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Comparative Antiviral Activity of Remdesivir and Anti-HIV Nucleoside Analogs Against Human Coronavirus 229E (HCoV-229E)
Remdesivir is a nucleotide prodrug that is currently undergoing extensive clinical trials for the treatment of COVID-19. The prodrug is metabolized to its active triphosphate form and interferes with the action of RNA-dependent RNA polymerase of…
Position: 9468 (31 views)
Comparative Antiviral Activity of Remdesivir and Anti-HIV Nucleoside Analogs Against Human Coronavirus 229E (HCoV-229E)
Remdesivir is a nucleotide prodrug that is currently undergoing extensive clinical trials for the treatment of COVID-19. The prodrug is metabolized to its active triphosphate form and interferes with the action of RNA-dependent RNA polymerase of…
Position: 15128 (24 views)
Comparative clinical and economic evaluation of two alternative antiviral therapy regimens for influenza patients
In the Russian Federation, the number of new cases of influenzaand SARS each year reaches 30 million people, and the annual total economic damage is estimated at 40 billion rubles, accounting for about 80% of the damage from all infectious…
Position: 10145 (30 views)
Comparative diagnostic performance of rapid antigen detection tests for COVID-19 in a hospital setting.
The availability of accurate and rapid diagnostic tools for COVID-19 is essential for tackling the ongoing pandemic. Our study aimed to quantify the performance of available antigen-detecting rapid diagnostic tests (Ag-RDTs) in a real-world hospital…
Position: 7643 (34 views)
Comparative diet of three sympatric Sceloporus in the semiarid Zapotitlan Valley, Mexico Comparación de la dieta de tres especies simpátridas de Sceloporus en el valle semiárido de Zapotitlán, México
Ecology, morphology, and phylogeny contribute to the organization of lizard assemblages; however, the number of lizard assemblages for which detailed knowledge of closely related sympatric species is available is limited. We studied the diet of 3…
Position: 15128 (24 views)
Comparative Effects of Organic and Conventional Cropping Systems on Trace Elements Contents in Vegetable Brassicaceae: Risk Assessment
Genotypes selected from 3 plant species (Brassica rapa, Eruca vesicaria and Sinapis alba) belonging to the Brassicaceae family were chosen to compare the concentrations of 9 inorganic elements (Cd, Co, Cr, Cu, Fe, Ni, Mn, Pb and Zn) in these…
Position: 17476 (21 views)
Comparative Epidemiology of Human Infections with Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome Coronaviruses among Healthcare Personnel.
The largest nosocomial outbreak of Middle East respiratory syndrome (MERS) occurred in South Korea in 2015. Health Care Personnel (HCP) are at high risk of acquiring MERS-Coronavirus (MERS-CoV) infections, similar to the severe acute respiratory…
Position: 10145 (30 views)
Comparative genomic profiling of Dutch clinical <it>Bordetella pertussis </it>isolates using DNA microarrays: Identification of genes absent from epidemic strains
Abstract Background Whooping cough caused by Bordetella pertussis in humans, is re-emerging in many countries despite vaccination. Several studies have shown that significant shifts have occurred in the B. pertussis population resulting in antigenic…
Position: 10897 (29 views)
Comparative Genomics, Evolution, and Drought-Induced Expression of Dehydrin Genes in Model Brachypodium Grasses.
Dehydration proteins (dehydrins, DHNs) confer tolerance to water-stress deficit in plants. We performed a comparative genomics and evolutionary study of DHN genes in four model Brachypodium grass species. Due to limited knowledge on dehydrin…
Position: 8208 (33 views)
Comparative in vivo analysis of recombinant type II feline coronaviruses with truncated and completed ORF3 region.
Our previous in vitro comparative study on a feline coronavirus (FCoV) pair, differing only in the intactness of their ORF3abc regions, showed that the truncated ORF3abc plays an important role in the efficient macrophage/monocyte tropism of type II…
Position: 2404 (55 views)