1005 10 20655 https://www.socictopen.socict.org/files/original/182aeb9e5991df132501200404483cee.pdf 11ebe0a4cc06f8dfddef1225a47e31df Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Chronic Neurology in COVID-19 Era: Clinical Considerations and Recommendations From the REPROGRAM Consortium Creator An entity primarily responsible for making the resource Vijay Kumar Chattu, Sonu Bhaskar, Sonu Bhaskar, Sonu Bhaskar, Sian Bradley, Sian Bradley, Simon Israeli-Korn, Simon Israeli-Korn, Bindu Menon, Bindu Menon, Vijay Kumar Chattu, Pravin Thomas, Pravin Thomas, Jasvinder Chawla, Jasvinder Chawla, Rajeev Kumar, Rajeev Kumar, Paolo Prandi, Paolo Prandi, Daniel Ray, Daniel Ray, Sailaja Golla, Sailaja Golla, Nirmal Surya, Nirmal Surya, Harvey Yang, Harvey Yang, Sandra Martinez, Sandra Martinez, Mihriban Heval Ozgen, Mihriban Heval Ozgen, Mihriban Heval Ozgen, John Codrington, John Codrington, Eva María Jiménez González, Eva María Jiménez González, Mandana Toosi, Mandana Toosi, Nithya Hariya Mohan, Nithya Hariya Mohan, Koravangattu Valsraj Menon, Koravangattu Valsraj Menon, Abderrahmane Chahidi, Abderrahmane Chahidi, Abderrahmane Chahidi, Abderrahmane Chahidi, Susana Mederer Hengstl, Susana Mederer Hengstl Description An account of the resource With the rapid pace and scale of the emerging coronavirus 2019 (COVID-19) pandemic, a growing body of evidence has shown a strong association of COVID-19 with pre- and post- neurological complications. This has necessitated the need to incorporate targeted neurological care for this subgroup of patients which warrants further reorganization of services, healthcare workforce, and ongoing management of chronic neurological cases. The social distancing and the shutdown imposed by several nations in the midst of COVID-19 have severely impacted the ongoing care, access and support of patients with chronic neurological conditions such as Multiple Sclerosis, Epilepsy, Neuromuscular Disorders, Migraine, Dementia, and Parkinson disease. There is a pressing need for governing bodies including national and international professional associations, health ministries and health institutions to harmonize policies, guidelines, and recommendations relating to the management of chronic neurological conditions. These harmonized guidelines should ensure patient continuity across the spectrum of hospital and community care including the well-being, safety, and mental health of the patients, their care partners and the health professionals involved. This article provides an in-depth analysis of the impact of COVID-19 on chronic neurological conditions and specific recommendations to minimize the potential harm to those at high risk. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource guidelines, coronavirus disease 2019 (covid-19), Protocols, healthcare services, neurodegenerative disorders, chronic neurological disease Identifier An unambiguous reference to the resource within a given context 10.3389/fneur.2020.00664 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Neurology. Diseases of the nervous system https://www.socictopen.socict.org/files/original/c309f969c41ee3bba6c210ffb2099fdf.pdf c1dac5a31752fc28495dda3fdac53059 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource SARS-CoV-2 Infection in Cancer Patients: A Picture of an Italian Onco-Covid Unit Creator An entity primarily responsible for making the resource Umberto Malapelle, Maria Lucia Reale, Paolo Bironzo, Valentina Bertaglia, Erica Palesandro, Gianmarco Leone, Fabrizio Tabbò, Maristella Bungaro, Marco Audisio, Annapaola Mariniello, Simonetta G. Rapetti, Rosario F. Di Stefano, Elisa Artusio, Enrica Capelletto, Paola Sperone, Adriana Boccuzzi, Marco Calandri, Alberto Perboni, Francesco Passiglia, Silvia Novello Description An account of the resource Background: The world, and Italy on the front lines, has experienced a major medical emergency due to the novel coronavirus outbreak. Cancer patients are one of the potentially most vulnerable cohorts of people, but data about their management are still few.Patients and Methods: In this monocentric retrospective study we included all SARS-CoV-2 oncological patients accepted, between March 27th and April 19th 2020, at the Onco-COVID Unit at San Luigi Gonzaga Hospital, one of the few Italian oncological-COVID wards. Data were obtained from medical records.Results: Eighteen cancer patients with COVID-19 were included. The mean (±SD) age of patients was 67 ± 14 years, 89% were men. Seven (39%) developed infection in communities and 11 (61%) during hospitalization. Lung cancer was the most frequent type of cancer (10, 56%). Seven patients (39%) were symptomatic for COVID-19 at the time of diagnosis and symptoms began 2 (±2) days before. The most common were shortness of breath and diarrhea. Fever was present in 5 patients (28%). Among the 11 asymptomatic patients, 8 (73%) became symptomatic during the hospitalization (mean time of symptoms onset 4 days ±4). Six patients (33%) were on active anti-tumor treatment: 2 (33%) received anti-tumor therapy within 2 weeks before the infection diagnosis and 2 (33%) continued oncological treatment after SARS-CoV-2 positivity. Eight (44%) patients died within a mean of 12 days (±8) from the infection diagnosis.Conclusions: Our series confirms the high mortality among cancer patients with COVID-19. The presence of asymptomatic cases evidences that typical symptoms and fever are not the only parameters to suspect the infection. The Onco-Covid unit suggests the importance of a tailored and holistic approach, even in this difficult situation. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, Lung cancer, Cancer patients, Asymptomatic patients, Italian retrospective study Identifier An unambiguous reference to the resource within a given context 10.3389/fonc.2020.01722 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Neoplasms. Tumors. Oncology. Including cancer and carcinogens https://www.socictopen.socict.org/files/original/c3a3df78372ba4c1e7ffd89d7364f100.pdf 3c82fe9c9c88150cb3356cafb7972e3a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource (Opportunities) Death of Newspaper Industry in Digital Age and Covid-19 Pandemic Creator An entity primarily responsible for making the resource Supadiyanto Supadiyanto Description An account of the resource Newspaper industry is entering a state of emergency in Indonesia. Dewan Pers demands that the government provide incentives to press companies during Covid-19. The growth in the number of internet users, the downward trend in advertising revenue, and the number of newspaper circulation are problems in the print media business. List of questions in this study: what are the trends in the use of internet technology and social media in Indonesia?; why did various newspaper companies in Indonesia collapse and die in the digital era?; how is the effort to save the newspaper business? Meanwhile, the research paradigm is qualitative. The time of the study is November 2019 to May 2020. The results of this research, the growth in the number of internet users has been extraordinary in the last 20 years. Signs of the newspaper era are over, strengthened by many newspaper companies turning to online media. The number of readers fell, the number of advertisers plummeted, number of copies narrowed, and the cost of producing newspapers became increasingly expensive to cause the closure of various newspaper companies. Rescue by attracting young readers and doing various innovations. Tragically, the print media industry will end and die on its own. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19 pandemic, Opportunities, Digital Age, collapse, newspaper industry Identifier An unambiguous reference to the resource within a given context 10.26623/themessenger.v12i2.2244 Source A related resource from which the described resource is derived Jurnal the Messenger Publisher An entity responsible for making the resource available Universitas Semarang Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Communication. Mass media https://www.socictopen.socict.org/files/original/fe4315ff45d5b6248e754d3c69b58a2c.pdf 481b7af21fad454e2051c2b5bcade263 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The Challenge of the Energy Sector of Russia during the 2020 COVID-19 Pandemic through the Example of the Republic of Tatarstan: Discussion on the Change of Open Innovation in the Energy Sector Creator An entity primarily responsible for making the resource Anastasia Kulachinskaya, Irina G. Akhmetova, Varvara Y. Kulkova, Svetlana B. Ilyashenko Description An account of the resource Today the world economy is handling an economic crisis caused by the pandemic of a new coronavirus infection (COVID-19), announced by the WHO, as well as by fluctuations in the international energy market and by the development of “green energy”. The crisis, named the “2020 crisis”, is notable for the divergence of the sectoral dynamics of development, with a declining development trend in some industries and the rapid growth of others. The crisis is etymologically relevant to the energy sector, a sector which is important for the survival and specialization of the Russian Federation. This research is aimed at describing the status and highlighting the socioeconomic effects, constraints (economic and social risks), and “growth points” of the energy sector in the modern realities of the 2020 crisis. Methods. The method of in-depth interview was used. The need for studying expert opinion is based on the fundamental principles of implementation research, according to which the success of state sectoral policy depends on its perception and support by stakeholders. Top managers of energy enterprises acted as the experts (N = 10). The interviews were conducted in April 2020. The method of incremental approximation and coding (open and axial) were used for a high-quality discourse analysis. Results. The conducted study revealed divergence of sectoral dynamics of energy consumption, which is a translation of the immanent features of the 2020 crisis into the energy sector. The detected constraints are reserved development prerequisites of “green energy” and reduced investments in development programs. The potential “growth points” include intensified digitalization of the energy sector and the need for institutional changes in taxation in the energy sector, recognized by experts. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource energy economy, state policy during the “2020 crisis”, anti-crisis actions of companies Identifier An unambiguous reference to the resource within a given context 10.3390/joitmc6030060 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Business, Management. Industrial management https://www.socictopen.socict.org/files/original/3afb177f9f2380a2127d39f8b26bdd57.pdf 6c05511be1024860f0cdc92443d27d65 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Complex Social Networks are Missing in the Dominant COVID-19 Epidemic Models Creator An entity primarily responsible for making the resource Gianluca Manzo Description An account of the resource In the COVID-19 crisis, compartmental models have been largely used to predict the macroscopic dynamics of infections and deaths and to assess different non-pharmaceutical interventions aimed to contain the microscopic dynamics of person-to-person contagions. Evidence shows that the predictions of these models are affected by high levels of uncertainty. However, the link between predictions and interventions is rarely questioned and a critical scrutiny of the dependency of interventions on model assumptions is missing in public debate. In this article, I have examined the building blocks of compartmental epidemic models so influential in the current crisis. A close look suggests that these models can only lead to one type of intervention, i.e., interventions that indifferently concern large subsets of the population or even the overall population. This is because they look at virus diffusion without modelling the topology of social interactions. Therefore, they cannot assess any targeted interventions that could surgically isolate specific individuals and/or cutting particular person-to-person transmission paths. If complex social networks are seriously considered, more sophisticated interventions can be explored that apply to specific categories or set of individuals with expected collective benefits. In the last section of the article, I sketch a research agenda to promote a new generation of network-driven epidemic models. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Compartmental models, small-world networks, Scale-free Networks, egocentered networks, agent-based computational models Identifier An unambiguous reference to the resource within a given context 10.6092/issn.1971-8853/10839 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Sociology (General), Social Sciences https://www.socictopen.socict.org/files/original/c8d852419a3266b0a11aeeb558a2c811.pdf 7db50938c10731eded4671db55386a6c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Optimized qRT-PCR Approach for the Detection of Intra- and Extra-Cellular SARS-CoV-2 RNAs Creator An entity primarily responsible for making the resource Tuna Toptan, Sebastian Hoehl, Sandra Westhaus, Denisa Bojkova, Annemarie Berger, Björn Rotter, Klaus Hoffmeier, Jindrich Cinatl, Sandra Ciesek, Marek Widera Description An account of the resource The novel coronavirus SARS-CoV-2 is the causative agent of the acute respiratory disease COVID-19, which has become a global concern due to its rapid spread. Meanwhile, increased demand for testing has led to a shortage of reagents and supplies and compromised the performance of diagnostic laboratories in many countries. Both the World Health Organization (WHO) and the Center for Disease Control and Prevention (CDC) recommend multi-step RT-PCR assays using multiple primer and probe pairs, which might complicate the interpretation of the test results, especially for borderline cases. In this study, we describe an alternative RT-PCR approach for the detection of SARS-CoV-2 RNA that can be used for the probe-based detection of clinical isolates in diagnostics as well as in research labs using a low-cost SYBR green method. For the evaluation, we used samples from patients with confirmed SARS-CoV-2 infections and performed RT-PCR assays along with successive dilutions of RNA standards to determine the limit of detection. We identified an M-gene binding primer and probe pair highly suitable for the quantitative detection of SARS-CoV-2 RNA for diagnostic and research purposes. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource coronavirus, covid-19, SARS-CoV-2, test protocol, qRT-PCR detection Identifier An unambiguous reference to the resource within a given context 10.3390/ijms21124396 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Chemistry https://www.socictopen.socict.org/files/original/54e9bb74fb201d9125d762321d87e3a6.pdf de67fda5ba94e7b199221c13321a3036 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource J.M. Coetzee and Elizabeth Costello: Landscapes and Animals Creator An entity primarily responsible for making the resource Lucilla Spini Description An account of the resource The South African writer John Maxwell Coetzee is well-known for references to animals in his fiction, also given the fact that he and one of his well-known characters, Elizabeth Costello, raise awareness of the cruelty enacted on animals. Many studies have been conducted on Coetzee’s animals, but less attention has been placed on the settings and landscapes in which the animals are situated. Hence, this study aims at understanding the role of the landscapes surrounding the animals via an ecocritical approach. The paper focuses on Coetzee’s fiction featuring Elizabeth Costello, namely, The Lives of Animals (1999), Elizabeth Costello: Eight Lessons (2003), Slow Man (2005), and Moral Tales (2017) by identifying the animals and by discussing the related settings and landscapes. The research concludes that, despite the presence of several animals, there are almost no references to animals in pristine habitats, that most of the animals are in anthropized settings, and that animals’ and humans’ suffering are hidden in a shared landscape. This understanding is discussed as an ecological message about the interlinkages between the human and nonhuman worlds and between animals’ and humans’ wellbeing, also referring to the animal/human interconnectedness within the COVID-19 pandemic. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource animals, landscape, ecocriticism, J.M. Coetzee, interlinkages, Elizabeth Costello Identifier An unambiguous reference to the resource within a given context 10.3390/h9030074 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant History of scholarship and learning. The humanities https://www.socictopen.socict.org/files/original/0357e516685381dc79723a391022550b.pdf b9f1f0d61191388dd272b2b526405d6b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The Antiaging Effect of Active Fractions and <i>Ent</i>-11α-Hydroxy-15-Oxo-Kaur-16-En-19-Oic Acid Isolated from <i>Adenostemma lavenia</i> (L.) O. Kuntze at the Cellular Level Creator An entity primarily responsible for making the resource Rika Indri Astuti, Irmanida Batubara, Muhammad Eka Prastya, Auliya Ilmiawati, Miwa Maeda, Mayu Suzuki, Akie Hamamoto, Hiroshi Takemori Description An account of the resource Background: The extract of Adenostemma lavenia (L.) O. Kuntze leaves has anti-inflammatory activities and is used as a folk medicine to treat patients with hepatitis and pneumonia in China and Taiwan. The diterpenoid ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic acid (11αOH-KA) is the major ingredient in the extract and has wide-spectrum biological activities, such as antitumor and antimelanogenic activities, as well as anti-inflammatory activity. However, the physical and biological properties of this compound as an antioxidant or antiaging agent have not been reported yet. Methods: In addition to in vitro assays, we monitored antioxidative and antiaging signals in Schizosaccharomyces pombe (yeast) and mouse melanoma B16F10 cells. Results: A. lavenia water and chloroform fractions showed antioxidant properties in vitro. The A. lavenia extracts and 11αOH-KA conferred resistance to H2O2 to S. pombe and B16F10 cells and extended the yeast lifespan in a concentration-dependent manner. These materials maintained the yeast mitochondrial activity, even in a high-glucose medium, and induced an antioxidant gene program, the transcriptional factor pap1+ and its downstream ctt1+. Accordingly, 11αOH-KA activated the antioxidative transcription factor NF-E2-related factor 2, NRF2, the mammalian ortholog of pap1+, in B16F10 cells, which was accompanied by enhanced hemeoxygenase expression levels. These results suggest that 11αOH-KA and A. lavenia extracts may protect yeast and mammalian cells from oxidative stress and aging. Finally, we hope that these materials could be helpful in treating COVID-19 patients, because A. lavenia extracts and NRF2 activators have been reported to alleviate the symptoms of pneumonia in model animals. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Nrf2, anti-aging, <i>adenostemma lavenia</i>, <i>ent</i>-11α-hydroxy-15-oxo-kaur-16-en-19-oic acid, <i>pap1</i>⁺ transcription factor Identifier An unambiguous reference to the resource within a given context 10.3390/antiox9080719 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Therapeutics. Pharmacology https://www.socictopen.socict.org/files/original/226f5c87071a74a5f033b8122498dfc7.pdf d9ae169ee0db600092fcbbc6982f6b0c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Current Status of Laboratory Diagnosis for COVID-19: A Narrative Review Creator An entity primarily responsible for making the resource Russo A, Minichini C, Starace M, Astorri R, Calò F, Coppola N Description An account of the resource Antonio Russo, Carmine Minichini, Mario Starace, Roberta Astorri, Federica Cal&ograve;, Nicola Coppola On behalf of the Vanvitelli COVID-19 groupDepartment of Mental Health and Public Medicine, Infectious Diseases Unit, University of Campania Luigi Vanvitelli, Naples, ItalyCorrespondence: Nicola CoppolaDepartment of Mental Health and Public Medicine, Infectious Diseases Unit, University of Campania Luigi Vanvitelli, Via: L. Armanni 5, Naples 80131, ItalyTel +39 0815666719Fax +39 0815666013Email nicola.coppola@unicampania.itAbstract: The outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the related disease (COVID-19) has spread rapidly to pandemic proportions, increasing the demands on healthcare systems for the containment and management of COVID-19. One of the critical issues to be addressed is the improvement in laboratory diagnosis and screening of large portions of the population to stop the virus spreading. Currently, the laboratory diagnosis of SARS-CoV-2 infection and the related disease is based on the research of viral RNA with rt-PCR methods in upper and lower respiratory airways. Serological tests to detect SARS-CoV-2 antibodies could help physicians and healthcare workers to support COVID-19 diagnosis and follow-up and perform population screening. Our review, using MEDLINE and EMBASE, summarizes the current knowledge of direct and serological tests performed to research RNA, antigens, or antibodies for SARS-CoV-2, evaluating the advantages and drawbacks for specific tests.Keywords: COVID-19, SARS-CoV-2, laboratory diagnosis, serological test, PCR Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource laboratory diagnosis, PCR, covid-19, SARS-CoV-2, Serological test Source A related resource from which the described resource is derived Biotemas Publisher An entity responsible for making the resource available Universidade Federal de Santa Catarina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases https://www.socictopen.socict.org/files/original/e6a5a991478d4763480f410379132427.pdf 9e4d7d95967eb244cad6bb2c1e4c5f73 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource COVID-19 and Obesity: Dangerous Liaisons Creator An entity primarily responsible for making the resource Grazia Caci, Adriana Albini, Mario Malerba, Douglas M. Noonan, Patrizia Pochetti, Riccardo Polosa Description An account of the resource Besides advanced age and the presence of multiple comorbidities as major contributors to increased risk of severe disease and fatal outcome from Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19), there is now emerging evidence that overweight and obesity predispose to severe symptoms and negative prognosis. Remarkably, the severity of COVID-19 appears to rise with increasing body mass index (BMI). The association between COVID-19 outcomes and overweight/obesity has biological and physiological plausibility. Potential pathophysiological mechanisms that may explain this strong association include the chronic pro-inflammatory state, the excessive oxidative stress response, and the impaired immunity that is commonly reported in these individuals. The role of cytokines, mammalian target of rapamycin (mTOR), and altered natural killer cell polarization in the dangerous liaison between COVID-19 and obesity are discussed here. These pathways can favor and accelerate the deleterious downstream cellular effects of SARS-CoV-2. Moreover, obesity is well known to be associated with reduced lung function and poor response to mechanical ventilation, thus placing these individuals at high risk of severe illness and mortality from COVID-19. Furthermore, obesity may lead to other complications, such as renal failure, cardiovascular dysfunction, hypertension, and vascular damage, which in turn can further accelerate negative clinical outcomes from COVID-19. Obese individuals should be shielded against any potential viral exposure to SARS-CoV-2 with consequential considerations for compulsory protection devices and social distancing. Health care providers should be aware that obesity predisposes to severe symptoms and negative prognosis in COVID-19 patients. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, SARS-CoV-2, ACE2, cytokine storm, obesity, renin–angiotensin system (RAS) pathway Identifier An unambiguous reference to the resource within a given context 10.3390/jcm9082511 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine