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                  <text>Dominio científico: Coronavirus</text>
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                <text>Avaliação de procedimentos rotineiros na suinocultura como métodos estimativos de estresse mediante a aplicação da vocalização e velocidade de manejo</text>
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                <text>Gisele Dela Ricci, Cristiane Gonçalves Titto, Késia Oliveira da Silva Miranda, Patricia Nardin Berto, Evaldo Lencioni Titto, Vera Letticie de Azevedo Ruiz</text>
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                <text>Vocalização e comportamento são métodos não invasivos de análise de bem-estar animal. O objetivo deste estudo foi avaliar o bem-estar de leitões durante as práticas de mossa australiana, desgaste de dentes e castração, a partir de vocalizações e aspectos comportamentais dos suínos. Para tal, foram utilizados 281 leitões, com aferições da intensidade máxima e mínima do ruído emitido pelos leitões e o tempo de realização. O comportamento dos leitões foi obtido de acordo com a atividade desempenhada durante o manejo e contenção. Para análise comportamental um etograma específico foi utilizado. A comparação de médias foi realizada pelo teste-T e PDIFF. A castração foi a prática com maior média de tempo de realização, seguida pelo desgaste de dentes e mossa. Os maiores valores de média de intensidade mínima e máxima foram encontrados para a castração de machos, no processo lento. Observou-se que o sexo não influenciou no tempo em que a mossa e o desgaste de dentes foram realizados, mas durante os mesmos o comportamento de esquiva foi o mais observado (P</text>
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                <text>DOI: 10.18004/investig.agrar.2019.diciembre.117-123</text>
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                <text>Investigación Agraria</text>
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                <text>Universidad Nacional de Asunción</text>
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                <text>Francesco  Di Gennaro, Damiano Pizzol, Claudia Marotta, Mario Antunes, Vincenzo Racalbuto, Nicola Veronese, Lee Smith</text>
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                <text>At the end of 2019 a novel virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing severe acute respiratory syndrome expanded globally from Wuhan, China. In March 2020 the World Health Organization declared the SARS-Cov-2 virus a global pandemic. We performed a narrative review to describe existing literature with regard to Corona Virus Disease 2019 (COVID-19) epidemiology, pathophysiology, diagnosis, management and future perspective. MEDLINE, EMBASE and Scopus databases were searched for relevant articles. Although only when the pandemic ends it will be possible to assess the full health, social and economic impact of this global disaster, this review represents a picture of the current state of the art. In particular, we focus on public health impact, pathophysiology and clinical manifestations, diagnosis, case management, emergency response and preparedness.</text>
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                <text>DOI: 10.3390/ijerph17082690</text>
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                <text>Mihaela Rus, Mihaela Luminiţa Sandu, Tănase Tasenţe</text>
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                <text>The 2019–2020 coronavirus pandemic, also known as Covid-19, debuted on December 12, 2019 in downtown Wuhan, China, when a group of people with pneumonia of unknown cause appeared, was mainly linked by the owners of stalls working on the Huanan fish market, who also sold live animals. The virus presents evidence of person-to-person transmission, and the transmission rate (infection rate) appears to have escalated by mid-January. As measures to prevent the spread of the virus, Romania has adapted a strategy to prevent and control this situation, such as: cancellation or closure of air flights, cancellation of residential meetings, closure of large stores, mandatory self – quarantine of infected persons. Thus, institutions and factories were closed, with the exception of the vital institutions, the closure of churches, educational institutions, universities, sports halls. Awareness campaigns have been launched through the media and social media, the use of disinfectant materials to clean the hands, the use of protective masks and medical gloves, the sanitizing of neighborhoods and roads with cleaning materials. The objective of the study was to determine the effects of the new Coronavirus (COVID19) on the population, both in perception and in attitude. The sample consists of 244 persons and the data obtained after the application of the questionnaire were statistically processed, obtaining the following conclusions: most of the respondents consider that the information received about Covid-19 is correct, a smaller percentage believe that the news about the new Coronavirus are exaggerated; At the same time, the respondents affirm that they will respect all the measures that the Government imposes on them: they will stay at home, they will go out only to buy the necessary products, they will wear masks, gloves, they will wash their hands often. Moreover, most respondents believe that both the country's economy and their personal economy will have to suffer greatly during this period of crisis.</text>
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                <text>effects, perception, Attitude, coronavirus, COVID-19, Romania, Health, Population</text>
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                <text>Technium Social Sciences Journal</text>
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                <text>I Wayan Sudarsa</text>
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                <text>DOI: 10.24843/JBN.2020.v04.is01.p01</text>
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                <text>JBN (Jurnal Bedah Nasional)</text>
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                <text>Universitas Udayana</text>
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                <text>Surgery</text>
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                <text>Pelayanan Terapi Radiasi Pada Pandemi COVID-19 di Instalasi Radioterapi RSUP Sanglah</text>
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                <text>Ngakan Putu Daksa Ganapati</text>
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                <text>DOI: 10.24843/JBN.2020.v04.is01.p05</text>
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                <text>JBN (Jurnal Bedah Nasional)</text>
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                <text>Universitas Udayana</text>
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                <text>Surgery</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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                <text>Pharmacological Therapeutics Targeting RNA-Dependent RNA Polymerase, Proteinase and Spike Protein: From Mechanistic Studies to Clinical Trials for COVID-19</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="15151">
                <text>Jiansheng Huang, Wen-liang Song, Hui Huang, Quancai Sun</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="15152">
                <text>An outbreak of novel coronavirus-related pneumonia COVID-19, that was identified in December 2019, has expanded rapidly, with cases now confirmed in more than 211 countries or areas. This constant transmission of a novel coronavirus and its ability to spread from human to human have prompted scientists to develop new approaches for treatment of COVID-19. A recent study has shown that remdesivir and chloroquine effectively inhibit the replication and infection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2, 2019-nCov) in vitro. In the United States, one case of COVID-19 was successfully treated with compassionate use of remdesivir in January of 2020. In addition, a clinically proven protease inhibitor, camostat mesylate, has been demonstrated to inhibit Calu-3 infection with SARS-CoV-2 and prevent SARS-2-spike protein (S protein)-mediated entry into primary human lung cells. Here, we systemically discuss the pharmacological therapeutics targeting RNA-dependent RNA polymerase (RdRp), proteinase and S protein for treatment of SARS-CoV-2 infection. This review should shed light on the fundamental rationale behind inhibition of SARS-CoV-2 enzymes RdRp as new therapeutic approaches for management of patients with COVID-19. In addition, we will discuss the viability and challenges in targeting RdRp and proteinase, and application of natural product quinoline and its analog chloroquine for treatment of coronavirus infection. Finally, determining the structural-functional relationships of the S protein of SARS-CoV-2 will provide new insights into inhibition of interactions between S protein and angiotensin-converting enzyme 2 (ACE2) and enable us to develop novel therapeutic approaches for novel coronavirus SARS-CoV-2.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>RNA dependent RNA polymerase, remdesivir, chloroquine, SARS-CoV-2, COVID-19, spike glycoproteins</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>DOI: 10.3390/jcm9041131</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="15156">
                <text>Journal of Clinical Medicine</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="15157">
                <text>MDPI AG</text>
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            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine</text>
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            </elementTextContainer>
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            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
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                <text>EN</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Dialyse péritonéale et pandémie COVID-19</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="15161">
                <text>Christian Verger, Max Dratwa, Jacques Chanliau, Pierre-Yves Durand</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>L’épidémie à Coronavirus COVID-19, qui touche la planète entière, oblige chaque pays et leurs habitants à adapter leurs modes de vie afin, à laLfois, de se préserver et de préserver son entourage. La prise en charge des personnes souffrant d’une maladie chronique associée doit évoluer durant cette période en fonction des pathologies et du lieu de traitement.  Rapidement, en sus des directives ministérielles, les sociétés savantes ont proposé des recommandations qu’il importe à chacun d’adapter en fonction des possibilités et de l’environnement d’exercice. Certaines sont synthétiques et générales, d’autres concernent des groupes plus particuliers d’individus.  Nous citerons ainsi les recommandations (en Anglais) de l’ERA-EDTA : https://www.era-edta.org/en/wp-content/uploads/2020/03/200311_Press-Release_SARS-CoV-2.pdf L’expérience de Wuhan en hémodialyse : https://doi.org/10.1101/2020.02.24.20027201 Les recommandations générales de la SFNDT :  https://www.sfndt.org/sites/www.sfndt.org/files/medias/documents/Conseils%20SFNDT%20COVID-19%20-%20090320%20vDef.pdf  Peu de recommandations étaient fournies concernant les patients traités par dialyse péritonéale en dehors de celles de l’ISPD récemment publiées en plusieurs langues: https://ispd.org/strategies-covid19/ (traduction française réalisée par le RDPLF)  La France et certains pays francophones se caractérisent aussi par une proportion importante de patients en dialyse péritonéale non autonomes assistés par infirmière. Les responsables du Registre de Dialyse Péritonéale de Langue Française (RDPLF) ont rédigé, en accord avec la Société Francophone de Néphrologie Dialyse et Transplantation (SFNDT) des recommandations, volontairement simples, et spécifiques du mode de prise en charge dans nos régions.  Ces recommandations complètent celles précédemment citées et ne concernent que le suivi du patient lors de son maintien à domicile pour le protéger et protéger son entourage de toute contamination.  Il appartient à chaque professionnel de s’inspirer de ces recommandations et de les adapter en fonction de ses possibilités..</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="15163">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="15164">
                <text>pandémie, Epidémie, COVID-19, coronavirus, RDPLF, recommandatiions</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="15165">
                <text>DOI: 10.25796/bdd.v3i1.54413</text>
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            </elementTextContainer>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="15166">
                <text>Bulletin de la Dialyse à Domicile</text>
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            </elementTextContainer>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>RDPLF</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Internal medicine</text>
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            </elementTextContainer>
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            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
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                <text>EN, FR</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Exploring the Relevance of Senotherapeutics for the Current SARS-CoV-2 Emergency and Similar Future Global Health Threats</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Marco Malavolta, Robertina Giacconi, Dario Brunetti, Mauro Provinciali, Fabrizio Maggi</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="15172">
                <text>The higher death rate caused by COVID-19 in older people, especially those with comorbidities, is a challenge for biomedical aging research. Here we explore the idea that an exacerbated inflammatory response, in particular that mediated by IL-6, may drive the deleterious consequences of the infection. Data shows that other RNA viruses, such as influenza virus, can display enhanced replication efficiency in senescent cells, suggesting that the accumulation of senescent cells with aging and age-related diseases may play a role in this phenomenon. However, at present, we are completely unaware of the response to SARS-CoV and SARS-COV-2 occurring in senescent cells. We deem that this is a priority area of research because it could lead to the development of several therapeutic strategies based on senotherapeutics or prevent unsuccessful attempts. Two of these senotherapeutics, azithromycin and ruxolitinib, are currently undergoing testing for their efficacy in treating COVID-19. The potential of these strategies is not only for ameliorating the consequences of the current emergence of SARS-CoV-2, but also for the future emergence of new viruses or mutated ones for which we are completely unprepared and for which no vaccines are available.</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2020</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>cellular senescence, Viral infection, inflammation, mitochondria, extracellular vesicles, senoptotics</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>DOI: 10.3390/cells9040909</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>Cells</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="15177">
                <text>MDPI AG</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="15178">
                <text>Biology (General)</text>
              </elementText>
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            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
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                <text>EN</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Spatio-Temporal Patterns of the 2019-nCoV Epidemic at the County Level in Hubei Province, China</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="15181">
                <text>Wentao Yang, Min Deng, Chaokui LI, JinCai Huang</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>Understanding the spatio-temporal characteristics or patterns of the 2019 novel coronavirus (2019-nCoV) epidemic is critical in effectively preventing and controlling this epidemic. However, no research analyzed the spatial dependency and temporal dynamics of 2019-nCoV. Consequently, this research aims to detect the spatio-temporal patterns of the 2019-nCoV epidemic using spatio-temporal analysis methods at the county level in Hubei province. The Mann–Kendall and Pettitt methods were used to identify the temporal trends and abrupt changes in the time series of daily new confirmed cases, respectively. The local Moran’s I index was applied to uncover the spatial patterns of the incidence rate, including spatial clusters and outliers. On the basis of the data from January 26 to February 11, 2020, we found that there were 11 areas with different types of temporal patterns of daily new confirmed cases. The pattern characterized by an increasing trend and abrupt change is mainly attributed to the improvement in the ability to diagnose the disease. Spatial clusters with high incidence rates during the period were concentrated in Wuhan Metropolitan Area due to the high intensity of spatial interaction of the population. Therefore, enhancing the ability to diagnose the disease and controlling the movement of the population can be confirmed as effective measures to prevent and control the regional outbreak of the epidemic.</text>
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            <name>Date</name>
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                <text>2020</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="15184">
                <text>2019 novel coronavirus, geographic information science, abrupt change, spatial cluster, Spatial outlier _______________, daily new confirmed cases</text>
              </elementText>
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          <element elementId="43">
            <name>Identifier</name>
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              <elementText elementTextId="15185">
                <text>DOI: 10.3390/ijerph17072563</text>
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            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="15186">
                <text>International Journal of Environmental Research and Public Health</text>
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          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="15187">
                <text>MDPI AG</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine</text>
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            <description>A language of the resource</description>
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                <text>EN</text>
              </elementText>
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          </element>
        </elementContainer>
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        <src>https://www.socictopen.socict.org/files/original/b983c1c9761bb5a6181b781e16c81128.pdf</src>
        <authentication>8886cb8bf1adb460807d4463c46e4653</authentication>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              </elementTextContainer>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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          <element elementId="50">
            <name>Title</name>
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                <text>Risk Prediction and Assessment: Duration, Infections, and Death Toll of the COVID-19 and Its Impact on China’s Economy</text>
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            <name>Creator</name>
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              <elementText elementTextId="15191">
                <text>Xiao-Guang Yue, Xuefeng Shao, Rita Yi Man Li, M. James C. Crabbe, Lili Mi, Siyan Hu, Julien S. Baker, Li-Ting Liu, Kechen Dong</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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                <text>This study first analyzes the national and global infection status of the Coronavirus Disease that emerged in 2019 (COVID-19). It then uses the trend comparison method to predict the inflection point and Key Point of the COVID-19 virus by comparison with the severe acute respiratory syndrome (SARS) graphs, followed by using the Autoregressive Integrated Moving Average model, Autoregressive Moving Average model, Seasonal Autoregressive Integrated Moving-Average with Exogenous Regressors, and Holt Winter’s Exponential Smoothing to predict infections, deaths, and GDP in China. Finally, it discusses and assesses the impact of these results. This study argues that even if the risks and impacts of the epidemic are significant, China’s economy will continue to maintain steady development.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="15193">
                <text>2020</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="15194">
                <text>COVID-19, China’s economy, severe acute respiratory syndrome, GDP, autoregressive moving average model, autoregressive integrated moving average model</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>DOI: 10.3390/jrfm13040066</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="15196">
                <text>Journal of Risk and Financial Management</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="15197">
                <text>MDPI AG</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="15198">
                <text>Finance, Risk in industry. Risk management</text>
              </elementText>
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          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="15199">
                <text>EN</text>
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