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                <text>DOI: 10.6016/ZdravVestn.3062</text>
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                <text>Pietro Emanuele Napoli, Matteo Nioi</text>
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                <text>In the current work, we discovered and analyzed the epidemiological paradox between coronavirus disease 2019 (COVID-19) and malaria in the initial phase of the ongoing pandemic. From the analysis of distribution data, the endemic presence of malaria seems to protect some populations from COVID-19 outbreak, particularly in the least developed countries. In this sense, molecular and genetic variations associated with malaria (e.g., in ACE2) might play a protective role against coronavirus infection. Moreover, the mechanism of action of some antimalarial drugs, e.g., the antiviral function, suggests their potential role in the chemoprophylaxis of coronavirus epidemics, despite possible adverse effects (e.g., retinal toxicity). All these data provide important insights to understand the spreading mechanisms of COVID-19, and to direct scientific research toward the study of some currently available medications.</text>
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                <text>DOI: 10.3390/jcm9041138</text>
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                <text>MDPI AG</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Response to the COVID-19 Epidemic: The Chinese Experience and Implications for Other Countries</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Wei Liu, Xiao-Guang Yue, Paul B. Tchounwou</text>
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                <text>The ongoing outbreak of the novel coronavirus disease (COVID-19) that occurred in China is rapidly spreading globally. China’s bond and strict containment measures have been proved (in practice) to significantly reduce the spread of the epidemic. This was obtained through the use of emergency control measures in the epidemic areas and the integration of resources from multiple systems, including business, community, technology, education, and transportation, across the country. In order to better understand how China has managed to reduce the public health and economic impacts of the COVID-19 epidemic, this editorial systematically reviews the specific measures for infection prevention and control of the disease. The best practices for COVID-19 eradication in China provide evidence-based strategies that could be replicated in other countries.</text>
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                <text>2020</text>
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                <text>COVID-19, epidemic, China, emergency control measures, Public Health</text>
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                <text>DOI: 10.3390/ijerph17072304</text>
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                <text>International Journal of Environmental Research and Public Health</text>
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                <text>MDPI AG</text>
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                <text>Medicine</text>
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                <text>EN</text>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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          <element elementId="50">
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                <text>What Does Plant-Based Vaccine Technology Offer to the Fight against COVID-19?</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Sergio Rosales-Mendoza, Verónica  A. Márquez-Escobar, Omar González-Ortega, Ricardo Nieto-Gómez, Jaime  I. Arévalo-Villalobos</text>
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                <text>The emergence of new pathogenic viral strains is a constant threat to global health, with the new coronavirus strain COVID-19 as the latest example. COVID-19, caused by the SARS-CoV-2 virus has quickly spread around the globe. This pandemic demands rapid development of drugs and vaccines. Plant-based vaccines are a technology with proven viability, which have led to promising results for candidates evaluated at the clinical level, meaning this technology could contribute towards the fight against COVID-19. Herein, a perspective in how plant-based vaccines can be developed against COVID-19 is presented. Injectable vaccines could be generated by using transient expression systems, which offer the highest protein yields and are already adopted at the industrial level to produce VLPs-vaccines and other biopharmaceuticals under GMPC-processes. Stably-transformed plants are another option, but this approach requires more time for the development of antigen-producing lines. Nonetheless, this approach offers the possibility of developing oral vaccines in which the plant cell could act as the antigen delivery agent. Therefore, this is the most attractive approach in terms of cost, easy delivery, and mucosal immunity induction. The development of multiepitope, rationally-designed vaccines is also discussed regarding the experience gained in expression of chimeric immunogenic proteins in plant systems.</text>
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                <text>2020</text>
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                <text>zoonosis, multi-epitope vaccine, Molecular Farming, oral vaccines, epitope-based vaccine, mucosal immunization</text>
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                <text>DOI: 10.3390/vaccines8020183</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="15760">
                <text>Vaccines</text>
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              <elementText elementTextId="15761">
                <text>MDPI AG</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine</text>
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                <text>EN</text>
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              <name>Title</name>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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                <text>In Silico Discovery of Candidate Drugs against Covid-19</text>
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                <text>Claudia Cava, Gloria Bertoli, Isabella Castiglioni</text>
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                <text>Previous studies reported that Angiotensin converting enzyme 2 (ACE2) is the main cell receptor of SARS-CoV and SARS-CoV-2. It plays a key role in the access of the virus into the cell to produce the final infection. In the present study we investigated in silico the basic mechanism of ACE2 in the lung and provided evidences for new potentially effective drugs for Covid-19. Specifically, we used the gene expression profiles from public datasets including The Cancer Genome Atlas, Gene Expression Omnibus and Genotype-Tissue Expression, Gene Ontology and pathway enrichment analysis to investigate the main functions of ACE2-correlated genes. We constructed a protein-protein interaction network containing the genes co-expressed with ACE2. Finally, we focused on the genes in the network that are already associated with known drugs and evaluated their role for a potential treatment of Covid-19. Our results demonstrate that the genes correlated with ACE2 are mainly enriched in the sterol biosynthetic process, Aryldialkylphosphatase activity, adenosylhomocysteinase activity, trialkylsulfonium hydrolase activity, acetate-CoA and CoA ligase activity. We identified a network of 193 genes, 222 interactions and 36 potential drugs that could have a crucial role. Among possible interesting drugs for Covid-19 treatment, we found Nimesulide, Fluticasone Propionate, Thiabendazole, Photofrin, Didanosine and Flutamide.</text>
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                <text>2020</text>
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            <name>Subject</name>
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                <text>Bioinformatics, COVID-19, Drugs, Gene network</text>
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              <elementText elementTextId="15769">
                <text>DOI: 10.3390/v12040404</text>
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              <elementText elementTextId="15770">
                <text>Viruses</text>
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              <elementText elementTextId="15771">
                <text>MDPI AG</text>
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                <text>Microbiology</text>
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            <description>A language of the resource</description>
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                <text>EN</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Lung Involvement Found on Chest CT Scan in a Pre-Symptomatic Person with SARS-CoV-2 Infection: A Case Report</text>
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                <text>Ali ASADOLLAHI-AMIN, Mehrdad Hasibi, Fatemeh Ghadimi, Hosnieh Rezaei, SeyedAhmad SEYEDALINAGHI</text>
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                <text>The novel coronavirus SARS-CoV-2 infection is spreading worldwide, and there are many reports of acute respiratory distress syndrome caused by this infection. However, asymptomatic lung involvement has not been reported. We hereby present the case of a 44-year-old health-care worker, who was found to be infected with the SARS-CoV-2 virus after a CT-scan performed for an unrelated condition revealed a lesion in the lung field compatible with COVID-19 infection. His condition deteriorated initially, but eventually improved with supportive treatment and the compassionate use of antivirals and antimalarials and is now in a stable condition.</text>
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                <text>COVID-19, SARS-CoV-2, Pneumonia, emerging infectious diseases</text>
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                <text>DOI: 10.3390/tropicalmed5020056</text>
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                <text>Tropical Medicine and Infectious Disease</text>
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            <name>Publisher</name>
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                <text>MDPI AG</text>
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                <text>Medicine</text>
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            <name>Language</name>
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                <text>EN</text>
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