1004 10 20655 https://www.socictopen.socict.org/files/original/d4b22059a844a042a9caa9e97c008745.pdf ac4bc13521abfc86f40e5902f8f09d02 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The Role of Extracellular Vesicles as Allies of HIV, HCV and SARS Viruses Creator An entity primarily responsible for making the resource Flavia Giannessi, Alessandra Aiello, Francesca Franchi, Zulema Antonia Percario, Elisabetta Affabris Description An account of the resource Extracellular vesicles (EVs) are lipid bilayer-enclosed entities containing proteins and nucleic acids that mediate intercellular communication, in both physiological and pathological conditions. EVs resemble enveloped viruses in both structural and functional aspects. In full analogy with viral biogenesis, some of these vesicles are generated inside cells and, once released into the extracellular milieu, are called “exosomes”. Others bud from the plasma membrane and are generally referred to as “microvesicles”. In this review, we will discuss the state of the art of the current studies on the relationship between EVs and viruses and their involvement in three important viral infections caused by HIV, HCV and Severe Acute Respiratory Syndrome (SARS) viruses. HIV and HCV are two well-known pathogens that hijack EVs content and release to create a suitable environment for viral infection. SARS viruses are a new entry in the world of EVs studies, but are equally important in this historical framework. A thorough knowledge of the involvement of the EVs in viral infections could be helpful for the development of new therapeutic strategies to counteract different pathogens. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Coronaviruses, HIV, HCV, Exosomes, Extracellular vesicles, SARS viruses Identifier An unambiguous reference to the resource within a given context 10.3390/v12050571 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology https://www.socictopen.socict.org/files/original/29d576bf3251446f847491137bc9a426.pdf de576fe3fa80ba418541177b1ca81dcc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Model of Quality Balance Development of Bali Tourism Destination Creator An entity primarily responsible for making the resource I Gusti Bagus Rai Utama, Ni Luh Christine Prawita Sari Suyasa, Sidhi Bayu Turker, Ni Kadek Widyastuti, Dermawan Waruwu Description An account of the resource the economic structure of Bali Province is very specific and has its characteristics compared to other provinces in Indonesia. This can be seen from the contribution of value-added to the economic sector, which is largely dominated by the tertiary sector, especially the tourism services sub-sector which has become the backbone of economic growth followed by the primary sector and the secondary sector. The dominance of the tertiary sector has the potential to be very risky because the tourism sector is very vulnerable to various phenomena including the Covid-19 pandemic. The debate between the purpose of preservation and economic empowerment in cultural tourism with all its manifestations is still a heated debate among tourism experts and tourism businesses. While the development of Bali tourism from time to time has experienced many changes along with the social dynamics that exist in society Bali. This study uses method desk research by conducting a study of literature related to the problem being solved, through a study of scientific journals, opinions, and online articles, then comparing and finding similarities and differences so that it can be used to explain the problem you want to solve. In the discussion of this study, it was found that there was still dualism that needed to be integrated to create a balance between the goals of cultural preservation and economic development for Bali. There are several solutions offered; such as Picard offers solutions to the understanding and function of art and culture and its activities in tourism and religious life. While Max-neef offers Tourism community relationships, while other solutions are the need for stakeholder involvement, Blueprint, and Carrying Capacity Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Tourism, Culture, heritage, commodity, destination, culture heritage Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Social sciences (General) https://www.socictopen.socict.org/files/original/83ba6f57757bad3b1a1d5f2a4764337e.pdf 3b4ce59d0410272d637ecb872106be34 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Control de la privacidad por parte de las autoridades sanitarias ante situaciones de emergencia Creator An entity primarily responsible for making the resource Juan Francisco Rodríguez Ayuso Description An account of the resource El presente estudio ofrece una investigación sistemática, exhaustiva y actualizada del tratamiento de datos personales relativos a la salud de los ciudadanos afectados y/o potencialmente afectados por la situación excepcional derivada del COVID-19. Para ello, y tomando en consideración toda la normativa, general y sectorial, aplicable en materia de protección de datos y de sanidad, se procede al análisis de las bases legitimadoras procedentes y de las excepciones que, aplicables a situaciones de emergencia sanitaria como la actual, habilitan el tratamiento atendiendo a la naturaleza de quien intervenga como responsable, haciendo especial énfasis en el interés público perseguido por las Administraciones Públicas y en el interés vital del propio interesado. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, Salud, tratamiento, legitimación, administraciones públicas, RGPD, Autoridades Sanitarias, dato personal Identifier An unambiguous reference to the resource within a given context 10.1344/rbd2020.50.31251 Source A related resource from which the described resource is derived Revista de Bioética y Derecho Publisher An entity responsible for making the resource available Universidad de Barcelona Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medical philosophy. Medical ethics, Jurisprudence. Philosophy and theory of law https://www.socictopen.socict.org/files/original/86ba9a266e58e639c4526e3eb8b57ae4.pdf 53086b7f09674eac520994ccb39a0058 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Lessons from SARS-CoV-2 Pandemic: Evolution, Disease Dynamics and Future Creator An entity primarily responsible for making the resource Saurabh Pandey, Bharat Yadav, Arvind Pandey, Takshashila Tripathi, Masuma Khawary, Sashi Kant, Deeksha Tripathi Description An account of the resource The COVID-19 pandemic is rising at an unprecedented rate. The surging number of deaths every day, global lockdown and travel restrictions have resulted in huge losses to society. The impact is massive and will leave a historical footprint. The Spanish Flu of 1918, which was the last pandemic that had a similar impact, was shadowed under the consequences of World War I. All the brilliance, strength and economies of countries worldwide are aimed at fighting the COVID-19 pandemic. The knowledge about coronavirus dynamics, its nature and epidemiology are expanding every day. The present review aims to summarize the structure, epidemiology, symptoms, statistical status of the disease status, intervention strategies and deliberates the lessons learnt during the pandemic. The intervention approaches, antiviral drug repurposing and vaccine trials are intensified now. Statistical interpretations of disease dynamics and their projections may help the decision-makers. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, Pandemic, SARS-CoV-2 Identifier An unambiguous reference to the resource within a given context 10.3390/biology9060141 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General) https://www.socictopen.socict.org/files/original/f1bb8721115b41308b8470966da0e586.pdf 063788ccef8c0311a8c1f6b24ddb9e09 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource COVID-19 Highest Incidence Forecast in Russia Based on Regression Model Creator An entity primarily responsible for making the resource Iosif Z. Aronov, Nataliia M. Galkina, Olga V. Maksimova Description An account of the resource The authors suggest a simple regression model of COVID-19 highest incidence prognosis in Russia on the basis of the revealed correlation between the duration of coronavirus peak (plateau) and air traffic volume. The study base included 37 countries in Europe, South America and Asia. Cluster analysis on the basis of the Euclidean metric for these countries showed the necessity of classifying the USA and China into a separate group, which gave grounds to exclude these countries from the analysis. In addition, Ireland was excluded from the analysis due to its special geographical location. For the remaining countries, the correlation coefficient between the number of airline passengers and the duration of the epidemic before reaching its peak was 0,87, which shows a high level of linear relationship between these indicators. Point forecast for the highest incidence in Russia by regression line falls on the 4th of May. The forecast interval with confidence levelγ=0.9 is ±14 days from the calculated date. The one-way analysis of variance showed that from April 22 to May 2, there was a slowdown in the growth rates of the diseased, which indicates an exit to the plateau. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, forecast, regression model, peak (plateau) Identifier An unambiguous reference to the resource within a given context 10.33889/IJMEMS.2020.5.5.063 Source A related resource from which the described resource is derived International Journal of Mathematical, Engineering and Management Sciences Publisher An entity responsible for making the resource available International Journal of Mathematical, Engineering and Management Sciences Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Mathematics, Technology https://www.socictopen.socict.org/files/original/b7e6dabea4cac946123f4508e075435b.pdf 904e7cd41ebb063e00208738043f8a0d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The Coronavirus PEDV Evades Type III Interferon Response Through the miR-30c-5p/SOCS1 Axis Creator An entity primarily responsible for making the resource Changlin Wang, Lingling Shan, Shuxin Qu, Mei Xue, Keliang Wang, Fang Fu, Lu Wang, Ziqi Wang, Li Feng, Wanhai Xu, Pinghuang Liu Description An account of the resource Porcine epidemic diarrhea virus (PEDV) is an economically important pathogen that has evolved several mechanisms to evade type I IFN responses. Type III interferon (IFN-λ), an innate cytokine that primarily targets the mucosal epithelia, is critical in fighting mucosal infection in the host and has been reported to potently inhibit PEDV infection in vitro. However, how PEDV escapes IFN-λ antiviral response remains unclear. In this study, we found that PEDV infection induced significant IFN-λ expression in type I IFN-defective Vero E6 cells, but virus-induced endogenous IFN-λ did not reduce PEDV titers. Moreover, we demonstrated that PEDV escaped IFN-λ responses by substantially upregulating the suppressor of cytokine signaling protein 1 (SOCS1) expression, which impaired the induction of IFN-stimulated genes (ISGs) and dampened the IFN-λ antiviral response and facilitated PEDV replication in Vero E6 cells. We further showed that PEDV infection increased SOCS1 expression by decreasing host miR-30c-5p expression. MiR-30c-5p suppressed SOCS1 expression through targeting the 3′ untranslated region (UTR) of SOCS1. The inhibition of IFN-λ elicited ISGs expression by SOCS1 was specifically rescued by overexpression of miR-30c-5p. Collectively, our findings identify a new strategy by PEDV to escape IFN-λ-mediated antiviral immune responses by engaging the SOCS1/miR-30c axis, thus improving our understanding of its pathogenesis. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource coronavirus, PEDV, microRNA, SOCS- 1, IFN-λ, miR-30c-5p Identifier An unambiguous reference to the resource within a given context 10.3389/fmicb.2020.01180 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology https://www.socictopen.socict.org/files/original/d660d67157be35e4e7ad7310b9a442d6.pdf 7844b7e83a86648afe23fe87bcf66e1b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis Creator An entity primarily responsible for making the resource Juntao Kan, Jun Du, Molly Hood, Liang Chen, Xue Zhang, Chun Hu, Lu Zhang Description An account of the resource Novel coronaviruses (CoV) have emerged periodically around the world in recent years. The recurrent spreading of CoVs imposes an ongoing threat to global health and the economy. Since no specific therapy for these CoVs is available, any beneficial approach (including nutritional and dietary approach) is worth investigation. Based on recent advances in nutrients and phytonutrients research, a novel combination of vitamin C, curcumin and glycyrrhizic acid (VCG Plus) was developed that has potential against CoV infection. System biology tools were applied to explore the potential of VCG Plus in modulating targets and pathways relevant to immune and inflammation responses. Gene target acquisition, gene ontology and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment were conducted consecutively along with network analysis. The results show that VCG Plus can act on 88 hub targets which are closely connected and associated with immune and inflammatory responses. Specifically, VCG Plus has the potential to regulate innate immune response by acting on NOD-like and Toll-like signaling pathways to promote interferons production, activate and balance T-cells, and regulate the inflammatory response by inhibiting PI3K/AKT, NF-κB and MAPK signaling pathways. All these biological processes and pathways have been well documented in CoV infections studies. Therefore, our findings suggest that VCG Plus may be helpful in regulating immune response to combat CoV infections and inhibit excessive inflammatory responses to prevent the onset of cytokine storm. However, further in vitro and in vivo experiments are warranted to validate the current findings with system biology tools. Our current approach provides a new strategy in predicting formulation rationale when developing new dietary supplements. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource coronavirus, vitamin C, Curcumin, inflammatory response, system biology, Glycyrrhizic acid Identifier An unambiguous reference to the resource within a given context 10.3390/nu12041193 Source A related resource from which the described resource is derived Biotemas Publisher An entity responsible for making the resource available Universidade Federal de Santa Catarina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Nutrition. Foods and food supply https://www.socictopen.socict.org/files/original/b1769e7a9fa5361be4e27bc4d6895413.pdf 19f7e284f8fb6b14731a8a3f2ca2f4a6 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Collaborative Facilitation and Collaborative Inhibition in Virtual Environments Creator An entity primarily responsible for making the resource Andrea Guazzini, Elisa Guidi, Cristina Cecchini, Eiko Yoneki Description An account of the resource Worldwide, organizations and small and medium-sized enterprises have already disruptively changed in many ways their physiological inner mechanisms, because of information and communication technologies (ICT) revolution. Nevertheless, the still ongoing COVID-19 worldwide emergency definitely promoted a wide adoption of teleworking modalities for many people around the world, making it more relevant than before to understand the real impact of virtual environments (VEs) on teamwork dynamics. From a psychological point of view, a critical question about teleworking modalities is how the social and cognitive dynamics of collaborative facilitation and collaborative inhibition would affect teamwork within VEs. This study analyzed the impact of a virtual environment (VE) on the recall of individuals and members of nominal and collaborative groups. The research assessed costs and benefits for collaborative retrieval by testing the effect of experimental conditions, stimulus materials, group size, experimental conditions order, anxiety state, personality traits, gender group composition and social interactions. A total of 144 participants were engaged in a virtual Deese-Roediger-McDermott (DRM) classical paradigm, which involved remembering word lists across two successive sessions, in one of four protocols: I-individual/nominal, I I - nominal/individual, I I I - nominal/collaborative, I V - collaborative/nominal. Results suggested, in general, a reduced collaborative inhibition effect in the collaborative condition than the nominal and individual condition. A combined effect between experimental condition and difficulty of the task appears to explain the presence of collaborative inhibition or facilitation. Nominal groups appeared to enhance the collaborative groups’ performance when virtual nominal groups come before collaborative groups. Variables such as personality traits, gender and social interactions may have a contribution to collaborative retrieval. In conclusion, this study indicated how VEs could maintain those peculiar social dynamics characterizing the participants’ engagement in a task, both working together and individually, and could affect their intrinsic motivation as well as performances. These results could be exploited in order to design brand new and evidenced-based practices, to improve teleworking procedures and workers well-being, as well as teleworking teamwork effectiveness. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource collaborative facilitation, DRM paradigm, collaborative inhibition, virtual dynamics, virtual teamwork Identifier An unambiguous reference to the resource within a given context 10.3390/fi12070118 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Information technology https://www.socictopen.socict.org/files/original/d4b55b7230a44bbfb54bb73d142a6d1e.pdf 7b5d116ce076a706646c1e8cd44da69a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Growth Rate and Acceleration Analysis of the COVID-19 Pandemic Reveals the Effect of Public Health Measures in Real Time Creator An entity primarily responsible for making the resource Marco Milanesi, Yuri Tani Utsunomiya, Yuri Tani Utsunomiya, Adam Taiti Harth Utsunomiya, Rafaela Beatriz Pintor Torrecilha, Silvana de Cássia Paulan, José Fernando Garcia, José Fernando Garcia, José Fernando Garcia Description An account of the resource Background: Ending the COVID-19 pandemic is arguably one of the most prominent challenges in recent human history. Following closely the growth dynamics of the disease is one of the pillars toward achieving that goal.Objective: We aimed at developing a simple framework to facilitate the analysis of the growth rate (cases/day) and growth acceleration (cases/day2) of COVID-19 cases in real-time.Methods: The framework was built using the Moving Regression (MR) technique and a Hidden Markov Model (HMM). The dynamics of the pandemic was initially modeled via combinations of four different growth stages: lagging (beginning of the outbreak), exponential (rapid growth), deceleration (growth decay), and stationary (near zero growth). A fifth growth behavior, namely linear growth (constant growth above zero), was further introduced to add more flexibility to the framework. An R Shiny application was developed, which can be accessed at https://theguarani.com.br/ or downloaded from https://github.com/adamtaiti/SARS-CoV-2. The framework was applied to data from the European Center for Disease Prevention and Control (ECDC), which comprised 3,722,128 cases reported worldwide as of May 8th 2020.Results: We found that the impact of public health measures on the prevalence of COVID-19 could be perceived in seemingly real-time by monitoring growth acceleration curves. Restriction to human mobility produced detectable decline in growth acceleration within 1 week, deceleration within ~2 weeks and near-stationary growth within ~6 weeks. Countries exhibiting different permutations of the five growth stages indicated that the evolution of COVID-19 prevalence is more complex and dynamic than previously appreciated.Conclusions: These results corroborate that mass social isolation is a highly effective measure against the dissemination of SARS-CoV-2, as previously suggested. Apart from the analysis of prevalence partitioned by country, the proposed framework is easily applicable to city, state, region and arbitrary territory data, serving as an asset to monitor the local behavior of COVID-19 cases. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource coronavirus, severe acute respiratory syndrome, Mathematical modeling, Hidden Markov Model, growth curve analysis, moving regression Identifier An unambiguous reference to the resource within a given context 10.3389/fmed.2020.00247 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General) https://www.socictopen.socict.org/files/original/a5e10b9f0277bdf42da859150e991b59.pdf da2579fe6637c514f2433d7377170b26 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Molecular Evolution and Structural Mapping of N-Terminal Domain in Spike Gene of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Creator An entity primarily responsible for making the resource Asif Naeem, Maaweya E. Hamed, Majed F. Alghoribi, Waleed Aljabr, Hadel Alsaran, Mushira A. Enani, Bandar Alosaimi Description An account of the resource The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a lethal zoonotic pathogen circulating in the Arabian Peninsula since 2012. There is no vaccine for MERS and anti-viral treatment is generally not applicable. We investigated the evolution of the MERS-CoV spike gene sequences and changes in viral loads over time from patients in Saudi Arabia from 2105–2017. All the MERS-CoV strains belonged to lineage 5, and showed high sequence homology (99.9%) to 2017 strains. Recombination analysis showed a potential recombination event in study strains from patients in Saudi Arabia. The spike gene showed eight amino acid substitutions, especially between the A1 and B5 lineage, and contained positively selected codon 1020. We also determined that the viral loads were significantly (p < 0.001) higher in fatal cases, and virus shedding was prolonged in some fatal cases beyond 21 days. The viral concentration peaked during the first week of illness, and the lower respiratory specimens had higher levels of MERS-CoV RNA. The presence of the diversifying selection and the topologies with the structural mapping of residues under purifying selection suggested that codon 1020 might have a role in the evolution of spike gene during the divergence of different lineages. This study will im­prove our understanding of the evolution of MERS-CoV, and also highlights the need for enhanced surveillance in humans and dromedaries. The presence of amino acid changes at the N-terminal domain and structural mapping of residues under positive selection at heptad repeat 1 provides better insight into the adaptive evolution of the spike gene and might have a potential role in virus-host tropism and pathogenesis. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Middle East respiratory syndrome coronavirus, evolution, viral load, Spike gene Identifier An unambiguous reference to the resource within a given context 10.3390/v12050502 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology