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                  <text>Dominio científico: Coronavirus</text>
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                <text>Acute Kidney Injury Can Predict In-Hospital Mortality in Elderly Patients with COVID-19 in the ICU: A Single-Center Study</text>
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                <text>Li Q, Zhang T, Li F, Mao Z, Kang H, Tao L, Zhou F, Cai Y</text>
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                <text>Qinglin Li, 1,* Tianyi Zhang, 2,* Fei Li, 3, 4,* Zhi Mao, 1 Hongjun Kang, 1 Ling Tao, 3,* Feihu Zhou, 1, 3,* Yue Cai 1, 3, 4,*  1Department of Critical Care Medicine, The First Medical Centre, Chinese PLA General Hospital, Beijing 100853, People&amp;rsquo;s Republic of China;  2Institution of Hospital Management, Medical Innovation Research Division of Chinese PLA General Hospital, Beijing 100853, People&amp;rsquo;s Republic of China;  3Department of Cardiology, Xijing Hospital, Xi&amp;rsquo;an 710032, People&amp;rsquo;s Republic of China;  4Department of Infectious Diseases, Huo Shen Shan Hospital, Wuhan, People&amp;rsquo;s Republic of China*These authors contributed equally to this workCorrespondence: Feihu Zhou Tel +86 10 6693 8148Email feihuzhou301@126.comYue Cai Tel + 86 159 0238 8078Email caiyueclear1981@163.comObjective: Severe or critical patients with coronavirus disease 2019 (COVID-19) are at increased risk for developing acute kidney injury (AKI). However, the rate of AKI in patients of different severities and independent predictive factors associated with AKI are not well understood.Patients and Methods: We enrolled 107 severely or critically ill elderly patients with COVID-19 who were admitted to the intensive care unit (ICU) in Wuhan, China. AKI was defined according to the 2012 KDIGO criteria. We explored the association between AKI and in-hospital mortality using logistic regression. A predictive nomogram was formulated to predict the AKI development of patients with COVID-19 based on multivariate logistic regression.Results: A total of 107 elderly patients were enrolled during the study period. The mean age was 70 (64&amp;ndash; 78) years, and 69 (64.5%) were men. For the 107 patients, the degree of severity of COVID-19 was categorized as 37 patients with the severe type (34.6%) and 70 patients with the critical type (65.4%). Overall, 48 of the 107 patients (44.9%) developed AKI during their hospitalization, while AKI occurred in 7 (18.9%) out of the 37 severe patients and 41 (44.9%) out of the 70 critical patients. Of the AKI patients, 35.4% (17/48) required continuous renal replacement therapy, including 14.3% of AKI patients in severe cases and 39.0% of AKI patients in critical cases. Kaplan&amp;ndash;Meier analysis demonstrated that patients with AKI had a significantly higher risk for in-hospital mortality than severely and critically ill patients without AKI. Multivariate logistic regression analysis showed that AKI (OR = 33.74; 95% CI = 3.34&amp;ndash; 341.29; P = 0.003), septic shock (OR = 15.58; 95% CI = 2.08&amp;ndash; 116.78; P = 0.008), invasive mechanical ventilation (OR = 18.44; 95% CI = 2.35&amp;ndash; 144.69; P = 0.006), and oxygenation index (OR = 0.99; 95% CI = 0.98&amp;ndash; 1.000; P = 0.014) were independent risk factors for in-hospital mortality. A nomogram was established based on the multivariate analysis results. The C-index for the developed AKI model was 0.935 (95% CI, 0.892&amp;ndash; 0.978); when 10-fold cross validation was used to validate the model, the corrected C-index was 0.825.Conclusion: AKI is common among COVID-19 patients admitted to the ICU and is recognized as a marker of disease severity. The proposed nomogram accurately predicted AKI development in ICU patients with COVID-19 based on individual characteristics. Therefore, the strategy for kidney protection against severe or critical pneumonia is appropriate.Keywords: coronavirus disease 2019, acute kidney injury, diagnosis, nomogram, in-hospital mortality</text>
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                <text>Diagnosis, acute kidney injury, Coronavirus disease 2019, nomogram, in-hospital mortality</text>
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                <text>Biotemas</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Vito Fanelli, Marco Fiorentino, Vincenzo Cantaluppi, Loreto Gesualdo, Giovanni Stallone, Claudio Ronco, Giuseppe Castellano</text>
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                <text>DOI: 10.1186/s13054-020-02872-z</text>
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                <text>Medical emergencies. Critical care. Intensive care. First aid</text>
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                <text>Acute Kidney Injury in SARS-CoV-2 Infection: Direct Effect of Virus on Kidney Proximal Tubule Cells</text>
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                <text>Manoocher Soleimani</text>
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                <text>Coronaviruses (CoVs), including Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and the novel coronavirus disease-2 (SARS-CoV-2) are a group of enveloped RNA viruses that cause a severe respiratory infection which is associated with a high mortality [...]</text>
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                <text>Acute kidney injury, lysosomes, ACE2, Proximal tubule cells, SARS-CoV-2</text>
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                <text>DOI: 10.3390/ijms21093275</text>
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                <text>International Journal of Molecular Sciences</text>
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                <text>Biology (General), Chemistry</text>
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                <text>Acute Kidney Injury in the 2019 Novel Coronavirus Disease</text>
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                <text>Bin Wang, Bicheng Liu, Jing-Yi Qian</text>
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                <text>Background: The 2019 novel coronavirus disease (CO­VID-19) is a newly defined serious infectious disease caused by the SARS-CoV-2 virus. The epidemic started in Wuhan, China, in December of 2019 and quickly spread to over 200 countries. It has affected 4,258,666 people, with 294,190 deaths worldwide by May 15, 2020. COVID-19 is characterized by acute respiratory disease, with 80% of patients presenting mild like flu-like symptoms; however, 20% of patients may have a severe or critical clinical presentation, which likely causes multiple organ injuries (e.g., kidney, heart, blood, and nervous system). Among them, acute kidney injury (AKI) is a critical complication due to its high incidence and mortality rate. Here we present a review of the current understanding of AKI in COVID-19. Summary: CO­VID-19 is a catastrophic contagious disease caused by the coronavirus, and the AKI induced by COVID-19 significantly increases the mortality rate. In this review, we summarize the clinical characteristics of COVID-19 induced AKI by focusing on its epidemiology, pathogenesis, clinical diagnosis, and treatment. Key Messages: Multiple studies have shown that COVID-19 may involve the kidneys and cause AKI. This article reviews the characteristics of COVID-19-induced AKI largely based on up-to-date studies in the hope that it will be helpful in the current global fight against and treatment of COVID-19.</text>
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                <text>Acute kidney injury, COVID-19, 2019 novel coronavirus disease</text>
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                <text>DOI: 10.1159/000509086</text>
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                <text>Kidney Diseases</text>
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                <text>Karger Publishers</text>
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                <text>Al-zoubi N, Shatnawi N, Jarbo H</text>
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                <text>Nabil Al-zoubi, Nawaf Shatnawi, Hamza Jarbo Department of General Surgery/Vascular Surgery, Jordan University of Science and Technology, Irbid, JordanCorrespondence: Nabil Al-zoubiDepartment of Surgery, Faculty of Medicine, Jordan University of Science and Technology, P.O. Box 3030, Irbid, 22110, JordanTel + 962 7955774637Email dr_nabeil_z3bi@yahoo.comBackground: The aim of this study was to investigate the prevalence of acute lower limb ischemia (ALLI) among patients infected with COVID-19 and to review their characteristics and outcomes.Methods: This study was performed at King Abdullah University Hospital (KAUH) in the north of Jordan. All patients with ALLI and COVID-19 infection, between November 1, 2020 and December 31, 2020, were retrospectively identified and reviewed.Results: A total number of 1300 COVID-19 patients were admitted to KAUH during the period of the study. Seven patients (0.54%) had ALLI. Of them, 5 were males (71.4%) with a mean age of 68 &amp;plusmn; 3 years and 2 were females (28.6%) with a mean age of 58 &amp;plusmn; 7 years. Five patients (71.4%) were admitted as COVID-19 infection and developed ALLI during hospitalization, all of them were males, had COVID-19 related pneumonia, and died within 24 hours of ALLI diagnosis. While 2 patients were presented with ALLI and found to have positive COVID-19, all of them were females, underwent successful thrombo-embolectomy, and had no deaths, however, one of them had recurrent ALLI which resulted in below knee amputation.Conclusion: The prevalence of ALLI in patients infected with COVID-19 was 0.54%. We observed that patients with COVID-19 related pneumonia who develop ALLI during hospitalization had a high mortality.Keywords: ALLI, COVID-19, KAUH</text>
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                <text>2021</text>
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            <name>Subject</name>
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                <text>covid-19, alli, kauh</text>
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                <text>Biotemas</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Universidade Federal de Santa Catarina</text>
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                <text>Medicine (General)</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Acute Middle East Respiratory Syndrome Coronavirus Infection in Livestock Dromedaries, Dubai, 2014</text>
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              <elementText elementTextId="10099">
                <text>Sung Sup Park, Ulrich Wernery, Victor M. Corman, Emily Y.M. Wong, Alan K.L. Tsang, Doreen Muth, Susanna K. P. Lau, Kamal Khazanehdari, Florian Zirkel, Mansoor Ali, Péter Nagy, Jutka Juhasz, Renate Wernery, Sunitha Joseph, Ginu Syriac, Shyna K. Elizabeth, Nissy Annie Georgy Patteril, Patrick C. Y. Woo, Christian Drosten</text>
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                <text>Camels carry Middle East respiratory syndrome coronavirus, but little is known about infection age or prevalence. We studied &gt;800 dromedaries of all ages and 15 mother–calf pairs. This syndrome constitutes an acute, epidemic, and time-limited infection in camels</text>
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                <text>2015</text>
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            <description>The topic of the resource</description>
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                <text>MERS-CoV, Middle East respiratory syndrome coronavirus, camels, coronavirus, Viruses, Dubai</text>
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                <text>DOI: 10.3201/eid2106.150038</text>
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              <elementText elementTextId="10104">
                <text>Emerging Infectious Diseases</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Centers for Disease Control and Prevention</text>
              </elementText>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="10106">
                <text>Infectious and parasitic diseases, Medicine</text>
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            </elementTextContainer>
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            <name>Language</name>
            <description>A language of the resource</description>
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                <text>EN</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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                <text>Acute Motor Axonal Neuropathy Related to COVID-19 Infection: A New Diagnostic Overview.</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="70706">
                <text>Cristina Petrelli, Roberto Scendoni, Marco Paglioriti, Francesco Ottavio Logullo</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2020</text>
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            <name>Identifier</name>
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                <text>10.1097/CND.0000000000000322</text>
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            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="70709">
                <text>Journal of clinical neuromuscular disease</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              </elementTextContainer>
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              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
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                <text>Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children</text>
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            <name>Creator</name>
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              <elementText elementTextId="33443">
                <text>Michael Levy, Marianne Leruez-Ville, Florence Moulin, Sylvain Renolleau, Pierre Quartier, Pierre-Louis Léger, Sandrine Jean, Matthieu Bendavid, Mehdi Oualha, Diala Khraiche, Guillaume Geslain, Marion Grimaud, Julie Starck, Clémence Marais, Judith Chareyre, Nada Semaan, Géraldine Poncelet</text>
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                <text>Abstract Background A recent increase in children admitted with hypotensive shock and fever in the context of the COVID-19 outbreak requires an urgent characterization and assessment of the involvement of SARS-CoV-2 infection. This is a case series performed at 4 academic tertiary care centers in Paris of all the children admitted to the pediatric intensive care unit (PICU) with shock, fever and suspected SARS-CoV-2 infection between April 15th and April 27th, 2020. Results 20 critically ill children admitted for shock had an acute myocarditis (left ventricular ejection fraction, 35% (25–55); troponin, 269 ng/mL (31–4607)), and arterial hypotension with mainly vasoplegic clinical presentation. The first symptoms before PICU admission were intense abdominal pain and fever for 6 days (1–10). All children had highly elevated C-reactive protein (&gt; 94 mg/L) and procalcitonin (&gt; 1.6 ng/mL) without microbial cause. At least one feature of Kawasaki disease was found in all children (fever, n = 20, skin rash, n = 10; conjunctivitis, n = 6; cheilitis, n = 5; adenitis, n = 2), but none had the typical form. SARS-CoV-2 PCR and serology were positive for 10 and 15 children, respectively. One child had both negative SARS-CoV-2 PCR and serology, but had a typical SARS-CoV-2 chest tomography scan. All children but one needed an inotropic/vasoactive drug support (epinephrine, n = 12; milrinone, n = 10; dobutamine, n = 6, norepinephrine, n = 4) and 8 were intubated. All children received intravenous immunoglobulin (2 g per kilogram) with adjuvant corticosteroids (n = 2), IL 1 receptor antagonist (n = 1) or a monoclonal antibody against IL-6 receptor (n = 1). All children survived and were afebrile with a full left ventricular function recovery at PICU discharge. Conclusions Acute myocarditis with intense systemic inflammation and atypical Kawasaki disease is an emerging severe pediatric disease following SARS-CoV-2 infection. Early recognition of this disease is needed and referral to an expert center is recommended. A delayed and inappropriate host immunological response is suspected. While underlying mechanisms remain unclear, further investigations are required to target an optimal treatment.</text>
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                <text>2020</text>
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            <name>Subject</name>
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                <text>Children, Shock, Acute myocarditis, SARS-CoV-2, Multisystem inflammatory syndrome</text>
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            <name>Identifier</name>
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              <elementText elementTextId="33447">
                <text>DOI: 10.1186/s13613-020-00690-8</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Annals of Intensive Care</text>
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                <text>SpringerOpen</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="33450">
                <text>Medical emergencies. Critical care. Intensive care. First aid</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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            <name>Title</name>
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                <text>Acute myocarditis as the main clinical manifestation of SARS-CoV 2 infection: A case report</text>
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          <element elementId="39">
            <name>Creator</name>
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              <elementText elementTextId="23372">
                <text>Alessandro Raimondi, Cristina Mussini, Giovanni Guaraldi, Guido Ligabue, Federica Carli, Marianna Menozzi, Gianluca Cuomo, Margherita Digaetano, Letizia Reggianini</text>
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                <text>We describe a case of acute myocarditis which was reported as the main COVID-19 clinical manifes-tation, with a favorable outcome. In addition to symptoms, laboratory tests (BNP and troponin), echo-cardiogram and cardiac MRI contributed to diagnosis. Regardless heart biopsy was not obtained, it is likely an immunological pathogenesis of this condition which pave the way to further therapeutic im-plications, since there are currently no standardized treatments.</text>
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                <text>2020</text>
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                <text>myocarditis, coronavirus, SARS-CoV-2, COVID-19, COVID-19 Extrapulmonary Manifestations</text>
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                <text>DOI: 10.4081/idr.2020.8609</text>
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                <text>Infectious Disease Reports</text>
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                <text>PAGEPress Publications</text>
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                <text>Other systems of medicine</text>
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              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="80263">
                <text>Acute Necrotizing Encephalopathy Associated With SARS-CoV-2 Exposure in a Pediatric Patient.</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="80264">
                <text>Claudia Lazarte-Rantes, Julissa Guevara-Castañón, Lelia Romero, Daniel Guillén-Pinto</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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                <text>We present the case of a nine-month-old male child with three days of fever, irritability, left focal seizure, and febrile focal status epilepticus. He had no history of previous comorbidities. A lumbar puncture was performed, which showed cerebrospinal fluid (CSF) leukocytosis; protein and glucose were normal, and the polymerase chain reaction (PCR) panel for 14 pathogens in CSF was negative. Immunoglobulin G (IgG) qualitative and quantitative tests were positive for coronavirus disease 2019 (COVID-19) upon arrival. An MRI performed one week after the initial onset showed findings suggestive of acute necrotizing encephalopathy (ANE). The patient required mechanical ventilation. However, his symptoms did not improve and follow-up imaging two weeks later showed progression of the disease with hemorrhagic changes. To our knowledge, this is the first reported case of ANE associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-​2) infection in a pediatric patient.</text>
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            <name>Date</name>
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                <text>2021</text>
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          <element elementId="49">
            <name>Subject</name>
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                <text>child, covid-19, SARS-CoV-2, Acute necrotizing encephalitis</text>
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            <name>Identifier</name>
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              <elementText elementTextId="80268">
                <text>10.7759/cureus.15018</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="80269">
                <text>Cureus</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
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