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Design, Synthesis and Antifungal Activity of Novel Benzofuran-Triazole Hybrids
A series of novel benzofuran-triazole hybrids was designed and synthesized by click chemistry, and their structures were characterized by HRMS, FTIR and NMR. The in vitro antifungal activity of target compounds was evaluated using the microdilution…
Position: 5914 (32 views)
MERS may not be SARS; but India is still vulnerable
Position: 8044 (28 views)
Synthesis and Antiviral Activity of Novel 1,4-Pentadien-3-one Derivatives Containing a 1,3,4-Thiadiazole Moiety
1,4-Pentadien-3-one derivatives derived from curcumin possess excellent inhibitory activity against plant viruses. On the basis of this finding, a series of novel 1,4-pentadien-3-one derivatives containing a 1,3,4-thiadiazole moiety were designed and…
Position: 8735 (27 views)
The Coronavirus Nucleocapsid Is a Multifunctional Protein
The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and…
Position: 10259 (25 views)
Elicitation of broadly neutralizing antibodies against HIV-1 – the germline/maturation hypothesis
We have previously observed that all known broadly neutralizing antibodies (bnAbs) against HIV-1 are highly divergent from their putative germline predecessors in contrast to bnAbs against henipaviruses and SARS coronavirus, which are much less…
Position: 11171 (24 views)
Polarimetric Scattering Properties of Landslides in Forested Areas and the Dependence on the Local Incidence Angle
This paper addresses the local incidence angle dependence of several polarimetric indices corresponding to landslides in forested areas. Landslide is deeply related to the loss of human lives and their property. Various kinds of remote sensing…
Position: 11171 (24 views)
Human Coronaviruses: A Review of Virus–Host Interactions
Human coronaviruses (HCoVs) are known respiratory pathogens associated with a range of respiratory outcomes. In the past 14 years, the onset of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus…
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European Bats as Carriers of Viruses with Zoonotic Potential
Bats are being increasingly recognized as reservoir hosts of highly pathogenic and zoonotic emerging viruses (Marburg virus, Nipah virus, Hendra virus, Rabies virus, and coronaviruses). While numerous studies have focused on the mentioned highly …
Position: 7391 (29 views)
Antigen Production in Plant to Tackle Infectious Diseases Flare Up: the Case of SARS
Severe Acute Respiratory Syndrome (SARS) is a dangerous infection with pandemic potential. It emerged in 2002 and its aetiological agent, the SARS Coronavirus (SARS-CoV), crossed the species barrier to infect humans, showing high morbidity and…
Position: 13073 (22 views)
New genus, three new species and new records of Herpyllobiidae Hansen, 1892 (Crustacea, Copepoda) parasites of polychaetes from Antarctica
During the Antarctic Polarstern cruises ANT XIX/3 (ANDEEP-I), XIX/5 (LAMPOS), and XXI/2 (BENDEX) new material of symbiotic copepods associated with polynoid polychaetes was collected. Here the authors present results for the highly modified family…
Position: 9466 (26 views)