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                <text>Coagulopathy of coronavirus disease 2019 is largely described as hypercoagulability, yet both thrombotic and hemorrhagic complications occur. Although therapeutic and prophylactic anticoagulant interventions have been recommended, empiric use of antifactor medications (heparin/enoxaparin) may result in hemorrhagic complications, including death. Furthermore, traditional (antifactor) anticoagulation does not address the impact of overactive platelets in coronavirus disease 2019. The primary aim was to evaluate if algorithm-guided thromboelastography with platelet mapping could better characterize an individual's coronavirus disease 2019-relatedcoagulopathic state and, secondarily, improve outcomes. Coronavirus disease 2019 patients (n = 100), receiving thromboelastography with platelet mapping assay upon admission to an 800-bed tertiary-care hospital, were followed prospectively by a hospital-based thromboelastography team. Treating clinicians were provided with the option of using a pre-established algorithm for anticoagulation, including follow-up thromboelastography with platelet mapping assays. Two groups evolved: 1) patients managed by thromboelastography with platelet mapping algorithm (algorithm-guided-thromboelastography); 2) those treated without thromboelastography with platelet mapping protocols (non-algorithm-guided). Outcomes included thrombotic/hemorrhagic complications, pulmonary failure, need for mechanical ventilation, acute kidney injury, dialysis requirement, and nonsurvival. Standard-of-care therapy with or without algorithm-guided-thromboelastography support. Although d-dimer, C-reactive protein, and ferritin were elevated significantly in critically ill (nonsurvivors, acute kidney injury, pulmonary failure), they did not distinguish between coagulopathic and noncoagulopathic patients. Platelet hyperactivity (maximum amplitude-arachidonic acid/adenosine diphosphate &gt; 50 min), with or without thrombocytosis, was associated with thrombotic/ischemic complications, whereas severe thrombocytopenia (platelet count &lt; 100,000/μL) was uniformly fatal. Hemorrhagic complications were observed with decreased factor activity (reaction time &gt; 8 min). Non-algorithm-guided patients had increased risk for subsequent mechanical ventilation (relative risk = 10.9; p &lt; 0.0001), acute kidney injury (relative risk = 2.3; p = 0.0017), dialysis (relative risk = 7.8; p &lt; 0.0001), and death (relative risk = 7.7; p &lt; 0.0001), with 17 of 28 non-algorithm-guided patients (60.7%) dying versus four algorithm-guided-thromboelastography patients (5.6%) (p &lt; 0.0001). Thromboelastography with platelet mapping-guided antiplatelet treatment decreased mortality 82% (p = 0.0002), whereas non-algorithm-guided (compared with algorithm-guided-thromboelastography) use of antifactor therapy (heparin/enoxaparin) resulted in 10.3-fold increased mortality risk (p = 0.0001). Thromboelastography with platelet mapping better characterizes the spectrum of coronavirus disease 2019 coagulation-related abnormalities and may guide more tailored, patient-specific therapies in those infected with coronavirus disease 2019.</text>
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                <text>Julian W. Tang, Paul A Tambyah, David Sc Hui</text>
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                <text>Núria Riera-Martí, Jorge Romaní, Joan Calvet</text>
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                <text>2021</text>
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                <text>10.1016/j.medcli.2020.11.005</text>
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                <text>Medicina clinica</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>#Everything Will Be Fine. Duration of Home Confinement and “All-or-Nothing” Cognitive Thinking Style as Predictors of Traumatic Distress in Young University Students on a Digital Platform During the COVID-19 Italian Lockdown</text>
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                <text>Anna Salza, Laura Giusti, Donatella Ussorio, Massimo Casacchia, Silvia Mammarella, Denise Bianco, Rita Roncone, Rita Roncone</text>
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                <text>On March 10, 2020, Italy announced its lockdown caused by the novel coronavirus (COVID-19) pandemic, and home confinement exposed individuals to a stressful situation of unknown duration. Our study aimed to analyze the emotional and cognitive experiences and the psychopathological symptoms of young Italian University students seeking help from our University student Counseling and Consultation Service during the COVID-19 lockdown. Also, our study aimed to identify the predictors of traumatic psychological distress, investigating variables that could influence the students' well-being, related to their socio-demographic and clinical condition, to the “exposition” to the social distancing, and related to their cognitive thinking style. One-hundred and three University students were included in our study. The traumatic impact was assessed by the Impact of Event Scale-Revised (IES-R). A digital platform was used in our study, focused on narrative dimensions analyses. Our results showed that 21.4% of our help-seeking students experienced lockdown as a traumatic experience. The main stressful factors reported by students were: adjustment to the new academic activities (23.3 %), lack of autonomy (19.4%), and conflicts with family members (6.8%). The three main areas impaired were: changes in the sleeping pattern (68%), difficulty in concentration (67%), and loss of energy (58.6%). Furthermore, 36% of our student sample reported being suffering from anxiety symptoms, whereas 26% showed depressive symptomatology. Students having previous psychological and psychiatric contacts with mental health services (23%) showed a more severe traumatic and depressive symptomatology. The problematic thinking style “all or nothing” was predominantly associated with psychological distress, anxiety, depression, and posttraumatic symptoms. “Everything Will Be Fine” could be identified by the “optimistic style” (27.2%), inversely correlated with the psychopathological measures and concentration problems. The results of the logistic regression analysis indicated that the length of home confinement (second month) seemed to increase by over 3 times the likelihood of experience posttraumatic symptomatology, and a thinking style “all or nothing” was the final strongest predictor increasing the risk by over 5 times. The implementation of psychological interventions to improve the mental health of vulnerable young subgroups to contain the structuring of psychopathological profiles represent a fundamental challenge.</text>
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                <text>2020</text>
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                <text>Covid-19 outbreak, digital platform, Thinking Styles, traumatic impact, narrative psychiatry, online psychological intervention</text>
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                <text>10.3389/fpsyt.2020.574812</text>
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                <text>Epidemiology and Health</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Korean Society of Epidemiology</text>
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                <text>Psychiatry</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>A Call to Arms: The War of the COVID.</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="72506">
                <text>Joseph S Alpert, Arthur William Boylston</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2021</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="72508">
                <text>10.1016/j.amjmed.2020.12.004</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="72509">
                <text>The American journal of medicine</text>
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              <name>Title</name>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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                <text>Out-of-hospital cardiac arrest incidence in the different phases of COVID-19 outbreak.</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="72511">
                <text>Enrico Baldi, Roberto Primi, Francesca Romana Gentile, Claudio Mare, Paola Centineo, Alessandra Palo, Francesca Reali, Ugo Rizzi, Pierpalo Parogni, Luigi Oltrona Visconti, Simone Savastano</text>
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                <text>2021</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="72513">
                <text>10.1016/j.resuscitation.2020.12.020</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Resuscitation</text>
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              <name>Title</name>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Anticoagulation therapy in COVID-19: Is there a dose-dependent benefit?</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Konstantinos G Kyriakoulis, Anastasios Kollias, Nikolaos K Syrigos, George S Stergiou</text>
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                <text>2021</text>
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                <text>covid-19, Anti coagulation, survival, Dose, thromboprophylaxis</text>
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                <text>10.1016/j.thromres.2020.12.013</text>
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                <text>Thrombosis research</text>
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