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MERS-CoV pathogenesis and antiviral efficacy of licensed drugs in human monocyte-derived antigen-presenting cells.
Middle East respiratory syndrome coronavirus (MERS-CoV) presents an emerging threat to public health worldwide by causing severe respiratory disease in humans with high virulence and case fatality rate (about 35%) since 2012. Little is known about…
Position: 15143 (20 views)
MERS-CoV pathogenesis and antiviral efficacy of licensed drugs in human monocyte-derived antigen-presenting cells.
Middle East respiratory syndrome coronavirus (MERS-CoV) presents an emerging threat to public health worldwide by causing severe respiratory disease in humans with high virulence and case fatality rate (about 35%) since 2012. Little is known about…
Position: 14073 (21 views)
Effect of Pandemic-Related Confinement on Vitamin D Status Among Children Aged 0–6 Years in Guangzhou, China: A Cross-Sectional Study
Li Yu, Hai-Jin Ke, Di Che, Shao-Lan Luo, Yong Guo, Jie-Ling Wu Department of Children’s Health Care, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of ChinaCorrespondence:…
Position: 13041 (22 views)
MAVS-mediated apoptosis and its inhibition by viral proteins.
BackgroundHost responses to viral infection include both immune activation and programmed cell death. The mitochondrial antiviral signaling adaptor, MAVS (IPS-1, VISA or Cardif) is critical for host defenses to viral infection by inducing type-1…
Position: 13041 (22 views)
MAVS-mediated apoptosis and its inhibition by viral proteins.
BACKGROUND:Host responses to viral infection include both immune activation and programmed cell death. The mitochondrial antiviral signaling adaptor, MAVS (IPS-1, VISA or Cardif) is critical for host defenses to viral infection by inducing type-1…
Position: 6325 (31 views)
Host susceptibility to severe COVID-19 and establishment of a host risk score: findings of 487 cases outside Wuhan
Position: 5884 (32 views)
Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CLpro) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates [version 1; peer review: 2 approved]
We prepared the three-dimensional model of the SARS-CoV-2 (aka 2019-nCoV) 3C-like protease (3CLpro) using the crystal structure of the highly similar (96% identity) ortholog from the SARS-CoV. All residues involved in the catalysis, substrate binding…
Position: 11146 (24 views)
Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CLpro) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates [version 1; peer review: 2 approved]
We prepared the three-dimensional model of the SARS-CoV-2 (aka 2019-nCoV) 3C-like protease (3CLpro) using the crystal structure of the highly similar (96% identity) ortholog from the SARS-CoV. All residues involved in the catalysis, substrate binding…
Position: 18616 (16 views)
Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CLpro) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates [version 1; peer review: 2 approved]
We prepared the three-dimensional model of the SARS-CoV-2 (aka 2019-nCoV) 3C-like protease (3CLpro) using the crystal structure of the highly similar (96% identity) ortholog from the SARS-CoV. All residues involved in the catalysis, substrate binding…
Position: 11146 (24 views)
How Did Chinese Government Implement Unconventional Measures Against COVID-19 Pneumonia
Xiang Yu,1 Na Li2,3 1School of Public Affairs, Fujian Jiangxia University, Fuzhou, Fujian Province, People’s Republic of China; 2School of Law, Ningbo University, Ningbo, Zhejiang Province, People’s Republic of China; 3Research Academy of…
Position: 17839 (17 views)