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                <text>An Intriguing Case of Pneumoperitoneum In a Patient With COVID-19: Do All Pneumoperitoneum Cases Need Surgery?</text>
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                <text>Salim Surani, Munish Sharma, Pratima Ojha, Pahnwat T Taweesedt, Iqbal Ratnani</text>
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                <text>Pneumoperitoneum is pneumatosis in the potential space of the abdominal cavity. It is generally considered a surgical emergency and is mostly due to perforated hollow viscus. Rarely, pneumoperitoneum might occur even in the absence of bowel perforation. We hereby present a case of pneumoperitoneum in a patient with COVID-19 pneumonia and pneumomediastinum, which was managed non-surgically.</text>
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                <text>10.7759/cureus.12279</text>
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                <text>Priyanka Pillai</text>
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                <text>How are data driving the response for the ongoing COVID-19 pandemic? How do data support preparedness toward epidemics and pandemics? How do data inform the potential severity and spread of an outbreak? Past infectious disease outbreaks have demonstrated several challenges associated with rapid aggregation, integration, and sharing of data to inform a response during an outbreak. The ongoing pandemic response has demonstrated the value of timely data collection and sharing and the usage of data for decision-making.</text>
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                <text>Patterns (New York, N.Y.)</text>
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                <text>I Narang, A P Panthagani, M Lewis, B Chohan, A Ferguson, R Nambi</text>
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                <text>10.1111/ced.14574</text>
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                <text>Clinical and experimental dermatology</text>
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                <text>Early remdesivir treatment in COVID-19: Why wait another day?</text>
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                <text>Luigi X Cubeddu, Robert J Cubeddu</text>
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                <text>10.1002/jmv.26792</text>
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                <text>Journal of medical virology</text>
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                <text>Tobias Boeckh-Behrens, Daniel Golkowski, Benno Ikenberg, Jürgen Schlegel, Ulrike Protzer, Christian Schulz, Julia Novotny, Kornelia Kreiser, Claus Zimmer, Bernhard Hemmer, Silke Wunderlich</text>
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                <text>Clinical neuroradiology</text>
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                <text>Hyperlipasemia in COVID-19: Statistical Significance vs Clinical Relevance.</text>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>The Impact of the COVID-19 Pandemic on Barrett's Esophagus and Esophagogastric Cancer.</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Richard C Turkington, Anita Lavery, David Donnelly, Victoria Cairnduff, Damian T McManus, Helen G Coleman</text>
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            <name>Date</name>
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                <text>2021</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>gastric cancer, endoscopy, Esophageal cancer, Barrett's Esophagus, Diagnostic and Therapeutic</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>10.1053/j.gastro.2021.01.208</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="73401">
                <text>Gastroenterology</text>
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  <item itemId="8617" public="1" featured="0">
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        <src>https://www.socictopen.socict.org/files/original/46f58368f62217f3f14d699e27da9710.pdf</src>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Potential effect of Maxing Shigan decoction against coronavirus disease 2019 (COVID-19) revealed by network pharmacology and experimental verification.</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="73403">
                <text>Yuan Li, Fuhao Chu, Ping Li, Nadia Johnson, Tao Li, Yan Wang, Rongxian An, Dantong Wu, Jiena Chen, Zeqi Su, Xiaohong Gu, Xia Ding</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="73404">
                <text>Since the occurrence of coronavirus disease 2019 (COVID-19) in Wuhan, China in December 2019, COVID-19 has been quickly spreading out to other provinces and countries. Considering that traditional Chinese medicine (TCM) played an important role during outbreak of SARS and H1N1, finding potential alternative approaches for COVID-19 treatment is necessary before vaccines are developed. According to previous studies, Maxing Shigan decoction (MXSGD) present a prominent antivirus effect and is often used to treat pulmonary diseases. Furthermore, we collected 115 open prescriptions for COVID-19 therapy from the National Health Commission, State Administration of TCM and other organizations, MXSGD was identified as the key formula. However, the underlying molecular mechanism of MXSGD against COVID-19 is still unknown. The present study aimed to evaluate the therapeutic mechanism of MXSGD against COVID-19 by network pharmacology and in vitro experiment verification, and screen the potential components which could bind to key targets of COVID-19 via molecular docking method. Multiple open-source databases related to TCM or compounds were employed to screen active ingredients and potential targets of MXSGD. Network pharmacology analysis methods were used to initially predict the antivirus and anti-inflammatory effects of MXSGD against COVID-19. IL-6 induced rat lung epithelial type Ⅱ cells (RLE-6TN) damage was established to explore the anti-inflammatory damage activity of MXSGD. After MXSGD intervention, the expression level of related proteins and their phosphorylation in the IL-6 mediated JAK-STAT signaling pathway were detected by Western blot. Molecular docking technique was used to further identify the potential substances which could bind to three key targets (ACE2, Mpro and RdRp) of COVID-19. In this study, 105 active ingredients and 1025 candidate targets were selected for MXSGD, 83 overlapping targets related to MXSGD and COVID-19 were identified, and the protein-protein interaction (PPI) network of MXSGD against COVID-19 was constructed. According to the results of biological enrichment analysis, 63 significant KEGG pathways were enriched, and most of them were related to signal transduction, immune system and virus infection. Furthermore, according the relationship between signal pathways, we confirmed MXSGD could effectively inhibit IL-6 mediated JAK-STAT signal pathway related protein expression level, decreased the protein expression levels of p-JAK2, p-STAT3, Bax and Caspase 3, and increased the protein expression level of Bcl-2, thereby inhibiting RLE-6TN cells damage. In addition, according to the LibDock scores screening results, the components with strong potential affinity (Top 10) with ACE2, Mpro and RdRp are mainly from glycyrrhiza uralensis (Chinese name: Gancao) and semen armeniacae amarum (Chinese name: Kuxingren). Among them, amygdalin was selected as the optimal candidate component bind to all three key targets, and euchrenone, glycyrrhizin, and glycyrol also exhibited superior affinity interactions with ACE2, Mpro and RdRp, respectively. This work explained the positive characteristics of multi-component, multi-target, and multi-approach intervention with MXSGD in combating COVID-19, and preliminary revealed the antiviral and anti-inflammatory pharmacodynamic substances and mechanism of MXSGD, which might provide insights into the vital role of TCM in the prevention and treatment of COVID-19.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="73405">
                <text>2021</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="73406">
                <text>antiviral, novel coronavirus, Anti-inflammatory, traditional Chinese medicine, Ma Xing Shi Gan Decoction, In vitro experiment</text>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="73407">
                <text>10.1016/j.jep.2021.113854</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="73408">
                <text>Journal of ethnopharmacology</text>
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  <item itemId="8618" public="1" featured="0">
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        <src>https://www.socictopen.socict.org/files/original/c531fac864a918f922781e4f6bb78a9a.pdf</src>
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          <name>Dublin Core</name>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="73409">
                <text>Addendum: A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology.</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="73410">
                <text>Oliver G Pybus, Áine O'Toole, Andrew Rambaut, Verity Hill, John T McCrone, Edward C Holmes, Louis du Plessis, Christopher Ruis</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="73411">
                <text>An Addendum to this paper has been published: https://doi.org/10.1038/s41564-021-00872-5.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="73412">
                <text>2021</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="73413">
                <text>10.1038/s41564-021-00872-5</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="73414">
                <text>Nature microbiology</text>
              </elementText>
            </elementTextContainer>
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  <item itemId="8619" public="1" featured="0">
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        <src>https://www.socictopen.socict.org/files/original/480495699ee688e09846f98e6f871ba3.pdf</src>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              </elementTextContainer>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
          </elementContainer>
        </elementSet>
      </elementSetContainer>
    </collection>
    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
    </itemType>
    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="73415">
                <text>Rationale of bedside ultrasound-guided inferior vena cava filter implantation in COVID-19 patients with deep venous thrombosis.</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="73416">
                <text>A Watanabe</text>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="73417">
                <text>2021</text>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="73418">
                <text>10.1093/qjmed/hcaa337</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="73419">
                <text>QJM : monthly journal of the Association of Physicians</text>
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