de decisiones. En este contexto, las evidencias provienen de diferentes sectores y de diferentes ramas del conocimiento. La pregunta que razonablemente surge entonces es: ¿A quién escuchar? La rapidez con que se deben tomar las decisiones en tiempos de pandemia requiere un ajuste al modelo de toma de decisiones basado en evidencia que demanda información con alta credibilidad y libre de sesgos. Por ejemplo, el resultado de investigación científica de calidad. Supone además que la información disponible sea el resultado de un exhaustivo análisis y una evaluación metódica, además de accesible y fácil de entender.En la actual coyuntura estos estrictos requerimientos son casi imposibles de atender. Se ha pasado de utilizar exclusivamente información de alta credibilidad, a aceptar información razonablemente creíble; de priorizar la información mediante una evaluación sistemática, se ha pasado a hacer una valoración desde la subjetividad del juicio profesional y la experiencia de quienes evalúan la información disponible</text>
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                <text>Iranian Journal of Microbiology</text>
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                <text>Tehran University of Medical Sciences</text>
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                <text>Beware of Steroid-Induced Avascular Necrosis of the Femoral Head in the Treatment of COVID-19&amp;mdash;Experience and Lessons from the SARS Epidemic</text>
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                <text>Zhang S, Wang C, Shi L, Xue Q</text>
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                <text>Shenqi Zhang,1&amp;ndash; 3 Chengbin Wang,3 Lei Shi,1 Qingyun Xue1,2 1Department of Orthopedics, Beijing Hospital, National Center of Gerontology, Beijing, People&amp;rsquo;s Republic of China; 2Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People&amp;rsquo;s Republic of China; 3Department of Joint and Sports Medicine, Zaozhuang Municipal Hospital Affiliated to Jining Medical University, Shandong, People&amp;rsquo;s Republic of ChinaCorrespondence: Qingyun XueBeijing Hospital, National Center of Gerontology, No. 1 Dongdan Dahua Road, Dongcheng District, Beijing, 100730, People&amp;rsquo;s Republic of ChinaTel +8613188929900Email bjyyxqy@163.comSummary: The recent outbreak of coronavirus disease 2019 (COVID-19) has become a global epidemic. Corticosteroids have been widely used in the treatment of severe acute respiratory syndrome (SARS), and the pathological findings seen in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are very similar to those observed in severe acute respiratory syndrome-related coronavirus (SARS-CoV) infection. However, the long-term use of corticosteroids (especially at high doses) is associated with potentially serious adverse events, particularly steroid-induced avascular necrosis of the femoral head (SANFH). In today&amp;rsquo;s global outbreak, whether corticosteroid therapy should be used, the dosage and duration of treatment, and ways for the prevention, early detection, and timely intervention of SANFH are some important issues that need to be addressed. This review aims to provide a reference for health care providers in COVID-19 endemic countries and regions.Article Focus: Hormones are a double-edged sword. This review aims to provide a reference for health care providers in coronavirus disease 2019 (COVID-19) endemic countries and regions, especially with respect to the pros and cons of corticosteroid use in the treatment of patients with COVID-19.Key Messages: In today&amp;rsquo;s global outbreak, whether corticosteroid therapy should be used, the dosage and duration of treatment, and ways for the prevention, early detection, and timely intervention of SANFH are some important issues that need to be addressed.Strengths and Limitations: Since SARS was mainly prevalent in China at that time, many evidences in this paper came from the reports of Chinese scholars. There is a bias in the selection of data, which may ignore the differences in environment, race, living habits, medical level and so on. SANFH may be the result of multiple factors. Whether the virus itself is an independent risk factor for SANFH has not been confirmed. In this paper, through literature retrieval, some reference opinions on glucocorticoid usage, diagnosis and treatment of SANFH are given. However, due to the lack of large-scale research data support, it can not be used as the gold standard for the above problems.Keywords: COVID-19, steroid, necrosis of the femoral head, SARS</text>
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                <text>Resshaya Roobini Murukesu,1 Devinder Kaur Ajit Singh,1 Suzana Shahar,2 Ponnusamy Subramaniam3 1Physiotherapy Programme, Centre for Healthy Ageing and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 2Dietetic Programme and Centre for Healthy Ageing and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 3Health Psychology Programme and Centre for Healthy Ageing and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaCorrespondence: Devinder Kaur Ajit SinghCentre for Healthy Ageing and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, 50300, MalaysiaTel/Fax +603 92897352Email devinder@ukm.edu.myPurpose: Older persons have been identified as a vulnerable population with respect to the novel coronavirus outbreak, COVID-19. Aiming to &amp;ldquo;flatten the curve&amp;rdquo; a strict Movement Control Order (MCO) was implemented in Malaysia. Older adults with cognitive frailty are prone to physical, cognitive and psychosocial decline. This study aims to compare physical activity patterns, psychological wellbeing and coping strategies of older persons with cognitive frailty in the &amp;ldquo;WE-RISE&amp;rdquo; trial (intervention versus control) throughout this period.Materials and Methods: This study was conducted as a sub-analysis of the ongoing &amp;ldquo;WE-RISE&amp;rdquo; randomized controlled trial. This study included 42 community-dwelling older adults, aged 60 years and above, with cognitive frailty, stratified into intervention (n=21) and control (n=21) groups who are receiving a multi-domain intervention and usual care, respectively, within the Klang Valley, Malaysia. Phone call interviews were conducted during the MCO period. Physical activity patterns were assessed using International Physical Activity Questionnaire (IPAQ) and Functional Activities Questionnaire (FAQ). Psychological wellbeing was assessed using Flourishing Scale (FS) and General Health Questionnaire (GHQ-12), while the Brief Coping Orientation to Problems Experienced (COPE) assessed coping strategies. Data were analysed descriptively and with independent samples t-test.Results: The WE-RISE intervention group had significantly higher levels of estimated resting energy expenditure (MET) for &amp;ldquo;walking activity&amp;rdquo; (I:&amp;mu;=1723.1&amp;plusmn; 780.7;C:&amp;mu;=537.4&amp;plusmn; 581.9)(p&amp;lt; 0.001), &amp;ldquo;moderate activity&amp;rdquo; (I:&amp;mu;=1422.8&amp;plusmn; 1215.1;C:&amp;mu;=405.7&amp;plusmn; 746.9)(p=0.002) and &amp;ldquo;total physical activity&amp;rdquo; (I: &amp;mu;=3625.9&amp;plusmn; 3399.3;C:&amp;mu;=994.6&amp;plusmn; 1193.9)(p=0.002). The intervention group was also significantly more independent in functional activities (&amp;mu;=1.76&amp;plusmn; 1.73) as compared to the control group (&amp;mu;=5.57&amp;plusmn; 8.31) (p&amp;lt; 0.05). Moreover, significant higher self-perception of living a meaningful life and feeling respected (p&amp;lt; 0.05) was demonstrated in regard to psychological well-being in the intervention group. Regarding coping strategies, the intervention group relied significantly on the domains of religion (I:&amp;mu;=6.43&amp;plusmn; 0.99;C:&amp;mu;=6.09&amp;plusmn; 1.09)(p&amp;lt; 0.05) and planning (I:&amp;mu;=4.81&amp;plusmn; 0.75; C:&amp;mu;=4.04&amp;plusmn; 1.28)(p&amp;lt; 0.05) whilst the control group relied on humour (C:&amp;mu;=3.14&amp;plusmn; 1.19; I:&amp;mu;=2.38&amp;plusmn; 0.74)(p&amp;lt; 0.05).Conclusion: Participants of the WE-RISE intervention group were more physically active, functionally independent and had higher self-perceived social-psychological prosperity regarding living a meaningful life and feeling respected; whilst both groups relied on positive coping strategies during the MCO. These results indicate that it is vital to ensure older persons with cognitive frailty remain physically active and preserve their psychosocial wellbeing to be more resilient in preventing further decline during a crisis such as the COVID-19 pandemic.Keywords: COVID-19, public health, cognitive frailty, physical activity, psychological well-being, geriatric health introduction</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                <text>Guest Editor’s Introduction. New economic and migratory trends in the Baltic Sea region during the COVID-19 pandemic</text>
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                <text>The articles in this special issue explore different types of migration processes in the countries of the Eurasian region and the EU amid the COVID-19 pandemic. The spread of the coronavirus and the ensuing closure of borders have caused a dramatic transformation in regional migration and economy. Many migrants were stranded: they could neither leave the country of employment nor return home. Having lost their jobs and sources of income, they turned into a highly vulnerable group.The countries the Baltic Sea region have a special place in Europe. With the exception of Russia, they are members of the EFTA and the EU — the alliances that benefit from a visa-free travel regime, unimpeded movement of people, a common labour market, and unrestricted labour mobility. The populations of the Baltics are different: 1.32 m people in Estonia, 1.9 m in Latvia, and 2.8 m in Lithuania (2019) with their geographical smallness (the area of each of the countries does not exceed that of any German or an average Russian region), limited labour markets, and few employment opportunities complicate the situation of migrants in these countries. Russia is the destination for a significant proportion of migrants, including those seeking employment. The state has a visa-free regime with the CIS and a common labour market with its fellow members of the Eurasian Economic Union.</text>
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                <text>Immanuel Kant Baltic Federal University</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Regional economics. Space in economics</text>
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                <text>Tiotropium is Predicted to be a Promising Drug for COVID-19 Through Transcriptome-Based Comprehensive Molecular Pathway Analysis</text>
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                <text>Keunsoo Kang, Hoo  Hyun Kim, Yoonjung Choi</text>
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                <text>The coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affects almost everyone in the world in many ways. We previously predicted antivirals (atazanavir, remdesivir and lopinavir/ritonavir) and non-antiviral drugs (tiotropium and rapamycin) that may inhibit the replication complex of SARS-CoV-2 using our molecular transformer–drug target interaction (MT–DTI) deep-learning-based drug–target affinity prediction model. In this study, we dissected molecular pathways upregulated in SARS-CoV-2-infected normal human bronchial epithelial (NHBE) cells by analyzing an RNA-seq data set with various bioinformatics approaches, such as gene ontology, protein–protein interaction-based network and gene set enrichment analyses. The results indicated that the SARS-CoV-2 infection strongly activates TNF and NFκB-signaling pathways through significant upregulation of the TNF, IL1B, IL6, IL8, NFKB1, NFKB2 and RELB genes. In addition to these pathways, lung fibrosis, keratinization/cornification, rheumatoid arthritis, and negative regulation of interferon-gamma production pathways were also significantly upregulated. We observed that these pathologic features of SARS-CoV-2 are similar to those observed in patients with chronic obstructive pulmonary disease (COPD). Intriguingly, tiotropium, as predicted by MT–DTI, is currently used as a therapeutic intervention in COPD patients. Treatment with tiotropium has been shown to improve pulmonary function by alleviating airway inflammation. Accordingly, a literature search summarized that tiotropium reduced expressions of IL1B, IL6, IL8, RELA, NFKB1 and TNF in vitro or in vivo, and many of them have been known to be deregulated in COPD patients. These results suggest that COVID-19 is similar to an acute mode of COPD caused by the SARS-CoV-2 infection, and therefore tiotropium may be effective for COVID-19 patients.</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>The Potential Effect of Novel Coronavirus SARS-CoV-2 on NK Cells; A Perspective on Potential Therapeutic Interventions</text>
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                <text>Coronavirus-induced disease-2019 (COVID-19) continues to cause significant morbidity and mortality worldwide. While studies on SARS-CoV-2 effects on immune cell function continue to progress, we know very little about the significance of depletion of key immune effectors by the virus in the mortality and morbidity of the disease. This commentary outlines what is the reported literature thus far on the effect of virus on NK cells known to kill virally infected cells. It also underscores the necessity for the future comprehensive studies of NK cells in SARS-CoV-2 infected individuals and animal models to better understand the role and significance of reported NK cell depletion and functional inactivation in disease morbidity and mortality, in hope to design effective therapeutic interventions for the disease.</text>
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                <text>virus, covid-19, SARS-CoV-2, NK cells, immune cell</text>
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                <text>10.3389/fimmu.2020.01692</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Immunologic diseases. Allergy</text>
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                <text>A recent pandemic caused by a single-stranded RNA virus, COVID-19, initially discovered in China, is now spreading globally. This poses a serious threat that needs to be addressed immediately. Genome analysis of SARS-CoV-2 has revealed its close relation to SARS-coronavirus along with few changes in its spike protein. The spike protein aids in receptor binding and viral entry within the host and therefore represents a potential target for vaccine and therapeutic development. In the current study, the spike protein of SARS-CoV-2 was explored for potential immunogenic epitopes to design multi-epitope vaccine constructs. The S1 and S2 domains of spike proteins were analyzed, and two vaccine constructs were prioritized with T-cell and B-cell epitopes. We adapted a comprehensive predictive framework to provide novel insights into immunogenic epitopes of spike proteins, which can further be evaluated as potential vaccine candidates against COVID-19. Prioritized epitopes were then modeled using linkers and adjuvants, and respective 3D models were constructed to evaluate their physiochemical properties and their possible interactions with ACE2, HLA Superfamily alleles, TLR2, and TLR4.</text>
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                <text>2020</text>
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                <text>coronavirus, spike protein, covid-19, s1 domain, corona vaccine, S2 domain</text>
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                <text>10.3389/fimmu.2020.01663</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Immunologic diseases. Allergy</text>
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        <src>https://www.socictopen.socict.org/files/original/d154b9e1eee3d8e9eeea541b64f23b49.pdf</src>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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            <name>Title</name>
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                <text>HOME AS POEM</text>
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                <text>Janine Certo, Alecia Beymer</text>
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                <text>What does it mean to be home? We began asking this provocative question well before COVID-19, well before the collective crisis the world experienced which sent both of us back into our current homes. Exploring such a question through poetry writing may provide insights about individuals’ lived experiences, and, therefore, we contend it is worthwhile for scholars, artists and educators to widen possibilities for poetic method and craft related to writing about home. In this paper, we, two poets, arts-based education scholars, and Pittsburgh natives, offer pathways into exploring notions of home through the writing of poetry grounded in the ideas of Gaston Bachelard’s (1958/1964) seminal text, The Poetics of Space. To do so, we each offer and discuss two original poems on the topic of home to illustrate a number of compelling avenues scholars and research participants; educators and students might explore as they write poems evoking their own unique conceptions of home.</text>
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                <text>2020</text>
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                <text>poetry, Home, Place, poetic inquiry, poetics of space</text>
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            <name>Identifier</name>
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                <text>10.18432/ari29509</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Arts in general</text>
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