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                <text>Severe cortical damage associated with COVID-19 case report.</text>
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                <text>Luca Zombori, Melody Bacon, Hannah Wood, Fiona Chatterjee, Ramesh Venkateswaran, Simona Lampariello, Michael Yoong</text>
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                <text>Symptoms of COVID-19, as reported during the SARS-CoV-2 pandemic in 2019-2020, are primarily respiratory and gastrointestinal, with sparse reports on neurological manifestations. We describe the case of a 17-year old female with Cornelia de Lange syndrome and well controlled epilepsy, who sustained significant cortical injury during a COVID-19 associated multi-inflammatory syndrome.</text>
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                <text>2021</text>
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                <text>coronavirus, covid-19, seizure, Cornelia de Lange syndrome, Cortical brain damage, Cortical injury</text>
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                <text>10.1016/j.seizure.2020.11.014</text>
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                <text>Lymphocyte-depleting chemotherapy for aggressive hematologic malignancies in two patients with positive SARS-CoV-2 PCR.</text>
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                <text>Ari Pelcovits, Aakriti Pandita, Dimitrios Farmakiotis, Pamela Egan</text>
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                <text>10.1016/j.leukres.2020.106473</text>
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                <text>Leukemia research</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Design of an epitope-based peptide vaccine against the SARS-CoV-2: a vaccine-informatics approach.</text>
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                <text>Aftab Alam, Arbaaz Khan, Nikhat Imam, Mohd Faizan Siddiqui, Mohd Waseem, Md Zubbair Malik, Romana Ishrat</text>
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                <text>The recurrent and recent global outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has turned into a global concern which has infected more than 42 million people all over the globe, and this number is increasing in hours. Unfortunately, no vaccine or specific treatment is available, which makes it more deadly. A vaccine-informatics approach has shown significant breakthrough in peptide-based epitope mapping and opens the new horizon in vaccine development. In this study, we have identified a total of 15 antigenic peptides [including thymus cells (T-cells) and bone marrow or bursa-derived cells] in the surface glycoprotein (SG) of SARS-CoV-2 which is nontoxic and nonallergenic in nature, nonallergenic, highly antigenic and non-mutated in other SARS-CoV-2 virus strains. The population coverage analysis has found that cluster of differentiation 4 (CD4+) T-cell peptides showed higher cumulative population coverage over cluster of differentiation 8 (CD8+) peptides in the 16 different geographical regions of the world. We identified 12 peptides ((LTDEMIAQY, WTAGAAAYY, WMESEFRVY, IRASANLAA, FGAISSVLN, VKQLSSNFG, FAMQMAYRF, FGAGAALQI, YGFQPTNGVGYQ, LPDPSKPSKR, QTQTNSPRRARS and VITPGTNTSN) that are $80\hbox{--} 90\%$ identical with experimentally determined epitopes of SARS-CoV, and this will likely be beneficial for a quick progression of the vaccine design. Moreover, docking analysis suggested that the identified peptides are tightly bound in the groove of human leukocyte antigen molecules which can induce the T-cell response. Overall, this study allows us to determine potent peptide antigen targets in the SG on intuitive grounds, which opens up a new horizon in the coronavirus disease (COVID-19) research. However, this study needs experimental validation by in vitro and in vivo.</text>
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                <text>2021</text>
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                <text>molecular docking, covid-19, epitope prediction, allergenicity, Immunogenicity, population coverage, T- and B-cell, vaccinomics</text>
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                <text>10.1093/bib/bbaa340</text>
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                <text>Briefings in bioinformatics</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Renal Manifestations of Covid-19: Physiology and Pathophysiology</text>
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                <text>Zaher Armaly, Safa Kinaneh, Karl Skorecki</text>
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                <text>Corona virus disease 2019 (COVID-19) imposes a serious public health pandemic affecting the whole world, as it is spreading exponentially. Besides its high infectivity, SARS-CoV-2 causes multiple serious derangements, where the most prominent is severe acute respiratory syndrome as well as multiple organ dysfunction including heart and kidney injury. While the deleterious impact of SARS-CoV-2 on pulmonary and cardiac systems have attracted remarkable attention, the adverse effects of this virus on the renal system is still underestimated. Kidney susceptibility to SARS-CoV-2 infection is determined by the presence of angiotensin-converting enzyme 2 (ACE2) receptor which is used as port of the viral entry into targeted cells, tissue tropism, pathogenicity and subsequent viral replication. The SARS-CoV-2 cellular entry receptor, ACE2, is widely expressed in proximal epithelial cells, vascular endothelial and smooth muscle cells and podocytes, where it supports kidney integrity and function via the enzymatic production of Angiotensin 1-7 (Ang 1-7), which exerts vasodilatory, anti-inflammatory, antifibrotic and diuretic/natriuretic actions via activation of the Mas receptor axis. Loss of this activity constitutes the potential basis for the renal damage that occurs in COVID-19 patients. Indeed, several studies in a small sample of COVID-19 patients revealed relatively high incidence of acute kidney injury (AKI) among them. Although SARS-CoV-1 -induced AKI was attributed to multiorgan failure and cytokine release syndrome, as the virus was not detectable in the renal tissue of infected patients, SARS-CoV-2 antigens were detected in kidney tubules, suggesting that SARS-CoV-2 infects the human kidney directly, and eventually induces AKI characterized with high morbidity and mortality. The mechanisms underlying this phenomenon are largely unknown. However, the fact that ACE2 plays a crucial role against renal injury, the deprivation of the kidney of this advantageous enzyme, along with local viral replication, probably plays a central role. The current review focuses on the critical role of ACE2 in renal physiology, its involvement in the development of kidney injury during SARS-CoV-2 infection, renal manifestations and therapeutic options. The latter includes exogenous administration of Ang (1-7) as an appealing option, given the high incidence of AKI in this ACE2-depleted disorder, and the benefits of ACE2/Ang1-7 including vasodilation, diuresis, natriuresis, attenuation of inflammation, oxidative stress, cell proliferation, apoptosis and coagulation.</text>
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                <text>2021</text>
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                <text>SARS-CoV-2, Kidney, acute kidney injury, covid-19 pandemic, dialysis, angiotensin-converting enzyme 2</text>
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                <text>10.3390/jcm10061216</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Corrigendum to Multimodality imaging of COVID-19 pneumonia: From diagnosis to follow-up. A comprehensive review" [Eur. J. Radiol. 131 (October) (2020) 109217]."</text>
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                <text>Anna Rita Larici, Giuseppe Cicchetti, Riccardo Marano, Biagio Merlino, Lorenzo Elia, Lucio Calandriello, Annemilia Del Ciello, Alessandra Farchione, Giancarlo Savino, Amato Infante, Luigi Larosa, Cesare Colosimo, Riccardo Manfredi, Luigi Natale</text>
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                <text>2021</text>
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                <text>10.1016/j.ejrad.2020.109364</text>
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                <text>European journal of radiology</text>
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