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                <text>The COVID-19 pandemic has had an enormous impact across the world. In this discussion paper, we examine the effect that lockdown has had on the mental health and well-being of children and young people. We write from a UK perspective in the light of the international evidence. Many of the discussion points raised resonate globally. We discuss how these issues can be dealt with and set out potential solutions as we emerge from this global crisis.</text>
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                <text>The COVID-19 pandemic has triggered a wave of digitalization in medicine. In the coming years, the use of state-of-the-art technologies will revolutionize routine diagnostic and treatment approaches, as well as have a positive effect on the physician-patient relationship. The application of AI (artificial intelligence) and Big Data, combined with the development of mHealth (mobile health), represents the most significant milestone in the creation of a digital and intelligent health system!</text>
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                <text>The COVID-19 outbreak and its control measures affect the life, livelihood and way of life of many. Vulnerable groups may require different information, practical, emotional and financial support, depending on their specific vulnerabilities. Early reports for the Dutch government on the impacts of COVID-19 control measures were used for drafting a preliminary overview of vulnerable groups and their vulnerabilities. The overview may serve as first step towards a scoping review and be of use in the professional discussion for targeting and finetuning the support to the groups most in need.</text>
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                <text>Antibody-based therapy for infectious diseases predates modern antibiotics and, in the absence of other therapeutic options, was deployed early in the SARS-CoV-2 pandemic through COVID-19 convalescent plasma (CCP) administration. Although most studies have demonstrated signals of efficacy for CCP, definitive assessment has proved difficult under pandemic conditions, with rapid changes in disease incidence and the knowledge base complicating the design and implementation of randomized controlled trials. Nevertheless, evidence from a variety of studies demonstrates that CCP is as safe as ordinary plasma and strongly suggests that it can reduce mortality if given early and with sufficient antibody content.</text>
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                <text>How does COVID-19 impact treatment decision-making for clinicians in localised kidney cancer.</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Mieke Van Hemelrijck, Katharina Beyer, Netty Kinsella, Ravi Barod</text>
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                <text>2020</text>
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                <text>10.1002/bco2.57</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>BJUI compass</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Mapping of type 2 diabetes proteins to COVID-19 biomarkers: A proteomic analysis.</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="72380">
                <text>Abu Saleh Md Moin, Thozhukat Sathyapalan, Stephen L. Atkin, Ahmed Al-Qaissi, Alexandra E Butler</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2021</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>covid-19, Biomarkers, SARS-CoV-2, type 2 diabetes</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="72383">
                <text>10.1016/j.metop.2020.100074</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="72384">
                <text>Metabolism open</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>COVID-19: The First 30 Days at a UK Level 1 Trauma Centre and Lessons Learnt.</text>
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            <name>Creator</name>
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                <text>Paul A Andrzejowski, Anthony Howard, James Shen Hwa Vun, Nauman Manzoor, Nikolaos Patsiogiannis, Nikolaos K Kanakaris, Peter V Giannoudis</text>
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                <text>Aims To analyse the learning points from the first 30 days of the COVID-19 lockdown at our institution. Patients &amp; methods Following ethical approval, data were collected prospectively on all patients admitted under orthopaedics between March 23, 2020, and April 22, 2020. This included baseline demographics (sex, age), biochemical (blood tests), radiological (chest X-ray (CXR), computed tomography (CT)), nature and mechanism of injury, comorbidities, regular medication, observations, specific respiratory symptoms of COVID-19, management, operations, time to theatre, and outcome including mortality incidence. The nature of injury and operations performed were compared to the same period of the previous year (2019). Results During the study period, 162 (74 males) patients were admitted, with a mean age of 60.7 (range 1-101, SD 2.1). On admission, 66 (41%) patients were tested for COVID, out of which eight (13.7%) patients tested positive. Subsequently, another four patients tested positive, who developed symptoms after admission. Four out 12 (33%) confirmed COVID patients died. During this period, 4/150 other patients also died of other causes (mortality incidence 2.6%). The average ages of COVID non-survivors vs survivors were 88, SD 1, vs 76, SD 12, respectively; 2/4 had concurrent diabetes and cancer, another cancer alone, and another complex autoimmune disease managed by immunosuppressive medication. Overall admissions significantly reduced by almost 50% compared with the previous year (162 vs 373, p=&lt;0.05), including cases of polytrauma (15 vs 33). Time to surgery was increased by an average of one day, mainly due to time taken for COVID-19 swab results to come back, and in positive patients, this was an average of 2.75 days (0-13). Lymphopenia was a useful biomarker of COVID, with levels significantly different between groups (p=&lt;0.05). Of the clinical symptoms assessed, 8/12 patients experienced positive chest symptoms or pyrexia but only four had positive CXR changes. Discussion &amp; lessons learnt Eight out of 12 patients who contracted COVID-19 survived without needing intensive care. Non-survivors were older with significant comorbidities. Lymphopenia is a good biomarker of the disease, but suspicious CXR was not sensitive for excluding it. Trauma volume reduced. We have highlighted significant changes to expect should there be a second wave of the virus. Key lessons learnt were that reduction in trauma volume and cessation of elective operating allowed for redeployment, including taking over the minor injury unit; more senior, consultant decision-makers 'at the front door' reduced unnecessary admissions. Increased use of conservative practice was effective at reducing operations required. Expedited COVID swab test processing allowed early de-escalation of isolation, reducing time to surgery. We expect approximately 12% of the typical orthopaedic population to be admitted with COVID, and up to 33% of these patients to die within 28 days of contracting the virus. The vast majority of patients, however, can be managed appropriately with ward-level care. An early decision on escalation and resuscitation status in the emergency department improves patient flow significantly. Remote working was effective and could be extended in the future. We have highlighted the significant changes to expect should there be a second wave of the virus and effective solutions for managing the problems that arise, which could be useful for other units.</text>
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                <text>2020</text>
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            <description>The topic of the resource</description>
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                <text>covid-19, biomarker, hospital epidemiology, lessons learnt, orthopedics and trauma</text>
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            <name>Identifier</name>
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                <text>10.7759/cureus.11547</text>
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                <text>Cureus</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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        <name>Dublin Core</name>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Neglected tropical disease control in a world with COVID-19: an opportunity and a necessity for innovation.</text>
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            <name>Creator</name>
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              <elementText elementTextId="72393">
                <text>Simon J Brooker, Kundai Ziumbe, Nebiyu Negussu, Siobhan Crowley, Mona Hammami</text>
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                <text>Countries have seen substantial disruptions to usual health services related to coronavirus disease 2019 and these are likely to have immediate and long-term indirect effects on many disease control programmes, including neglected tropical diseases (NTDs). The pandemic has highlighted the usefulness of mathematical modelling to understand the impacts of these disruptions and future control measures on progress towards 2030 NTD goals. The pandemic also provides an opportunity, and a practical necessity, to transform NTD programmes through innovation.</text>
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            <name>Date</name>
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                <text>2021</text>
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                <text>covid-19, innovation, neglected tropical diseases</text>
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              <elementText elementTextId="72397">
                <text>10.1093/trstmh/traa157</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="72398">
                <text>Transactions of the Royal Society of Tropical Medicine and Hygiene</text>
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