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The Time Required to Estimate the Case Fatality Ratio of Influenza Using Only the Tip of an Iceberg: Joint Estimation of the Virulence and the Transmission Potential
Estimating the case fatality ratio (CFR) of a novel strain of influenza virus during the early stage of the pandemic is one of key epidemiological tasks to be conducted as rapid research response. Past experience during the epidemics of severe acute…
Position: 4141 (48 views)
Early SNS-Based Monitoring System for the COVID-19 Outbreak in Japan: A Population-Level Observational Study
Background: The World Health Organization declared the novel coronavirus outbreak (COVID-19) to be a pandemic on March 11, 2020. Large-scale monitoring for capturing the current epidemiological situation of COVID-19 in Japan would improve preparation…
Position: 9024 (35 views)
Early epidemiological assessment of the virulence of emerging infectious diseases: a case study of an influenza pandemic.
BACKGROUND:The case fatality ratio (CFR), the ratio of deaths from an infectious disease to the number of cases, provides an assessment of virulence. Calculation of the ratio of the cumulative number of deaths to cases during the course of an…
Position: 15944 (26 views)
Initial Cluster of Novel Coronavirus (2019-nCoV) Infections in Wuhan, China Is Consistent with Substantial Human-to-Human Transmission
Reanalysis of the epidemic curve from the initial cluster of cases with novel coronavirus (2019-nCoV) in December 2019 indicates substantial human-to-human transmission. It is possible that the common exposure history at a seafood market in Wuhan…
Position: 7348 (38 views)
The Extent of Transmission of Novel Coronavirus in Wuhan, China, 2020
A cluster of pneumonia cases linked to a novel coronavirus (2019-nCoV) was reported by China in late December 2019. Reported case incidence has now reached the hundreds, but this is likely an underestimate. As of 24 January 2020, with reports of…
Position: 11916 (31 views)
The Rate of Underascertainment of Novel Coronavirus (2019-nCoV) Infection: Estimation Using Japanese Passengers Data on Evacuation Flights
From 29 to 31 January 2020, a total of 565 Japanese citizens were evacuated from Wuhan, China on three chartered flights. All passengers were screened upon arrival in Japan for symptoms consistent with novel coronavirus (2019-nCoV) infection and…
Position: 12692 (30 views)
The pivotal role of the angiotensin-II-NF-κB axis in the development of COVID-19 pathophysiology.
Position: 20446 (17 views)
Mitigación del cambio climático versus desarrollo económico -El debate asiático frente a la Conferencia de Copenhague-
Los compromisos post Kioto serán definidos en la próxima Conferencia de las Naciones Unidas sobre el Cambio Climático, que se celebrará en Copenhague en diciembre de 2009. Este proceso de negociación debe resolver de forma comprensiva los objetivos…
Position: 16797 (25 views)
Epidemiological correlation between COVID-19 epidemic and prevalence of α-1 antitrypsin deficiency in the world.
Among 68 countries in the world, severity of the COVID-19 epidemic was correlated with the prevalence of α-1 antitrypsin (AAT) deficiency. For the severe variant, PI*Z, the correlation coefficient (CC) was 0.8584 for the number of patients and 0.8713…
Position: 15166 (27 views)
COVID-19 and stroke, a case series and review of literature.
Corona Virus Disease 2019 (COVID-19) cases continue to increase around the World. Typical symptoms include fever and respiratory illness but a constellation of multisystem involvement including central nervous system (CNS) and peripheral nervous…
Position: 3576 (51 views)