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Diminished COX-2/PGE2-Mediated Antiviral Response Due to Impaired NOX/MAPK Signaling in G6PD-Knockdown Lung Epithelial Cells.
Glucose-6-phosphate dehydrogenase (G6PD) provides the reducing agent NADPH to meet the cellular needs for reductive biosynthesis and the maintenance of redox homeostasis. G6PD-deficient cells experience a high level of oxidative stress and an…
Position: 374 (44 views)
Viral etiology of acute respiratory infections in hospitalized children in Novosibirsk City, Russia (2013 - 2017).
BACKGROUND:Acute respiratory infections (ARIs) cause a considerable morbidity and mortality worldwide especially in children. However, there are few studies of the etiological structure of ARIs in Russia. In this work, we analyzed the etiology of…
Position: 2404 (25 views)
Environmental persistence of porcine coronaviruses in feed and feed ingredients.
Porcine Epidemic Diarrhea Virus (PEDV), Porcine Delta Corona Virus (PDCoV), and Transmissible Gastroenteritis Virus (TGEV) are major threats to swine health and contaminated feed plays a role in virus transmission. The objective of our study was to…
Position: 190 (53 views)
Full-length genome sequences of porcine epidemic diarrhoea virus strain CV777; Use of NGS to analyse genomic and sub-genomic RNAs.
Porcine epidemic diarrhoea virus, strain CV777, was initially characterized in 1978 as the causative agent of a disease first identified in the UK in 1971. This coronavirus has been widely distributed among laboratories and has been passaged both…
Position: 221 (51 views)
De Novo Assembled Wheat Transcriptomes Delineate Differentially Expressed Host Genes in Response to Leaf Rust Infection.
Pathogens like Puccinia triticina, the causal organism for leaf rust, extensively damages wheat production. The interaction at molecular level between wheat and the pathogen is complex and less explored. The pathogen induced response was…
Position: 301 (47 views)
Thermocyclops oblongatus (Sars) (Crustacea: Copepoda): A New Cyclopid for the Fauna of India, and Zoogeography of the Species
Thermocyclops oblongatus (Sars) (Crustacea: Copepoda): A New Cyclopid for the Fauna of India, and Zoogeography of the Species
Position: 2065 (26 views)
Cyclomorphosis in Daphnia lumholtzi Sars (Crustacea: Cladocera) -An Intermittent Species from a Subtropical Water body
Cyclomorphosis in Daphnia lumholtzi Sars (Crustacea: Cladocera) -An Intermittent Species from a Subtropical Water body
Position: 2404 (25 views)
Genetic characterization of the hemagglutinin genes of wild-type measles virus circulating in china, 1993-2009.
BACKGROUND: China experienced several large measles outbreaks in the past two decades, and a series of enhanced control measures were implemented to achieve the goal of measles elimination. Molecular epidemiologic surveillance of wild-type measles…
Position: 240 (50 views)
Evaluation of phage display discovered peptides as ligands for prostate-specific membrane antigen (PSMA).
The aim of this study was to identify potential ligands of PSMA suitable for further development as novel PSMA-targeted peptides using phage display technology. The human PSMA protein was immobilized as a target followed by incubation with a 15-mer…
Position: 301 (47 views)
Differential sensitivity of bat cells to infection by enveloped RNA viruses: coronaviruses, paramyxoviruses, filoviruses, and influenza viruses.
Bats (Chiroptera) host major human pathogenic viruses including corona-, paramyxo, rhabdo- and filoviruses. We analyzed six different cell lines from either Yinpterochiroptera (including African flying foxes and a rhinolophid bat) or Yangochiroptera…
Position: 2065 (26 views)