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                <text>First viral replication of Covid-19 identified in the peritoneal dialysis fluid of a symptomatic patient</text>
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                <text>Mathilde Nouvier, Elodie Chalençon, Etienne Novel-Catin, Solenne Pelletier, Patrick Hallonet, Caroline Charre, Laetitia Koppe, Denis Fouque</text>
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                <text>The COVID-19 pandemic is characterized by a disease with mainly respiratory tropism and varying severity.  Viral excretion of COVID-19 has been described in both urine and stool  with the risk of contamination by stool. No viral replication in the peritoneal dialysis fluid has been reported to date.  We report an observation demonstrating the presence of the virus in the peritoneal dialysis drainage fluid of a COVID-19 patient. This underlines the importance in COVID-19 patients of considering dialysis fluid as a possible source of contamination.</text>
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                <text>DOI: 10.25796/bdd.v3i1.54503</text>
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                <text>Bulletin de la Dialyse à Domicile</text>
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                <text>Dear Reader,  As the 21st century unfolds before us and humanity passed the eight-billion mark, global challange to human security are increasing in number and magnitude. The current coronavirus pandemic reminds us that the health- related pillar of human security plays no minor part in this escalation. The pandemic has followed first resport of a novel kind of pneumonia on 8 December 2019. From 31 December, when the outbreak was reported to the WHO, the epidemic was official. Current time courses of morbidity and mortality indicate that an inflection point has not yet been reached. According to a Lancet Global Health report [1], 45 204 cases of coronavirus disease 2019 (COVID-19) were confirmed as of 12 February, and 1116 deaths had been reported in twenty-five countries. More recently, the WHO [2] reported 77 923 cases in twenty-nine countries and 2361 deaths as of 22 February.</text>
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                <text>DOI: 10.12924/johs2020.16010001</text>
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                <text>The Tipping Point in the Status of Socially Responsible Consumer Behavior Research? A Bibliometric Analysis</text>
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                <text>Andrés Nova-Reyes, Francisco Muñoz-Leiva, TEODORO LUQUE MARTÍNEZ</text>
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                <text>Looking at the impact of society on the environment or, as we write this manuscript in the midst of the COVID-19 crisis, the scenes of consumers hoarding products, we wonder if consumers really do exhibit socially responsible consumer behaviors (SRCB). An initial literature review showed that few studies have addressed this issue, which creates opportunities for the development of new research lines. Furthermore, no study had examined the conceptual evolution or whether SRCB is a developed or fragmented theme from an exhaustive compilation of all previous academic research. To address the proposed research questions, we conducted a bibliometric analysis applied to a corpus of manuscripts on SRCB indexed in the Web of Science (WoS) bibliographic database, from its inception in 1991 up to 2019. Co-word analysis provided a structure of conceptual sub-domains classified based on their density and centrality. In addition, thematic networks were extracted that showed the important associations between the main issues that the SRCB community has addressed, which enabled the authors to examine the subject’s intellectual structuring over almost three decades. The findings showed that the research, over time, has focused most on corporate social responsibility (CSR), this being a motor theme between 2013 and 2016. In general, SRCB has been a very fragmented field of study, however in the last three years, it has developed into a distinct entity; in the past, it was basically addressed through CSR. The most productive thematic areas during the last 30 years have been: (a) Research into consumer attitude, (b) research on CSR, and (c) research on social and sustainable consumption behavior. In response to calls for greater theoretical clarification of the SRCB discipline, the authors providing experts and novices with a better understanding of the current state of the art and suggest future research directions.</text>
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                <text>DOI: 10.3390/su12083141</text>
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                <text>Eric Daniel Tenda, Moses Mazmur Asaf</text>
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                <text>In late 2019, a mass of patients showing symptoms of a pneumonia-like disease of unknown origin emerged in Wuhan, China. Little did the world know it was the prelude of what would be a devastating pandemic. Samples were collected from these patients and the use of unbiased sequencing, and subsequent isolation of the pathogen using human airway epithelial cells led to the discovery of a novel coronavirus, named 2019-nCoV by the World Health Organization (WHO) and Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) by the International Committee on Taxonomy of Viruses. The disease caused by this virus is officially called the coronavirus disease 2019 (COVID-19).</text>
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                <text>Acta Medica Indonesiana</text>
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                <text>Coronavirus Disease 2019 (COVID-19), previously called 2019-nCoV, is a novel disease caused by SARS- CoV-2 which was first identified as outbreak of unknown respiratory illness in Wuhan, China. COVID- 19 was declared as global health emergency by WHO on March 11, 2020 and quickly elevated to global pandemic on 11 March 2020. COVID-19 symptom is highly various in each patient, with fever, fatigue, shortness of breath, and cough as the main presenting symptoms. Patient with COVID-19 may shows severe symptom with severe pneumonia and ARDS, mild symptom resembling simple upper respiration tract infection, or even completely asymptomatic. Approximately 80% of cases is mild. However the number may changes as more people are getting tested. Some experts are estimating that up to 50% of all cases may be asymptomatic carrier.</text>
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                <text>Coronavirus disease 2019 (COVID-19) pandemic is an ongoing problem in more than 200 countries in the world. Indonesia has been greatly affected by COVID-19 with case fatality rate (CFR) being 8.9% in the end of March 2020. We have some room for improvement related to the unreadingess of healthcare facility and the major steps taken by the government. It is suggested that the country should have stricter Stay-at-Home notice, suppress the spread by imposing lockdown on a large scale, improve healthcare service, and increase the availability of personal protective equipments (PPE). It is important to avoid an epidemic peak that potentially overwhelms healthcare service by quarantining the case contacts. Lockdown may prolong the epidemic doubling time significantly. Demand of health system is likely to grow since the number of COVID-19 case is likely to rise. Effective procedures for protecting medical staff from infection are essential. Scientific research in Indonesia is also crucial to provide suggestion and recommendation pertinent to COVID-19.</text>
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                <text>DOI: 10.3390/atmos11040377</text>
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                <text>Fibrosis is a fundamental feature of systemic sclerosis (SSc) and is characterized by excessive accumulation of extracellular matrix components like proteoglycans (PG) or collagens in skin and internal organs. Serum analysis from SSc patients showed an increase in the enzyme activity of xylosyltransferase (XT), the initial enzyme in PG biosynthesis. There are two distinct XT isoforms—XT-I and XT-II—in humans, but until now only XT-I is associated with fibrotic remodelling for an unknown reason. The aim of this study was to identify new XT mediators and clarify the underlying mechanisms, in view of developing putative therapeutic anti-fibrotic interventions in the future. Therefore, we used different cytokines and growth factors, small molecule inhibitors as well as small interfering RNAs, and assessed the cellular XT activity and XYLT1 expression in primary human dermal fibroblasts by radiochemical activity assays and qRT-PCR. We identified a new function of activin A as a regulator of XYLT1 mRNA expression and XT activity. While the activin A-induced XT-I increase was found to be mediated by activin A receptor type 1B, MAPK and Smad pathways, the activin A treatment did not alter the XYLT2 expression. Furthermore, we observed a reciprocal regulation of XYLT1 and XYLT2 transcription after inhibition of the activin A pathway components. These results improve the understanding of the differential expression regulation of XYLT isoforms under pathological fibroproliferative conditions.</text>
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                <text>activin A, fibrosis, MAPK, proteoglycan, SMAD, Systemic sclerosis</text>
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                <text>DOI: 10.3390/biom10040609</text>
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                <text>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently causing a widespread infection in the world. During the pandemic, physicians may need to raise the index of suspicion earlier in at-risk patients presenting with gastrointestinal symptoms, which are uncommon findings in coronavirus disease 2019 (COVID-19) patients. We report a patient in Indonesia with chest pain and gastrointestinal symptoms who was later confirmed to have SARS-CoV-2 infection after spending days of hospitalisation in the standard ward.</text>
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                <text>Chemistry, History (General) and history of Europe</text>
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