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                <text>Host–Viral Interactions Revealed among Shared Transcriptomics Signatures of ARDS and Thrombosis: A Clue into COVID-19 Pathogenesis</text>
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                <text>Shankar Chanchal, Aastha Mishra, Mohammad Z. Ashraf</text>
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                <text>Severe novel corona virus disease 2019 (COVID-19) infection is associated with a considerable activation of coagulation pathways, endothelial damage, and subsequent thrombotic microvascular injuries. These consistent observations may have serious implications for the treatment and management of this highly pathogenic disease. As a consequence, the anticoagulant therapeutic strategies, such as low molecular weight heparin, have shown some encouraging results. Cytokine burst leading to sepsis which is one of the primary reasons for acute respiratory distress syndrome (ARDS) drive that could be worsened with the accumulation of coagulation factors in the lungs of COVID-19 patients. However, the obscurity of this syndrome remains a hurdle in making decisive treatment choices. Therefore, an attempt to characterize shared biological mechanisms between ARDS and thrombosis using comprehensive transcriptomics meta-analysis is made. We conducted an integrated gene expression meta-analysis of two independently publicly available datasets of ARDS and venous thromboembolism (VTE). Datasets GSE76293 and GSE19151 derived from National Centre for Biotechnology Information–Gene Expression Omnibus (NCBI-GEO) database were used for ARDS and VTE, respectively. Integrative meta-analysis of expression data (INMEX) tool preprocessed the datasets and effect size combination with random effect modeling was used for obtaining differentially expressed genes (DEGs). Network construction was done for hub genes and pathway enrichment analysis. Our meta-analysis identified a total of 1,878 significant DEGs among the datasets, which when subjected to enrichment analysis suggested inflammation–coagulation–hypoxemia convolutions in COVID-19 pathogenesis. The top hub genes of our study such as tumor protein 53 (TP53), lysine acetyltransferase 2B (KAT2B), DExH-box helicase 9 (DHX9), REL-associated protein (RELA), RING-box protein 1 (RBX1), and proteasome 20S subunit beta 2 (PSMB2) gave insights into the genes known to be participating in the host–virus interactions that could pave the way to understand the various strategies deployed by the virus to improve its replication and spreading.</text>
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                <text>2020</text>
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                <text>inflammation, covid-19, SARS-CoV-2, Thrombosis, ARDS</text>
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                <text>10.1055/s-0040-1721706</text>
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                <text>TH Open</text>
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                <text>Georg Thieme Verlag KG</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Diseases of the circulatory (Cardiovascular) system</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Muscle Biopsy Findings in a Case of SARS-CoV-2-Associated Muscle Injury.</text>
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                <text>Jody E Hooper, Meral Uner, David S Priemer, Avi Rosenberg, Liam Chen</text>
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                <text>2021</text>
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                <text>10.1093/jnen/nlaa155</text>
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                <text>Journal of neuropathology and experimental neurology</text>
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                  <text>Dominio científico: Coronavirus</text>
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          <element elementId="50">
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                <text>Neuropsychology in the Times of COVID-19. The Role of the Psychologist in Taking Charge of Patients With Alterations of Cognitive Functions</text>
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                <text>Michela Balconi, Davide Crivelli, Davide Crivelli, Michela Balconi, Matteo Sozzi, Matteo Sozzi, Lorella Algeri, Lorella Algeri, Matteo Corsano, Matteo Corsano, Davide Crivelli, Maria Angela Daga, Francesca Fumagalli, Francesca Fumagalli, Paola Gemignani, Paola Gemignani, Maria Concetta Granieri, Maria Concetta Granieri, Maria Grazia Inzaghi, Maria Grazia Inzaghi, Francesca Pala, Simone Turati, Michela Balconi</text>
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                <text>covid-19, health care, cognitive impairment, neuropsychological assessment, Neuropsychology, neurorehabilitation</text>
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                <text>10.3389/fneur.2020.573207</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Neurology. Diseases of the nervous system</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Optimal Respiratory Assistance Strategy for Patients with COVID-19.</text>
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                <text>Umur Hatipoğlu, Robert Chatburn, Abhijit Duggal</text>
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                <text>2021</text>
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                <text>10.1513/AnnalsATS.202010-1339LE</text>
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                <text>Annals of the American Thoracic Society</text>
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