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Trans-splicing of mRNAs links gene transcription to translational control regulated by mTOR
Abstract Background In phylogenetically diverse organisms, the 5′ ends of a subset of mRNAs are trans-spliced with a spliced leader (SL) RNA. The functions of SL trans-splicing, however, remain largely enigmatic. Results We quantified translation…
Position: 3482 (51 views)
Distinct core promoter codes drive transcription initiation at key developmental transitions in a marine chordate
Abstract Background Development is largely driven by transitions between transcriptional programs. The initiation of transcription at appropriate sites in the genome is a key component of this and yet few rules governing selection are known. Here, we…
Position: 14934 (27 views)
Ecofeminismo y políticas culturales locales
La política cultural ha estado vinculada a lo lar-go de estos cuarenta años en España a poner en valor la identidad local y la democratización de la cultura en los barrios y territorios sin renunciar a la universalidad de las formas de expresión…
Position: 5041 (44 views)
Editorial−Embracing How Scholarly Publishing Can Build a New Research Culture, Post-COVID-19
It is an absolute pleasure to be writing this, my first Editorial as Editor in Chief for Publications. What a time to be taking on this role—mid-COVID-19 lockdown. I take the reins as Editor-in-chief from the amazing Dr Tony Ross-Hellauer at an…
Position: 17380 (24 views)
Responsabilidad Social Corporativa en las Pérdidas y Desperdicios de Alimentos en México
El objetivo de esta investigación es desarrollar un índice de pérdidas y desperdicios de alimentos e investigar el grado de compromiso de las empresas mexicanas para disminuir los desechos de alimentos. El índice muestra que al menos 35.3% de los…
Position: 3482 (51 views)
DRREP: deep ridge regressed epitope predictor
Abstract Introduction The ability to predict epitopes plays an enormous role in vaccine development in terms of our ability to zero in on where to do a more thorough in-vivo analysis of the protein in question. Though for the past decade there have…
Position: 10900 (32 views)
Economía Solidaria y Territorialización de la Artículo: Economía. Un Desafío a la Solidaridad, un Objetivo para la Ecología
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Position: 13246 (29 views)
Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets in Human Cells
Genes required for SARS-CoV-2 entry into human cells, ACE2 and FURIN, were employed as baits to build genomic-guided molecular maps of upstream regulatory elements, their expression and functions in the human body, and pathophysiologically relevant…
Position: 19197 (21 views)
Comparative Perturbation-Based Modeling of the SARS-CoV-2 Spike Protein Binding with Host Receptor and Neutralizing Antibodies: Structurally Adaptable Allosteric Communication Hotspots Define Spike Sites Targeted by Global Circulating Mutations.
In this study, we used an integrative computational approach to examine molecular mechanisms and determine functional signatures underlying the role of functional residues in the SARS-CoV-2 spike protein that are targeted by novel mutational variants…
Position: 19659 (20 views)
Ecología-Mundo, Capitaloceno y Acumulación Global Parte 2
Position: 16617 (25 views)